Standard name
Human Ortholog
Description Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 0.07 0 0.06 0.08 0.13 0.08 0.11 – 0.1 0.06 0.06 0.07 0.14 0.2 0.06 0 0.05 0 0 0 0 0 0
Endoplasmic Reticulum – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 0 0.63 0.31 0.52 0.72 0.79 0.63 – 0.66 0.78 0.79 0 0 0 0.08 0.07 0.06 0 0 0 0 0 0
Nucleus – 0.79 0.69 0.77 0.62 0.52 0.5 0.5 – 0.51 0.54 0.53 0.9 0.83 0.77 0.88 0.9 0.86 0.71 0.71 0.62 0.67 0.63 0.65
Nuclear Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0.07 0.07 0.1 0.07 0.07 0.07
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0.07 0 0 0 0 0 0 0 0.06 0 0.05 0
Vac/Vac Membrane – 0 0 0 0.05 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0.1 0.1 0.08 0.1 0.12 0.13
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Bud – 0 0 0 0 5 10 13 – 9 8 18 0 0 0 1 0 1 0 2 1 1 3 5
Bud Neck – 0 0 0 0 0 0 0 – 0 1 0 1 2 1 0 0 0 0 0 1 0 2 1
Bud Site – 0 1 0 2 15 22 9 – 15 22 21 0 0 0 0 0 1 – – – – – –
Cell Periphery – 0 0 0 0 0 0 1 – 0 0 1 2 0 0 0 2 0 0 0 0 0 0 0
Cytoplasm – 2 3 19 35 80 69 93 – 67 35 45 13 36 66 21 15 19 1 1 2 0 5 8
Endoplasmic Reticulum – 1 1 0 0 0 0 0 – 0 0 0 1 2 1 7 5 7 0 0 0 0 1 2
Endosome – 1 0 3 4 1 1 15 – 3 1 0 0 1 2 3 2 4 0 1 4 1 3 6
Golgi – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 1 61 99 220 443 648 539 – 452 431 569 6 6 3 29 30 21 0 0 2 0 4 3
Nucleus – 23 67 248 261 320 411 421 – 350 298 379 179 209 257 322 374 312 28 51 66 36 126 200
Nuclear Periphery – 0 0 1 0 2 2 3 – 1 3 3 0 0 0 1 2 3 0 0 0 0 0 0
Nucleolus – 1 2 10 7 8 9 24 – 14 7 18 0 0 0 15 15 17 2 5 10 3 14 20
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
SpindlePole – 1 2 5 5 6 1 13 – 9 4 7 15 9 9 8 4 8 1 2 6 1 10 10
Vac/Vac Membrane – 1 0 5 22 18 24 21 – 34 16 19 2 1 5 12 12 14 4 6 8 5 24 41
Unique Cell Count 29 97 323 421 612 817 849 688 550 718 200 253 334 368 414 361 40 72 106 54 202 311
Labelled Cell Count 31 137 390 556 898 1197 1152 954 826 1080 219 266 344 420 462 408 40 72 106 54 202 311


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 5.1 3.7 4.2 3.7 3.5 3.0 3.4 – 3.2 3.3 3.1 5.3 5.2 5.2 6.8 6.6 6.9 5.1 5.7 6.0
Std Deviation (1e-4) – 1.2 0.9 1.3 1.2 1.3 1.1 1.4 – 1.1 1.4 0.7 0.9 0.9 1.2 1.2 1.2 1.4 1.3 1.5 1.6
Intensity Change (Log2) – – – 0.18 0.01 -0.1 -0.3 -0.13 – -0.23 -0.17 -0.26 0.51 0.47 0.5 0.86 0.82 0.9 0.47 0.63 0.69

