Standard name
Human Ortholog
Description Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.99 0.95 0.95 0.99 0.94 0.85 0.9 0.9 0.73 0.71 0.61 0.68 0.98 1.0 0.99 – – – 0.77 0.81 0.68 0.89 0.87 0.84
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0 0.14 0.07 0.07 0.05 0.24 0.15 0.16 0.4 0.42 0.48 0.5 0 0 0 – – – 0.12 0.1 0.14 0 0.05 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 – – – 2 1 2 0 0 4
Bud 0 1 2 0 0 0 2 3 0 4 2 3 1 0 5 – – – 1 0 1 0 1 2
Bud Neck 1 0 4 2 3 1 0 2 1 2 2 0 0 1 0 – – – 1 2 1 0 2 1
Bud Site 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 – – – – – – – – –
Cell Periphery 3 0 0 0 0 0 0 2 1 1 0 0 0 1 0 – – – 1 0 1 0 1 1
Cytoplasm 357 186 198 163 234 157 203 226 108 111 56 84 127 219 234 – – – 287 156 113 139 195 216
Endoplasmic Reticulum 1 0 1 1 0 0 0 1 1 0 2 1 0 0 0 – – – 2 0 1 1 0 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 6 2 2 0 1 2
Golgi 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 – – – 4 0 1 0 0 1
Mitochondria 5 27 15 11 13 44 34 41 59 65 44 62 1 0 9 – – – 43 19 23 5 10 10
Nucleus 1 1 0 0 0 0 1 1 0 0 0 0 0 1 1 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 0 0 0 0 1 1 0 1 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 1 1 0 1 1 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 1 0 2 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 1 0 0 0 4 4 4 3 3 3 2 3 0 0 0 – – – 7 2 1 0 1 1
Vac/Vac Membrane 1 0 0 0 1 0 0 1 1 1 0 2 0 0 0 – – – 4 4 2 1 2 8
Unique Cell Count 362 195 209 165 249 185 225 250 147 156 92 123 129 220 237 372 194 167 157 223 257
Labelled Cell Count 370 216 221 178 256 207 245 280 174 190 111 157 130 222 249 372 194 167 157 223 257


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.3 3.0 2.8 2.9 3.2 2.9 3.1 3.1 2.7 2.4 2.6 2.6 3.4 3.6 3.1 – – – 3.6 3.6 4.2
Std Deviation (1e-4) 0.9 0.7 1.0 1.4 1.3 1.3 1.8 1.6 1.9 1.1 1.6 1.6 0.8 0.9 0.7 – – – 1.0 1.2 1.5
Intensity Change (Log2) – – – 0.07 0.18 0.06 0.13 0.13 -0.06 -0.22 -0.09 -0.09 0.29 0.38 0.15 – – – 0.36 0.38 0.56

