Standard name
Human Ortholog
Description Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0 0.05 0.1 0.1 0.07 0.14 0.12 0.18 0.13 0 0 0 0.08 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0.05 0.08 0.1 0.11 0.09 0.05 0.09 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0.1 0.05 0 0 0 0 0 0 0 0 0 0.1 0.14 0.17 0 0 0 0 0 0
Mitochondria 0.1 0 0.16 0.26 0.13 0.3 0.42 0.46 0.52 0.52 0.56 0.6 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.11 0.11 0.05 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0.06 0 0.05 0 0
Nuclear Periphery 0.1 0.29 0.16 0.36 0.16 0.21 0.27 0.14 0.13 0.1 0 0.12 0.05 0.2 0.21 0.17 0.26 0.24 0 0.08 0.09 0.05 0 0
Nucleolus 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.83 0.79 0.78 0.72 0.72 0.53 0.42 0.41 0.36 0.35 0.37 0.33 0.91 0.91 0.91 0.83 0.8 0.86 0.9 0.84 0.8 0.84 0.87 0.89
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 1 3 9 4 6 1 4 0 0 0 0 1 0 0 0 0 0 0 0
Bud 0 0 0 0 0 2 1 0 1 1 4 4 0 0 0 0 0 1 0 0 0 0 1 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 1 0 7 17 15 22 26 10 30 0 2 2 10 7 7 0 0 0 0 0 0
Cytoplasm 0 0 6 12 20 50 62 44 75 71 70 79 17 6 13 26 14 18 0 0 0 0 0 2
Endoplasmic Reticulum 0 0 0 0 10 24 51 59 57 53 18 55 0 1 1 14 7 15 0 0 1 0 0 0
Endosome 0 0 0 0 4 1 2 3 1 0 3 1 0 1 4 1 1 1 0 0 0 0 1 5
Golgi 2 0 2 7 41 24 26 14 4 6 2 5 18 2 6 30 30 52 0 0 0 0 1 1
Mitochondria 10 0 20 107 56 151 265 281 279 309 215 372 12 12 6 7 8 8 1 0 5 0 5 0
Nucleus 11 3 7 4 10 18 16 11 4 12 3 5 40 10 19 5 5 7 3 3 5 3 15 21
Nuclear Periphery 10 8 20 146 67 104 168 86 67 62 16 72 36 102 135 54 57 71 4 4 12 3 14 14
Nucleolus 5 1 2 17 15 10 5 7 1 4 2 4 4 16 18 4 4 2 0 0 0 1 6 3
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 83 22 100 291 303 266 265 252 195 209 142 206 611 464 580 261 176 258 98 45 115 65 332 476
Unique Cell Count 100 28 129 405 419 498 631 612 535 594 383 620 672 510 639 313 221 301 110 54 145 79 381 533
Labelled Cell Count 121 34 158 585 526 658 881 782 710 760 486 839 738 616 784 412 310 440 110 54 145 79 381 533


Vacuole Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.9 19.7 9.3 13.1 12.8 10.1 8.9 8.7 8.3 8.5 8.0 7.7 17.8 17.5 16.5 25.1 23.7 24.2 13.6 17.5 18.1
Std Deviation (1e-4) 3.4 4.5 2.7 3.0 3.0 2.7 2.2 1.9 2.1 2.0 1.9 1.8 4.6 4.2 4.1 8.6 7.5 8.3 3.7 4.8 5.0
Intensity Change (Log2) – – – 0.49 0.46 0.12 -0.06 -0.1 -0.17 -0.13 -0.22 -0.28 0.93 0.91 0.82 1.43 1.35 1.38 0.54 0.91 0.96


