Standard name
Human Ortholog
Description Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.12 0.2 0.31 0.27 0.79 0.73 0.76 0.72 0.52 0.51 0.44 0.47 0.28 0.59 0.84 0.47 0.27 0.33 0.05 0.09 0.1 0.12 0.17 0.29
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.06 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.05 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.11 0.16 0.05 0.14 0.13 0.22 0.21 0.19 0.63 0.43 0.59 0.52 0 0 0 0.09 0.07 0 0 0 0 0 0.05 0.05
Nucleus 0.65 0.62 0.52 0.59 0.06 0.08 0.06 0.07 0.1 0.16 0.18 0.18 0.67 0.28 0.05 0.18 0.49 0.44 0.63 0.61 0.51 0.48 0.27 0.15
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07
Vac/Vac Membrane 0.24 0.15 0.15 0.1 0.06 0.1 0 0.05 0 0.05 0 0 0.09 0.17 0.14 0.3 0.22 0.22 0.22 0.21 0.24 0.26 0.31 0.32
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 0 1 4 1 0 0 1
Bud 0 0 0 1 2 1 2 4 4 8 4 3 0 0 0 0 1 0 3 5 2 2 4 5
Bud Neck 0 0 1 2 7 7 5 15 2 8 3 3 1 0 0 0 0 0 0 1 1 0 2 3
Bud Site 0 0 0 1 0 1 0 0 9 4 6 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 0 0 0 0 0 0 0 0 3 0 0 0 0 1 0 1 0 0 0 0 0 0
Cytoplasm 34 102 52 53 168 231 314 247 179 197 173 205 49 110 163 257 98 117 16 52 23 22 39 78
Endoplasmic Reticulum 1 4 2 0 0 0 0 0 0 0 0 1 0 1 0 48 22 28 1 1 1 0 2 2
Endosome 1 0 5 2 0 0 6 2 0 1 0 1 1 3 4 26 18 19 3 7 2 0 7 8
Golgi 1 1 1 0 1 0 0 0 0 0 0 0 0 0 0 2 0 2 2 2 1 0 1 0
Mitochondria 31 85 9 27 27 70 86 64 220 166 235 225 0 1 2 51 24 4 5 12 5 3 10 12
Nucleus 185 323 88 115 13 25 26 23 33 61 73 80 116 52 10 100 180 156 208 374 121 86 61 41
Nuclear Periphery 0 0 0 0 0 0 1 0 0 0 0 2 0 0 0 0 1 0 0 0 0 1 1 1
Nucleolus 0 0 0 0 0 0 1 0 1 1 1 1 0 0 0 1 0 1 0 0 0 3 6 4
Peroxisomes 0 0 0 0 0 1 0 0 0 1 0 0 0 0 2 1 0 0 0 1 1 0 0 0
SpindlePole 0 1 1 5 1 2 8 10 4 10 1 8 1 0 0 4 1 3 12 12 8 5 9 17
Vac/Vac Membrane 67 79 26 20 13 30 14 16 6 18 5 15 15 32 27 161 82 79 70 129 56 47 72 87
Unique Cell Count 283 520 169 196 213 315 412 343 347 386 396 435 174 186 194 542 368 357 329 615 239 179 230 274
Labelled Cell Count 321 596 185 226 233 368 463 381 459 475 504 548 183 199 208 652 427 410 329 615 239 179 230 274


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.7 4.0 5.3 4.9 4.3 4.0 4.1 4.3 3.2 3.7 3.3 3.6 5.2 4.9 4.8 5.0 6.0 6.6 6.2 6.7 6.3
Std Deviation (1e-4) 1.0 0.5 1.3 1.5 1.6 1.0 1.7 1.3 0.9 1.1 0.9 1.1 1.3 1.1 1.4 1.8 2.0 2.2 3.0 4.0 3.1
Intensity Change (Log2) – – – -0.11 -0.3 -0.41 -0.34 -0.29 -0.73 -0.51 -0.66 -0.54 -0.01 -0.12 -0.14 -0.07 0.19 0.33 0.23 0.36 0.26

