Standard name
Human Ortholog
Description Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.95 0.68 0.59 0.65 0.51 0.55 0.42 0.41 0.54 0.43 0.4 0.45 0.62 0.62 0.57 0.06 0.07 0 0 0 0 0 0 0
Nucleus 0.15 0.18 0.07 0.06 0 0 0 0 0 0 0.05 0 0.08 0 0.05 0.08 0.19 0.17 0 0.12 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.95 0.92 0.95 0.96 0.95 0.96 0.93 0.95 0.94 0.93 0.96 0.92 0.93 0.94 0.9 0.94 0.88 0.89 0.93 0.83 0.87 0.91 0.91 0.89
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0.07 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0 1 1 0 0 1
Bud Neck 0 1 0 0 0 0 1 3 0 1 0 0 0 0 0 0 0 0 0 0 0 1 3 2
Bud Site 0 0 0 0 0 0 1 0 2 2 0 3 1 1 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 1 4 1 4 2 4 3 0 3 2 3 3 12 13 10 6 1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Endosome 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 1
Golgi 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 19 119 115 77 104 116 138 174 109 92 69 100 73 156 150 16 10 3 0 0 0 1 0 1
Nucleus 3 31 13 7 3 5 2 3 7 4 8 5 9 8 13 21 26 17 1 20 8 0 3 3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 19 160 186 113 194 203 306 402 189 199 166 205 110 235 237 238 122 90 47 137 169 77 144 172
Peroxisomes 0 1 0 2 3 0 13 6 1 3 3 3 1 2 3 1 0 0 0 0 1 0 0 1
SpindlePole 0 1 0 0 3 2 23 21 5 9 6 7 0 3 5 0 0 1 0 0 5 0 0 2
Vac/Vac Membrane 0 0 1 0 0 0 1 0 0 1 0 1 0 1 2 0 0 1 1 3 2 0 4 4
Unique Cell Count 20 174 195 118 204 211 330 422 201 215 173 224 118 250 262 252 139 101 51 166 196 85 159 194
Labelled Cell Count 41 314 320 200 312 329 490 612 313 314 255 327 197 418 423 289 166 113 51 166 196 85 159 194


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 45.7 55.2 42.6 42.2 35.4 31.4 25.3 26.0 24.7 22.8 22.6 21.8 52.0 51.9 46.1 45.4 59.4 63.4 41.8 52.1 54.3
Std Deviation (1e-4) 11.3 20.1 17.9 18.3 15.5 11.5 11.9 11.8 10.1 11.6 9.6 8.7 27.3 24.9 19.8 24.9 26.3 26.7 15.4 19.8 24.3
Intensity Change (Log2) – – – -0.01 -0.27 -0.44 -0.75 -0.71 -0.78 -0.9 -0.91 -0.97 0.29 0.29 0.12 0.09 0.48 0.58 -0.03 0.29 0.35


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 1.5 1.6 1.2 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.1 -1.6 -0.8 -3.8 -4.1 -1.0 -3.3 -3.7 -2.9 0.5 0.7 -0.4 -12.1 -9.6 -9.3
Nucleus -0.3 -2.6 -2.1 -4.0 -4.3 -1.4 -2.4 -0.8 -2.2 0.3 -1.7 -0.8 0.7 3.4 2.7
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.2 -0.1 0.4 -1.2 -0.1 -0.6 -1.2 0.3 -1.6 -0.8 -0.6 -2.0 -0.4 -2.6 -2.0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 3.8 3.2 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0113 0 0.0118 0 0.0004 0 0.0018 0 0 0 0 0 – – – – – –
Bud 0.0001 0 0.0001 0 0 0 0.0001 0 0 0 0 0 – – – – – –
Bud Neck 0.0001 0 0.0004 0 0.0002 0 0.0004 0.0001 0.0001 0.0001 0 0 – – – – – –
Bud Periphery 0.0001 0 0 0 0 0 0.0001 0 0 0 0 0 – – – – – –
Bud Site 0.0003 0 0.002 0 0.0001 0 0.0005 0.0001 0 0.0002 0 0 – – – – – –
Cell Periphery 0.0001 0.0005 0.0003 0.0002 0.0003 0.0002 0.0003 0.0002 0.0004 0.0003 0.0009 0.0002 – – – – – –
Cytoplasm 0.0005 0 0 0 0 0 0.0005 0 0 0 0 0 – – – – – –
Cytoplasmic Foci 0.0436 0 0.0049 0.0004 0.0004 0.0003 0.1256 0.0001 0.0002 0.0007 0.0002 0.0008 – – – – – –
Eisosomes 0.0002 0 0 0 0.0006 0 0.0003 0 0 0 0.0001 0 – – – – – –
Endoplasmic Reticulum 0.0005 0 0 0 0 0 0.0001 0 0 0 0 0 – – – – – –
Endosome 0.0066 0 0.0001 0 0 0 0.0043 0 0 0 0 0 – – – – – –
Golgi 0.0083 0 0.0006 0 0.0001 0 0.0037 0 0 0 0 0 – – – – – –
Lipid Particles 0.1845 0 0.0008 0.0005 0.0063 0.0013 0.0228 0.0001 0.0003 0.0004 0.0022 0.0009 – – – – – –
Mitochondria 0.0069 0.0054 0.0078 0.0028 0.3227 0.0234 0.0133 0.0008 0.0072 0.0072 0.2169 0.0266 – – – – – –
None 0.0038 0 0 0 0 0 0.0054 0 0 0 0 0 – – – – – –
Nuclear Periphery 0.0027 0.0001 0 0 0 0 0.0001 0 0 0 0 0 – – – – – –
Nucleolus 0.6534 0.8101 0.8994 0.9698 0.6495 0.9414 0.755 0.8975 0.9627 0.955 0.7268 0.9372 – – – – – –
Nucleus 0.012 0.1823 0.0603 0.0259 0.0114 0.0321 0.0391 0.1002 0.028 0.0343 0.0476 0.0323 – – – – – –
Peroxisomes 0.052 0.0001 0.0108 0.0001 0.0068 0.0008 0.0224 0 0.0003 0.0003 0.0023 0.0007 – – – – – –
Punctate Nuclear 0.0121 0 0.0001 0 0 0 0.0036 0 0 0.0007 0 0.0008 – – – – – –
Vacuole 0.0002 0.0006 0.0003 0.0002 0.0003 0.0002 0.0004 0.0005 0.0004 0.0003 0.001 0.0002 – – – – – –
Vacuole Periphery 0.0007 0.0007 0.0002 0.0001 0.0009 0.0001 0.0004 0.0003 0.0003 0.0002 0.0019 0.0001 – – – – – –