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 2.5 0 0 0 0 0 0
Cytoplasm 0 0.1 1.9 1.9 1.0 2.9 2.4 3.8 2.6 0 0 0 1.3 0.7 0.6
Endoplasmic Reticulum 0 0 0 3.3 3.7 3.9 3.5 0 3.5 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 3.0 1.7 0 0 0 0 0 0 0 0 0 3.0 3.8 4.5
Mitochondria 2.5 -0.6 3.4 5.7 6.4 7.5 7.5 8.0 9.2 -7.3 -6.1 0 -5.3 -4.0 -4.9
Nucleus 0 0 -0.9 0 0 0 0 0 0 0.2 0 0 0 0 0
Nuclear Periphery 4.4 0.1 1.4 2.7 -0.4 -0.9 -1.6 -4.4 -1.2 -4.1 1.2 1.5 0.4 2.2 1.9
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.3 -1.2 -4.9 -7.4 -7.5 -8.4 -8.8 -8.0 -9.3 4.4 4.2 4.3 1.4 0.5 2.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 12.1143 16.1032 13.3896 13.6387 12.095 13.9792 12.8958 17.3359 14.2042 13.7962 13.0046 14.2637 13.5887 20.2332 17.149 17.7408 15.8504 17.5397
Actin 0.0119 0.0006 0.0171 0.0088 0.0005 0.0007 0.0002 0 0.0059 0.0003 0.0001 0.0019 0.028 0 0.0066 0 0.0005 0
Bud 0.0002 0.0001 0.0002 0.0002 0 0 0.0001 0 0.0018 0.0013 0.0002 0.0005 0.0007 0 0.0021 0 0 0.0027
Bud Neck 0.0008 0 0.0006 0.0046 0 0.0001 0 0 0.0001 0.0001 0 0.0006 0.0029 0 0.0005 0 0 0
Bud Periphery 0.0003 0.0002 0.0004 0.0002 0.0001 0.0001 0.0003 0.0001 0.0051 0.004 0.0005 0.0016 0.0013 0.0001 0.0015 0.0001 0.0001 0.0017
Bud Site 0.0009 0.0002 0.0013 0.0037 0.0001 0.0001 0.0001 0 0.0006 0.0083 0.0003 0.0015 0.0067 0 0.0139 0 0.0001 0.0002
Cell Periphery 0.0008 0.0005 0.0009 0.0002 0.0002 0.0003 0.0007 0.0003 0.0006 0.0005 0.0001 0.0009 0.0034 0.0004 0.0009 0.0003 0.0003 0.0003
Cytoplasm 0.003 0 0.0019 0.0027 0.0001 0.0003 0.0019 0 0.0056 0.003 0.0017 0.0003 0.0034 0.0001 0.0013 0 0.0005 0.001
Cytoplasmic Foci 0.0103 0.0004 0.0062 0.0112 0.0016 0.0013 0.0003 0 0.0058 0.0059 0.0021 0.0012 0.0134 0 0.0146 0 0.0614 0.0002
Eisosomes 0.0002 0 0.0002 0.0001 0 0 0 0 0 0 0 0.0004 0.0012 0 0 0 0 0
Endoplasmic Reticulum 0.0019 0.0001 0.0016 0.0005 0.0003 0.0004 0.0031 0.0002 0.0012 0.0009 0.0015 0.0008 0.0028 0.0001 0.0004 0.0001 0.0002 0.0001
Endosome 0.0155 0.0023 0.0065 0.006 0.0076 0.0045 0.0185 0.0014 0.0144 0.0152 0.0628 0.0053 0.0141 0.002 0.0129 0.0012 0.0139 0.0014
Golgi 0.0037 0.0015 0.0034 0.0024 0.0018 0.0009 0.0007 0.0001 0.0087 0.0012 0.0025 0.0014 0.0045 0.0001 0.0021 0 0.0034 0.0002
Lipid Particles 0.0135 0.0012 0.0097 0.0111 0.0173 0.002 0.0008 0.0002 0.0021 0.0019 0.0013 0.0056 0.0086 0.0003 0.0033 0.0005 0.0448 0.0058
Mitochondria 0.0085 0.0024 0.0144 0.0052 0.0062 0.0145 0.0022 0.0154 0.0114 0.0025 0.0105 0.0292 0.0303 0.0064 0.0049 0.0006 0.0003 0.0053
None 0.0047 0 0.0036 0.0034 0.0003 0.0003 0.0002 0 0.002 0.0019 0.0003 0.0007 0.0024 0 0.0007 0 0.0005 0
Nuclear Periphery 0.0157 0.006 0.0064 0.0029 0.0056 0.0203 0.0125 0.0173 0.0153 0.0231 0.0123 0.0253 0.0105 0.0073 0.018 0.0141 0.002 0.0207
Nucleolus 0.0078 0.0003 0.001 0.0008 0.0007 0.0033 0.0004 0.0002 0.0006 0.0014 0.0001 0.0071 0.002 0.0085 0.0008 0.0003 0.0001 0.0008
Nucleus 0.0026 0.0004 0.001 0.0008 0.0006 0.0024 0.0012 0.0003 0.0066 0.0028 0.001 0.0052 0.0041 0.0015 0.0013 0.0004 0.0002 0.0019
Peroxisomes 0.0083 0.0003 0.0103 0.01 0.0026 0.0004 0 0 0.0007 0.0008 0.0002 0.002 0.0099 0 0.0152 0 0.0152 0.0001
Punctate Nuclear 0.004 0.0002 0.0027 0.0088 0.0012 0.0014 0 0 0.0004 0.0012 0.0001 0.0011 0.0055 0 0.0052 0 0.0025 0
Vacuole 0.1795 0.1877 0.1671 0.1655 0.1192 0.0886 0.2113 0.1596 0.1458 0.1645 0.0977 0.0939 0.2442 0.2316 0.2174 0.1919 0.1831 0.1169
Vacuole Periphery 0.706 0.7955 0.7434 0.7511 0.8339 0.8581 0.7452 0.805 0.7654 0.7592 0.8047 0.8136 0.5999 0.7413 0.6764 0.7903 0.6707 0.8408

