Standard name | |
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Human Ortholog | |
Description | Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 1 | 0 | – | 1 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 1 | 1 | 4 | 4 | – | 6 | 4 | 8 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 6 | 6 | 11 | 11 | 16 | 13 | – | 6 | 15 | 9 | 9 | 42 | 50 | 80 | 21 | 25 | 11 | 2 | 0 | 2 | 2 | 5 | 1 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 1 |
Endosome | 0 | 0 | 1 | 4 | 3 | 2 | 1 | – | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 1 | 3 | 2 | 0 | 1 | 3 | 0 | 4 | 4 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 3 |
Mitochondria | 35 | 10 | 0 | 6 | 9 | 36 | 34 | – | 75 | 64 | 101 | 101 | 0 | 2 | 3 | 6 | 5 | 3 | 0 | 1 | 1 | 2 | 6 | 7 |
Nucleus | 147 | 435 | 170 | 162 | 170 | 234 | 269 | – | 180 | 194 | 160 | 160 | 285 | 242 | 375 | 194 | 192 | 138 | 143 | 440 | 165 | 187 | 352 | 268 |
Nuclear Periphery | 0 | 2 | 0 | 3 | 1 | 7 | 0 | – | 1 | 1 | 3 | 3 | 5 | 3 | 1 | 3 | 4 | 2 | 0 | 0 | 0 | 1 | 0 | 2 |
Nucleolus | 3 | 4 | 0 | 0 | 1 | 4 | 3 | – | 7 | 7 | 17 | 17 | 0 | 1 | 2 | 2 | 1 | 4 | 0 | 5 | 0 | 4 | 11 | 8 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 3 | 1 | 2 | 0 | 3 | 2 | – | 2 | 3 | 1 | 1 | 2 | 6 | 7 | 0 | 1 | 3 | 1 | 1 | 0 | 1 | 2 | 2 |
Vac/Vac Membrane | 1 | 20 | 3 | 3 | 10 | 10 | 5 | – | 1 | 3 | 1 | 2 | 3 | 4 | 10 | 17 | 15 | 6 | 5 | 14 | 10 | 10 | 34 | 44 |
Unique Cell Count | 158 | 459 | 181 | 179 | 191 | 278 | 299 | 206 | 241 | 203 | 203 | 330 | 299 | 472 | 233 | 239 | 158 | 155 | 473 | 187 | 214 | 426 | 351 | |
Labelled Cell Count | 189 | 481 | 183 | 192 | 206 | 317 | 331 | 280 | 293 | 302 | 302 | 339 | 313 | 486 | 252 | 250 | 173 | 155 | 473 | 187 | 214 | 426 | 351 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.9 | 6.7 | 6.8 | 6.1 | 6.7 | 5.3 | 5.4 | – | 4.5 | 4.9 | 4.0 | 4.0 | 6.9 | 6.7 | 6.5 | 8.5 | 8.9 | 8.2 | 6.3 | 6.3 | 6.5 |
Std Deviation (1e-4) | 0.8 | 1.0 | 1.8 | 1.5 | 2.1 | 1.8 | 1.5 | – | 1.1 | 1.6 | 0.9 | 0.9 | 1.4 | 1.4 | 1.5 | 2.0 | 2.0 | 2.0 | 1.4 | 1.2 | 1.3 |
Intensity Change (Log2) | – | – | – | -0.16 | -0.03 | -0.35 | -0.34 | – | -0.6 | -0.47 | -0.75 | -0.75 | 0.01 | -0.02 | -0.07 | 0.32 | 0.38 | 0.28 | -0.11 | -0.11 | -0.06 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.3 | 1.1 | 1.2 | 0.6 | – | -0.2 | 1.4 | 0.6 | 0.6 | 3.5 | 4.4 | 4.6 | 2.3 | 2.8 | 1.5 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 5.0 | 4.7 | – | 0 | 7.5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -1.2 | -1.7 | -3.1 | -1.5 | – | -2.2 | -4.0 | -4.3 | -4.3 | -2.6 | -4.0 | -4.5 | -3.3 | -4.0 | -2.1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 1.9 | 1.2 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.7 | 2.3 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.4243 | 0.558 | 0.2575 | 0.2304 | -0.036 | 0.2285 | 1.5436 | 1.4143 | 1.3354 | 1.6474 | 1.6363 | 1.2313 | 0.822 | 1.3574 | 0.9892 | 0.9589 | 0.5324 | 1.0339 |
Actin | 0.0129 | 0.0044 | 0 | 0 | 0.0046 | 0.0004 | 0.0088 | 0 | 0.0001 | 0.004 | 0.0146 | 0.0014 | 0.0015 | 0 | 0 | 0 | 0 | 0 |
Bud | 0.0001 | 0.0001 | 0 | 0 | 0.0005 | 0 | 0.0011 | 0 | 0.0048 | 0.0005 | 0.0003 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0.0002 | 0.0016 | 0.0001 | 0 | 0.0004 | 0.0008 | 0.0061 | 0.0001 | 0.0001 | 0.0001 | 0.0007 | 0.0009 | 0.0003 | 0 | 0 | 0 | 0.0003 | 0.0004 |
