Standard name
Human Ortholog
Description Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.06 0.06 0.06 0 – 0 0.06 0 0 0.13 0.17 0.17 0.09 0.1 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.22 0 0 0 0.05 0.13 0.11 – 0.36 0.27 0.5 0.5 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.93 0.95 0.94 0.91 0.89 0.84 0.9 – 0.87 0.8 0.79 0.79 0.86 0.81 0.79 0.83 0.8 0.87 0.92 0.93 0.88 0.88 0.83 0.77
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0.08 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.05 0 0 – 0 0 0 0 0 0 0 0.07 0.06 0 0 0 0.06 0.05 0.08 0.13
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 1 0 – 1 1 2 2 0 0 0 0 0 0 1 1 1 1 1 1
Bud Neck 0 0 1 0 0 0 0 – 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 1 1 4 4 – 6 4 8 7 0 1 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 6 6 11 11 16 13 – 6 15 9 9 42 50 80 21 25 11 2 0 2 2 5 1
Endoplasmic Reticulum 0 1 0 0 0 0 0 – 0 0 0 0 1 0 0 7 4 3 0 0 0 0 0 1
Endosome 0 0 1 4 3 2 1 – 0 0 0 0 1 2 5 1 3 2 0 1 3 0 4 4
Golgi 0 0 1 0 0 0 0 – 0 0 0 0 0 1 1 1 0 1 0 1 0 0 1 3
Mitochondria 35 10 0 6 9 36 34 – 75 64 101 101 0 2 3 6 5 3 0 1 1 2 6 7
Nucleus 147 435 170 162 170 234 269 – 180 194 160 160 285 242 375 194 192 138 143 440 165 187 352 268
Nuclear Periphery 0 2 0 3 1 7 0 – 1 1 3 3 5 3 1 3 4 2 0 0 0 1 0 2
Nucleolus 3 4 0 0 1 4 3 – 7 7 17 17 0 1 2 2 1 4 0 5 0 4 11 8
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 3 1 2 0 3 2 – 2 3 1 1 2 6 7 0 1 3 1 1 0 1 2 2
Vac/Vac Membrane 1 20 3 3 10 10 5 – 1 3 1 2 3 4 10 17 15 6 5 14 10 10 34 44
Unique Cell Count 158 459 181 179 191 278 299 206 241 203 203 330 299 472 233 239 158 155 473 187 214 426 351
Labelled Cell Count 189 481 183 192 206 317 331 280 293 302 302 339 313 486 252 250 173 155 473 187 214 426 351


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 6.7 6.8 6.1 6.7 5.3 5.4 – 4.5 4.9 4.0 4.0 6.9 6.7 6.5 8.5 8.9 8.2 6.3 6.3 6.5
Std Deviation (1e-4) 0.8 1.0 1.8 1.5 2.1 1.8 1.5 – 1.1 1.6 0.9 0.9 1.4 1.4 1.5 2.0 2.0 2.0 1.4 1.2 1.3
Intensity Change (Log2) – – – -0.16 -0.03 -0.35 -0.34 – -0.6 -0.47 -0.75 -0.75 0.01 -0.02 -0.07 0.32 0.38 0.28 -0.11 -0.11 -0.06