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 86.3072 76.7577 81.6196 84.846 68.2883 74.3158 75.4094 81.0695 70.8582 88.1467
Translational Efficiency 0.4617 0.4628 0.4621 0.3539 0.3951 0.4569 0.4041 0.2928 0.4232 0.3853

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
17 883 1014 653 1049 664 140 1145 1066 1547 1154 1798

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1350.47 1478.78 1503.18 1536.54 1033.80 1431.20 1472.25 1505.92 1038.85 1458.36 1499.43 1517.04
Standard Deviation 282.54 338.21 315.47 320.69 251.28 323.35 265.87 295.93 254.92 332.75 310.04 305.51
Intensity Change Log 2 — 0.130946 0.154556 0.186224 — 0.469268 0.510066 0.542688 — 0.287462 0.319551 0.351691

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000304 0.000044 0.000087 0.000201 0.000053 0.000079 0.000051 0.000109 0.000057 0.000059 0.000082 0.000142
Bud Neck 0.004524 0.000148 0.001400 0.001492 0.000362 0.000233 0.001548 0.000783 0.000428 0.000185 0.001418 0.001040
Bud Site 0.002622 0.000823 0.003101 0.001952 0.005713 0.000911 0.001051 0.002361 0.005664 0.000861 0.002852 0.002213
Cell Periphery 0.000108 0.000999 0.000442 0.000812 0.001236 0.000468 0.000207 0.001147 0.001218 0.000771 0.000414 0.001025
Cytoplasm 0.009558 0.001502 0.000437 0.000212 0.007352 0.001181 0.000329 0.000340 0.007387 0.001364 0.000423 0.000293
Cytoplasmic Foci 0.018869 0.000467 0.001543 0.000678 0.001124 0.000612 0.000770 0.002140 0.001407 0.000529 0.001449 0.001609
Eisosomes 0.000033 0.000006 0.000043 0.000045 0.000004 0.000007 0.000012 0.000023 0.000005 0.000006 0.000039 0.000031
Endoplasmic Reticulum 0.004589 0.000450 0.000175 0.000428 0.000817 0.000571 0.000295 0.000464 0.000877 0.000502 0.000190 0.000451
Endosome 0.014250 0.000846 0.002476 0.004284 0.005061 0.001322 0.003288 0.006452 0.005207 0.001051 0.002575 0.005665
Golgi 0.006356 0.000784 0.002642 0.003428 0.002513 0.001832 0.010696 0.012905 0.002575 0.001234 0.003619 0.009464
Lipid Particles 0.025430 0.000329 0.000701 0.000735 0.000159 0.000569 0.000285 0.001138 0.000562 0.000432 0.000651 0.000992
Mitochondria 0.013449 0.003800 0.018841 0.010181 0.002861 0.006722 0.003376 0.014178 0.003030 0.005054 0.016965 0.012726
Mitotic Spindle 0.001131 0.000162 0.000869 0.000297 0.000035 0.000097 0.001456 0.000316 0.000053 0.000134 0.000941 0.000309
None 0.000197 0.000339 0.000705 0.000461 0.000761 0.000400 0.000118 0.000392 0.000752 0.000365 0.000633 0.000417
Nuclear Periphery 0.003073 0.000688 0.001815 0.004908 0.000189 0.000589 0.011556 0.001177 0.000235 0.000646 0.002997 0.002532
Nuclear Periphery Foci 0.003684 0.000763 0.000885 0.002254 0.000175 0.000588 0.003605 0.000735 0.000231 0.000688 0.001215 0.001286
Nucleolus 0.006383 0.000716 0.004952 0.010100 0.000727 0.001324 0.003393 0.001574 0.000817 0.000977 0.004763 0.004670
Nucleus 0.005864 0.000954 0.002032 0.003385 0.001595 0.001049 0.001310 0.000381 0.001663 0.000995 0.001945 0.001472
Peroxisomes 0.004805 0.000080 0.000490 0.000231 0.000308 0.000253 0.000141 0.000159 0.000380 0.000154 0.000448 0.000185
Vacuole 0.448547* 0.112567 0.247922* 0.300729* 0.120103 0.150006 0.359774* 0.352016* 0.125341 0.128637 0.261491* 0.333390*
Vacuole Periphery 0.426223* 0.873532* 0.708442* 0.653186* 0.848851* 0.831187* 0.596739* 0.601208* 0.842111* 0.855357* 0.694891* 0.620085*