Bud Periphery | 0.0002 | 0.0002 | 0 | 0 | 0.0012 | 0 | 0.0021 | 0 | 0.0015 | 0.0018 | 0.0004 | 0.0006 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0.0004 | 0.0083 | 0 | 0 | 0.0016 | 0.0001 | 0.0067 | 0 | 0.0007 | 0.001 | 0.0058 | 0.0005 | 0.0012 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.0001 | 0.0006 | 0 | 0 | 0.0001 | 0 | 0.0005 | 0 | 0.0001 | 0.0005 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.0025 | 0.0053 | 0.001 | 0.0003 | 0.0006 | 0.0004 | 0.0056 | 0.0014 | 0.0006 | 0.0131 | 0.0014 | 0.001 | 0.0014 | 0.0003 | 0.0003 | 0 | 0.0002 | 0.0002 |
Cytoplasmic Foci | 0.0148 | 0.004 | 0 | 0.0003 | 0.0074 | 0.0022 | 0.0272 | 0 | 0.0029 | 0.0007 | 0.0105 | 0.0014 | 0.0007 | 0 | 0 | 0 | 0 | 0 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0007 | 0.0002 | 0.0001 | 0 | 0.0007 | 0.0003 | 0.0023 | 0.0001 | 0 | 0.0013 | 0.0004 | 0.0013 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0.0212 | 0.0013 | 0.0001 | 0 | 0.0165 | 0.013 | 0.0364 | 0.0001 | 0.0012 | 0.0094 | 0.0101 | 0.0049 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0.0069 | 0.0018 | 0 | 0 | 0.0064 | 0.0081 | 0.0095 | 0 | 0.0004 | 0.0019 | 0.0099 | 0.0011 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Lipid Particles | 0.0228 | 0.0013 | 0 | 0 | 0.0087 | 0.0002 | 0.0322 | 0 | 0.0051 | 0.002 | 0.0311 | 0.0032 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.0033 | 0.0006 | 0.0002 | 0.0001 | 0.095 | 0.0007 | 0.0162 | 0.0001 | 0.0009 | 0.0703 | 0.0458 | 0.0024 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 |
None | 0.0023 | 0.0001 | 0.002 | 0.0001 | 0.0004 | 0 | 0.0053 | 0.0012 | 0.0007 | 0.0048 | 0.0006 | 0.0006 | 0.0054 | 0.0004 | 0.0051 | 0 | 0.0002 | 0.001 |
Nuclear Periphery | 0.0059 | 0.0066 | 0.0081 | 0.0053 | 0.0115 | 0.0018 | 0.0245 | 0.0087 | 0.0017 | 0.0098 | 0.015 | 0.0081 | 0.0036 | 0.0024 | 0.0024 | 0.0004 | 0.0008 | 0.0005 |
Nucleolus | 0.0054 | 0.0065 | 0.0055 | 0.0033 | 0.0139 | 0.0183 | 0.0138 | 0.0055 | 0.0059 | 0.0015 | 0.0133 | 0.0194 | 0.0114 | 0.0077 | 0.0062 | 0.0032 | 0.0372 | 0.0123 |
Nucleus | 0.8731 | 0.931 | 0.9801 | 0.9173 | 0.7996 | 0.9524 | 0.7609 | 0.97 | 0.9573 | 0.8707 | 0.8236 | 0.9408 | 0.958 | 0.9843 | 0.977 | 0.9958 | 0.9405 | 0.9803 |
Peroxisomes | 0.0177 | 0.0063 | 0 | 0 | 0.023 | 0.0001 | 0.0095 | 0 | 0.0019 | 0.0003 | 0.008 | 0.0023 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Punctate Nuclear | 0.0076 | 0.0173 | 0.0026 | 0.073 | 0.0049 | 0.0006 | 0.017 | 0.0127 | 0.0134 | 0.0012 | 0.0062 | 0.0078 | 0.0154 | 0.0045 | 0.0087 | 0.0004 | 0.0207 | 0.0051 |
Vacuole | 0.0011 | 0.0024 | 0.0001 | 0 | 0.0013 | 0.0002 | 0.0099 | 0.0001 | 0.0003 | 0.003 | 0.0007 | 0.0014 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Vacuole Periphery | 0.0005 | 0.0001 | 0.0001 | 0 | 0.0013 | 0.0001 | 0.0043 | 0.0001 | 0.0002 | 0.0018 | 0.0013 | 0.0006 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 10.6919 | 14.8148 | 8.8655 | 16.3057 | 13.8625 | 10.686 | 14.1336 | 15.0018 | 16.9385 | 18.1047 |
Translational Efficiency | 0.966 | 0.7518 | 1.0255 | 0.5997 | 0.7188 | 1.0602 | 0.8416 | 0.5837 | 0.6431 | 0.6343 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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