Standard name
Human Ortholog
Description Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.25 0.28 0.26 0.19 0.23 0.09 0.14 0.11 0.1 0.09 0.06 0.08 0.14 0 0 0.23 0.29 0.2 0.27 0.18 0.14 0.26 0.2 0.21
Bud 0.14 0.16 0.12 0.11 0.18 0.12 0.1 0.07 0.1 0.11 0.12 0.12 0.09 0 0 0.06 0.08 0 0.13 0.17 0.16 0.37 0.41 0.39
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0.07 0.08 0.05 0
Bud Site 0 0 0.05 0.05 0.05 0 0.05 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0.05 0 0 0 0.05 0.07 0 0 0 0.06 0 0 0 0 0 0
Cytoplasm 0.47 0.47 0.41 0.45 0.49 0.5 0.63 0.65 0.6 0.48 0.54 0.55 0.7 0.83 0.84 0.25 0.29 0.35 0.21 0.25 0.19 0 0.07 0.11
Endoplasmic Reticulum 0.05 0.09 0 0.05 0 0 0.06 0.06 0 0 0 0 0 0 0.08 0 0.05 0 0.09 0 0.05 0.05 0.06 0.08
Endosome 0.07 0.07 0.11 0.14 0.1 0.14 0.06 0.06 0 0 0 0 0.06 0 0 0.16 0.1 0.1 0.09 0.07 0.09 0 0.05 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.22 0.26 0.23 0 0 0 0 0 0
Mitochondria 0.13 0.05 0 0.14 0.05 0.14 0.12 0.06 0.3 0.41 0.42 0.26 0 0 0 0.06 0.09 0 0 0.05 0.09 0.06 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.16 0 0.12 0.05 0 0.05 0 0 0 0.05 0 0 0 0.16 0.11 0.15 0 0 0.06 0 0 0
Vac/Vac Membrane 0 0 0.06 0 0 0.05 0 0.06 0 0 0 0 0 0 0 0.12 0.06 0.11 0.05 0.09 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 52 56 57 26 35 24 37 36 23 23 12 19 35 12 14 40 31 28 70 51 37 53 70 63
Bud 29 32 25 15 28 31 28 22 22 28 26 27 22 14 9 10 9 3 35 46 43 74 144 116
Bud Neck 0 1 2 1 0 0 1 1 0 2 0 0 0 0 0 1 4 0 14 17 19 16 17 10
Bud Site 9 7 10 7 8 10 14 1 7 9 5 4 5 0 0 4 0 0 – – – – – –
Cell Periphery 8 6 8 3 3 4 6 3 12 10 3 8 12 21 12 6 3 9 3 1 1 0 0 0
Cytoplasm 97 95 88 63 76 133 172 213 137 116 113 125 177 260 304 44 31 49 55 69 51 5 23 32
Endoplasmic Reticulum 11 18 9 7 2 4 17 20 7 0 5 4 5 14 30 4 5 5 23 11 13 9 22 23
Endosome 15 14 24 19 15 37 16 20 5 6 5 7 15 6 7 28 11 14 22 19 24 8 18 13
Golgi 6 9 2 5 6 1 3 0 0 0 0 0 6 4 4 39 28 33 5 8 8 1 8 4
Mitochondria 28 10 5 19 7 36 34 20 68 99 89 59 8 2 5 11 10 6 11 13 24 11 10 9
Nucleus 1 2 0 1 0 0 3 5 1 3 2 2 2 0 0 0 1 1 0 0 1 0 0 0
Nuclear Periphery 1 0 0 1 0 0 0 1 0 3 0 0 0 0 0 0 0 0 1 1 0 0 0 1
Nucleolus 4 2 4 1 1 3 1 5 1 5 2 2 1 0 0 5 0 0 1 0 1 0 1 1
Peroxisomes 9 6 11 5 4 15 0 0 0 2 1 2 11 3 0 3 2 0 1 1 2 5 5 0
SpindlePole 2 5 34 6 18 14 8 16 3 8 7 11 1 3 2 28 12 21 3 9 16 7 10 9
Vac/Vac Membrane 7 5 14 5 5 13 5 18 5 6 4 8 3 8 3 22 7 15 13 24 13 3 7 4
Unique Cell Count 208 202 216 140 155 264 272 326 228 244 211 226 253 314 360 176 108 141 265 280 265 202 348 298
Labelled Cell Count 279 268 293 184 208 325 345 381 291 320 274 278 303 347 390 245 154 184 265 280 265 202 348 298


