Standard name | |
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Human Ortholog | |
Description | Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | – | – | 0 | 0 | 2 | – | 1 | 3 | 5 | 5 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 2 | – | – | 5 | 9 | 10 | – | 3 | 13 | 8 | 15 | – | – | 4 | 33 | 25 | 26 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 120 | 76 | – | – | 145 | 166 | 176 | – | 137 | 129 | 104 | 142 | – | – | 54 | 300 | 254 | 226 | 112 | 91 | 22 | 17 | 59 | 30 |
Endoplasmic Reticulum | 2 | 0 | – | – | 2 | 2 | 5 | – | 6 | 10 | 12 | 9 | – | – | 0 | 9 | 12 | 5 | 1 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 1 | 0 | 0 | – | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 3 | 0 | – | – | 0 | 1 | 0 | – | 1 | 6 | 12 | 4 | – | – | 0 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 1 | 0 | – | – | 0 | 0 | 0 | – | 1 | 0 | 1 | 2 | – | – | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | – | – | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | – | – | 0 | 0 | 0 | – | 3 | 2 | 3 | 6 | – | – | 0 | 1 | 2 | 2 | 0 | 1 | 0 | 0 | 1 | 0 |
Unique Cell Count | 124 | 76 | 147 | 169 | 186 | 148 | 150 | 131 | 165 | 54 | 318 | 260 | 234 | 121 | 95 | 24 | 21 | 66 | 38 | |||||
Labelled Cell Count | 128 | 78 | 152 | 178 | 193 | 152 | 164 | 145 | 183 | 58 | 351 | 295 | 260 | 121 | 95 | 24 | 21 | 66 | 38 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 19.7 | 29.2 | – | – | 23.1 | 21.9 | 20.9 | – | 17.1 | 18.1 | 16.0 | 17.9 | – | – | 28.0 | 36.2 | 35.3 | 34.1 | – | 22.2 | – |
Std Deviation (1e-4) | 5.1 | 5.6 | – | – | 3.9 | 3.7 | 4.4 | – | 3.9 | 4.3 | 3.7 | 4.5 | – | – | 8.4 | 9.4 | 8.1 | 8.8 | – | 7.7 | – |
Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 15.9237 | 22.8316 | 20.2528 | 20.0038 | 13.6472 | 21.0389 | 16.6276 | 22.7725 | 19.4417 | 17.9633 | 15.0168 | 20.2903 | 19.0587 | 26.7243 | 22.7726 | 21.9648 | 16.916 | 23.5057 |
Actin | 0.0082 | 0.0002 | 0.0069 | 0.0042 | 0.0011 | 0.0005 | 0.0149 | 0.0001 | 0.0004 | 0.0063 | 0.0274 | 0.0007 | 0.0278 | 0.0001 | 0.009 | 0.0381 | 0.0046 | 0.0001 |
Bud | 0.0007 | 0.0009 | 0.0001 | 0.0017 | 0.0004 | 0.0002 | 0.001 | 0 | 0.0001 | 0.0003 | 0.0011 | 0.0003 | 0.0074 | 0 | 0.0021 | 0.0008 | 0.0011 | 0.0001 |
Bud Neck | 0.0009 | 0.0002 | 0.0003 | 0.0006 | 0.0006 | 0.0008 | 0.0003 | 0.0001 | 0.0002 | 0.0003 | 0.0016 | 0.0005 | 0.011 | 0.0001 | 0.0014 | 0.0013 | 0.001 | 0.0004 |
Bud Periphery | 0.0005 | 0.0002 | 0.0001 | 0.0004 | 0.0002 | 0.0003 | 0.0017 | 0 | 0 | 0.0004 | 0.001 | 0.0002 | 0.0024 | 0 | 0.0006 | 0.001 | 0.0007 | 0 |
Bud Site | 0.0067 | 0.0009 | 0.0002 | 0.0004 | 0.0029 | 0 | 0.0038 | 0 | 0.0001 | 0.0011 | 0.0116 | 0.0001 | 0.0148 | 0 | 0.0008 | 0.0009 | 0.0022 | 0 |
Cell Periphery | 0.0002 | 0.0003 | 0 | 0.0003 | 0.0004 | 0.0001 | 0.0002 | 0 | 0 | 0.0002 | 0.0004 | 0 | 0.0006 | 0 | 0.0002 | 0.0002 | 0.0003 | 0 |
Cytoplasm | 0.8758 | 0.9883 | 0.9589 | 0.9795 | 0.7094 | 0.9613 | 0.8793 | 0.9966 | 0.956 | 0.9301 | 0.7302 | 0.9471 | 0.8377 | 0.9968 | 0.9231 | 0.8213 | 0.7548 | 0.9946 |