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.7 1.9 1.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.9525 3.4342 3.6964 2.5938 4.0337 3.4563 6.4927 6.7073 6.4822 6.8443 6.1945 6.5071 4.2658 4.1467 4.1655 3.8432 4.268 3.8376
Actin 0.0343 0.0002 0.0207 0.021 0.0506 0.0066 0.0346 0.0001 0.0235 0.0049 0.0108 0.0071 0.0297 0.0002 0.0085 0.0104 0.002 0.0007
Bud 0.0005 0.0001 0.0004 0.0001 0.0007 0.0001 0.0012 0.0001 0.0003 0.0021 0.0002 0.0003 0.0005 0.0001 0.0001 0.0001 0.0009 0.0001
Bud Neck 0.0028 0.0004 0.0007 0.0002 0.0024 0.0023 0.0004 0.0002 0.0052 0.0192 0.0012 0.0013 0.0086 0.0003 0.0011 0.0002 0.0006 0.0018
Bud Periphery 0.0019 0.0002 0.0011 0.0001 0.0014 0.0004 0.0025 0.0001 0.0005 0.0086 0.0001 0.0001 0.0009 0.0003 0.0001 0.0001 0.0011 0.0004
Bud Site 0.0038 0.0011 0.0017 0.0003 0.0126 0.0022 0.0012 0.0004 0.0021 0.0124 0.0007 0.0002 0.0039 0.0002 0.0014 0.0002 0.0014 0.0003
Cell Periphery 0.0024 0.0001 0.0004 0 0.0005 0.0002 0.0002 0 0.0002 0.0019 0.0001 0 0.0002 0 0.0001 0 0.0002 0
Cytoplasm 0.0145 0.0018 0.0052 0.0008 0.0072 0.0047 0.0015 0.0098 0.0026 0.0019 0.0184 0.0061 0.0084 0.0036 0.012 0.0038 0.0258 0.0008
Cytoplasmic Foci 0.0149 0.0007 0.0039 0.0066 0.0251 0.0018 0.0014 0.0002 0.0064 0.0002 0.0043 0.004 0.0202 0.0002 0.0043 0.0025 0.0104 0.0026
Eisosomes 0.0004 0 0.0005 0.0001 0.0013 0.0001 0.0004 0 0.0001 0.0003 0 0 0.0003 0 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0044 0.0002 0.0035 0.0002 0.0027 0.001 0.0063 0.0007 0.0017 0.0007 0.0067 0.0002 0.0034 0.0024 0.0009 0.0004 0.0102 0.0002
Endosome 0.0179 0.002 0.0093 0.0011 0.0485 0.0077 0.0114 0.0014 0.0033 0.0013 0.0141 0.0012 0.0302 0.0018 0.0057 0.0027 0.0452 0.001
Golgi 0.0065 0.0004 0.0054 0.0017 0.0463 0.003 0.0035 0 0.0027 0.0004 0.0022 0.001 0.0073 0.0001 0.0027 0.0015 0.0033 0.0005
Lipid Particles 0.037 0.0005 0.0042 0.0102 0.0498 0.0035 0.0036 0 0.0007 0.0002 0.0014 0.0067 0.0156 0.0001 0.0043 0.0044 0.0088 0.0005
Mitochondria 0.0143 0.0055 0.014 0.0012 0.0304 0.0025 0.0058 0.0004 0.0009 0.0075 0.0018 0.0005 0.0041 0.0007 0.004 0.0009 0.0076 0.0004
None 0.0159 0.0006 0.0041 0.0005 0.0104 0.0117 0.003 0.0088 0.0015 0.0009 0.003 0.0011 0.002 0.0079 0.0055 0.0099 0.075 0.0003
Nuclear Periphery 0.0365 0.0096 0.0104 0.0029 0.0178 0.0022 0.0261 0.0117 0.0127 0.0105 0.0179 0.0019 0.0436 0.008 0.0089 0.0044 0.0222 0.0015
Nucleolus 0.0132 0.0291 0.0157 0.0122 0.0146 0.032 0.0055 0.0123 0.0153 0.0289 0.013 0.0293 0.0185 0.0126 0.012 0.0149 0.0085 0.0338
Nucleus 0.7399 0.9424 0.8803 0.9294 0.6265 0.9115 0.8471 0.9476 0.8866 0.8913 0.8859 0.9302 0.7672 0.9569 0.9163 0.9355 0.7547 0.9493
Peroxisomes 0.0117 0.0007 0.0074 0.0098 0.0125 0.0008 0.0008 0 0.012 0.0003 0.0007 0.0027 0.0137 0 0.0057 0.0045 0.001 0.0011
Punctate Nuclear 0.0139 0.0028 0.0087 0.0012 0.0306 0.0022 0.0387 0.0027 0.0195 0.0019 0.016 0.0053 0.015 0.0027 0.0056 0.0034 0.0079 0.0042
Vacuole 0.0098 0.0013 0.0015 0.0002 0.0033 0.003 0.0016 0.003 0.0017 0.0037 0.0011 0.0005 0.0041 0.0013 0.0005 0.0002 0.0077 0.0005
Vacuole Periphery 0.0034 0.0004 0.0008 0.0001 0.0048 0.0006 0.0033 0.0005 0.0006 0.0008 0.0005 0.0002 0.0027 0.0005 0.0003 0.0002 0.0055 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 55.4221 39.41 49.2969 36.6084 31.0293 39.0258 42.6937 34.9626 30.4839 36.2957
Translational Efficiency 1.5047 2.4104 1.564 1.6493 1.985 1.5668 1.4604 1.5818 1.6162 1.6674

