ORF
Human Ortholog
Description Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.97 0.99 0.98 0.94 0.9 – 0.78 0.76 0.61 0.71 1.0 0.99 0.99 0.92 0.87 0.89 0.88 0.9 0.76 0.64 0.69 0.68
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.13 0.14 – 0.35 0.29 0.41 0.25 0 0 0 0 0 0 0.06 0 0.11 0.17 0.13 0.1
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0.06 0.12 0.11 0 0 0 0.05 0.07 0.06 0 0 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 1 0 0 0 – 1 0 0 0 0 0 0 0 1 0 1 1 6 6 3 9
Bud 0 1 0 1 0 4 3 – 13 11 7 8 3 1 0 0 1 0 0 5 1 9 4 17
Bud Neck 1 2 16 15 1 1 1 – 3 1 0 1 0 1 0 0 0 0 0 1 1 6 5 6
Bud Site 0 0 0 0 0 0 0 – 2 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 5 5 4 0 – 2 4 1 2 1 0 1 8 11 7 0 1 8 6 6 7
Cytoplasm 162 376 374 343 320 404 425 – 363 394 286 379 526 604 667 344 243 235 143 340 270 236 270 359
Endoplasmic Reticulum 0 0 4 0 2 0 7 – 0 2 0 0 0 1 1 13 10 9 0 0 1 5 6 8
Endosome 0 0 1 0 0 0 0 – 0 0 0 6 1 2 0 13 15 9 1 0 4 3 3 12
Golgi 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 2 2 0 1 2 0 1 1
Mitochondria 3 3 0 0 3 54 66 – 163 152 190 136 5 4 3 4 2 5 9 8 37 61 50 54
Nucleus 0 1 0 0 0 3 3 – 5 9 4 11 0 1 2 2 2 2 0 2 0 1 0 0
Nuclear Periphery 0 0 0 0 0 0 1 – 0 0 2 0 0 1 1 1 0 1 0 0 1 0 0 1
Nucleolus 0 0 0 0 0 0 0 – 0 0 1 1 0 2 0 3 3 5 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 2 1 0 0 0 0 0 0 0 1 1
SpindlePole 0 0 2 1 1 0 0 – 3 0 3 7 0 1 0 9 4 5 0 1 5 5 8 12
Vac/Vac Membrane 1 1 1 0 1 5 5 – 16 31 55 57 0 2 0 19 20 16 2 4 1 15 19 21
Unique Cell Count 165 378 384 346 325 430 471 467 520 469 537 528 610 672 375 278 263 163 377 355 369 390 527
Labelled Cell Count 167 385 400 366 333 475 511 571 604 549 608 536 622 676 416 314 296 163 377 355 369 390 527


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 3.8 4.7 4.4 5.3 4.4 4.6 – 4.2 4.4 4.2 4.8 4.0 4.3 5.0 7.1 7.7 7.4 3.8 3.9 4.3
Std Deviation (1e-4) 0.9 0.8 0.9 1.0 1.3 1.1 0.8 – 1.0 1.1 1.1 1.2 0.9 0.9 1.1 1.3 1.5 1.7 1.2 1.4 1.6
Intensity Change (Log2) – – – -0.08 0.19 -0.08 -0.03 – -0.17 -0.1 -0.14 0.04 -0.21 -0.12 0.1 0.6 0.73 0.65 -0.31 -0.27 -0.13

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 4.1 5.0 4.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.4561 0.0801 -0.1365 -0.6542 -0.6313 -0.3469 0.6822 0.2355 -0.0005 0.7373 0.0049 0.2885 -0.4454 0.4832 0.1876 0.2552 -0.0782 0.1873
Actin 0.0005 0.0004 0.0008 0.0001 0.0003 0.0003 0.0377 0.0012 0.0286 0.0367 0.0083 0.007 0.0038 0.0004 0.0007 0.0001 0.0569 0.0001
Bud 0.0001 0.0012 0.0003 0.0001 0 0.0002 0.0007 0.0025 0.0029 0.0042 0.0003 0.004 0.0001 0.0004 0.0011 0.0004 0.0004 0.0001
Bud Neck 0.0001 0.0001 0.0002 0 0.0001 0.0006 0.003 0.0005 0.0006 0.0015 0.0006 0.0048 0.0001 0.0001 0.0002 0.0001 0.0035 0.0003
