Standard name
Human Ortholog
Description Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0.05 0.05 0.06 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0.05 0 0.08 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.99 0.96 0.91 0.87 0.75 0.65 0.77 0.64 0.62 0.68 0.98 0.98 0.98 0.97 0.98 0.98 0.97 0.93 0.91 0.86 0.87 0.89
Endoplasmic Reticulum 0 0 0 0 0.05 0.11 0.16 0.19 0.11 0.2 0.17 0.11 0 0 0 0.06 0.07 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0.06 0.11 0.07 0.13 0.19 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 9 11 14 11 6 8 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 0 0 2 1 0 0 0 3 1 1 0 0 1 1 0 0 0 0 0 2 3 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 2 1 3 8 10 12 8 19 3 6 2 2 3 1 2 0 0 0 1 0 0 0
Cytoplasm 109 167 239 155 160 212 208 161 210 152 63 70 192 281 269 184 146 120 107 152 198 140 194 261
Endoplasmic Reticulum 0 2 3 4 9 26 43 46 31 48 17 11 3 1 3 11 11 10 1 1 9 5 6 12
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 2 5 16 26 18 32 19 8 1 2 1 1 1 2 0 0 0 0 1 0
Mitochondria 0 0 0 0 0 0 0 3 6 4 4 12 0 0 0 2 0 0 0 0 0 0 1 0
Nucleus 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1
Nucleolus 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 2 2 2 0 2 4 0 2 1 3 0 0 1 0 1 0 0 4 0 5 7 8
Unique Cell Count 109 169 242 161 176 245 276 246 271 238 101 103 196 286 275 190 149 123 111 163 217 163 225 294
Labelled Cell Count 110 169 246 162 178 253 288 264 290 271 114 119 198 286 279 200 161 133 111 163 217 163 225 294


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 189.1 156.1 139.3 125.6 76.1 78.1 67.9 61.1 58.2 59.0 54.5 49.4 149.7 150.6 133.0 152.9 177.3 177.1 150.1 165.3 165.8
Std Deviation (1e-4) 43.3 33.3 33.5 35.9 26.9 22.0 20.4 18.9 16.9 17.1 18.5 13.7 44.2 38.6 40.2 45.9 62.9 72.3 48.4 51.4 51.6
Intensity Change (Log2) – – – -0.15 -0.87 -0.83 -1.04 -1.19 -1.26 -1.24 -1.35 -1.5 0.1 0.11 -0.07 0.14 0.35 0.35 0.11 0.25 0.25

