Standard name
Human Ortholog
Description Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm – 0.05 0 0.08 0.1 0.06 0.07 0.08 0 0.06 0.05 0.05 0.12 0.19 0.18 0.13 0.1 0.09 0 0 0 0 0 0
Endoplasmic Reticulum – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria – 0.07 0.13 0.16 0.19 0.63 0.65 0.57 0.73 0.66 0.7 0.62 0 0 0 0.06 0.07 0.08 0 0 0 0 0.05 0.05
Nucleus – 0.88 0.85 0.82 0.7 0.64 0.58 0.63 0.64 0.58 0.61 0.6 0.83 0.79 0.75 0.75 0.73 0.77 0.7 0.8 0.71 0.58 0.47 0.41
Nuclear Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0.06 0
Peroxisomes – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.05
Vac/Vac Membrane – 0 0 0 0.07 0.05 0 0 0 0 0 0 0 0 0 0.11 0.12 0.09 0.11 0.08 0.09 0.24 0.28 0.31
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 3 0 0 0 1
Bud – 0 0 2 0 2 5 5 13 2 8 8 0 0 0 1 0 0 1 6 0 1 4 4
Bud Neck – 0 0 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 1 0 1 4 4
Bud Site – 0 0 0 0 5 18 15 16 12 18 14 0 0 0 0 0 1 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm – 26 10 14 23 29 43 46 18 33 22 23 16 49 45 27 11 14 1 7 3 7 5 12
Endoplasmic Reticulum – 0 1 0 0 0 0 0 0 0 1 0 1 1 2 8 2 8 0 0 2 1 3 3
Endosome – 3 7 3 10 1 2 2 2 2 0 2 0 0 5 3 8 3 0 3 5 2 7 10
Golgi – 0 1 0 1 0 0 1 0 0 0 0 1 1 0 1 1 0 0 2 1 0 3 1
Mitochondria – 39 33 28 46 298 389 340 316 364 332 306 1 2 0 13 8 12 1 8 2 5 18 23
Nucleus – 458 216 145 169 303 349 371 278 322 286 296 108 204 190 152 81 118 31 441 203 149 184 179
Nuclear Periphery – 1 0 1 0 1 2 2 0 5 2 4 0 1 0 1 0 0 0 1 3 0 2 2
Nucleolus – 0 2 2 2 6 8 9 12 21 17 12 0 2 1 2 0 1 0 17 25 10 24 14
Peroxisomes – 0 0 0 1 0 0 0 0 0 0 1 0 1 1 0 0 0 0 0 0 0 0 1
SpindlePole – 4 2 5 3 2 4 9 6 6 0 7 2 3 6 3 0 4 2 6 5 10 11 22
Vac/Vac Membrane – 23 9 2 17 23 20 20 14 21 19 22 3 7 11 23 13 14 5 46 26 62 111 136
Unique Cell Count 522 255 177 241 474 597 593 435 552 472 495 130 259 252 203 111 153 45 551 287 258 395 433
Labelled Cell Count 554 281 203 272 670 840 820 675 789 706 695 132 271 262 234 124 176 45 551 287 258 395 433


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 4.9 4.7 4.5 4.7 3.4 3.4 3.9 3.4 3.6 3.5 3.6 5.9 6.1 6.1 5.9 5.8 5.8 5.1 5.4 5.5
Std Deviation (1e-4) – 0.9 1.3 1.4 2.0 1.1 1.1 1.4 0.9 1.3 0.8 1.0 1.2 1.1 1.3 1.0 1.1 1.0 0.7 1.1 1.0
Intensity Change (Log2) – – – -0.07 -0.02 -0.46 -0.45 -0.26 -0.46 -0.38 -0.45 -0.4 0.33 0.38 0.36 0.32 0.3 0.3 0.13 0.19 0.22