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.35 1.11 0.48 -1.73 -1.23 -0.81 0.09 -1.79 -0.68 -1.64 -0.11 -1.50 -2.17 -2.05 -1.43
Bud Neck 1.22 0.86 0.83 -6.22 -0.29 1.06 -2.63 -2.46 -3.82 1.69 1.94 -3.64 -3.73 -7.18 1.40
Bud Site 1.37 -0.30 0.46 -1.98 1.04 3.44 3.35 2.28 -2.21 -2.05 3.55 1.75 2.45 -2.95 0.70
Cell Periphery -4.63 -4.57 -2.36 0.54 -1.23 3.51 4.82 0.28 -2.56 -3.60 1.93 3.85 0.69 -1.14 -3.05
Cytoplasm 1.44 1.64 1.68 1.20 0.95 3.23 3.98 3.98 1.02 0.04 3.27 4.03 4.09 1.52 0.62
Cytoplasmic Foci 1.96 1.85 1.94 -1.26 2.61 1.46 0.98 -1.61 -2.56 -2.28 2.55 -0.13 -0.41 -2.86 -0.32
Eisosomes 1.32 -0.43 -0.53 -3.71 -0.26 -1.84 -2.44 -7.47 -6.08 -3.01 -1.54 -8.15 -6.30 -5.89 1.30
Endoplasmic Reticulum 1.31 1.40 1.32 0.08 -2.43 0.75 4.48 2.98 0.34 -1.97 1.97 5.77 3.44 0.30 -3.94
Endosome 2.97 2.58 2.12 -2.79 -1.36 3.59 1.19 -0.97 -4.70 -2.14 4.18 2.38 -0.38 -5.64 -3.28
Golgi 2.01 1.31 1.00 -2.99 -0.75 0.66 -1.80 -5.26 -5.76 -0.46 1.61 -1.01 -4.81 -6.66 -4.16
Lipid Particles 1.00 0.99 0.99 -4.43 -0.33 -1.62 -1.89 -8.67 -2.06 -6.84 0.31 -0.23 -1.05 -4.16 -3.74
Mitochondria 0.88 -0.48 0.29 -2.85 2.82 -2.00 -0.25 -5.02 -2.87 -4.04 -1.53 -6.25 -5.37 -4.49 1.71
Mitotic Spindle 1.45 0.28 1.23 -0.89 0.96 -1.90 -1.44 -3.95 -2.82 1.18 -1.55 -1.72 -3.93 -2.14 1.23
None -0.83 -3.14 -1.65 -1.33 3.28 1.49 2.94 1.67 0.07 -5.83 1.74 0.54 1.55 -0.72 3.75
Nuclear Periphery 1.27 0.66 -0.87 -4.14 -2.93 -2.44 -2.44 -6.85 -2.78 2.22 -3.64 -4.37 -6.01 -4.80 0.64
Nuclear Periphery Foci 1.50 1.46 0.73 -2.77 -3.13 -1.85 -3.82 -6.41 -0.63 3.19 -2.08 -6.23 -6.11 -2.25 -0.30
Nucleolus 0.96 0.24 -0.61 -5.27 -2.59 -0.94 -3.21 -2.00 -0.35 2.19 -0.43 -4.71 -5.20 -5.04 0.10
Nucleus 1.53 1.14 0.64 -2.38 -1.21 0.63 0.31 1.69 1.43 2.81 0.84 -0.41 0.03 -1.19 0.53
Peroxisomes 1.55 1.42 1.50 -3.20 2.35 0.27 1.21 1.12 0.62 -0.30 1.49 -0.44 1.40 -0.44 2.76
Vacuole 4.81 2.88 2.12 -19.18 -4.96 -3.48 -11.89 -27.86 -20.68 0.43 -0.49 -16.86 -28.31 -30.31 -8.70
Vacuole Periphery -5.82 -3.67 -2.94 19.62 4.48 1.69 11.49 24.81 21.04 -0.28 -1.60 14.63 24.50 30.97* 7.86
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication
Localization
Cell Percentages vacuolar membrane (84%)
Cell Cycle Regulation No
Subcompartmental Group vac memb-2

Ybt1

Ybt1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ybt1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available