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 1.1 1.8 2.8 1.9 2.4 – 2.2 1.3 1.2 1.2 3.0 3.9 1.0 0 0
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 – 0 0 0 -11.6 -12.9 -15.1 -12.2 -12.9 -13.0
Nucleus 1.5 -1.3 -3.1 -3.5 -3.6 – -3.4 -2.7 -3.0 4.4 2.8 1.6 4.4 5.5 4.0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 1.9 0 0 0 0 0
Vacuole 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.4284 0.6932 0.4743 0.2275 0.5347 0.6032 0.3682 0.791 0.5608 0.7468 0.8085 0.5588 -1.0673 -0.894 -1.2939 -0.6502 -1.4259 -0.8459
Actin 0.0052 0.0001 0.0072 0 0.0118 0.0005 0.0091 0.0001 0.0008 0.0273 0.0049 0.0002 0.0124 0 0.0001 0.0024 0 0.0082
Bud 0.0001 0.0001 0 0 0.0001 0 0.0002 0 0.0002 0.0005 0.0001 0.0001 0.0003 0 0 0.0067 0.0001 0.0003
Bud Neck 0.0005 0.0005 0.0002 0.0001 0.0019 0.0012 0.0011 0.0004 0.0004 0.0016 0.0023 0.002 0.0003 0.0005 0.0002 0.0021 0.001 0.0031
Bud Periphery 0.0003 0.0001 0 0 0.0002 0 0.0004 0 0.0003 0.0017 0.0004 0.0004 0.0003 0 0 0.0271 0.0001 0.0003
Bud Site 0.0002 0.0004 0.0001 0 0.0004 0 0.0016 0.0003 0.0009 0.0009 0.0004 0.0002 0.0029 0.0004 0.0003 0.0053 0.0002 0.0007
Cell Periphery 0 0 0 0 0.0001 0 0.0004 0 0.0001 0.0002 0.0001 0.0001 0.0001 0 0 0.0011 0 0
Cytoplasm 0.0033 0.0082 0.0009 0.0002 0.008 0.0017 0.0081 0.003 0.0051 0.0008 0.0071 0.004 0.0175 0.0018 0.0023 0.0113 0.0004 0.0018
Cytoplasmic Foci 0.0003 0.0002 0.0001 0 0.0038 0.0033 0.0066 0.0002 0.0007 0.0055 0.0029 0.0007 0.0366 0.0001 0 0.0016 0 0.0236
Eisosomes 0.0001 0 0.0002 0 0.0003 0 0.0002 0 0 0.0003 0.0002 0 0.0001 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0002 0.0003 0 0 0.0023 0.0002 0.0037 0.0001 0.0014 0.0019 0.0024 0.0002 0.0017 0.0001 0.0003 0.0108 0 0.0003
Endosome 0.0006 0.0004 0.0001 0 0.0251 0.0007 0.013 0.0001 0.0076 0.007 0.0136 0.0017 0.0124 0.0001 0.0002 0.0166 0.0001 0.0141
Golgi 0.0003 0 0.0003 0 0.0051 0.0001 0.0018 0 0.0008 0.0044 0.0018 0.0009 0.0045 0 0 0.0012 0 0.0139
Lipid Particles 0.0003 0 0.0002 0 0.0121 0.0001 0.0077 0.0001 0.0007 0.017 0.0169 0.0062 0.0074 0 0 0.0008 0 0.0032
Mitochondria 0.0007 0.0002 0.0001 0 0.0016 0.0002 0.0019 0.0002 0.0011 0.0051 0.0041 0.0021 0.0018 0.0001 0.0002 0.0145 0.0004 0.0098
None 0.0095 0.0036 0.0008 0.0001 0.072 0.0033 0.0268 0.0389 0.029 0.0033 0.0206 0.0166 0.0458 0.0128 0.0011 0.0027 0.0001 0.0007
Nuclear Periphery 0.0036 0.011 0.0018 0.0008 0.0214 0.0065 0.0172 0.007 0.0074 0.024 0.027 0.0062 0.002 0.0039 0.0127 0.0207 0.0025 0.0098
Nucleolus 0.0185 0.0215 0.0127 0.0088 0.0171 0.0305 0.0171 0.0187 0.0121 0.0143 0.0504 0.0354 0.0171 0.025 0.0227 0.0147 0.0448 0.0499
Nucleus 0.9296 0.9317 0.9468 0.982 0.7404 0.9259 0.8362 0.9098 0.9129 0.8623 0.8055 0.9029 0.8139 0.9332 0.9496 0.7551 0.8953 0.8195
Peroxisomes 0.0002 0 0.0002 0 0.0018 0.0001 0.0036 0 0.0005 0.0103 0.0078 0.0002 0.0132 0 0 0.0004 0 0.0218
Punctate Nuclear 0.0261 0.0203 0.028 0.008 0.071 0.0254 0.0314 0.0208 0.0149 0.0091 0.0291 0.0192 0.0089 0.0217 0.0096 0.0699 0.0547 0.0184
Vacuole 0.0004 0.0012 0 0 0.0018 0.0001 0.0102 0.0002 0.0023 0.0011 0.0016 0.0006 0.0005 0.0002 0.0003 0.027 0.0001 0.0003
Vacuole Periphery 0.0001 0.0002 0 0 0.0015 0.0001 0.0018 0 0.0005 0.0013 0.0008 0.0002 0.0003 0 0.0002 0.0081 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.8129 6.4979 12.5364 8.914 12.2516 7.2648 9.198 9.0903 8.1013 9.9317
Translational Efficiency 1.3849 1.755 0.6389 0.9612 0.8632 1.0963 0.9882 0.9826 0.9951 0.9498

