Standard name
Human Ortholog
Description Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Bud – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Bud Neck – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Bud Site – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – – – – – – –
Cell Periphery – 0.18 – 0.65 0.6 0.49 0.53 – 0.69 0.41 0.52 0.65 – 0.5 – – – – 0.3 0.4 0.29 0.25 0.35 0.25
Cytoplasm – 0.94 – 0.74 0.55 0.64 0.6 – 0.43 0.68 0.48 0.5 – 0.88 – – – – 0.67 0.52 0.59 0.63 0.5 0.58
Endoplasmic Reticulum – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0.07 0 0
Endosome – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Golgi – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Mitochondria – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Nucleus – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0.08
Nuclear Periphery – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Nucleolus – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Peroxisomes – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
SpindlePole – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Vac/Vac Membrane – 0 – 0 0.12 0 0 – 0 0.05 0 0 – 0 – – – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Bud – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Bud Neck – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Bud Site – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – – – – – – –
Cell Periphery – 3 – 50 36 34 30 – 37 15 12 13 – 8 – – – – 19 19 19 5 17 11
Cytoplasm – 16 – 57 33 45 34 – 23 25 11 10 – 14 – – – – 42 26 39 14 24 27
Endoplasmic Reticulum – 0 – 0 0 0 0 – 1 0 0 0 – 0 – – – – 0 0 0 1 0 0
Endosome – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Golgi – 0 – 0 2 1 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Mitochondria – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Nucleus – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 1 2 0 2 3
Nuclear Periphery – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 1 0 0 0
Nucleolus – 0 – 0 0 0 0 – 0 0 1 0 – 0 – – – – 0 0 0 0 0 0
Peroxisomes – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
SpindlePole – 0 – 0 0 0 0 – 0 0 0 0 – 0 – – – – 0 0 0 0 0 0
Vac/Vac Membrane – 0 – 0 7 0 0 – 1 2 0 0 – 0 – – – – 0 0 0 0 0 0
Unique Cell Count 17 77 60 70 57 54 37 23 20 16 64 50 67 23 50 47
Labelled Cell Count 19 107 78 80 64 62 42 24 23 22 64 50 67 23 50 47


Ambiguous, Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 829.2 – 765.0 632.9 818.7 762.5 – 771.5 757.5 771.6 762.6 – 721.2 – – – – – – –
Std Deviation (1e-4) – 140.3 – 153.4 251.7 206.5 114.3 – 142.1 204.6 127.4 123.4 – 106.5 – – – – – – –
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –

RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70005001000HU12005001000024605001000024605001000
rapamycinhydroxy-ureaMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0001 0.0002 0.0003 0.0007 0.0002 0.0005 0.0014 0.0014 0.0015 0.0015 0.0029 0.0004 0.0046 0.0007 0.0147 0.0003 0.0071 0.0003
Bud 0 0.0001 0.0002 0.0001 0.0003 0.0001 0.0004 0.0011 0.0005 0.0005 0.0003 0.0002 0.003 0.0068 0.0011 0.0006 0.0012 0.0004
Bud Neck 0 0 0 0 0.0002 0.0001 0.0001 0.0001 0.0003 0 0.0002 0.0001 0.0004 0.0001 0.0002 0.0002 0.0008 0.0002
Bud Periphery 0 0 0 0 0.0001 0 0.0003 0.0006 0.0003 0.0002 0.0003 0.0001 0.0024 0.0014 0.0008 0.0009 0.002 0.0002
Bud Site 0 0 0.0001 0 0 0 0.0012 0.0003 0.0002 0.0002 0.0003 0.0001 0.003 0.0057 0.0018 0.0002 0.0016 0.0001
Cell Periphery 0 0.0002 0.0003 0.0002 0.0007 0.0001 0.0039 0.0013 0.0034 0.0009 0.0063 0.0002 0.0033 0.0038 0.0016 0.0012 0.0064 0.0005
Cytoplasm 0.1183 0.4273 0.1995 0.0502 0.1099 0.0337 0.0667 0.2909 0.0519 0.0159 0.0105 0.0119 0.0404 0.3526 0.0039 0.0029 0.0031 0.0879
Cytoplasmic Foci 0 0 0 0 0.0001 0 0.0112 0.0001 0.0026 0 0.0025 0.0018 0.0115 0.0005 0.037 0.0669 0.0032 0.0006
Eisosomes 0 0 0.0001 0 0 0 0.0161 0.0002 0.0016 0.0003 0.0043 0.0001 0.0013 0.0003 0.0055 0.001 0.0052 0.0001
Endoplasmic Reticulum 0 0.0001 0.0001 0.0001 0.0002 0 0.0001 0.0003 0.0003 0.0002 0.0006 0 0.0011 0.0003 0.0005 0.0001 0.0003 0
Endosome 0 0 0 0 0.0002 0 0.0002 0.0001 0.0004 0.0001 0.0034 0 0.0042 0 0.0057 0.0003 0.0019 0
Golgi 0 0 0 0 0 0 0.0003 0 0.0004 0 0.0026 0 0.0007 0 0.0055 0.0001 0.0026 0
Lipid Particles 0 0 0 0 0 0 0.0032 0 0.0032 0 0.0105 0.0001 0.0049 0.0002 0.0148 0.0035 0.0184 0.0001
Mitochondria 0.0031 0.0099 0.0227 0.011 0.0171 0.0056 0.0707 0.0289 0.0421 0.0444 0.0508 0.0107 0.0583 0.0168 0.1147 0.0995 0.0966 0.0203
None 0.0002 0.0005 0.0013 0.0008 0.0006 0.0002 0.0093 0.0013 0.0037 0.002 0.0076 0.0011 0.0397 0.0037 0.0121 0.0363 0.0095 0.001
Nuclear Periphery 0.0731 0.0559 0.1291 0.2819 0.181 0.109 0.0554 0.0883 0.1317 0.1354 0.2163 0.0615 0.0589 0.048 0.0318 0.0189 0.0315 0.0308
Nucleolus 0.0336 0.0213 0.0474 0.0334 0.0082 0.017 0.3664 0.0777 0.2114 0.0437 0.4705 0.1366 0.3474 0.0279 0.3589 0.4868 0.3571 0.1491
Nucleus 0.771 0.4757 0.5912 0.6176 0.6129 0.8286 0.3691 0.4854 0.5113 0.7412 0.1141 0.7628 0.3511 0.5258 0.3644 0.2497 0.3809 0.6976
Peroxisomes 0 0 0.0001 0 0.0001 0 0.0014 0.0002 0.0004 0.0001 0.0006 0.0001 0.0012 0.0001 0.0035 0.0026 0.0012 0.0002
Punctate Nuclear 0 0.0001 0.0003 0.0002 0.0001 0.0001 0.0037 0.0002 0.0019 0.0002 0.0069 0.0032 0.0286 0.0005 0.008 0.0032 0.0022 0.0002
Vacuole 0.0001 0.0009 0.0011 0.0003 0.0095 0.0003 0.0039 0.0049 0.0069 0.0015 0.0117 0.0008 0.0148 0.0021 0.0028 0.0045 0.0113 0.0015
Vacuole Periphery 0.0005 0.0076 0.0062 0.0034 0.0586 0.0047 0.0149 0.0167 0.0239 0.0116 0.077 0.0082 0.0192 0.0027 0.0106 0.0203 0.0558 0.0089

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10610.4858 11961.2685 14296.0664 12291.003 12403.2885 11875.236 13502.6284 12682.7842 14456.8009 12040.0934
Translational Efficiency 1.2948 1.256 1.1625 1.1445 1.169 1.2333 1.3659 1.3519 1.2544 1.4974

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
178 165 1620 528 728 1406 1211 945 906 1571 2831 1473