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700024WT3HU80HU120HU160024WT3024WT1AF100AF140AF180024
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.467 1.1001 0.2943 0.493 0.677 0.8266 -0.1818 0.6339 0.1501 0.1845 0.566 0.4785 1.2492 0.9892 1.2043 1.383 1.5842 1.6705
Actin 0.0121 0.0001 0.0029 0.0001 0.053 0.0035 0.0067 0 0.0048 0.0002 0.0116 0.0072 0.0158 0.0019 0.0047 0.0231 0.0046 0.0015
Bud 0.0004 0 0.0002 0 0.001 0.0004 0.001 0 0.002 0.0005 0.0001 0.0004 0.0002 0.0002 0.0035 0 0.0012 0.0004
Bud Neck 0.0005 0 0.0002 0 0.0015 0.0077 0.0006 0 0.0003 0.0001 0.0006 0.0005 0.0012 0 0.0002 0.0002 0.0003 0.0003
Bud Periphery 0.0012 0 0.0004 0 0.0021 0.001 0.0037 0 0.0017 0.001 0.0002 0.0023 0.0003 0.0007 0.0031 0 0.0023 0.0015
Bud Site 0.0038 0.0001 0.0007 0 0.0299 0.0014 0.0013 0.0001 0.0039 0.0003 0.0005 0.0001 0.0013 0.0007 0.0062 0.0003 0.0038 0.0008
Cell Periphery 0.0007 0.0002 0.0002 0.0001 0.0006 0.0002 0.0002 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0 0.0004 0 0.0001 0.0001
Cytoplasm 0.0403 0.0356 0.0599 0.043 0.0316 0.0717 0.0129 0.0114 0.0122 0.0118 0.0062 0.0348 0.0164 0.0464 0.0234 0.0198 0.0153 0.0114
Cytoplasmic Foci 0.0103 0.0009 0.0069 0.0015 0.0028 0.0036 0.013 0.0008 0.0048 0.0154 0.0403 0.0025 0.0082 0.0115 0.0083 0.0074 0.02 0.0159
Eisosomes 0.0006 0.0011 0.0004 0.0003 0.0008 0.0002 0.0009 0.0002 0.0006 0.0002 0.0002 0.0002 0.0005 0.0003 0.0005 0.0005 0.0003 0.0001
Endoplasmic Reticulum 0.0013 0.0004 0.0023 0.0003 0.0013 0.0022 0.0016 0.0002 0.0002 0.0002 0.0002 0.0006 0.0006 0.0002 0.0013 0.0002 0.0011 0.0007
Endosome 0.007 0 0.0052 0.0001 0.0044 0.0086 0.0122 0 0.0013 0.0008 0.0324 0.003 0.0015 0.0003 0.002 0.0003 0.0095 0.0004
Golgi 0.0024 0 0.0011 0 0.0028 0.004 0.0055 0 0.0047 0.0002 0.0384 0.0022 0.0015 0.0002 0.002 0.0011 0.0025 0.0001
Lipid Particles 0.0123 0.0002 0.004 0.0001 0.0068 0.0054 0.0116 0.0001 0.0045 0.0011 0.0376 0.0015 0.0021 0.0005 0.0018 0.0028 0.0052 0.0005
Mitochondria 0.0067 0 0.0066 0.0001 0.0695 0.0043 0.0021 0.0001 0.0085 0.0004 0.0151 0.0029 0.0005 0.0006 0.0022 0.0003 0.0092 0.0004
None 0.8834 0.9609 0.9014 0.9531 0.7545 0.8584 0.9026 0.9859 0.9348 0.9632 0.7727 0.9352 0.9396 0.9256 0.9352 0.9225 0.8971 0.9621
Nuclear Periphery 0.0009 0.0001 0.0023 0.0002 0.0044 0.0098 0.0009 0.0001 0.0001 0.0002 0.0001 0.0007 0.0002 0.0001 0.0004 0 0.0036 0.0013
Nucleolus 0.0007 0.0001 0.0004 0.0001 0.0063 0.0008 0.0017 0.0001 0.0002 0.0004 0.0001 0.0001 0.0001 0.0001 0.0005 0 0.0008 0.0001
Nucleus 0.0008 0.0001 0.0009 0.0003 0.0075 0.0051 0.0008 0.0001 0.0002 0.0003 0.0001 0.0003 0.0002 0.0001 0.0006 0 0.0017 0.0001
Peroxisomes 0.0087 0 0.0019 0 0.0133 0.0046 0.016 0 0.0143 0.0008 0.0422 0.0045 0.0083 0.0093 0.0012 0.0211 0.0043 0.0015
Punctate Nuclear 0.0011 0.0001 0.0009 0.0003 0.0022 0.002 0.0024 0.0007 0.0005 0.0022 0.0005 0.0005 0.0012 0.0012 0.0017 0.0002 0.0144 0.0004
Vacuole 0.0037 0.0001 0.0007 0.0002 0.0031 0.0027 0.0018 0.0001 0.0001 0.0005 0.0005 0.0004 0.0002 0.0001 0.0004 0 0.0012 0.0002
Vacuole Periphery 0.0011 0 0.0006 0 0.001 0.0024 0.0005 0 0.0001 0.0001 0.0004 0.0003 0 0 0.0001 0 0.0013 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.0768 7.7239 10.6814 13.9373 9.6749 12.9533 15.2643 16.5317 15.2578 17.7167
Translational Efficiency 0.3811 0.2833 0.3255 0.2182 0.282 0.3755 0.2572 0.1539 0.2584 0.2173

