Standard name | |
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Human Ortholog | |
Description | Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 15 | 8 | 5 | 6 | 12 | 9 |
Bud | 5 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 4 | 3 | 12 |
Bud Neck | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 1 | 0 | 6 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 0 | 1 | 0 | 1 | 3 | 5 | 3 | 3 | 8 | 6 | 10 | 4 | 7 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 160 | 50 | 49 | 95 | 91 | 113 | 152 | 181 | 142 | 139 | 112 | 135 | 139 | 149 | 130 | 133 | 98 | 55 | 134 | 59 | 49 | 41 | 33 | 10 |
Endoplasmic Reticulum | 1 | 1 | 3 | 4 | 4 | 1 | 11 | 15 | 1 | 11 | 5 | 6 | 1 | 2 | 0 | 20 | 6 | 6 | 6 | 1 | 3 | 4 | 8 | 9 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 14 | 9 | 7 | 5 | 29 | 47 |
Golgi | 1 | 0 | 1 | 1 | 1 | 4 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 4 | 2 | 11 | 2 | 1 | 2 | 1 | 1 | 1 | 13 | 14 |
Mitochondria | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 2 |
Nucleus | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 2 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 3 |
Nucleolus | 47 | 18 | 16 | 4 | 2 | 6 | 2 | 1 | 2 | 1 | 0 | 2 | 13 | 8 | 8 | 45 | 11 | 2 | 1 | 0 | 0 | 1 | 5 | 8 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 | 4 | 8 | 9 | 21 | 22 |
SpindlePole | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 22 | 8 | 12 | 6 | 21 | 16 |
Vac/Vac Membrane | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 5 | 0 | 3 | 6 | 5 |
Unique Cell Count | 212 | 68 | 69 | 106 | 97 | 124 | 168 | 201 | 147 | 154 | 120 | 145 | 160 | 165 | 143 | 202 | 118 | 63 | 244 | 112 | 106 | 97 | 185 | 195 |
Labelled Cell Count | 217 | 71 | 70 | 107 | 98 | 126 | 172 | 206 | 151 | 157 | 128 | 153 | 167 | 168 | 147 | 216 | 121 | 70 | 244 | 112 | 106 | 97 | 185 | 195 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 195.8 | 192.8 | 140.7 | 149.2 | 128.4 | 109.0 | 86.9 | 85.5 | 75.5 | 75.4 | 77.5 | 78.0 | 336.0 | 326.4 | 317.1 | 169.4 | 227.9 | 245.0 | 181.1 | 192.4 | 188.3 |
Std Deviation (1e-4) | 40.2 | 48.8 | 38.8 | 39.0 | 40.4 | 34.1 | 28.5 | 23.1 | 22.1 | 23.1 | 18.1 | 22.8 | 76.6 | 78.4 | 71.3 | 57.0 | 65.7 | 78.3 | 64.2 | 52.4 | 70.6 |
Intensity Change (Log2) | – | – | – | 0.08 | -0.13 | -0.37 | -0.7 | -0.72 | -0.9 | -0.9 | -0.86 | -0.85 | 1.26 | 1.21 | 1.17 | 0.27 | 0.7 | 0.8 | 0.36 | 0.45 | 0.42 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3.2 | 4.0 | 3.6 | 3.8 | 3.8 | 5.5 | 3.7 | 4.2 | 4.4 | 2.9 | 3.7 | 3.7 | -0.8 | 1.9 | 2.3 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.4 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | -3.9 | -4.3 | -3.8 | -5.8 | 0 | -5.4 | -5.9 | -5.5 | -5.4 | -3.1 | -4.2 | -3.8 | -0.2 | -2.6 | -3.3 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Actin | 0.0224 | 0.0009 | 0.0161 | 0.0005 | 0.001 | 0.0004 | – | – | – | – | – | – | 0.009 | 0.0005 | 0.0086 | 0.0068 | 0.0002 | 0.0141 |
Bud | 0.0016 | 0.0005 | 0.0006 | 0.0007 | 0.0004 | 0.0005 | – | – | – | – | – | – | 0.0008 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0006 |
Bud Neck | 0.0011 | 0.0003 | 0.0041 | 0.0004 | 0.0007 | 0.0009 | – | – | – | – | – | – | 0.0005 | 0.0002 | 0.0007 | 0.0002 | 0.0002 | 0.0005 |