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.8 2.5 1.3 1.8 2.1 0.1 1.2 0.5 0.5 3.1 5.3 5.0 3.7 2.3 2.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 -0.6 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 -4.0 -5.5 -5.9 -2.3 -1.6 -1.6
Nucleus -0.8 -3.9 -5.9 -7.4 -6.4 -5.8 -7.4 -6.7 -6.9 -0.4 -1.7 -2.6 -2.6 -2.6 -1.9
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.8 0.8 -0.1 -0.1 -0.2 0.2 0.3 0.6 0 -0.5 0.5 3.3 3.0 2.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.8335 -0.6914 -0.84 -0.4515 -1.6107 -0.563 0.7589 0.9525 1.1251 0.9603 1.179 0.9351 -0.1423 0.0425 -0.163 -0.5127 0.1682 -0.7201
Actin 0.0136 0.0009 0.003 0.0003 0.0005 0.0016 0.007 0.0115 0.0128 0.0013 0.0325 0.0048 0.038 0.0003 0.0039 0.0495 0 0.0001
Bud 0.0002 0.0001 0.0001 0.0008 0.0001 0.001 0.0004 0.0009 0.0005 0.0001 0.0006 0.0019 0.0012 0.0002 0.0002 0.0009 0 0.0003
Bud Neck 0.0009 0.0004 0.0003 0.0021 0.0025 0.0039 0.0009 0.0011 0.002 0.0003 0.0015 0.0027 0.0251 0.0004 0.0004 0.0004 0.0004 0.0042
Bud Periphery 0.0002 0.0001 0.0001 0.0015 0.0001 0.0024 0.0004 0.0004 0.0006 0.0001 0.0016 0.001 0.0017 0.0002 0.0002 0.0012 0 0.0004
Bud Site 0.0006 0.0006 0.0003 0.0031 0.0002 0.0029 0.0092 0.0049 0.0062 0.0002 0.0013 0.0003 0.006 0.0005 0.0007 0.0019 0.0001 0.0004
Cell Periphery 0.0001 0 0 0.0006 0 0.0003 0.0002 0.0001 0.0001 0 0.0004 0 0.0003 0.0001 0 0.0001 0 0.0001
Cytoplasm 0.0193 0.0492 0.0241 0.0053 0.0075 0.0047 0.0211 0.0283 0.0135 0.0164 0.0029 0.0041 0.0144 0.0346 0.0128 0.0084 0.0052 0.0124
Cytoplasmic Foci 0.0027 0.0047 0.004 0.0038 0.0001 0.0036 0.033 0.0008 0.0113 0.0007 0.0046 0.0038 0.0339 0.0092 0.0033 0.0032 0 0.0001
Eisosomes 0.0011 0.0001 0 0 0 0.0001 0.0001 0.0001 0.0001 0 0.0003 0 0.0003 0 0.0001 0.0003 0 0
Endoplasmic Reticulum 0.0058 0.0035 0.0008 0.0002 0.0034 0.0004 0.0026 0.001 0.0024 0.0002 0.0043 0.0004 0.0012 0.002 0.0015 0.0027 0.0002 0.0003
Endosome 0.0084 0.0046 0.0022 0.0098 0.0009 0.0043 0.0349 0.0009 0.0149 0.0002 0.0373 0.0029 0.0202 0.0034 0.0161 0.0114 0.0002 0.0002
Golgi 0.0034 0.0003 0.0028 0.0026 0 0.0024 0.0057 0.0001 0.0034 0 0.0209 0.0016 0.0187 0.0001 0.0041 0.0098 0 0
Lipid Particles 0.0021 0.0011 0.0076 0.0054 0 0.0039 0.0232 0.0003 0.0034 0.0001 0.0154 0.0013 0.0301 0.002 0.0071 0.0045 0 0
Mitochondria 0.0013 0.0005 0.0018 0.0137 0.001 0.0044 0.0032 0.0005 0.0019 0.0004 0.067 0.0017 0.0117 0.0006 0.0018 0.0098 0.0002 0.0002
None 0.0385 0.0888 0.0688 0.0027 0.0047 0.0066 0.0141 0.0589 0.0299 0.0545 0.0392 0.0089 0.0121 0.07 0.0381 0.0057 0.0043 0.0091
Nuclear Periphery 0.0262 0.0409 0.0316 0.0048 0.0489 0.0071 0.0125 0.0178 0.0138 0.0119 0.0158 0.0078 0.004 0.0313 0.0284 0.0058 0.0057 0.003
Nucleolus 0.0098 0.0101 0.0088 0.0132 0.0233 0.0259 0.0105 0.0156 0.0191 0.0197 0.0345 0.027 0.0057 0.0143 0.008 0.0099 0.0074 0.0182
Nucleus 0.8464 0.7441 0.7951 0.8941 0.8818 0.8896 0.7784 0.8289 0.813 0.8339 0.6913 0.9001 0.7531 0.8091 0.8152 0.8687 0.9708 0.9453
Peroxisomes 0.0009 0.0008 0.0042 0.0054 0 0.0031 0.009 0.0001 0.0016 0.0001 0.0146 0.0019 0.0143 0.0004 0.0011 0.0012 0 0
Punctate Nuclear 0.0165 0.0454 0.0431 0.0186 0.0238 0.0288 0.0287 0.0261 0.0477 0.0597 0.0072 0.0272 0.006 0.0184 0.0511 0.0036 0.0051 0.005
Vacuole 0.0011 0.003 0.0008 0.0103 0.0006 0.0022 0.0038 0.0014 0.0014 0.0001 0.0036 0.0004 0.0014 0.0024 0.0042 0.0006 0.0003 0.0005
Vacuole Periphery 0.0008 0.0009 0.0005 0.0018 0.0004 0.0009 0.0011 0.0003 0.0006 0.0001 0.003 0.0003 0.0007 0.0007 0.0016 0.0006 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.209 5.2639 3.6056 6.4907 2.0555 4.5271 6.3459 6.7699 5.4811 7.4653
Translational Efficiency 1.0039 0.7889 1.299 0.4626 2.6992 1.8565 0.876 0.9302 1.0674 0.8648