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.3 1.1 1.2 0.6 – -0.2 1.4 0.6 0.6 3.5 4.4 4.6 2.3 2.8 1.5
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.0 4.7 – 0 7.5 0 0 0 0 0 0 0 0
Nucleus -1.2 -1.7 -3.1 -1.5 – -2.2 -4.0 -4.3 -4.3 -2.6 -4.0 -4.5 -3.3 -4.0 -2.1
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.9 1.2 0 – 0 0 0 0 0 0 0 2.7 2.3 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.4243 0.558 0.2575 0.2304 -0.036 0.2285 1.5436 1.4143 1.3354 1.6474 1.6363 1.2313 0.822 1.3574 0.9892 0.9589 0.5324 1.0339
Actin 0.0129 0.0044 0 0 0.0046 0.0004 0.0088 0 0.0001 0.004 0.0146 0.0014 0.0015 0 0 0 0 0
Bud 0.0001 0.0001 0 0 0.0005 0 0.0011 0 0.0048 0.0005 0.0003 0.0003 0 0 0 0 0 0
Bud Neck 0.0002 0.0016 0.0001 0 0.0004 0.0008 0.0061 0.0001 0.0001 0.0001 0.0007 0.0009 0.0003 0 0 0 0.0003 0.0004
Bud Periphery 0.0002 0.0002 0 0 0.0012 0 0.0021 0 0.0015 0.0018 0.0004 0.0006 0 0 0 0 0 0
Bud Site 0.0004 0.0083 0 0 0.0016 0.0001 0.0067 0 0.0007 0.001 0.0058 0.0005 0.0012 0 0 0 0 0
Cell Periphery 0.0001 0.0006 0 0 0.0001 0 0.0005 0 0.0001 0.0005 0.0001 0.0001 0 0 0 0 0 0
Cytoplasm 0.0025 0.0053 0.001 0.0003 0.0006 0.0004 0.0056 0.0014 0.0006 0.0131 0.0014 0.001 0.0014 0.0003 0.0003 0 0.0002 0.0002
Cytoplasmic Foci 0.0148 0.004 0 0.0003 0.0074 0.0022 0.0272 0 0.0029 0.0007 0.0105 0.0014 0.0007 0 0 0 0 0
Eisosomes 0.0001 0 0 0 0.0001 0 0.0001 0 0 0.0003 0.0001 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0007 0.0002 0.0001 0 0.0007 0.0003 0.0023 0.0001 0 0.0013 0.0004 0.0013 0.0001 0 0 0 0 0
Endosome 0.0212 0.0013 0.0001 0 0.0165 0.013 0.0364 0.0001 0.0012 0.0094 0.0101 0.0049 0.0002 0 0 0 0 0
Golgi 0.0069 0.0018 0 0 0.0064 0.0081 0.0095 0 0.0004 0.0019 0.0099 0.0011 0.0001 0 0 0 0 0
Lipid Particles 0.0228 0.0013 0 0 0.0087 0.0002 0.0322 0 0.0051 0.002 0.0311 0.0032 0.0001 0 0 0 0 0
Mitochondria 0.0033 0.0006 0.0002 0.0001 0.095 0.0007 0.0162 0.0001 0.0009 0.0703 0.0458 0.0024 0.0001 0.0001 0.0001 0 0.0001 0
None 0.0023 0.0001 0.002 0.0001 0.0004 0 0.0053 0.0012 0.0007 0.0048 0.0006 0.0006 0.0054 0.0004 0.0051 0 0.0002 0.001
Nuclear Periphery 0.0059 0.0066 0.0081 0.0053 0.0115 0.0018 0.0245 0.0087 0.0017 0.0098 0.015 0.0081 0.0036 0.0024 0.0024 0.0004 0.0008 0.0005
Nucleolus 0.0054 0.0065 0.0055 0.0033 0.0139 0.0183 0.0138 0.0055 0.0059 0.0015 0.0133 0.0194 0.0114 0.0077 0.0062 0.0032 0.0372 0.0123
Nucleus 0.8731 0.931 0.9801 0.9173 0.7996 0.9524 0.7609 0.97 0.9573 0.8707 0.8236 0.9408 0.958 0.9843 0.977 0.9958 0.9405 0.9803
Peroxisomes 0.0177 0.0063 0 0 0.023 0.0001 0.0095 0 0.0019 0.0003 0.008 0.0023 0.0001 0 0 0 0 0
Punctate Nuclear 0.0076 0.0173 0.0026 0.073 0.0049 0.0006 0.017 0.0127 0.0134 0.0012 0.0062 0.0078 0.0154 0.0045 0.0087 0.0004 0.0207 0.0051
Vacuole 0.0011 0.0024 0.0001 0 0.0013 0.0002 0.0099 0.0001 0.0003 0.003 0.0007 0.0014 0.0001 0 0 0 0 0
Vacuole Periphery 0.0005 0.0001 0.0001 0 0.0013 0.0001 0.0043 0.0001 0.0002 0.0018 0.0013 0.0006 0 0 0 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.6919 14.8148 8.8655 16.3057 13.8625 10.686 14.1336 15.0018 16.9385 18.1047
Translational Efficiency 0.966 0.7518 1.0255 0.5997 0.7188 1.0602 0.8416 0.5837 0.6431 0.6343