Cytoplasmic Foci | 0.0139 | 0.002 | 0.0022 | 0.0044 | 0.0636 | 0.0023 | 0.018 | 0.0005 | 0.0088 | 0.0047 | 0.0297 | 0.014 | 0.0186 | 0.0005 | 0.0139 | 0.0051 | 0.0661 | 0.0011 |
Eisosomes | 0.0003 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0002 | 0 | 0.0003 | 0 | 0.0001 | 0.0019 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0051 | 0.0006 | 0.0064 | 0.0011 | 0.0114 | 0.0032 | 0.005 | 0.0016 | 0.0011 | 0.0024 | 0.0105 | 0.0027 | 0.0068 | 0.0002 | 0.0019 | 0.0016 | 0.0158 | 0.0009 |
Endosome | 0.03 | 0.0009 | 0.0063 | 0.0004 | 0.0896 | 0.0096 | 0.0212 | 0.0001 | 0.0036 | 0.0258 | 0.052 | 0.011 | 0.0172 | 0.0003 | 0.0107 | 0.0275 | 0.0385 | 0.0008 |
Golgi | 0.0097 | 0.0001 | 0.0043 | 0.0001 | 0.01 | 0.0006 | 0.0058 | 0 | 0.0015 | 0.0086 | 0.0281 | 0.0015 | 0.0043 | 0 | 0.0027 | 0.0129 | 0.0029 | 0.0001 |
Lipid Particles | 0.0058 | 0 | 0.0038 | 0.0001 | 0.0154 | 0.0001 | 0.0075 | 0 | 0.0057 | 0.005 | 0.0184 | 0.0014 | 0.0089 | 0 | 0.007 | 0.0055 | 0.0245 | 0 |
Mitochondria | 0.0186 | 0.0018 | 0.0036 | 0.0002 | 0.0032 | 0.0138 | 0.0065 | 0 | 0.0027 | 0.0074 | 0.0214 | 0.0062 | 0.0036 | 0 | 0.0042 | 0.0101 | 0.0047 | 0.0001 |
None | 0.0026 | 0.0009 | 0.0002 | 0.0021 | 0.0453 | 0.0005 | 0.0013 | 0.0003 | 0.0096 | 0.0013 | 0.007 | 0.0021 | 0.0072 | 0.0001 | 0.0056 | 0.0428 | 0.0236 | 0.0002 |
Nuclear Periphery | 0.004 | 0.0003 | 0.0009 | 0.0008 | 0.0093 | 0.0016 | 0.0028 | 0.0001 | 0.0005 | 0.0009 | 0.0024 | 0.0033 | 0.0061 | 0.0002 | 0.0014 | 0.0033 | 0.0118 | 0.0004 |
Nucleolus | 0.0006 | 0.0004 | 0 | 0 | 0.0008 | 0 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0018 | 0 | 0.0006 | 0.0011 | 0.0021 | 0 |
Nucleus | 0.0038 | 0.001 | 0.0013 | 0.0019 | 0.0038 | 0.0016 | 0.0016 | 0.0004 | 0.0011 | 0.0008 | 0.0014 | 0.0031 | 0.0055 | 0.0015 | 0.0015 | 0.003 | 0.011 | 0.0009 |
Peroxisomes | 0.0023 | 0.0001 | 0.001 | 0.0001 | 0.0012 | 0 | 0.0129 | 0 | 0.0038 | 0.0011 | 0.0457 | 0.0009 | 0.0052 | 0 | 0.0039 | 0.0027 | 0.0033 | 0 |
Punctate Nuclear | 0.0022 | 0.0001 | 0.0001 | 0.0006 | 0.0046 | 0.0001 | 0.0123 | 0 | 0.0039 | 0.0002 | 0.0011 | 0.001 | 0.0071 | 0 | 0.0054 | 0.0026 | 0.0138 | 0 |
Vacuole | 0.0057 | 0.0007 | 0.0025 | 0.001 | 0.0206 | 0.0023 | 0.0023 | 0.0001 | 0.0006 | 0.002 | 0.0057 | 0.0024 | 0.0042 | 0.0002 | 0.0028 | 0.0118 | 0.0138 | 0.0002 |
Vacuole Periphery | 0.0021 | 0.0002 | 0.0007 | 0.0002 | 0.0059 | 0.001 | 0.0013 | 0 | 0.0002 | 0.0011 | 0.0032 | 0.0011 | 0.0013 | 0 | 0.0012 | 0.0043 | 0.0032 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 65.5457 | 73.3117 | 85.3098 | 100.1079 | 78.1359 | 81.9644 | 107.6784 | 118.4414 | 124.1455 | 97.8369 |
Translational Efficiency | 1.6845 | 1.6669 | 1.4612 | 1.3518 | 1.1526 | 1.4814 | 1.4084 | 1.3099 | 1.2122 | 1.1174 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✔ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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