Bud Periphery 0.0001 0.0013 0.0002 0.0001 0 0.0002 0.0019 0.004 0.0033 0.0114 0.0005 0.0015 0.0001 0.0003 0.0028 0.0003 0.0004 0.0001
Bud Site 0.0005 0.0052 0.0008 0.0001 0 0.0001 0.0041 0.0103 0.0026 0.0182 0.0009 0.003 0.0002 0.002 0.0033 0.0002 0.0059 0
Cell Periphery 0.0001 0.0001 0 0 0 0 0.0002 0.0003 0.0001 0.0006 0.0001 0.0001 0.0001 0.0001 0.0002 0 0.0003 0
Cytoplasm 0.0939 0.1553 0.1159 0.0955 0.1151 0.1613 0.0656 0.1276 0.1049 0.1073 0.0942 0.2042 0.1429 0.3448 0.3142 0.2493 0.2115 0.39
Cytoplasmic Foci 0.0064 0.005 0.005 0.0043 0.0073 0.0152 0.018 0.01 0.007 0.0148 0.016 0.0146 0.0146 0.0127 0.0074 0.0064 0.0209 0.0063
Eisosomes 0.0001 0.0002 0.0002 0 0.0001 0 0.0004 0.0002 0.0002 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0009 0.0011 0.0008 0.0006 0.0006 0.0013 0.0025 0.002 0.0011 0.0076 0.0017 0.0011 0.0014 0.0018 0.0013 0.0016 0.0012 0.0017
Endosome 0.0013 0.0024 0.0016 0.0017 0.0018 0.0063 0.0117 0.0022 0.0029 0.0306 0.0095 0.0069 0.0068 0.0032 0.0033 0.0039 0.0031 0.0035
Golgi 0.0001 0.0002 0.0001 0.0001 0.0001 0.0002 0.0075 0.0003 0.003 0.0107 0.0165 0.0023 0.001 0.0003 0.0005 0.0002 0.0007 0.0001
Lipid Particles 0.0006 0.0002 0.0001 0.0001 0.0002 0.0005 0.0168 0.0005 0.002 0.0073 0.0321 0.003 0.003 0.0003 0.0006 0.0001 0.0023 0.0001
Mitochondria 0.0002 0.0004 0.0003 0.0003 0.0002 0.0002 0.0254 0.0009 0.007 0.0128 0.0123 0.0012 0.001 0.0009 0.0096 0.0006 0.0003 0.0001
None 0.8915 0.8209 0.8679 0.8925 0.871 0.8003 0.7338 0.8266 0.8218 0.644 0.789 0.7224 0.8119 0.6283 0.649 0.7326 0.6707 0.595
Nuclear Periphery 0.0003 0.0006 0.0005 0.0007 0.0004 0.001 0.014 0.0013 0.0023 0.017 0.0003 0.0047 0.003 0.0006 0.0006 0.0006 0.0003 0.0006
Nucleolus 0.0002 0.0003 0.0004 0.0002 0.0001 0.0003 0.0007 0.0005 0.0004 0.0023 0.0001 0.0005 0.0004 0.0001 0.0002 0.0001 0.0088 0
Nucleus 0.0013 0.0025 0.0021 0.0014 0.0008 0.0043 0.0201 0.0025 0.0017 0.0189 0.0002 0.0082 0.0022 0.0012 0.0011 0.0012 0.0029 0.0009
Peroxisomes 0.0004 0.0001 0.0002 0.0001 0.0001 0.0007 0.0212 0.001 0.0028 0.0101 0.016 0.0024 0.0029 0.0002 0.0007 0.0001 0.0013 0.0001
Punctate Nuclear 0.0007 0.0009 0.0013 0.0012 0.0011 0.0064 0.0107 0.0029 0.0038 0.0272 0.0006 0.0069 0.0034 0.001 0.0013 0.0005 0.0046 0.0004
Vacuole 0.0006 0.0014 0.0011 0.0008 0.0004 0.0008 0.0023 0.002 0.0009 0.0118 0.0006 0.0007 0.0006 0.001 0.0013 0.0015 0.0037 0.0006
Vacuole Periphery 0.0001 0.0002 0.0001 0.0002 0.0001 0.0001 0.0016 0.0005 0.0002 0.0047 0.0003 0.0003 0.0003 0.0001 0.0004 0.0004 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2.2642 0.8996 1.6688 5.2662 1.3047 8.0459 3.9793 9.0548 10.3343 4.8417