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1572 518 1561 1407 2206 2010 154 763 3778 2528 1715 2170

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 645.96 811.91 841.45 939.34 765.84 768.91 924.64 816.42 715.96 777.72 848.92 896.12
Standard Deviation 100.58 155.14 105.55 136.67 93.97 109.30 132.57 147.35 113.39 121.37 110.83 152.28
Intensity Change Log 2 — 0.329875 0.381433 0.540203 — 0.005772 0.271849 0.092269 — 0.163137 0.323023 0.314560

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000122 0.001530 0.000633 0.000987 0.000101 0.000270 0.001152 0.001798 0.000110 0.000528 0.000680 0.001272
Bud Neck 0.002666 0.004979 0.014363 0.033653 0.003641 0.006227 0.003586 0.014943 0.003235 0.005971 0.013395 0.027074
Bud Site 0.001700 0.004696 0.001965 0.011551 0.000535 0.001432 0.000689 0.019317 0.001020 0.002101 0.001851 0.014281
Cell Periphery 0.000206 0.000175 0.000079 0.000170 0.000102 0.000122 0.000148 0.000995 0.000145 0.000133 0.000085 0.000460
Cytoplasm 0.034017 0.010460 0.002747 0.014745 0.002485 0.006447 0.002015 0.086007 0.015605 0.007270 0.002681 0.039801
Cytoplasmic Foci 0.003163 0.004214 0.000028 0.003714 0.000405 0.002771 0.000069 0.011658 0.001553 0.003067 0.000032 0.006507
Eisosomes 0.000016 0.000034 0.000022 0.000025 0.000010 0.000017 0.000043 0.000721 0.000012 0.000020 0.000024 0.000270
Endoplasmic Reticulum 0.001547 0.007347 0.005326 0.008286 0.003177 0.004117 0.008669 0.004053 0.002499 0.004779 0.005626 0.006797
Endosome 0.000347 0.001574 0.000167 0.003288 0.000234 0.001824 0.000259 0.005909 0.000281 0.001773 0.000175 0.004210
Golgi 0.000135 0.000802 0.000048 0.005002 0.000100 0.000794 0.000079 0.002461 0.000114 0.000796 0.000051 0.004108
Lipid Particles 0.000495 0.000825 0.000072 0.000640 0.000322 0.001134 0.000268 0.002163 0.000394 0.001071 0.000090 0.001175
Mitochondria 0.001526 0.005691 0.001204 0.004242 0.001438 0.005051 0.000772 0.004021 0.001474 0.005182 0.001165 0.004164
Mitotic Spindle 0.000729 0.005216 0.000544 0.035814 0.002298 0.005013 0.000109 0.012287 0.001645 0.005055 0.000505 0.027542
None 0.045011 0.009495 0.001906 0.005848 0.002606 0.005868 0.004212 0.030071 0.020250 0.006611 0.002113 0.014365
Nuclear Periphery 0.000552 0.000877 0.000498 0.004334 0.001069 0.001641 0.000495 0.001047 0.000854 0.001485 0.000498 0.003178
Nuclear Periphery Foci 0.000441 0.000648 0.000083 0.002807 0.000214 0.000375 0.000249 0.000952 0.000308 0.000431 0.000098 0.002155
Nucleolus 0.012761 0.011722 0.005553 0.004542 0.006486 0.009694 0.008847 0.006291 0.009097 0.010109 0.005849 0.005157
Nucleus 0.893163* 0.923814* 0.963327* 0.848733* 0.973635* 0.940857* 0.965408* 0.781681* 0.940152* 0.937365* 0.963514* 0.825157*
Peroxisomes 0.000388 0.003162 0.000255 0.000598 0.000559 0.000988 0.000330 0.001667 0.000488 0.001433 0.000262 0.000974
Vacuole 0.000820 0.002263 0.001081 0.008951 0.000409 0.004276 0.002487 0.010223 0.000580 0.003864 0.001207 0.009398
Vacuole Periphery 0.000195 0.000476 0.000099 0.002072 0.000172 0.001082 0.000113 0.001736 0.000182 0.000958 0.000100 0.001953

