Standard name
Human Ortholog
Description Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.07 0 0 0 0 0 0 0.1
Bud 0 0 0 0.09 0 0 0 0 0 0.07 0.05 0.05 0 0 0 0 0 0.06 0 0 0 0.06 0.05 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.07 0 0 0 0 0 0 0
Cytoplasm 0.21 0.28 0.34 0.26 0.21 0.11 0.05 0.09 0.05 0.1 0.1 0.08 0.5 0.63 0.69 0.23 0.27 0.22 0 0.06 0.05 0.06 0.09 0
Endoplasmic Reticulum 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08
Endosome 0 0.07 0 0.11 0.14 0.05 0 0.08 0 0 0 0 0 0 0.08 0.17 0.13 0.11 0.07 0.09 0.1 0.06 0.07 0.08
Golgi 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.13 0.29 0.11 0 0 0 0 0.05 0.07
Mitochondria 0.76 0.5 0.56 0.71 0.53 0.73 0.82 0.7 0.9 0.85 0.85 0.88 0.4 0.3 0.22 0.17 0 0.11 0.64 0.53 0.6 0.6 0.5 0.39
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.06 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.06 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.17 0 0 0.19 0.17 0.1 0.15 0.07 0.05 0.07 0.06 0.11 0.06 0.08 0.21 0.22 0.33 0.08 0.12 0 0.05 0.05 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 5 1 0 0 0 2 0 2 2 0 1 1 0 0 13 3 0 3 15 7 3 6 15
Bud 2 10 6 7 3 3 4 8 5 16 8 15 1 1 1 4 0 1 3 12 5 4 8 9
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 6 2 0 6 9
Bud Site 0 1 0 0 0 2 4 2 3 4 1 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 8 4 1 3 3 0 1 2 1 0 2 2 2 2 13 3 0 0 3 1 0 1 2
Cytoplasm 24 89 49 21 32 22 15 27 11 24 17 22 68 114 117 35 12 4 5 23 8 4 14 3
Endoplasmic Reticulum 4 15 5 0 1 2 5 10 6 7 5 4 4 6 3 6 2 0 2 11 3 2 4 12
Endosome 4 22 3 9 21 11 7 23 1 1 0 2 5 3 14 26 6 2 9 35 17 4 11 11
Golgi 2 10 1 0 7 1 2 2 1 0 0 1 5 2 2 20 13 2 4 14 3 1 7 9
Mitochondria 86 157 80 57 81 148 223 201 193 206 143 245 55 55 38 26 2 2 84 220 106 45 81 58
Nucleus 1 0 0 0 0 3 7 5 2 1 0 4 0 1 0 1 0 0 0 0 0 0 0 0
Nuclear Periphery 0 5 0 0 0 2 13 7 6 5 3 7 0 0 0 0 0 1 0 0 1 0 1 1
Nucleolus 1 0 1 0 4 12 9 12 8 14 6 12 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 1 2 1 4 2 4 2 6 2 2 2 0 3 6 2 10 1 1 1 2 4 0 1 2
SpindlePole 1 4 3 1 3 4 7 9 2 2 1 4 0 3 0 5 4 0 3 10 4 0 3 2
Vac/Vac Membrane 11 52 6 3 29 34 26 43 16 13 11 17 15 11 14 32 10 6 10 50 6 3 8 9
Unique Cell Count 113 315 144 80 152 203 273 288 214 241 168 277 136 181 170 153 45 18 133 413 177 76 165 150
Labelled Cell Count 138 380 160 103 186 251 326 356 260 298 197 338 159 204 193 192 56 19 133 413 177 76 165 150


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 5.0 5.5 4.6 6.4 6.1 5.5 6.3 5.6 5.3 5.4 5.3 5.2 5.1 5.4 7.7 9.0 11.9 4.5 5.5 7.6
Std Deviation (1e-4) 1.0 1.2 3.5 1.3 2.3 2.8 2.1 2.3 1.8 2.1 1.8 1.8 1.3 1.6 2.0 3.1 3.2 7.9 1.0 1.7 2.8
Intensity Change (Log2) – – – -0.26 0.22 0.17 0.01 0.2 0.03 -0.04 -0.02 -0.04 -0.08 -0.1 -0.01 0.49 0.72 1.12 -0.3 0.0 0.47