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700050100150200WT3HU80HU120HU160050100150200WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100150200WT1AF100AF140AF180050100150200
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 3.3 3.6 3.4 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 2.1 2.7 0 3.8 0 0 0 0 0 0 0 0
Cytoplasm -1.7 -3.8 -5.2 -7.7 -9.6 -7.3 -9.8 -9.5 -8.6 -0.7 -0.5 -0.8 -1.4 -0.6 -0.9
Endoplasmic Reticulum 0 2.3 4.4 5.7 6.4 4.6 6.7 5.6 0 0 0 0 2.7 3.2 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 3.8 5.2 4.1 5.9 6.9 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 144.2422 184.8548 163.3948 171.3258 111.631 108.6535 185.9413 232.1701 207.9186 197.4994 199.948 109.5544 152.0069 200.8201 182.0814 159.5784 168.0825 177.6941
Actin 0.0044 0.0008 0.0254 0.0005 0.0542 0.0057 0.001 0.0005 0.005 0.0004 0.0058 0.004 0.0075 0.0083 0.018 0.0044 0.0015 0.0045
Bud 0.0031 0.0024 0.004 0.0026 0.0031 0.0051 0.003 0.0018 0.003 0.005 0.0056 0.0069 0.0052 0.004 0.0072 0.0077 0.0067 0.007
Bud Neck 0.0016 0.0015 0.0018 0.0007 0.0014 0.0027 0.0009 0.0012 0.0011 0.0008 0.0013 0.0014 0.0011 0.0022 0.0022 0.002 0.0021 0.0016
Bud Periphery 0.0046 0.0018 0.0039 0.0018 0.0024 0.0036 0.0039 0.0012 0.0031 0.0035 0.0063 0.0036 0.0093 0.0029 0.006 0.0089 0.0042 0.0063
Bud Site 0.0041 0.0017 0.0093 0.0005 0.0076 0.0014 0.0007 0.0038 0.0011 0.0008 0.0008 0.0025 0.0023 0.0052 0.0024 0.0057 0.0017 0.0012
Cell Periphery 0.0663 0.0471 0.0665 0.0644 0.0155 0.0333 0.0407 0.0162 0.039 0.0226 0.0226 0.0095 0.0825 0.0496 0.0596 0.0918 0.0458 0.0926
Cytoplasm 0.3375 0.5833 0.3348 0.263 0.2009 0.4297 0.5252 0.7684 0.5753 0.417 0.4886 0.2794 0.4144 0.71 0.5255 0.2402 0.3186 0.4392
Cytoplasmic Foci 0.0129 0.0122 0.0058 0.0024 0.0356 0.0475 0.0032 0.0023 0.0062 0.0027 0.011 0.0996 0.0055 0.0024 0.0042 0.0016 0.0272 0.0025
Eisosomes 0.0076 0.0001 0.0016 0.0001 0.0009 0.0011 0.0004 0.0005 0.0003 0.0001 0.0001 0.0009 0.0016 0.0036 0.0001 0.0014 0.0028 0.0001
Endoplasmic Reticulum 0.0542 0.0191 0.0143 0.0016 0.0018 0.0115 0.0409 0.0192 0.0186 0.0137 0.0222 0.0361 0.0183 0.0066 0.0104 0.0103 0.0053 0.0052
Endosome 0.0131 0.0074 0.0185 0.0123 0.0175 0.0295 0.018 0.0122 0.0166 0.0144 0.0469 0.0734 0.0142 0.0039 0.0239 0.0153 0.0215 0.0051
Golgi 0.0054 0.001 0.01 0.0008 0.0073 0.0126 0.0032 0.0017 0.0029 0.0004 0.0091 0.019 0.0022 0.0022 0.0038 0.0048 0.0027 0.001
Lipid Particles 0.0074 0.002 0.0056 0.0008 0.0127 0.0091 0.0016 0.0005 0.0022 0.0009 0.0042 0.061 0.0041 0.003 0.0024 0.0058 0.0082 0.0086
Mitochondria 0.0312 0.0072 0.0168 0.0016 0.0573 0.0397 0.0134 0.0103 0.0147 0.0055 0.0191 0.0907 0.0339 0.0045 0.0346 0.0169 0.0268 0.0038
None 0.006 0.001 0.0022 0.0002 0.0204 0.0197 0.002 0.0003 0.0016 0.003 0.0014 0.0384 0.0108 0.004 0.0014 0.0016 0.0126 0.0008
Nuclear Periphery 0.0574 0.0189 0.0167 0.0076 0.0135 0.0112 0.0222 0.0041 0.0112 0.006 0.0107 0.0127 0.0361 0.0115 0.0135 0.0368 0.0293 0.0264
Nucleolus 0.0143 0.0021 0.007 0.0028 0.0317 0.0901 0.0046 0.0006 0.0023 0.0041 0.0017 0.0174 0.0138 0.0047 0.004 0.011 0.0404 0.0039
Nucleus 0.0186 0.0077 0.0102 0.0117 0.0181 0.0178 0.009 0.0029 0.0061 0.006 0.0056 0.0129 0.0294 0.01 0.0132 0.0232 0.0189 0.0179
Peroxisomes 0.0041 0.0003 0.0019 0.0001 0.0028 0.0018 0.0002 0.0001 0.0007 0.0002 0.0016 0.0041 0.0006 0.0006 0.0014 0.0006 0.0023 0.0003
Punctate Nuclear 0.0004 0.0001 0.001 0 0.0004 0.0021 0.0001 0 0.0003 0.0001 0.001 0.0054 0.0013 0.0003 0.0002 0.0005 0.0008 0.0002
Vacuole 0.2267 0.2177 0.3159 0.436 0.2571 0.1313 0.22 0.1229 0.2221 0.3518 0.2345 0.121 0.2274 0.136 0.2023 0.3799 0.2718 0.2639
Vacuole Periphery 0.1189 0.0646 0.1268 0.1885 0.2377 0.0935 0.0858 0.0292 0.0665 0.1409 0.1 0.1 0.0787 0.0247 0.0636 0.1295 0.1488 0.108