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.0 9.8 9.2 8.0 8.6 7.4 7.2 7.2 6.4 5.9 5.9 6.2 10.3 10.4 10.2 12.0 12.2 11.7 9.5 9.1 9.8
Std Deviation (1e-4) 1.5 1.8 1.1 1.1 1.2 1.2 1.3 1.1 1.0 0.9 1.1 1.1 1.3 1.4 1.6 2.2 2.1 2.1 1.8 1.6 1.9
Intensity Change (Log2) – – – -0.19 -0.09 -0.31 -0.36 -0.34 -0.52 -0.63 -0.64 -0.56 0.16 0.19 0.15 0.39 0.41 0.35 0.05 -0.01 0.09


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.7 -0.8 -5.0 -3.6 -4.6 -4.5 -4.8 -5.8 -5.0 -3.4 -7.6 -8.0 -0.8 0.4 -1.4
Bud -0.3 1.8 0.1 -0.5 -2.0 -0.7 0 0.2 0.1 -1.0 -3.1 -4.5 -2.0 -0.9 -3.2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0.2 0.2 -0.5 0.3 0 -0.9 -0.5 -1.3 -1.7 -1.6 0 0 -1.3 0 0
Cell Periphery 0 0 -1.5 -1.0 0 0.8 0.2 -1.5 -0.1 0.6 1.5 -0.2 -0.2 0 1.2
Cytoplasm 0.8 1.6 2.1 4.9 5.6 4.1 1.5 2.7 3.1 6.4 10.0 10.9 -3.3 -2.1 -1.1
Endoplasmic Reticulum 0.4 0 -1.8 1.0 1.0 -0.6 0 -1.0 -1.5 -1.4 0.2 1.9 -1.0 0 -0.3
Endosome 0.7 -0.4 1.0 -2.1 -2.1 -3.8 -3.8 -3.6 -3.3 -2.0 -4.5 -4.7 1.4 -0.3 -0.4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 6.8 7.3 7.0
Mitochondria 4.1 1.2 4.4 4.1 2.1 7.8 9.8 9.9 7.1 0.6 0 0 2.0 2.8 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes -0.7 -1.2 0.3 0 0 -3.5 -2.8 -2.9 -2.6 -0.4 -2.9 0 -1.8 0 0
SpindlePole -3.3 -1.1 -3.8 -5.0 -4.3 -5.5 -4.6 -4.4 -3.8 -6.3 -6.6 -7.3 0 -1.1 -0.2
Vacuole -1.2 -1.4 -0.7 -2.6 -0.5 -2.2 -2.1 -2.4 -1.4 -3.1 -2.2 -3.9 2.1 0 1.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.4528 5.4043 4.9934 4.676 5.1531 5.4351 5.9347 6.9547 6.2885 6.9706 6.3219 7.0962 4.926 5.8515 5.1597 5.1652 4.8558 5.6117
Actin 0.1453 0.1036 0.1783 0.1793 0.3182 0.1035 0.2456 0.1626 0.2582 0.2871 0.3735 0.2021 0.1786 0.0792 0.196 0.2132 0.2734 0.141
Bud 0.046 0.0408 0.1917 0.0395 0.0315 0.0083 0.0343 0.0344 0.1495 0.0633 0.0324 0.0083 0.051 0.0311 0.1744 0.0537 0.0522 0.0064
Bud Neck 0.0408 0.0057 0.0063 0.0064 0.0088 0.4577 0.0293 0.004 0.0078 0.0058 0.0547 0.4408 0.0414 0.0072 0.0071 0.0739 0.0044 0.4641
Bud Periphery 0.0426 0.027 0.1758 0.1214 0.0386 0.0135 0.0293 0.0203 0.1544 0.1364 0.0449 0.0084 0.0517 0.0158 0.1885 0.0421 0.0936 0.0082
Bud Site 0.1053 0.3005 0.0844 0.029 0.0386 0.0097 0.1626 0.3268 0.0681 0.0131 0.009 0.0129 0.166 0.3789 0.0989 0.0315 0.0118 0.0042
Cell Periphery 0.0027 0.0023 0.0016 0.0022 0.0012 0.0015 0.0021 0.0014 0.0016 0.0022 0.0037 0.0013 0.0052 0.0021 0.0028 0.002 0.0015 0.001
Cytoplasm 0.1614 0.3213 0.1439 0.3263 0.1648 0.1268 0.1489 0.227 0.1485 0.2089 0.1988 0.0986 0.1574 0.277 0.1768 0.3566 0.218 0.1109