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 3.2 0 0
Bud 0 0 0 0 0 0 1.0 0.3 0.6 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 2.1 0 0
Cytoplasm -1.2 -2.5 -5.3 -7.7 -6.3 -7.2 -5.8 -5.2 -6.8 2.7 5.2 6.2 -2.1 -0.9 -1.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.2 0 0
Endosome 0 3.7 1.6 0 2.4 0 0 0 0 0 0 2.4 4.3 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 4.2 0 0
Mitochondria 0 -0.4 3.4 5.7 2.9 7.6 6.5 5.8 7.6 -2.5 -4.6 -6.1 -6.9 -6.0 -3.6
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 2.5 0 0 0 2.5 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 2.7 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 4.0 3.6 2.0 3.3 1.3 0.5 0.9 0.8 2.2 0.8 1.5 4.3 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.1215 1.8092 1.3501 0.8484 0.551 1.1315 2.1851 2.6058 2.833 3.1291 3.257 2.5248 3.4371 2.9664 3.348 2.5406 3.0511 3.0313
Actin 0.0504 0.0281 0.0355 0.0121 0.1506 0.0254 0.0546 0.0197 0.0569 0.0149 0.0234 0.0201 0.0977 0.0184 0.0573 0.0437 0.0436 0.0243
Bud 0.0068 0.0034 0.0072 0.0025 0.0069 0.0036 0.0047 0.0167 0.0094 0.0019 0.0074 0.0036 0.0044 0.0211 0.0125 0.0033 0.0117 0.0054
Bud Neck 0.0032 0.0056 0.008 0.0008 0.0029 0.0141 0.0029 0.0076 0.0189 0.0034 0.0021 0.0124 0.0054 0.0035 0.0082 0.0019 0.0502 0.0234
Bud Periphery 0.0346 0.0078 0.0214 0.0078 0.0191 0.0078 0.0169 0.0351 0.0228 0.0033 0.02 0.0135 0.0366 0.0199 0.0233 0.0081 0.0607 0.0226
Bud Site 0.0304 0.1233 0.0756 0.0052 0.0177 0.004 0.0165 0.0868 0.0345 0.0111 0.0035 0.0035 0.0082 0.1188 0.0366 0.0149 0.0068 0.0019
Cell Periphery 0.0049 0.0198 0.0133 0.0025 0.0043 0.0017 0.0036 0.0033 0.0049 0.0011 0.0014 0.0019 0.0139 0.0282 0.0218 0.0015 0.0037 0.0054
Cytoplasm 0.1139 0.1386 0.1268 0.0785 0.0693 0.1306 0.1009 0.1691 0.1382 0.0695 0.0872 0.1248 0.1507 0.1541 0.1196 0.1236 0.0859 0.1529
Cytoplasmic Foci 0.0344 0.049 0.0611 0.0943 0.0567 0.0897 0.0961 0.0704 0.0874 0.1376 0.1052 0.0887 0.0782 0.0885 0.0684 0.041 0.0775 0.071
Eisosomes 0.0013 0.0026 0.0027 0.0012 0.0013 0.0007 0.0014 0.001 0.0012 0.0011 0.0005 0.0005 0.0017 0.0016 0.0076 0.0007 0.0017 0.0014
Endoplasmic Reticulum 0.0225 0.0304 0.032 0.0391 0.0123 0.0133 0.012 0.0079 0.0048 0.0022 0.0033 0.0089 0.0177 0.0089 0.0095 0.0027 0.0096 0.0047
Endosome 0.0456 0.0959 0.0665 0.1182 0.0908 0.1249 0.1724 0.1073 0.089 0.0999 0.1514 0.0684 0.1086 0.1077 0.0469 0.0566 0.0894 0.0852
Golgi 0.0183 0.04 0.032 0.0247 0.0475 0.0633 0.078 0.0355 0.0601 0.0383 0.1268 0.0417 0.0379 0.0413 0.0376 0.0325 0.0455 0.0415
Lipid Particles 0.0275 0.0121 0.0242 0.0132 0.0324 0.0207 0.037 0.005 0.0112 0.0079 0.0684 0.0133 0.0234 0.0098 0.0165 0.007 0.014 0.0161
Mitochondria 0.1463 0.218 0.1623 0.2242 0.3243 0.2137 0.1062 0.13 0.1897 0.3 0.1838 0.2036 0.0596 0.1591 0.2585 0.3711 0.166 0.2204
None 0.4216 0.1828 0.2621 0.3193 0.1026 0.2482 0.2278 0.2682 0.2262 0.2753 0.093 0.3437 0.2797 0.1665 0.2267 0.2651 0.2968 0.2995
Nuclear Periphery 0.0076 0.0056 0.0041 0.0039 0.0055 0.0034 0.0039 0.0013 0.0014 0.0006 0.0007 0.0038 0.0159 0.0014 0.0014 0.0009 0.0026 0.0018
Nucleolus 0.0018 0.0007 0.0022 0.0006 0.0014 0.0006 0.0011 0.0017 0.001 0.0013 0.0005 0.0005 0.001 0.0017 0.0014 0.0006 0.0033 0.0005
Nucleus 0.0029 0.0024 0.0031 0.0018 0.0029 0.0015 0.0025 0.0021 0.0015 0.002 0.0008 0.0013 0.0042 0.0021 0.002 0.0013 0.0029 0.001
Peroxisomes 0.009 0.0025 0.0222 0.0265 0.0195 0.0151 0.0446 0.0147 0.0235 0.0151 0.0938 0.0318 0.0192 0.014 0.0243 0.0098 0.0117 0.0118
Punctate Nuclear 0.0044 0.001 0.0022 0.001 0.0029 0.0022 0.005 0.0011 0.0011 0.0013 0.0011 0.0021 0.0158 0.0008 0.0012 0.0005 0.0058 0.0008
Vacuole 0.0089 0.0215 0.0265 0.0163 0.0222 0.0112 0.0091 0.012 0.0131 0.0099 0.019 0.0073 0.0123 0.0292 0.0147 0.0088 0.0076 0.0055
Vacuole Periphery 0.0038 0.0088 0.0088 0.0064 0.0065 0.0044 0.0029 0.0035 0.0032 0.0022 0.0066 0.0043 0.0078 0.0035 0.004 0.0046 0.003 0.0028