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
417 321 1143 144 1977 2073 1882 58 2394 2394 3025 202

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 549.99 687.92 793.99 801.58 572.53 649.56 733.50 720.68 568.60 654.70 756.36 778.35
Standard Deviation 81.54 70.87 85.63 116.70 92.39 75.02 88.76 100.30 91.00 75.62 92.37 118.06
Intensity Change Log 2 — 0.322835 0.529715 0.543441 — 0.182112 0.357446 0.332008 — 0.252776 0.444422 0.439474

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000073 0.000239 0.000144 0.001712 0.000030 0.000250 0.000112 0.000211 0.000037 0.000248 0.000124 0.001281
Bud Neck 0.011995 0.029894 0.002998 0.016735 0.008927 0.034151 0.005542 0.003415 0.009461 0.033580 0.004580 0.012911
Bud Site 0.004617 0.005965 0.006323 0.049372 0.001451 0.011387 0.014080 0.005171 0.002002 0.010660 0.011149 0.036681
Cell Periphery 0.000378 0.000164 0.000100 0.000263 0.000458 0.000177 0.000179 0.000410 0.000444 0.000176 0.000149 0.000305
Cytoplasm 0.420782 0.220546 0.270557 0.319393 0.454489 0.356148 0.410793 0.344682 0.448618 0.337966 0.357805 0.326654
Cytoplasmic Foci 0.154130 0.394686 0.008111 0.061197 0.124804 0.230342 0.014671 0.099096 0.129912 0.252378 0.012192 0.072079
Eisosomes 0.000243 0.000263 0.000025 0.000115 0.000847 0.000159 0.000044 0.000245 0.000742 0.000173 0.000037 0.000153
Endoplasmic Reticulum 0.000928 0.000617 0.001891 0.015636 0.001753 0.000731 0.000724 0.001091 0.001609 0.000716 0.001165 0.011460
Endosome 0.003386 0.028878 0.001226 0.029188 0.002849 0.018675 0.002223 0.006795 0.002942 0.020043 0.001846 0.022758
Golgi 0.000514 0.008203 0.000046 0.013905 0.001684 0.004801 0.000405 0.006560 0.001480 0.005257 0.000269 0.011796
Lipid Particles 0.013041 0.019410 0.001061 0.018734 0.014623 0.015539 0.000958 0.008363 0.014347 0.016058 0.000997 0.015756
Mitochondria 0.002137 0.031283 0.000598 0.004549 0.005022 0.028228 0.002017 0.008088 0.004519 0.028638 0.001481 0.005565
Mitotic Spindle 0.000052 0.000742 0.000735 0.026052 0.001125 0.005942 0.008739 0.010669 0.000938 0.005245 0.005714 0.021635
None 0.009744 0.001269 0.003964 0.002949 0.024025 0.004263 0.005563 0.008911 0.021538 0.003861 0.004959 0.004661
Nuclear Periphery 0.001255 0.000523 0.001195 0.001612 0.000925 0.000939 0.001094 0.001218 0.000982 0.000883 0.001132 0.001499
Nuclear Periphery Foci 0.000173 0.000264 0.000488 0.001751 0.000437 0.000215 0.000187 0.000924 0.000391 0.000222 0.000301 0.001513
Nucleolus 0.001597 0.001650 0.000576 0.000621 0.001370 0.002894 0.000833 0.001874 0.001409 0.002727 0.000736 0.000981
Nucleus 0.354559 0.167988 0.683119 0.222410 0.338838 0.224583 0.502042 0.420182 0.341577 0.216994 0.570462 0.279196
Peroxisomes 0.002809 0.046024 0.000239 0.004753 0.002707 0.014833 0.000474 0.004845 0.002725 0.019015 0.000385 0.004780
Vacuole 0.017120 0.039478 0.016369 0.204024 0.013210 0.042865 0.028842 0.066866 0.013891 0.042411 0.024129 0.164642
Vacuole Periphery 0.000466 0.001917 0.000235 0.005027 0.000427 0.002878 0.000478 0.000383 0.000434 0.002749 0.000386 0.003693