Bud Periphery | 0.0013 | 0.0002 | 0.0006 | 0.0001 | 0.0002 | 0.0001 | – | – | – | – | – | – | 0.0006 | 0 | 0.0001 | 0.0002 | 0 | 0.0013 |
Bud Site | 0.0028 | 0.0004 | 0.0004 | 0 | 0.0009 | 0.0001 | – | – | – | – | – | – | 0.0027 | 0 | 0.0002 | 0.0005 | 0 | 0.0009 |
Cell Periphery | 0.0025 | 0.0011 | 0.0008 | 0.0001 | 0.0004 | 0.0007 | – | – | – | – | – | – | 0.0013 | 0.0001 | 0 | 0.0003 | 0 | 0.0003 |
Cytoplasm | 0.8032 | 0.9706 | 0.9436 | 0.9755 | 0.7991 | 0.9679 | – | – | – | – | – | – | 0.8584 | 0.9844 | 0.9617 | 0.7714 | 0.9888 | 0.8452 |
Cytoplasmic Foci | 0.0176 | 0.0026 | 0.0024 | 0.0002 | 0.0307 | 0.0005 | – | – | – | – | – | – | 0.0136 | 0.0029 | 0.001 | 0.0494 | 0.0001 | 0.0012 |
Eisosomes | 0.0007 | 0.0003 | 0.0034 | 0 | 0.0006 | 0 | – | – | – | – | – | – | 0.001 | 0 | 0 | 0.0006 | 0 | 0.0006 |
Endoplasmic Reticulum | 0.0027 | 0.0001 | 0.0006 | 0.0001 | 0.0006 | 0.0002 | – | – | – | – | – | – | 0.0042 | 0.0001 | 0.0003 | 0.001 | 0 | 0.0093 |
Endosome | 0.0088 | 0 | 0.0008 | 0.0001 | 0.0026 | 0.0001 | – | – | – | – | – | – | 0.0034 | 0 | 0.0028 | 0.0121 | 0 | 0.029 |
Golgi | 0.004 | 0 | 0.0024 | 0 | 0.0012 | 0 | – | – | – | – | – | – | 0.0013 | 0 | 0.0039 | 0.0059 | 0 | 0.0084 |
Lipid Particles | 0.0064 | 0.0003 | 0.0006 | 0 | 0.026 | 0.0001 | – | – | – | – | – | – | 0.0059 | 0 | 0.0007 | 0.0282 | 0 | 0.0011 |
Mitochondria | 0.012 | 0.0065 | 0.0094 | 0.0016 | 0.0357 | 0.0004 | – | – | – | – | – | – | 0.0123 | 0.0003 | 0.0015 | 0.0253 | 0.0002 | 0.0554 |
None | 0.0131 | 0.0014 | 0.0038 | 0.0003 | 0.0097 | 0.0007 | – | – | – | – | – | – | 0.0271 | 0.0007 | 0.0004 | 0.0067 | 0.0002 | 0.0019 |
Nuclear Periphery | 0.0193 | 0.0015 | 0.0022 | 0.0032 | 0.0055 | 0.0047 | – | – | – | – | – | – | 0.0129 | 0.0012 | 0.0036 | 0.0037 | 0.0008 | 0.0098 |
Nucleolus | 0.0179 | 0.0055 | 0.0004 | 0.0002 | 0.0529 | 0.0017 | – | – | – | – | – | – | 0.016 | 0.0001 | 0.0001 | 0.0582 | 0 | 0.0004 |
Nucleus | 0.0457 | 0.0058 | 0.0062 | 0.0139 | 0.0173 | 0.0169 | – | – | – | – | – | – | 0.0218 | 0.0037 | 0.0132 | 0.0093 | 0.0092 | 0.0147 |
Peroxisomes | 0.0028 | 0.0005 | 0.0004 | 0.0001 | 0.0041 | 0 | – | – | – | – | – | – | 0.001 | 0 | 0.0004 | 0.0068 | 0 | 0.0003 |
Punctate Nuclear | 0.0053 | 0.0001 | 0.0002 | 0.0001 | 0.0035 | 0.0003 | – | – | – | – | – | – | 0.0031 | 0.0056 | 0.0003 | 0.0104 | 0.0001 | 0.0005 |
Vacuole | 0.0055 | 0.001 | 0.0007 | 0.0012 | 0.0027 | 0.0025 | – | – | – | – | – | – | 0.0018 | 0.0001 | 0.0001 | 0.0009 | 0 | 0.0019 |
Vacuole Periphery | 0.0033 | 0.0006 | 0.0004 | 0.0016 | 0.0042 | 0.0014 | – | – | – | – | – | – | 0.0011 | 0 | 0.0001 | 0.0018 | 0 | 0.0028 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 546.6156 | 202.8717 | 117.8361 | 147.5718 | 118.2031 | 471.6202 | 206.7148 | 204.8023 | 244.7106 | 242.846 |
Translational Efficiency | 1.5646 | 1.6596 | 1.6631 | 1.5816 | 1.6855 | 2.0651 | 1.8191 | 1.8299 | 1.8814 | 1.8436 |
Dataset | Hit |
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Protein Concentration | – |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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