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.2394 9.0434 2.876 9.1536 35.1329 36.1098 9.4703 5.951 7.4783 35.4971
Translational Efficiency 0.9392 0.7762 0.755 0.6637 0.8313 0.8647 0.4876 0.6863 0.5084 0.8076

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2049 222 298 2004 1917 285 196 2829 3966 507 494 4833

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 671.59 716.09 934.84 1146.34 723.89 775.73 1022.37 1177.14 696.87 749.62 969.57 1164.37
Standard Deviation 81.14 117.59 124.41 384.33 95.65 119.33 133.07 341.29 92.23 122.21 134.90 360.09
Intensity Change Log 2 — 0.092560 0.477139 0.771382 — 0.099784 0.498075 0.701444 — 0.096312 0.488037 0.735526

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000498 0.001842 0.007359 0.012713 0.000519 0.001023 0.015079 0.009240 0.000508 0.001382 0.010422 0.010680
Bud Neck 0.067949 0.030441 0.014307 0.006701 0.033718 0.034427 0.014160 0.007137 0.051403 0.032681 0.014248 0.006956
Bud Site 0.046265 0.040972 0.043516 0.187645* 0.035264 0.047653 0.098821 0.169807* 0.040948 0.044728 0.065459 0.177203*
Cell Periphery 0.000904 0.000402 0.000293 0.001943 0.000534 0.000643 0.000783 0.001762 0.000725 0.000538 0.000488 0.001837
Cytoplasm 0.229877* 0.054153 0.184862* 0.072689 0.123813* 0.061955 0.212977* 0.088862 0.178610* 0.058539 0.196017* 0.082156
Cytoplasmic Foci 0.201066* 0.178708 0.091268 0.061127 0.197413* 0.189028* 0.145981 0.051267 0.199300* 0.184509* 0.112976 0.055355
Eisosomes 0.000384 0.000186 0.000135 0.000131 0.000188 0.000177 0.000187 0.000111 0.000289 0.000181 0.000156 0.000119
Endoplasmic Reticulum 0.003845 0.000887 0.012712 0.003411 0.003161 0.000906 0.011649 0.002840 0.003514 0.000898 0.012290 0.003076
Endosome 0.055701 0.131505 0.035629 0.059005 0.080464 0.121099 0.053393 0.055397 0.067671 0.125656 0.042677 0.056893
Golgi 0.021501 0.132710* 0.010597 0.162413* 0.063961 0.106339 0.034595 0.125593* 0.042024 0.117887* 0.020118 0.140860*
Lipid Particles 0.031456 0.009825 0.011248 0.000953 0.021880 0.009172 0.010555 0.000762 0.026827 0.009458 0.010973 0.000842
Mitochondria 0.137542* 0.243179* 0.004187 0.212588* 0.277819* 0.272477* 0.012249 0.276078* 0.205346* 0.259648* 0.007386 0.249751*
Mitotic Spindle 0.006483 0.029086 0.051995 0.084224 0.015104 0.021472 0.043368 0.052473 0.010650 0.024806 0.048572 0.065638
None 0.006564 0.003463 0.003729 0.000775 0.002366 0.000933 0.001824 0.000841 0.004535 0.002041 0.002973 0.000814
Nuclear Periphery 0.001190 0.000342 0.003066 0.000309 0.000972 0.000228 0.001763 0.000287 0.001085 0.000278 0.002549 0.000296
Nuclear Periphery Foci 0.000773 0.001487 0.006611 0.000848 0.000711 0.000316 0.007396 0.000630 0.000743 0.000829 0.006923 0.000720
Nucleolus 0.003835 0.004036 0.002359 0.000277 0.002621 0.002376 0.001055 0.000177 0.003248 0.003103 0.001841 0.000219
Nucleus 0.078201 0.017082 0.340034* 0.002199 0.035930 0.012820 0.121386 0.001658 0.057769 0.014686 0.253283* 0.001882
Peroxisomes 0.021926 0.060653 0.017101 0.013440 0.030407 0.052669 0.031632 0.006613 0.026025 0.056165 0.022866 0.009444
Vacuole 0.069693 0.039809 0.153705 0.071346 0.053105 0.039620 0.171311 0.087694 0.061675 0.039703 0.160690 0.080915
Vacuole Periphery 0.014349 0.019231 0.005287 0.045263 0.020049 0.024666 0.009838 0.060771 0.017104 0.022286 0.007093 0.054341