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 51469.41 53486.43 48347.29 50091.35 51805.37 47890.80 48637.61 49298.04 51739.36 48478.50 48471.48 49582.40
Standard Deviation 6380.71 4961.57 5422.70 7879.61 5334.47 8580.30 5221.91 8378.31 5557.20 8450.91 5339.66 8211.85
Intensity Change Log 2 — 0.055458 -0.090280 -0.039154 — -0.113353 -0.091029 -0.071571 — -0.026754 -0.090656 -0.055324

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000009 0.000030 0.000027 0.000472 0.000012 0.000131 0.000078 0.000163 0.000011 0.000121 0.000049 0.000274
Bud Neck 0.000099 0.000503 0.000128 0.000890 0.000072 0.000622 0.000576 0.000785 0.000077 0.000610 0.000320 0.000822
Bud Site 0.000014 0.000045 0.000014 0.000967 0.000026 0.000489 0.000200 0.001170 0.000024 0.000442 0.000094 0.001097
Cell Periphery 0.274430 0.239937 0.197501 0.314039 0.183761 0.147755 0.161675 0.265423 0.201575 0.157437 0.182176 0.282850
Cytoplasm 0.004990 0.045271 0.029818 0.073465 0.032576 0.119501 0.097794 0.085295 0.027156 0.111705 0.058895 0.081055
Cytoplasmic Foci 0.000003 0.000059 0.000015 0.000597 0.000009 0.001160 0.000044 0.000263 0.000008 0.001044 0.000028 0.000382
Eisosomes 0.000094 0.000067 0.000011 0.000055 0.000019 0.000016 0.000021 0.000033 0.000034 0.000022 0.000015 0.000041
Endoplasmic Reticulum 0.000153 0.000048 0.000188 0.000055 0.000038 0.000244 0.000064 0.000063 0.000060 0.000223 0.000135 0.000060
Endosome 0.000003 0.000006 0.000005 0.000129 0.000002 0.000017 0.000006 0.000035 0.000002 0.000016 0.000005 0.000069
Golgi 0.000030 0.000472 0.000098 0.000082 0.000151 0.000218 0.000060 0.000058 0.000127 0.000244 0.000082 0.000067
Lipid Particles 0.000241 0.000667 0.000429 0.000690 0.000523 0.001539 0.002218 0.000572 0.000468 0.001447 0.001194 0.000614
Mitochondria 0.000001 0.000037 0.000005 0.000336 0.000002 0.000266 0.000003 0.000225 0.000001 0.000242 0.000004 0.000265
Mitotic Spindle 0.000010 0.000010 0.000004 0.000352 0.000008 0.000022 0.000006 0.000890 0.000008 0.000020 0.000005 0.000697
None 0.000000 0.000006 0.000001 0.000106 0.000001 0.001126 0.000002 0.000032 0.000001 0.001008 0.000001 0.000059
Nuclear Periphery 0.000135 0.000790 0.000340 0.000068 0.000412 0.000391 0.000256 0.000093 0.000358 0.000432 0.000304 0.000084
Nuclear Periphery Foci 0.000080 0.000451 0.000165 0.000127 0.000191 0.000523 0.000390 0.000154 0.000169 0.000515 0.000261 0.000145
Nucleolus 0.000008 0.000039 0.000008 0.000665 0.000007 0.000309 0.000019 0.001848 0.000007 0.000281 0.000013 0.001424
Nucleus 0.000057 0.001633 0.000430 0.000934 0.000220 0.004279 0.001217 0.001123 0.000188 0.004001 0.000766 0.001055
Peroxisomes 0.000008 0.000002 0.000003 0.000274 0.000005 0.000020 0.000007 0.000623 0.000005 0.000019 0.000005 0.000498
Vacuole 0.718556 0.706597 0.769678 0.605354 0.780957 0.719115 0.734590 0.640375 0.768698 0.717800 0.754669 0.627822
Vacuole Periphery 0.001079 0.003329 0.001133 0.000343 0.001009 0.002257 0.000775 0.000775 0.001023 0.002370 0.000980 0.000620