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 447.9167 457.7046 447.3733 334.2323 350.3347 353.7675 305.451 272.5829 239.3467 300.0886
Translational Efficiency 1.2699 1.3137 1.1413 1.4629 1.3152 1.3377 1.3428 1.2422 1.1869 1.2437

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1240 147 1851 1656 1452 841 1038 2705 2692 988 2889 4361

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2634.97 3255.55 4666.10 4792.36 3058.10 3346.06 5057.48 4439.78 2863.20 3332.59 4806.72 4573.66
Standard Deviation 886.28 1252.97 1343.38 1631.48 946.55 1018.37 1270.65 1670.51 943.16 1057.06 1331.02 1664.61
Intensity Change Log 2 — 0.305115 0.824431 0.862950 — 0.129828 0.725783 0.537853 — 0.213611 0.772281 0.697458

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000379 0.000355 0.000563 0.000825 0.000316 0.000278 0.000629 0.000828 0.000345 0.000289 0.000587 0.000827
Bud Neck 0.003038 0.001966 0.002663 0.005087 0.001322 0.001485 0.003533 0.006146 0.002113 0.001556 0.002976 0.005744
Bud Site 0.001307 0.000887 0.000729 0.001210 0.000447 0.000820 0.000890 0.001682 0.000843 0.000830 0.000787 0.001503
Cell Periphery 0.000073 0.000085 0.000040 0.000131 0.000019 0.000059 0.000051 0.000383 0.000044 0.000063 0.000044 0.000287
Cytoplasm 0.001030 0.000363 0.000135 0.000179 0.000057 0.000212 0.000068 0.001599 0.000505 0.000234 0.000111 0.001060
Cytoplasmic Foci 0.034967 0.019447 0.009470 0.010966 0.015372 0.019429 0.006910 0.011050 0.024398 0.019432 0.008550 0.011018
Eisosomes 0.000875 0.000322 0.001157 0.002155 0.000824 0.000467 0.001779 0.002081 0.000848 0.000446 0.001380 0.002109
Endoplasmic Reticulum 0.000109 0.000432 0.000076 0.000134 0.000066 0.000066 0.000083 0.000217 0.000086 0.000120 0.000078 0.000186
Endosome 0.000029 0.000164 0.000012 0.000025 0.000011 0.000020 0.000011 0.000048 0.000020 0.000042 0.000012 0.000039
Golgi 0.000149 0.000686 0.000098 0.000122 0.000105 0.000124 0.000087 0.000157 0.000125 0.000207 0.000094 0.000144
Lipid Particles 0.000065 0.000683 0.000036 0.000039 0.000038 0.000045 0.000031 0.000027 0.000050 0.000140 0.000034 0.000032
Mitochondria 0.001799 0.001469 0.002149 0.003064 0.001348 0.001248 0.002272 0.002921 0.001556 0.001281 0.002193 0.002975
Mitotic Spindle 0.001119 0.005601 0.001043 0.002040 0.002033 0.002483 0.000775 0.000972 0.001612 0.002947 0.000946 0.001378
None 0.001788 0.004619 0.000533 0.000797 0.000437 0.000704 0.000507 0.003180 0.001059 0.001287 0.000524 0.002275
Nuclear Periphery 0.000078 0.000035 0.000070 0.000143 0.000046 0.000056 0.000281 0.000218 0.000061 0.000053 0.000145 0.000189
Nuclear Periphery Foci 0.000106 0.001306 0.000049 0.000068 0.000060 0.000070 0.000064 0.000071 0.000081 0.000254 0.000054 0.000070
Nucleolus 0.558400* 0.521639* 0.592661* 0.627008* 0.577709* 0.565767* 0.622026* 0.470965* 0.568815* 0.559201* 0.603211* 0.530219*
Nucleus 0.227650* 0.198775* 0.247642* 0.274053* 0.165881* 0.178791* 0.267382* 0.453559* 0.194333* 0.181764* 0.254734* 0.385395*
Peroxisomes 0.164160* 0.235846* 0.138157* 0.062124 0.232613* 0.226539* 0.087022 0.032757 0.201082* 0.227924* 0.119785* 0.043909
Vacuole 0.001490 0.001572 0.001051 0.004539 0.000567 0.000613 0.002692 0.005113 0.000992 0.000756 0.001641 0.004895
Vacuole Periphery 0.001388 0.003748 0.001666 0.005291 0.000731 0.000723 0.002909 0.006027 0.001034 0.001173 0.002113 0.005747