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.64 -2.91 -10.94 -7.86 -3.15 -2.97 -3.50 -10.66 -9.83 0.87 -2.37 -4.55 -15.25 -12.21 -1.21
Bud Neck 6.43 14.92 20.43 4.56 2.87 -0.12 7.40 12.98 4.93 2.52 4.46 16.09 23.93 6.67 3.75
Bud Site 0.93 1.82 -24.89 -19.83 -20.47 -1.83 -4.74 -28.77* -15.93 -8.28 -0.82 -2.44 -37.63 -24.60 -20.30
Cell Periphery 4.77 6.69 -4.87 -7.73 -8.61 -0.71 -0.99 -4.70 -3.81 -3.77 1.87 3.73 -6.23 -6.84 -7.84
Cytoplasm 18.30 3.64 23.97 -2.67 9.08 7.04 -5.02 5.48 -3.78 6.94 18.25 -1.56 21.07 -4.68 11.05
Cytoplasmic Foci 1.72 15.93 28.76 10.46 2.34 0.67 6.28 30.75 11.72 7.40 1.60 15.69 42.62 15.70 7.12
Eisosomes 1.61 2.02 2.09 3.08 0.85 0.59 -0.22 7.27 3.62 4.99 1.69 2.04 2.72 4.79 4.62
Endoplasmic Reticulum 6.98 -8.43 0.77 -6.66 8.88 4.75 -4.50 0.69 -6.02 4.75 8.15 -9.13 1.24 -8.97 9.75
Endosome -6.64 6.30 -0.85 6.46 -7.16 -4.26 5.94 7.98 7.21 -1.64 -7.93 9.15 5.50 9.70 -6.31
Golgi -8.41 4.84 -26.76* -1.95 -27.10* -4.37 6.19 -12.94 -1.76 -15.04 -9.54 8.75 -28.61 -2.52 -30.90*
Lipid Particles 8.02 10.03 18.05 4.34 7.68 5.44 3.51 14.58 4.55 3.36 9.75 9.21 23.19 6.29 7.04
Mitochondria -5.14 26.25 -9.06 1.60 -34.10* 0.25 34.57* 0.51 -0.01 -41.25* -3.82 42.88* -6.71 0.91 -55.38*
Mitotic Spindle -3.83 -4.46 -20.75 -7.99 -4.52 -1.63 -3.22 -14.16 -7.37 -2.17 -4.19 -5.33 -25.27 -10.68 -4.15
None 1.03 2.38 9.28 1.43 1.88 3.65 1.21 5.82 0.34 1.49 2.04 2.25 10.70 1.46 2.20
Nuclear Periphery 4.42 -6.81 5.28 0.17 10.05 3.81 -1.55 3.55 -0.90 2.82 6.01 -5.71 6.25 -0.39 8.70
Nuclear Periphery Foci -0.66 -5.45 -0.40 0.58 5.32 2.89 -6.45 0.38 -2.32 6.51 -0.23 -8.13 0.07 0.24 8.11
Nucleolus -0.51 3.35 9.14 2.71 6.12 0.28 3.73 6.74 2.87 4.39 -0.15 4.48 11.64 3.83 8.02
Nucleus 10.11 -14.72 24.45 2.80 18.88 5.94 -6.39 15.09 3.44 8.71 12.33 -15.24 28.43 4.34 19.41
Peroxisomes -4.91 2.57 5.04 5.99 0.33 -3.54 0.50 14.20 7.58 3.82 -6.13 2.23 14.35 9.61 3.66
Vacuole 4.94 -9.70 -1.74 -5.99 9.08 2.87 -9.95 -10.94 -10.31 7.80 5.84 -14.00 -8.79 -11.66 11.62
Vacuole Periphery -1.79 7.98 -14.11 -7.97 -18.27 -1.35 4.37 -16.89 -9.09 -15.62* -2.28 8.42 -22.40 -12.04 -25.21*
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
Localization
Cell Percentages mitochondrion (45%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Yps3

Yps3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yps3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available