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1840.3497 1963.1526 2206.4862 1743.0561 2168.5434 1986.9067 1691.0222 1693.0522 1827.5761 1405.6159
Translational Efficiency 2.0463 1.9741 1.7468 2.2142 1.9938 1.9305 1.7884 2.1941 1.7882 2.1175

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
84 752 2275 1751 1995 1907 1289 1774 2079 2659 3564 3525

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 7466.29 8649.53 12354.29 13083.25 8440.58 9926.40 12236.86 13966.02 8401.21 9565.28 12311.82 13527.51
Standard Deviation 2162.11 2025.97 2747.51 3926.51 1851.08 2290.51 3550.61 3534.90 1874.49 2292.21 3062.90 3760.56
Intensity Change Log 2 — 0.212230 0.726549 0.809258 — 0.233928 0.535819 0.726507 — 0.223784 0.628489 0.765940

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000214 0.000094 0.000042 0.000310 0.000032 0.000076 0.000150 0.000153 0.000040 0.000081 0.000081 0.000231
Bud Neck 0.000439 0.000664 0.000633 0.001363 0.000276 0.000313 0.002234 0.000689 0.000282 0.000412 0.001212 0.001023
Bud Site 0.003596 0.003145 0.002927 0.010675 0.001960 0.002405 0.003706 0.007192 0.002026 0.002615 0.003209 0.008922
Cell Periphery 0.079408 0.028865 0.006642 0.022094 0.005878 0.010967 0.012583 0.034291 0.008849 0.016028 0.008791 0.028232
Cytoplasm 0.043510 0.348460 0.437063 0.393849 0.456801 0.492707 0.380683 0.350736 0.440102 0.451912 0.416672 0.372152
Cytoplasmic Foci 0.007447 0.012056 0.005466 0.007751 0.016855 0.018420 0.010475 0.009159 0.016475 0.016620 0.007277 0.008460
Eisosomes 0.000011 0.000003 0.000001 0.000004 0.000001 0.000002 0.000003 0.000003 0.000001 0.000002 0.000002 0.000004
Endoplasmic Reticulum 0.002847 0.000852 0.000648 0.000832 0.000914 0.001039 0.000541 0.001147 0.000992 0.000986 0.000609 0.000990
Endosome 0.001250 0.001073 0.000828 0.001173 0.000765 0.000916 0.000789 0.001152 0.000785 0.000961 0.000814 0.001162
Golgi 0.287594 0.132726 0.031753 0.037907 0.108184 0.134429 0.061312 0.075907 0.115433 0.133947 0.042444 0.057031
Lipid Particles 0.048819 0.024164 0.004701 0.012236 0.004042 0.010723 0.009685 0.017376 0.005851 0.014524 0.006504 0.014822
Mitochondria 0.000478 0.000227 0.000304 0.001467 0.000402 0.000423 0.000582 0.000595 0.000405 0.000367 0.000404 0.001028
Mitotic Spindle 0.000896 0.002014 0.000535 0.001291 0.001430 0.001138 0.000945 0.000790 0.001409 0.001386 0.000683 0.001039
None 0.000556 0.002729 0.001459 0.003053 0.002126 0.004344 0.002877 0.001695 0.002063 0.003887 0.001972 0.002370
Nuclear Periphery 0.001305 0.001155 0.000651 0.000461 0.000797 0.000783 0.001663 0.000644 0.000817 0.000889 0.001017 0.000553
Nuclear Periphery Foci 0.007051 0.019579 0.006008 0.004881 0.010819 0.011259 0.012584 0.006866 0.010667 0.013612 0.008386 0.005880
Nucleolus 0.000097 0.000181 0.000196 0.000323 0.000081 0.000218 0.000302 0.000250 0.000082 0.000208 0.000234 0.000286
Nucleus 0.009951 0.005588 0.008204 0.008227 0.002633 0.003421 0.030730 0.004711 0.002929 0.004033 0.016351 0.006457
Peroxisomes 0.000028 0.000021 0.000040 0.000151 0.000011 0.000021 0.000016 0.000071 0.000012 0.000021 0.000031 0.000111
Vacuole 0.223569 0.213579 0.302849 0.349769 0.074836 0.101925 0.298639 0.279214 0.080846 0.133502 0.301326 0.314261
Vacuole Periphery 0.280934 0.202824 0.189051 0.142184 0.311154 0.204472 0.169500 0.207360 0.309933 0.204006 0.181980 0.174985