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
119 680 2140 1494 1794 1757 2872 1558 1913 2437 5012 3052

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 581.28 778.64 818.01 877.32 677.20 831.54 870.73 885.59 671.23 816.78 848.22 881.54
Standard Deviation 52.16 108.35 102.74 136.58 86.15 103.41 116.57 124.83 87.56 107.46 113.90 130.78
Intensity Change Log 2 — 0.421723 0.492885 0.593870 — 0.296204 0.362643 0.387057 — 0.355540 0.424265 0.486277

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000081 0.000397 0.000301 0.000625 0.000019 0.000328 0.000258 0.000522 0.000023 0.000347 0.000277 0.000573
Bud Neck 0.015035 0.009824 0.010981 0.024941 0.002018 0.006829 0.015800 0.016319 0.002828 0.007664 0.013742 0.020540
Bud Site 0.002374 0.003147 0.003731 0.008906 0.000625 0.004858 0.001096 0.003121 0.000734 0.004381 0.002221 0.005953
Cell Periphery 0.000295 0.000224 0.000102 0.000223 0.000093 0.000254 0.000125 0.000187 0.000105 0.000246 0.000115 0.000205
Cytoplasm 0.300103 0.078480 0.014420 0.025212 0.116034 0.064295 0.003485 0.016755 0.127484 0.068253 0.008154 0.020895
Cytoplasmic Foci 0.217706 0.018403 0.000430 0.003368 0.008116 0.008716 0.000083 0.000998 0.021154 0.011419 0.000231 0.002158
Eisosomes 0.000157 0.000036 0.000018 0.000024 0.000013 0.000027 0.000021 0.000021 0.000022 0.000030 0.000020 0.000022
Endoplasmic Reticulum 0.000443 0.006921 0.004393 0.006320 0.000899 0.002882 0.005429 0.006831 0.000871 0.004009 0.004987 0.006581
Endosome 0.002618 0.002287 0.001442 0.003709 0.000401 0.002459 0.000375 0.001475 0.000539 0.002411 0.000831 0.002569
Golgi 0.001265 0.000968 0.000180 0.001569 0.000382 0.000559 0.000031 0.000718 0.000437 0.000673 0.000095 0.001135
Lipid Particles 0.022030 0.002851 0.000221 0.000310 0.000886 0.002326 0.000056 0.000254 0.002201 0.002472 0.000126 0.000281
Mitochondria 0.021573 0.003161 0.001011 0.003910 0.001962 0.006439 0.000814 0.001400 0.003182 0.005524 0.000898 0.002628
Mitotic Spindle 0.000180 0.008457 0.002341 0.031794 0.000808 0.005252 0.001727 0.006238 0.000769 0.006146 0.001989 0.018748
None 0.014309 0.005046 0.004688 0.006235 0.005616 0.011401 0.002175 0.005980 0.006156 0.009627 0.003248 0.006105
Nuclear Periphery 0.000950 0.002190 0.000936 0.003478 0.001784 0.001971 0.000991 0.001079 0.001732 0.002032 0.000968 0.002253
Nuclear Periphery Foci 0.000252 0.001713 0.000132 0.001413 0.000073 0.000314 0.000089 0.000197 0.000084 0.000704 0.000107 0.000793
Nucleolus 0.004057 0.003945 0.002015 0.003523 0.001408 0.005048 0.001514 0.001816 0.001572 0.004740 0.001728 0.002651
Nucleus 0.373588 0.839960 0.948016 0.856419 0.856133 0.863954 0.964183 0.930943 0.826116 0.857259 0.957280 0.894462
Peroxisomes 0.014060 0.003461 0.000163 0.000465 0.000335 0.002779 0.000037 0.000126 0.001189 0.002970 0.000091 0.000292
Vacuole 0.008038 0.008030 0.004218 0.014241 0.002051 0.008365 0.001568 0.004266 0.002423 0.008272 0.002700 0.009149
Vacuole Periphery 0.000889 0.000500 0.000261 0.003313 0.000344 0.000944 0.000144 0.000754 0.000378 0.000820 0.000194 0.002006