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.57 -3.20 -2.90 -2.25 -2.54 -4.87 -5.01 -2.45 -0.92 -1.82 -5.27 -6.68 -3.45 -2.39 -2.94
Bud Neck -3.15 3.29 0.45 3.07 -1.57 -12.24 2.72 4.32 14.98 2.19 -12.39 4.60 0.51 7.44 -1.01
Bud Site -0.49 -0.83 -2.33 -2.16 -2.12 -7.89 -6.34 -1.48 1.76 2.01 -7.43 -6.42 -2.78 -1.45 -1.49
Cell Periphery 2.89 3.77 2.59 -0.55 -2.86 5.94 6.22 1.00 -2.06 -2.22 6.52 7.41 4.17 -1.75 -2.84
Cytoplasm 11.62 10.64 5.30 -2.06 -0.45 12.60 7.93 4.05 1.08 2.02 15.31 15.23 7.94 2.45 2.61
Cytoplasmic Foci -15.79 18.16 11.23 24.87 -5.74 -17.92 30.87 2.39 8.81 -4.65 -21.80 36.19 10.58 25.29 -6.85
Eisosomes -0.44 8.68 4.80 3.49 -9.41 4.41 5.15 3.81 -1.34 -3.69 4.41 5.46 4.58 1.45 -6.87
Endoplasmic Reticulum 0.70 -3.07 -1.44 -1.49 -1.20 3.98 2.87 -0.83 -2.45 -2.00 3.96 0.39 -1.37 -1.59 -1.39
Endosome -5.40 2.16 -2.77 2.21 -3.32 -14.22 1.69 -2.18 6.11 -2.56 -14.79 3.29 -3.23 2.33 -3.60
Golgi -4.87 3.32 -1.63 0.59 -1.77 -5.67 4.34 -0.68 -0.00 -0.98 -7.28 5.42 -1.52 -0.13 -1.99
Lipid Particles -2.12 6.06 0.57 1.55 -1.38 -0.75 14.41 2.90 3.33 -2.78 -1.49 15.54 1.24 1.64 -1.81
Mitochondria -4.97 4.54 -0.08 4.88 -1.55 -10.88 3.00 -0.16 3.90 -0.77 -12.10 3.75 0.67 10.13 -1.12
Mitotic Spindle -3.19 -2.96 -2.70 -2.59 -2.55 -4.33 -4.61 -1.45 -1.17 -1.03 -4.51 -4.52 -2.78 -2.11 -2.06
None 5.49 3.79 4.20 -2.06 1.54 8.22 7.75 3.42 -0.98 -0.81 8.79 8.43 7.42 -0.28 0.19
Nuclear Periphery 1.22 -0.13 -1.89 -4.13 -2.66 -0.20 -5.94 -1.81 -1.74 0.39 0.71 -3.40 -3.37 -3.72 -2.43
Nuclear Periphery Foci -1.52 -5.62 -5.03 -4.58 -3.46 4.12 3.34 -1.22 -1.30 -1.29 3.54 -0.03 -2.29 -2.49 -2.29
Nucleolus -0.31 4.76 3.69 4.30 -0.40 -5.49 2.38 -1.30 1.52 -2.19 -5.43 4.33 1.67 5.65 -1.39
Nucleus 10.75 -20.92 2.63 -4.29 15.79 15.29 -19.75 -1.99 -5.21 2.88 18.03 -31.62 1.10 -4.88 12.29
Peroxisomes -7.72 6.51 0.22 7.68 -2.51 -11.80 5.06 -0.71 5.19 -1.93 -13.84 6.32 -0.33 11.37 -3.11
Vacuole -5.40 -1.27 -11.14 -10.19 -11.02 -16.32 -13.47 -3.94 -2.60 -2.51 -16.94 -13.10 -11.41 -9.93 -10.26
Vacuole Periphery -3.77 1.50 -1.60 -0.28 -1.82 -8.55 0.08 0.64 8.52 0.36 -9.13 0.86 -1.61 1.27 -1.71
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex
Localization
Cell Percentages nucleus (14%), cytoplasm (13%), mixed (51%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ubr2

Ubr2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ubr2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available