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2013 1723 3379 1518 1868 1925 3338 2045 3881 3648 6717 3563

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 691.87 798.22 878.34 898.43 686.15 722.74 880.81 896.21 689.12 758.39 879.57 897.16
Standard Deviation 78.80 102.91 112.71 126.29 87.51 94.51 114.48 123.07 83.16 105.53 113.60 124.46
Intensity Change Log 2 — 0.206285 0.344279 0.376905 — 0.074953 0.360307 0.385313 — 0.142385 0.352282 0.381098

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000076 0.000264 0.000210 0.000946 0.000097 0.000205 0.000238 0.000604 0.000086 0.000233 0.000224 0.000749
Bud Neck 0.002640 0.003871 0.018080 0.028065 0.002414 0.007955 0.027053 0.027145 0.002531 0.006026 0.022539 0.027537
Bud Site 0.000541 0.001080 0.001480 0.015271 0.000328 0.002082 0.001915 0.010323 0.000439 0.001609 0.001696 0.012431
Cell Periphery 0.000087 0.000107 0.000091 0.000274 0.000084 0.000120 0.000103 0.000164 0.000085 0.000113 0.000097 0.000211
Cytoplasm 0.050639 0.038256 0.006023 0.038214 0.035225 0.059419 0.013643 0.039215 0.043220 0.049424 0.009810 0.038788
Cytoplasmic Foci 0.005365 0.006520 0.000033 0.003632 0.004204 0.010752 0.000079 0.001181 0.004806 0.008753 0.000056 0.002225
Eisosomes 0.000017 0.000026 0.000013 0.000030 0.000017 0.000028 0.000014 0.000023 0.000017 0.000027 0.000013 0.000026
Endoplasmic Reticulum 0.001194 0.002775 0.002418 0.008146 0.001343 0.001958 0.002661 0.005730 0.001266 0.002344 0.002539 0.006759
Endosome 0.000710 0.001190 0.000184 0.003756 0.000520 0.002049 0.000244 0.002819 0.000619 0.001643 0.000214 0.003218
Golgi 0.000384 0.001225 0.000043 0.001446 0.000161 0.001540 0.000047 0.001413 0.000277 0.001391 0.000045 0.001427
Lipid Particles 0.001657 0.001779 0.000041 0.000814 0.001802 0.003041 0.000069 0.000291 0.001727 0.002445 0.000055 0.000514
Mitochondria 0.001850 0.002541 0.000968 0.009874 0.002733 0.007285 0.001436 0.005887 0.002275 0.005044 0.001200 0.007585
Mitotic Spindle 0.002842 0.003405 0.001226 0.028670 0.000649 0.006685 0.002037 0.022889 0.001787 0.005136 0.001629 0.025352
None 0.012229 0.009446 0.002673 0.010272 0.014052 0.009847 0.003254 0.008618 0.013106 0.009657 0.002961 0.009323
Nuclear Periphery 0.001495 0.001274 0.000948 0.004035 0.000905 0.002894 0.001411 0.002707 0.001211 0.002128 0.001178 0.003273
Nuclear Periphery Foci 0.000651 0.000742 0.000046 0.002389 0.000554 0.000852 0.000110 0.001121 0.000605 0.000800 0.000078 0.001661
Nucleolus 0.008474 0.012658 0.005261 0.004562 0.013816 0.009090 0.003479 0.004410 0.011045 0.010776 0.004375 0.004475
Nucleus 0.906156* 0.908582* 0.959223* 0.821936* 0.919093* 0.868841* 0.940727* 0.852769* 0.912383* 0.887611* 0.950031* 0.839633*
Peroxisomes 0.001255 0.001314 0.000031 0.000257 0.001098 0.002116 0.000040 0.000269 0.001179 0.001737 0.000036 0.000264
Vacuole 0.001334 0.002633 0.000857 0.014433 0.000712 0.002586 0.001340 0.010239 0.001034 0.002608 0.001097 0.012026
Vacuole Periphery 0.000403 0.000313 0.000154 0.002976 0.000192 0.000657 0.000100 0.002187 0.000302 0.000494 0.000127 0.002523