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1329 1269 194 1231 1393 1568 1623 129 2722 2837 1817 1360

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 588.30 694.05 1006.34 809.29 625.97 692.16 782.24 843.18 607.58 693.01 806.17 812.50
Standard Deviation 81.34 89.96 120.39 123.18 66.26 85.92 98.16 108.38 76.36 87.75 122.24 122.26
Intensity Change Log 2 — 0.238488 0.774494 0.460105 — 0.145012 0.321518 0.429747 — 0.191057 0.558725 0.444535

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000062 0.000352 0.000521 0.001233 0.000103 0.000611 0.000208 0.000247 0.000083 0.000495 0.000242 0.001140
Bud Neck 0.025726 0.037897 0.002077 0.008817 0.020279 0.045972 0.004148 0.006628 0.022938 0.042360 0.003927 0.008609
Bud Site 0.004386 0.010536 0.003186 0.035679 0.002710 0.017563 0.008266 0.008765 0.003528 0.014420 0.007724 0.033127
Cell Periphery 0.000263 0.000141 0.000293 0.000140 0.000116 0.000172 0.000118 0.000241 0.000188 0.000158 0.000137 0.000149
Cytoplasm 0.459770 0.391603 0.336344 0.471731 0.460400 0.344287 0.448644 0.433485 0.460092 0.365452 0.436654 0.468104
Cytoplasmic Foci 0.167151 0.242824 0.030596 0.018294 0.227637 0.297320 0.013125 0.061625 0.198105 0.272944 0.014990 0.022404
Eisosomes 0.000285 0.000141 0.000116 0.000035 0.000179 0.000200 0.000033 0.000099 0.000231 0.000173 0.000042 0.000041
Endoplasmic Reticulum 0.001380 0.000910 0.007508 0.001828 0.000498 0.000430 0.001807 0.001701 0.000929 0.000645 0.002415 0.001816
Endosome 0.010067 0.026481 0.007800 0.005284 0.008295 0.036935 0.001765 0.024981 0.009160 0.032259 0.002410 0.007153
Golgi 0.001383 0.004514 0.000163 0.000989 0.001804 0.010611 0.000407 0.003089 0.001598 0.007884 0.000381 0.001188
Lipid Particles 0.011683 0.007340 0.004362 0.001211 0.009862 0.011399 0.001089 0.002564 0.010751 0.009583 0.001439 0.001339
Mitochondria 0.005588 0.015834 0.000397 0.002298 0.005439 0.028191 0.000918 0.000675 0.005511 0.022663 0.000863 0.002144
Mitotic Spindle 0.001719 0.007411 0.001710 0.097278 0.000451 0.015322 0.011140 0.008638 0.001070 0.011783 0.010133 0.088870
None 0.008117 0.002349 0.002536 0.007979 0.002341 0.002233 0.008005 0.007478 0.005161 0.002285 0.007421 0.007932
Nuclear Periphery 0.000609 0.000592 0.001970 0.002048 0.000511 0.000311 0.001981 0.001191 0.000559 0.000437 0.001980 0.001967
Nuclear Periphery Foci 0.000205 0.000484 0.003977 0.001612 0.000209 0.000234 0.000605 0.001398 0.000208 0.000346 0.000965 0.001592
Nucleolus 0.001555 0.001749 0.000740 0.000860 0.000993 0.001986 0.000432 0.001704 0.001267 0.001880 0.000465 0.000940
Nucleus 0.247581 0.146620 0.420286 0.260928 0.210081 0.079352 0.444929 0.298780 0.228391 0.109441 0.442298 0.264518
Peroxisomes 0.002611 0.022120 0.000453 0.003228 0.007440 0.029223 0.001317 0.005689 0.005082 0.026046 0.001225 0.003462