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.21 -6.80 -1.77 -1.68 -1.70 -4.97 -11.36 -3.76 -1.13 -2.58 -5.06 -12.26 -2.97 -1.67 -2.60
Bud Neck -1.71 -1.06 -2.02 -0.89 -1.93 -3.63 -8.21 -3.55 -0.89 -1.77 -3.83 -7.47 -4.03 -0.96 -3.01
Bud Site -1.46 -0.18 -2.49 -2.42 -2.49 -2.56 -3.63 -3.32 -2.01 -2.95 -2.58 -3.02 -4.06 -2.30 -3.86
Cell Periphery 1.70 4.80 -1.93 -4.04 -9.17 5.41 3.39 -7.85 -13.15 -11.37 6.68 3.19 -8.87 -16.29 -13.47
Cytoplasm -4.42 -12.72 -10.46 -2.55 -6.35 -15.21 -13.08 -9.06 5.26 2.28 -16.56 -9.83 -11.49 5.48 -4.71
Cytoplasmic Foci -1.77 -1.41 -1.53 -1.39 -1.49 -1.95 -2.23 -2.02 1.45 -1.70 -1.96 -2.32 -2.37 1.18 -2.22
Eisosomes 1.01 3.56 0.94 0.19 -2.03 0.62 -0.62 -2.40 -2.75 -2.09 2.06 3.48 -1.10 -2.31 -3.03
Endoplasmic Reticulum 0.93 -0.44 0.84 -0.29 3.28 -4.55 -1.40 -1.36 3.27 -0.33 -3.65 -2.61 -0.40 3.54 2.46
Endosome -1.08 -1.61 -1.06 -1.03 -1.04 -3.18 -6.23 -1.38 -0.78 -1.25 -3.23 -5.38 -1.51 -1.18 -1.44
Golgi -2.13 -3.98 -0.78 1.82 0.24 -1.53 1.69 1.36 3.46 -0.14 -2.54 0.95 0.99 3.71 0.35
Lipid Particles -2.90 -1.76 -1.75 -0.35 -1.14 -5.86 -10.88 -0.99 4.79 9.31 -6.30 -8.79 -1.68 4.06 4.13
Mitochondria -1.38 -2.40 -1.53 -1.36 -1.51 -3.85 -2.11 -2.34 -0.08 -2.33 -3.90 -2.33 -2.72 -0.45 -2.70
Mitotic Spindle -0.57 4.27 -0.99 -0.99 -1.01 -2.35 3.03 -1.37 -1.35 -1.38 -2.33 6.92 -1.60 -1.56 -1.60
None -1.98 -2.42 -1.13 -1.07 -1.12 -2.87 -3.73 -1.83 2.75 -1.79 -2.87 -2.68 -1.77 2.65 -1.75
Nuclear Periphery -1.96 -7.71 2.99 2.12 12.25 0.06 2.54 5.16 7.47 10.57 -1.37 1.04 5.48 6.83 14.87
Nuclear Periphery Foci -1.78 -3.01 -1.60 1.52 0.96 -6.73 -5.88 1.00 7.21 6.55 -7.02 -4.40 0.58 7.28 4.98
Nucleolus -1.30 -0.03 -1.43 -1.37 -1.43 -2.45 -9.12 -1.93 -1.49 -1.92 -2.47 -5.82 -2.29 -1.68 -2.28
Nucleus -1.99 -4.28 -1.25 0.58 -0.73 -4.71 -7.56 -2.77 3.38 -0.44 -4.86 -7.36 -2.86 3.57 -1.27
Peroxisomes 1.19 0.98 -1.06 -1.08 -1.08 -2.51 -2.17 -1.72 -1.67 -1.71 -2.33 0.41 -1.99 -1.93 -1.99
Vacuole 0.57 -3.15 5.71 5.19 12.61 7.87 5.87 13.35 7.29 9.69 6.94 2.09 15.33 9.75 16.45
Vacuole Periphery -1.56 -0.24 1.70 2.02 4.25 -2.42 0.57 0.17 2.49 -0.30 -2.83 0.01 0.75 3.46 1.07
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo
Localization
Cell Percentages cytoplasm (91%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pdc1

Pdc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pdc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available