Cytoplasmic Foci 0.1503 0.0677 0.0567 0.0885 0.1111 0.0968 0.1175 0.092 0.0443 0.0588 0.0569 0.0813 0.118 0.1048 0.0327 0.0492 0.0505 0.1098
Eisosomes 0.0007 0.0003 0.0004 0.0002 0.0004 0.0002 0.0005 0.0002 0.0003 0.0002 0.0002 0.0025 0.0014 0.0001 0.0004 0.0001 0.0003 0.0004
Endoplasmic Reticulum 0.012 0.0074 0.0025 0.0066 0.0068 0.0099 0.0164 0.0028 0.0035 0.003 0.0036 0.0044 0.0257 0.0049 0.0038 0.0121 0.0136 0.0038
Endosome 0.0888 0.0613 0.0637 0.099 0.1373 0.0575 0.0719 0.0573 0.0548 0.1023 0.0662 0.0313 0.0609 0.0392 0.0387 0.086 0.0746 0.0428
Golgi 0.0695 0.0353 0.0516 0.0623 0.069 0.0706 0.082 0.0447 0.0565 0.0962 0.1001 0.0761 0.055 0.0324 0.035 0.0238 0.09 0.0579
Lipid Particles 0.0148 0.0011 0.0041 0.0014 0.0057 0.0047 0.0092 0.0008 0.0069 0.0024 0.003 0.0028 0.0117 0.0019 0.0029 0.0223 0.005 0.0027
Mitochondria 0.0359 0.0037 0.0151 0.0091 0.0113 0.0182 0.0192 0.0059 0.0277 0.0074 0.011 0.0067 0.0098 0.0034 0.0131 0.005 0.0587 0.0081
None 0.0072 0.0038 0.0034 0.0015 0.0014 0.0007 0.0025 0.0012 0.0009 0.001 0.0006 0.0004 0.0083 0.0018 0.0093 0.0018 0.0035 0.0068
Nuclear Periphery 0.0187 0.0007 0.0012 0.0009 0.0025 0.0007 0.0036 0.0007 0.0012 0.0005 0.0006 0.0003 0.0128 0.0005 0.0012 0.0011 0.0193 0.0023
Nucleolus 0.0023 0.0003 0.0005 0.0003 0.0001 0.0002 0.0005 0.0003 0.0002 0.0001 0.0002 0.0002 0.0016 0.0004 0.0007 0.0006 0.0006 0.0007
Nucleus 0.0055 0.0011 0.0016 0.0011 0.0007 0.0006 0.0013 0.0008 0.0007 0.0006 0.0006 0.0003 0.0085 0.0007 0.0016 0.0013 0.0067 0.0013
Peroxisomes 0.0249 0.0072 0.0055 0.0037 0.0421 0.012 0.0152 0.0093 0.0083 0.0036 0.0324 0.0175 0.0223 0.0136 0.0056 0.0105 0.0074 0.0188
Punctate Nuclear 0.0144 0.0013 0.002 0.0012 0.0022 0.0012 0.0028 0.0007 0.0008 0.0003 0.0006 0.0014 0.0039 0.0014 0.0008 0.0011 0.0072 0.0061
Vacuole 0.0078 0.0064 0.0075 0.0161 0.0048 0.0036 0.0039 0.0057 0.004 0.0051 0.0048 0.002 0.0057 0.0031 0.0079 0.0103 0.005 0.0017
Vacuole Periphery 0.0033 0.0011 0.002 0.0041 0.0026 0.0018 0.0015 0.0012 0.0017 0.0016 0.002 0.0006 0.003 0.0006 0.0018 0.0018 0.0026 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.9142 30.0855 23.2816 26.327 22.7527 13.9351 24.9874 28.3036 29.0126 26.9924
Translational Efficiency 0.9249 0.7129 0.8274 0.7362 0.7105 1.1145 0.8311 0.5474 0.5709 0.606

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1835 811 2091 1222 1467 1578 1631 552 3302 2389 3722 1774

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 957.65 1130.59 1501.17 1246.83 910.64 1099.42 1255.17 1209.78 936.76 1110.00 1393.37 1235.30
Standard Deviation 120.91 180.98 194.77 171.57 185.26 162.73 163.20 187.47 154.65 169.79 218.82 177.50