Vacuole 0.048618 0.077881 0.174625 0.075563 0.040069 0.074500 0.050702 0.130249 0.044243 0.076012 0.063933 0.080750
Vacuole Periphery 0.001242 0.002221 0.000339 0.002965 0.000584 0.003150 0.000359 0.000772 0.000906 0.002735 0.000357 0.002757

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.37 -10.01 -4.41 -2.58 -0.37 -4.01 -2.88 -4.12 1.27 -2.14 -5.70 -5.05 -4.49 -1.66 -3.07
Bud Neck -3.68 11.72 5.57 8.73 -10.99 -9.03 9.70 5.58 12.70 -0.96 -9.03 14.01 6.55 14.84 -8.68
Bud Site -4.88 -0.19 -8.02 -5.50 -8.32 -10.35 -2.62 -2.90 0.70 -2.07 -11.08 -1.98 -9.07 -3.79 -7.45
Cell Periphery 6.20 -0.26 8.94 1.07 5.43 -4.33 1.41 -1.83 -0.02 -2.24 2.65 6.81 6.07 2.82 -0.62
Cytoplasm 6.85 10.95 11.95 4.60 -4.15 11.90 9.97 5.44 0.86 1.63 13.50 13.45 14.10 3.07 1.65
Cytoplasmic Foci -9.58 26.28 29.70 34.39 -0.40 -8.33 37.83 20.24 27.55 -5.31 -12.88 48.73 43.23 54.48 -7.07
Eisosomes 6.39 7.19 10.45 7.49 5.51 -1.37 16.45 4.47 5.07 -7.88 4.43 16.09 14.06 12.52 -6.24
Endoplasmic Reticulum 1.46 -9.19 -7.63 -10.30 6.98 1.09 -17.30 -6.24 -6.43 0.87 1.82 -13.62 -13.22 -15.88 0.73
Endosome -7.67 2.27 3.95 10.36 1.85 -14.09 10.56 -1.29 3.58 -2.49 -15.59 12.19 2.66 16.48 -6.29
Golgi -4.89 7.45 4.28 6.36 -3.71 -7.82 6.85 0.37 6.34 -1.35 -9.13 7.82 5.39 10.52 -2.40
Lipid Particles 4.00 6.87 9.37 9.56 4.02 -1.39 11.73 8.06 8.50 -5.19 1.39 15.02 13.31 12.75 -6.83
Mitochondria -4.54 5.56 4.35 7.15 -6.69 -8.98 4.74 4.94 11.87 1.36 -9.96 7.02 5.94 13.49 -4.20
Mitotic Spindle -3.20 -0.49 -13.63 -12.45 -13.48 -6.96 -5.67 -3.11 -1.62 -2.09 -7.52 -5.29 -14.12 -11.75 -11.95
None 4.44 4.68 -0.27 -8.60 -8.96 -0.19 -4.10 -2.11 -2.05 -0.72 3.94 -0.32 -3.57 -8.41 -2.99
Nuclear Periphery -0.19 -11.39 -18.20 -19.19 -7.79 3.35 -17.65 -5.10 -5.82 3.23 1.82 -18.71 -19.76 -20.83 -5.97
Nuclear Periphery Foci -2.73 -9.03 -6.88 -6.43 -0.31 -1.41 -5.94 -2.17 -2.15 -2.02 -3.09 -9.42 -6.97 -6.75 -5.51
Nucleolus -0.83 5.12 -4.47 -4.03 -6.43 -3.26 4.02 -1.67 -1.42 -1.78 -3.08 6.55 -4.95 -3.76 -6.17
Nucleus 12.70 -8.11 -3.55 -15.15 6.48 21.62 -31.36 -2.06 -7.91 9.91 24.01 -32.00 -6.38 -22.77 21.05
Peroxisomes -10.96 12.58 -0.81 10.07 -4.30 -10.46 7.10 0.24 5.76 -1.68 -15.08 7.62 2.03 15.31 -3.59
Vacuole -8.29 -11.01 -20.40 -14.46 2.92 -10.47 -13.47 -9.13 -7.60 -6.61 -13.05 -15.93 -23.29 -17.49 -11.07
Vacuole Periphery -2.99 4.60 0.75 2.84 -1.69 -8.75 4.11 0.87 7.78 -0.87 -8.34 5.59 0.07 4.76 -1.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (11%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YLR149C

YLR149C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ylr149c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available