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.06 1.43 -0.99 -3.94 -4.69 -2.50 -7.86 -4.96 -2.98 0.90 -2.77 -5.30 -6.00 -4.87 -4.49
Bud Neck -1.55 -3.20 -5.36 -4.93 -3.67 -0.22 -9.28 -4.37 -5.27 8.14 -1.47 -10.27 -7.13 -7.02 3.67
Bud Site 0.41 0.40 -3.09 -8.80 -9.80 -1.17 -5.21 -6.87 -6.26 -3.34 -1.67 -5.01 -12.27 -11.33 -9.59
Cell Periphery 4.32 6.34 5.03 3.55 -11.86 -8.10 -7.13 -17.63 -13.75 -12.59 -7.81 0.72 -16.02 -9.55 -18.07
Cytoplasm -15.03 -22.67 -19.96 -3.09 3.71 -3.08 6.41 9.23 12.20 2.10 -1.06 2.59 6.84 8.60 5.07
Cytoplasmic Foci -1.64 0.88 -0.25 3.13 -3.51 -1.25 2.87 6.81 7.93 2.44 -0.25 7.86 7.25 8.61 -1.14
Eisosomes 2.10 2.50 1.52 -3.08 -5.34 -2.29 -8.24 -6.17 -4.46 1.12 -1.99 -2.96 -6.41 -5.56 -4.73
Endoplasmic Reticulum 2.60 2.92 2.68 0.47 -1.70 -1.16 4.44 -1.95 -0.81 -6.44 0.10 4.79 0.36 0.30 -5.34
Endosome 1.08 2.57 0.51 -0.68 -2.70 -2.26 -1.54 -2.92 -1.76 -2.04 -2.84 -1.19 -3.89 -2.11 -3.40
Golgi 6.10 10.33 10.09 18.70 -2.89 -5.85 15.49 9.32 14.61 -6.40 -4.39 24.15 18.13 24.89 -9.11
Lipid Particles 2.71 5.01 4.17 6.56 -9.01 -8.94 -8.34 -14.32 -5.86 -7.32 -10.12 -1.07 -11.60 0.01 -12.59
Mitochondria 0.68 0.49 -1.85 -4.49 -4.21 -0.32 -2.91 -2.78 -2.18 0.74 0.66 -0.93 -4.37 -4.60 -4.07
Mitotic Spindle -1.31 1.21 -1.52 0.39 -2.12 1.81 2.58 2.24 1.20 0.41 0.05 3.99 0.47 0.34 -1.93
None -4.64 -2.12 -3.94 -0.56 -2.33 -3.07 -1.68 1.16 3.29 2.07 -3.40 0.30 -0.99 2.26 -0.98
Nuclear Periphery 0.60 2.73 3.98 7.37 2.06 0.12 -6.96 2.62 1.15 8.14 -0.74 -3.46 4.42 3.52 6.68
Nuclear Periphery Foci -8.19 0.77 2.01 11.73 2.86 -0.52 -1.69 6.19 7.77 6.46 -3.83 3.30 8.00 14.26 6.18
Nucleolus -1.61 -3.46 -6.01 -3.40 -4.25 -1.04 -7.61 -1.94 -0.20 1.24 -1.31 -11.00 -4.58 -0.81 -0.59
Nucleus 0.73 -0.25 -0.15 -4.16 0.44 -2.00 -13.87 -4.90 -3.48 12.48 -2.48 -15.87 -8.08 -6.42 10.61
Peroxisomes 0.53 -0.48 -3.58 -4.34 -3.70 -2.24 -3.40 -5.97 -4.56 -5.19 -2.67 -4.42 -6.36 -5.63 -4.96
Vacuole 0.39 -3.78 -5.61 -13.32 -4.96 -6.51 -30.24 -34.18 -28.11 2.77 -12.24 -43.90 -46.26 -33.24 -1.33
Vacuole Periphery 3.30 4.37 6.37 8.87 8.23 14.24 21.50 14.95 0.31 -8.56 15.41 21.63 22.02 7.44 -0.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
Localization
Cell Percentages cytoplasm (96%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Stm1

Stm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Stm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available