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
920 1441 180 713 1109 1043 797 520 2029 2484 977 1233

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 693.62 739.28 979.03 913.22 625.26 721.26 838.55 954.77 656.26 731.71 864.43 930.74
Standard Deviation 78.17 108.08 90.65 115.28 95.86 95.48 115.75 124.50 94.61 103.36 124.14 121.01
Intensity Change Log 2 — 0.091975 0.497208 0.396817 — 0.206063 0.423441 0.610697 — 0.147189 0.462706 0.502173

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000169 0.000476 0.002224 0.001421 0.000201 0.000386 0.001103 0.002112 0.000186 0.000438 0.001309 0.001712
Bud Neck 0.001206 0.004117 0.011085 0.014689 0.001902 0.005103 0.015510 0.016306 0.001586 0.004531 0.014695 0.015371
Bud Site 0.001358 0.001457 0.002430 0.015606 0.000576 0.002348 0.001775 0.014282 0.000930 0.001831 0.001896 0.015047
Cell Periphery 0.000108 0.000130 0.000114 0.000187 0.000148 0.000148 0.000090 0.000137 0.000130 0.000137 0.000095 0.000166
Cytoplasm 0.134152 0.040667 0.005735 0.037051 0.104082 0.020947 0.004977 0.020004 0.117716 0.032387 0.005116 0.029862
Cytoplasmic Foci 0.025355 0.005541 0.000183 0.005365 0.019792 0.010436 0.000091 0.002494 0.022314 0.007597 0.000108 0.004154
Eisosomes 0.000039 0.000033 0.000069 0.000039 0.000045 0.000042 0.000028 0.000037 0.000042 0.000036 0.000035 0.000038
Endoplasmic Reticulum 0.000889 0.003251 0.012035 0.007889 0.001595 0.002629 0.004682 0.008024 0.001275 0.002990 0.006037 0.007946
Endosome 0.001271 0.001019 0.000669 0.007177 0.001067 0.001274 0.000311 0.004715 0.001159 0.001126 0.000377 0.006138
Golgi 0.000578 0.000393 0.000194 0.003312 0.000333 0.001976 0.000131 0.006904 0.000444 0.001058 0.000143 0.004827
Lipid Particles 0.004038 0.002313 0.000652 0.001289 0.002878 0.004204 0.000184 0.000454 0.003404 0.003107 0.000271 0.000937
Mitochondria 0.002196 0.005446 0.001404 0.004349 0.001992 0.009984 0.001162 0.004048 0.002084 0.007351 0.001206 0.004222
Mitotic Spindle 0.002636 0.003426 0.001673 0.062057 0.000564 0.006212 0.002141 0.014893 0.001503 0.004596 0.002055 0.042166
None 0.011852 0.013894 0.002745 0.012803 0.036599 0.011650 0.005871 0.007759 0.025378 0.012951 0.005295 0.010676
Nuclear Periphery 0.001171 0.001408 0.000745 0.002615 0.000971 0.001426 0.000511 0.001111 0.001062 0.001415 0.000554 0.001980
Nuclear Periphery Foci 0.000699 0.000938 0.000558 0.003360 0.001052 0.000869 0.000445 0.000925 0.000892 0.000909 0.000466 0.002333
Nucleolus 0.006350 0.020006 0.020888 0.007145 0.015968 0.031639 0.014676 0.008036 0.011607 0.024890 0.015820 0.007521
Nucleus 0.801197 0.891120 0.930385 0.770374 0.806395 0.881943 0.944624 0.874586 0.804038 0.887266 0.942001 0.814324
Peroxisomes 0.001493 0.001977 0.000643 0.000375 0.001255 0.003560 0.000289 0.002654 0.001363 0.002642 0.000354 0.001336
Vacuole 0.003007 0.001931 0.005334 0.030115 0.002343 0.002553 0.001245 0.009677 0.002644 0.002192 0.001998 0.021496
Vacuole Periphery 0.000235 0.000458 0.000234 0.012781 0.000243 0.000673 0.000154 0.000841 0.000239 0.000548 0.000169 0.007746