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.34 -14.42 -17.00 0.37 -8.10 -3.38 -8.99 -2.23 -1.99 -0.20 -3.19 -17.13 -5.38 -3.25 -2.72
Bud Neck -2.83 -11.59 -16.33 -14.31 -8.32 -3.34 -2.22 -7.89 -6.23 -6.18 -4.53 -11.73 -17.89 -15.48 -7.58
Bud Site -1.68 -0.74 -5.45 -2.14 -5.31 -3.11 -2.52 -4.93 -4.60 -4.61 -2.27 -2.47 -7.70 -6.66 -6.69
Cell Periphery 0.73 4.15 2.09 1.19 -3.87 -0.40 -0.45 -6.73 -5.99 -5.08 0.33 2.92 -5.13 -4.23 -7.60
Cytoplasm 7.17 11.92 7.62 -0.86 -7.34 -4.38 0.73 -11.98 -11.05 -12.06 5.94 10.17 -6.46 -10.68 -13.29
Cytoplasmic Foci -0.69 5.27 2.55 1.81 -3.23 -3.91 3.18 -6.61 -3.92 -6.98 -2.33 5.94 -3.53 -0.56 -7.50
Eisosomes -4.24 -4.50 -12.01 -0.44 -8.80 -5.54 -8.35 -1.89 -1.86 -1.71 -5.75 -11.15 -2.08 -1.98 -1.92
Endoplasmic Reticulum -8.28 -14.58 -21.48 -3.44 -10.55 -2.50 -7.75 -6.33 -5.07 3.10 -7.92 -11.13 -18.37 -11.23 -8.42
Endosome -1.30 3.28 -3.96 -0.06 -4.45 -4.15 -1.87 -4.33 -2.28 -4.20 -4.10 2.33 -5.91 -1.39 -6.11
Golgi -1.70 2.78 -2.40 -1.27 -2.51 -3.42 -0.52 -2.05 -1.02 -2.03 -3.78 2.53 -3.09 -1.71 -3.20
Lipid Particles -1.81 4.74 0.11 1.84 -4.09 -2.27 0.10 -2.62 -0.77 -2.93 -2.54 2.50 -2.27 0.80 -4.68
Mitochondria -1.72 0.38 -4.76 0.57 -9.96 -3.51 0.81 -1.98 1.40 -2.78 -3.96 0.46 -5.02 1.32 -7.36
Mitotic Spindle -1.76 -1.11 -7.99 -5.48 -7.79 -1.80 2.30 -4.37 -3.52 -5.10 -2.85 0.77 -8.85 -7.12 -9.12
None 9.80 13.22 12.21 2.65 -5.45 -2.86 -0.91 -5.97 -4.74 -5.40 8.19 12.55 5.33 -2.80 -7.37
Nuclear Periphery -1.48 -0.70 -11.13 -9.36 -11.18 -1.18 0.05 -3.11 -0.87 -2.60 -1.73 1.24 -10.43 -6.17 -12.27
Nuclear Periphery Foci -0.91 3.67 -2.99 -2.26 -3.92 -1.31 -1.44 -2.97 -2.31 -1.87 -1.14 2.64 -4.17 -3.51 -4.81
Nucleolus 0.63 6.14 6.93 3.23 1.10 -3.23 -1.64 0.52 3.50 1.88 -1.09 3.43 5.11 5.11 1.49
Nucleus -2.98 -11.20 4.69 6.67 16.25 7.61 3.63 16.11 12.22 13.93 0.80 -5.37 17.19 15.52 21.23
Peroxisomes -2.56 1.06 0.50 2.63 -0.60 -1.35 0.81 -1.28 -0.26 -2.17 -3.04 1.42 -0.47 2.81 -2.10
Vacuole -3.36 -2.56 -10.82 -8.83 -10.51 -4.58 -5.57 -7.94 -5.40 -5.81 -4.96 -6.34 -13.52 -9.08 -12.65
Vacuole Periphery -2.33 2.08 -2.07 -1.20 -2.35 -3.90 0.76 -2.36 -0.11 -2.45 -4.16 2.34 -3.04 -0.08 -3.33
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
Localization
Cell Percentages nucleus (97%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Clf1

Clf1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Clf1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available