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.68 -10.40 -16.10 -11.16 -13.66 -3.12 -9.20 -13.21 -9.65 -9.14 -5.66 -13.74 -20.85 -14.51 -16.33
Bud Neck -2.36 -19.70 -16.45 -15.61 -4.68 -5.92 -23.57 -18.17 -12.46 1.57 -6.15 -30.50 -24.32 -19.53 -2.01
Bud Site -3.04 -2.94 -7.94 -7.40 -6.91 -4.66 -7.89 -7.89 -5.80 -6.16 -5.43 -6.71 -11.11 -9.23 -9.18
Cell Periphery -1.55 0.39 -4.18 -3.11 -4.15 -2.18 -0.50 -3.26 -0.57 -3.04 -2.65 0.03 -5.27 -2.64 -5.08
Cytoplasm 3.16 16.66 6.03 2.29 -11.66 -6.36 9.70 0.53 7.00 -9.83 -2.19 18.94 4.87 6.69 -15.33
Cytoplasmic Foci -0.88 8.93 5.48 5.38 -2.92 -4.88 6.58 5.45 9.05 -3.36 -4.47 10.93 8.03 10.56 -4.22
Eisosomes -4.31 2.82 -12.84 -6.83 -15.82 -4.45 1.97 -7.29 -0.57 -11.08 -6.17 3.39 -14.11 -4.71 -19.00
Endoplasmic Reticulum -8.35 -11.18 -20.76 -16.27 -17.28 -4.18 -10.99 -16.85 -14.18 -10.19 -9.09 -15.59 -26.49 -21.21 -19.55
Endosome -1.68 3.27 -3.63 -1.84 -5.93 -3.52 3.27 -2.85 0.64 -3.72 -3.83 4.42 -4.24 -0.36 -6.14
Golgi -1.74 2.09 -0.78 1.36 -3.16 -2.99 2.84 -2.20 1.57 -2.70 -3.32 2.69 -2.07 2.04 -3.84
Lipid Particles -0.54 6.49 3.70 4.35 -5.41 -1.68 3.51 2.95 5.66 -8.32 -1.84 6.09 4.50 7.09 -8.24
Mitochondria -1.08 2.15 -4.22 -3.08 -5.51 -3.70 1.51 -1.82 2.49 -4.86 -3.94 2.30 -4.26 0.14 -7.43
Mitotic Spindle -0.59 1.30 -8.02 -7.73 -8.72 -4.24 -3.51 -8.89 -5.55 -7.85 -3.47 -0.61 -11.75 -9.36 -11.75
None 1.54 7.45 3.67 1.94 -7.22 2.76 9.11 5.25 2.24 -7.26 2.96 11.58 6.19 2.94 -10.30
Nuclear Periphery 0.64 1.57 -8.96 -9.74 -10.38 -3.08 -7.55 -10.78 -1.34 -7.01 -2.68 -2.56 -13.32 -5.58 -12.59
Nuclear Periphery Foci -0.57 3.79 -2.19 -1.83 -4.00 -0.74 2.58 -0.87 -0.20 -3.48 -0.96 4.35 -2.17 -1.43 -5.33
Nucleolus -3.81 2.36 2.26 5.62 0.25 4.15 7.74 8.23 5.33 0.65 0.33 7.50 7.82 7.84 0.77
Nucleus -0.14 -11.13 9.90 9.61 19.68 7.49 -3.52 9.36 1.30 14.00 5.48 -10.40 13.32 7.34 23.98
Peroxisomes -0.13 3.10 2.69 3.82 -9.35 -2.10 2.56 2.18 7.11 -4.92 -1.66 4.00 3.44 7.78 -8.05
Vacuole -2.54 1.22 -12.66 -11.71 -12.87 -5.35 -4.15 -11.19 -9.37 -10.18 -5.11 -1.71 -16.76 -14.91 -16.39
Vacuole Periphery 0.52 1.60 -1.97 -2.42 -2.97 -2.71 1.76 -2.04 -0.98 -2.27 -1.53 2.05 -2.67 -2.05 -3.41
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
Localization
Cell Percentages nucleus (96%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Rfx1

Rfx1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rfx1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available