Intensity Change Log 2 — 0.239505 0.648517 0.380694 — 0.271790 0.462930 0.409792 — 0.255332 0.561035 0.394950

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.036530 0.034351 0.061871 0.120087* 0.030388 0.056380 0.084290 0.093508 0.033802 0.048902 0.071695 0.111816*
Bud Neck 0.023264 0.013412 0.008557 0.015069 0.021208 0.024383 0.015649 0.013162 0.022351 0.020659 0.011665 0.014476
Bud Site 0.345139* 0.357624* 0.312244* 0.407461* 0.266120* 0.343712* 0.418674* 0.353976* 0.310033* 0.348435* 0.358882* 0.390818*
Cell Periphery 0.003173 0.003829 0.003192 0.003046 0.003474 0.003337 0.001395 0.033665 0.003307 0.003504 0.002405 0.012573
Cytoplasm 0.119758* 0.127927* 0.269168* 0.165039* 0.130289* 0.132070* 0.138869* 0.100005* 0.124437* 0.130664* 0.212070* 0.144803*
Cytoplasmic Foci 0.227466* 0.242754* 0.127987 0.115675 0.261308* 0.208532* 0.139320 0.150362 0.242501* 0.220149* 0.132954 0.126469
Eisosomes 0.001128 0.000342 0.000230 0.000385 0.000953 0.000813 0.000248 0.000851 0.001051 0.000653 0.000238 0.000530
Endoplasmic Reticulum 0.004833 0.008296 0.009033 0.003573 0.008598 0.005656 0.003545 0.004951 0.006506 0.006552 0.006628 0.004002
Endosome 0.042341 0.048346 0.035019 0.033825 0.074007 0.049175 0.053612 0.082088 0.056409 0.048894 0.043166 0.048843
Golgi 0.135771* 0.117976* 0.096093 0.060950 0.131233* 0.133302* 0.081430 0.086258 0.133755* 0.128099* 0.089668 0.068825
Lipid Particles 0.002008 0.004696 0.025991 0.010183 0.009194 0.002125 0.006588 0.012217 0.005200 0.002998 0.017489 0.010816
Mitochondria 0.030239 0.007550 0.003278 0.004557 0.019483 0.011493 0.004005 0.002615 0.025460 0.010154 0.003597 0.003952
Mitotic Spindle 0.001336 0.003662 0.011147 0.015150 0.001597 0.002653 0.015424 0.013259 0.001452 0.002996 0.013021 0.014562
None 0.000177 0.000102 0.000170 0.000324 0.003285 0.000103 0.000049 0.000082 0.001558 0.000103 0.000117 0.000249
Nuclear Periphery 0.000009 0.000021 0.000051 0.000130 0.000091 0.000014 0.000025 0.000109 0.000045 0.000017 0.000039 0.000123
Nuclear Periphery Foci 0.000110 0.000199 0.002073 0.000725 0.001455 0.000170 0.000385 0.001249 0.000708 0.000180 0.001333 0.000888
Nucleolus 0.000056 0.000103 0.000032 0.000116 0.000859 0.000029 0.000024 0.001469 0.000413 0.000054 0.000029 0.000537
Nucleus 0.000658 0.000452 0.000785 0.000833 0.001790 0.000248 0.000348 0.000568 0.001161 0.000317 0.000594 0.000751
Peroxisomes 0.012914 0.009053 0.006641 0.017680 0.009480 0.011357 0.015767 0.016492 0.011388 0.010575 0.010640 0.017311
Vacuole 0.004123 0.010232 0.020464 0.021713 0.011639 0.007375 0.017100 0.026604 0.007462 0.008345 0.018990 0.023235