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.83 -4.97 -13.05 -6.13 -7.59 -3.47 -19.52 -10.35 -2.39 -5.21 -4.96 -14.83 -19.88 -4.66 -9.46
Bud Neck 0.72 0.42 -2.15 -7.79 -8.22 -4.75 -15.83 -13.37 -8.18 -1.49 -5.08 -14.80 -17.88 -12.09 -6.96
Bud Site -0.95 -1.33 -4.85 -4.56 -3.86 -4.08 -2.11 -4.87 1.16 -3.97 -4.75 -4.22 -8.63 -1.59 -5.62
Cell Periphery 0.89 3.47 1.53 0.32 -4.99 -4.29 -1.32 -2.83 2.27 -1.68 -4.41 -0.29 -4.58 1.91 -4.25
Cytoplasm 9.77 13.08 12.43 8.09 -5.92 9.43 26.07 21.53 12.52 -8.33 11.21 27.14 23.11 14.25 -10.34
Cytoplasmic Foci 9.90 10.92 10.79 6.06 -4.83 -0.59 9.46 8.16 8.78 -1.90 4.48 11.24 10.24 9.81 -5.17
Eisosomes 8.72 10.48 9.26 0.51 -8.42 -8.02 -6.26 -8.19 1.70 -2.32 -4.01 0.88 -4.83 0.34 -7.90
Endoplasmic Reticulum -10.67 -14.34 -20.18 -2.08 -7.43 -5.68 -19.64 -17.04 -8.91 -4.14 -10.00 -21.28 -24.44 -9.60 -8.26
Endosome 0.57 2.02 0.38 -0.19 -1.73 -5.35 0.70 -1.70 2.56 -1.93 -5.98 -0.79 -3.79 1.76 -2.80
Golgi 0.55 2.84 1.03 0.50 -2.41 -0.62 1.44 -0.29 0.15 -1.42 -0.92 1.50 -0.70 0.12 -2.66
Lipid Particles 3.44 3.91 3.88 4.84 -3.24 -5.09 8.31 5.54 7.51 -3.81 -0.70 5.44 4.88 8.80 -5.48
Mitochondria 1.90 2.13 1.85 -0.62 -6.54 -3.72 1.51 0.51 4.78 -5.56 -2.12 2.47 0.60 3.78 -7.98
Mitotic Spindle -2.87 -3.26 -8.63 -4.80 -7.75 -3.24 -1.45 -3.86 -1.08 -3.20 -4.11 -2.21 -9.05 -5.39 -8.32
None 1.81 1.96 1.77 -0.34 -1.40 -3.46 3.84 0.32 3.76 -3.73 -2.48 3.42 0.87 3.67 -4.03
Nuclear Periphery -2.95 -0.49 -7.01 -5.47 -8.65 -0.49 1.46 0.66 1.54 -2.29 -0.81 1.54 -3.42 -3.41 -8.79
Nuclear Periphery Foci -1.55 0.71 -5.47 0.07 -5.88 -4.44 -0.42 -3.69 1.53 -3.07 -2.36 -1.65 -6.76 -0.71 -6.37
Nucleolus 0.04 1.62 -1.42 -2.16 -4.93 -5.00 -0.11 -1.21 4.22 -1.40 -5.41 -0.44 -4.58 1.23 -5.13
Nucleus -16.32 -21.24 -16.87 -0.02 15.04 -0.77 -19.42 -10.12 -8.33 9.22 -3.83 -21.54 -7.89 -3.96 17.72
Peroxisomes 2.55 3.44 3.40 2.92 -1.63 -5.28 5.52 3.69 5.79 -3.13 -3.39 4.09 3.61 6.15 -2.71
Vacuole -0.51 2.00 -7.57 -7.57 -9.46 -5.84 0.05 -6.87 0.95 -7.04 -7.12 -2.41 -12.30 -5.75 -11.38
Vacuole Periphery 1.13 1.85 -1.46 -2.59 -3.11 -2.08 1.18 -0.71 1.11 -1.64 -1.90 1.12 -2.42 -0.95 -3.55
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress
Localization
Cell Percentages nucleus (84%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Cms1

Cms1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cms1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available