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.62 -11.94 -15.43 -13.69 3.36 -4.09 -14.27 -6.76 -6.01 -2.27 -6.44 -17.50 -13.73 -11.67 -2.32
Bud Neck -7.34 -6.18 -16.31 -12.33 -0.56 -3.96 -13.40 -9.94 -8.10 0.26 -6.75 -15.30 -17.10 -13.77 1.16
Bud Site -0.55 -2.97 -4.86 -4.89 -3.43 -2.10 -8.34 -3.82 -3.03 -2.98 -2.09 -5.50 -6.13 -5.26 -4.71
Cell Periphery -1.11 -1.04 -2.24 -0.36 -0.90 0.04 3.87 1.93 1.09 -1.81 -0.42 3.06 0.17 0.53 -2.97
Cytoplasm 14.57 20.87 16.90 3.60 -6.34 14.10 18.25 14.34 1.20 -5.27 19.36 28.16 21.55 3.69 -9.50
Cytoplasmic Foci 8.49 11.23 10.41 4.71 -1.86 3.98 10.62 9.48 5.49 -2.71 9.17 15.46 14.04 7.22 -3.17
Eisosomes 2.48 -4.51 -7.06 -9.42 0.49 1.26 5.34 -1.63 -2.85 -6.57 2.92 2.30 -6.37 -9.21 -8.33
Endoplasmic Reticulum -11.28 -14.33 -19.61 -14.46 0.32 -4.25 -12.72 -10.09 -8.83 -6.17 -10.74 -18.58 -20.12 -16.14 -8.99
Endosome 1.21 2.44 -2.05 -2.81 -3.50 -0.46 5.51 -1.68 -1.54 -2.78 0.70 6.56 -2.71 -2.99 -4.89
Golgi 0.43 0.96 -0.53 -1.34 -2.03 -2.42 1.89 -1.42 -0.42 -1.55 -1.89 1.75 -1.57 -0.70 -2.02
Lipid Particles 3.36 6.72 6.01 3.81 -1.09 -1.37 10.23 7.82 4.12 -3.96 0.99 11.74 9.00 5.46 -4.36
Mitochondria -2.24 0.59 -0.54 2.42 -3.25 -4.10 0.93 -0.85 3.72 -2.07 -4.63 1.13 -1.04 4.41 -4.01
Mitotic Spindle -0.66 -0.86 -6.76 -6.60 -5.98 -3.56 -2.62 -4.48 -3.03 -3.52 -3.04 -2.17 -8.20 -7.18 -7.15
None -1.12 8.08 3.23 4.67 -4.82 7.61 10.43 9.82 3.99 -0.95 6.50 11.79 10.08 6.14 -2.84
Nuclear Periphery -0.85 1.54 -7.71 -5.85 -9.17 -1.29 1.16 -3.00 -1.35 -7.67 -1.58 2.29 -7.48 -5.52 -12.69
Nuclear Periphery Foci -0.90 0.17 -2.18 -1.79 -2.22 1.07 3.38 -0.44 -0.90 -1.69 0.22 3.28 -1.68 -1.86 -3.31
Nucleolus -9.25 -3.11 2.39 11.17 3.68 -6.19 -0.41 6.82 10.24 6.29 -9.44 -3.50 7.51 14.86 8.15
Nucleus -9.80 -11.23 -2.59 6.02 7.96 -7.12 -15.28 -4.78 1.12 6.74 -12.08 -20.49 -4.86 5.32 12.14
Peroxisomes -1.05 2.28 3.78 4.54 3.33 -3.09 3.62 0.33 2.76 -1.58 -2.92 4.80 2.47 4.85 -1.19
Vacuole 1.83 -3.42 -9.42 -9.82 -8.45 -0.17 2.76 -5.90 -5.82 -6.19 1.20 1.11 -11.12 -11.32 -11.32
Vacuole Periphery -2.07 -0.30 -2.01 -1.82 -1.99 -2.95 2.52 -1.41 0.96 -1.96 -3.66 1.70 -2.14 -1.67 -2.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
Localization
Cell Percentages nucleus (93%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Bre2

Bre2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bre2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available