Vacuole Periphery 0.008966 0.009073 0.005973 0.003479 0.013548 0.007070 0.003251 0.006508 0.011001 0.007750 0.004780 0.004421

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.51 -6.17 -11.86 -11.26 -7.87 -5.97 -10.14 -6.89 -3.78 -0.80 -4.69 -11.56 -13.94 -10.42 -6.57
Bud Neck 4.33 8.29 3.86 -1.00 -5.57 -1.16 2.53 3.42 5.01 1.53 0.90 7.69 4.90 3.76 -3.05
Bud Site -0.86 3.53 -4.87 -3.19 -8.64 -6.82 -13.19 -5.30 -0.42 4.06 -4.39 -6.07 -8.18 -3.83 -3.37
Cell Periphery -0.81 0.08 0.49 1.06 0.43 0.20 4.43 -4.95 -4.96 -5.32 -0.38 3.11 -4.72 -4.54 -5.25
Cytoplasm -1.16 -21.44 -6.66 -4.53 11.63 -0.27 -1.66 2.76 2.95 3.91 -1.34 -17.73 -4.26 -2.94 9.92
Cytoplasmic Foci -1.60 16.89 15.76 13.41 1.71 6.75 16.88 11.06 6.00 -1.25 3.85 23.86 20.21 15.21 0.96
Eisosomes 6.57 7.86 6.10 -0.54 -2.95 0.86 4.82 0.45 -0.04 -2.31 3.83 8.94 4.33 1.40 -3.28
Endoplasmic Reticulum -2.29 -4.02 1.55 3.11 5.10 2.31 4.70 2.55 0.60 -1.02 -0.04 -0.21 3.36 2.86 3.50
Endosome -1.92 3.49 3.55 4.68 0.77 6.68 5.38 -0.94 -5.15 -4.40 3.24 6.40 3.04 0.38 -1.87
Golgi 2.62 7.76 13.97 8.86 7.42 -0.33 9.07 6.18 6.38 -0.44 1.25 11.75 15.32 12.94 5.51
Lipid Particles -2.49 -15.52 -6.68 -3.66 7.59 5.16 1.33 -1.47 -4.65 -2.42 3.03 -10.95 -4.86 -6.96 4.12
Mitochondria 10.07 13.75 12.47 2.31 -1.45 5.03 10.61 11.30 8.07 1.52 10.83 17.21 16.04 7.15 -0.43
Mitotic Spindle -2.90 -9.94 -7.58 -5.96 -2.22 -1.91 -8.12 -4.09 -3.78 0.03 -3.49 -12.42 -8.46 -7.41 -1.39
None 1.98 0.16 -0.64 -0.96 -0.67 2.81 2.86 2.83 0.83 -1.98 2.89 2.86 2.50 -0.94 -0.83
Nuclear Periphery -1.10 -6.15 -1.75 -1.27 -1.09 2.73 2.25 -0.36 -1.90 -1.63 1.51 0.14 -1.53 -1.99 -1.61
Nuclear Periphery Foci -2.81 -4.31 -4.54 -3.60 2.68 3.14 2.54 0.21 -2.58 -2.04 2.77 -2.15 -1.10 -4.37 1.32
Nucleolus -0.82 1.00 -1.51 0.41 -2.12 2.73 2.74 -0.40 -1.03 -1.04 2.08 2.82 -0.27 -1.04 -1.21
Nucleus -0.24 -0.80 -1.20 -0.41 -0.85 3.95 2.81 2.65 -1.99 -0.30 2.35 1.69 0.78 -1.93 -1.08
Peroxisomes 3.22 7.01 -3.30 -6.18 -9.92 -1.82 -5.37 -3.66 -2.60 -0.27 1.01 1.21 -5.31 -6.03 -6.47
Vacuole -4.73 -14.18 -10.85 -6.07 -1.28 3.83 -4.66 -5.58 -7.12 -3.25 -1.38 -13.42 -11.26 -10.31 -3.12
Vacuole Periphery -0.07 4.33 7.61 4.57 4.59 5.92 10.27 4.55 0.55 -2.39 4.32 10.54 9.15 4.80 0.86
Standard name
Human Ortholog
Description Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress
Localization
Cell Percentages cytoplasm (41%), actin (8%), mixed (32%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Avl9

Avl9


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Avl9-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available