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.31 -6.53 -11.91 -5.55 -7.39 1.73 -9.73 -19.13 -18.72 -5.12 2.49 -12.24 -21.66 -20.22 -9.75
Bud Neck 1.81 1.09 -5.11 -5.91 -9.92 -1.68 -9.37 -16.29 -15.30 -7.24 2.83 -4.39 -14.26 -18.56 -12.46
Bud Site 1.30 3.06 0.39 -1.26 -6.75 -1.86 -5.32 -4.95 -2.49 -3.02 -0.07 0.61 -3.73 -2.64 -4.51
Cell Periphery -0.21 2.60 -1.77 -0.86 -2.83 -1.18 -2.24 -6.63 -4.84 -5.84 -0.66 -0.01 -6.69 -4.59 -6.60
Cytoplasm 1.10 1.57 1.47 0.62 -1.02 -1.80 -0.55 -6.65 -5.54 -6.59 0.97 1.49 -1.82 -4.91 -6.46
Cytoplasmic Foci 4.09 9.49 8.69 2.64 -1.45 -2.02 7.30 3.36 4.02 -4.60 2.11 11.20 9.19 4.59 -3.49
Eisosomes 5.94 -2.60 -4.52 -6.80 -3.59 6.25 -3.12 -5.65 -7.44 -0.78 7.51 -4.24 -7.18 -9.83 -3.52
Endoplasmic Reticulum -0.88 4.50 -2.08 0.81 -5.98 -0.10 -2.85 -7.39 -6.85 -6.58 -0.64 1.75 -7.35 -1.11 -8.20
Endosome -0.93 4.03 0.96 0.96 -3.82 -1.75 0.16 -3.83 -2.34 -3.92 -1.05 3.24 -3.12 0.16 -4.54
Golgi -0.94 3.37 1.54 0.99 -2.50 -1.54 1.85 -3.25 -1.88 -4.67 -0.96 3.50 -1.58 0.73 -4.88
Lipid Particles -0.92 0.90 1.10 0.97 -0.04 -0.44 0.40 0.59 1.16 0.47 -0.90 0.81 1.29 1.13 0.26
Mitochondria 0.94 -1.52 -4.88 -4.74 -4.43 0.61 -4.00 -9.41 -9.70 -2.64 1.79 -4.26 -9.57 -11.41 -5.35
Mitotic Spindle -0.93 0.36 -1.47 0.74 -1.64 -0.67 2.10 1.65 1.85 -0.40 -1.42 1.99 0.49 1.61 -1.32
None -0.72 2.19 1.72 0.98 -4.16 -2.07 -1.60 -7.82 -6.57 -7.60 -0.36 2.01 -3.51 -1.56 -7.94
Nuclear Periphery 4.77 0.87 -4.04 -6.83 -4.63 -0.99 -1.10 -6.43 -5.73 0.27 0.76 -1.10 -7.30 -7.12 -0.63
Nuclear Periphery Foci -0.95 1.95 1.45 0.98 -1.17 -0.64 -0.08 -0.79 0.16 -0.27 -0.92 1.48 0.87 1.00 -1.04
Nucleolus 1.83 -4.17 -7.38 -5.23 -4.08 1.46 -4.92 13.51 10.38 16.31 1.30 -5.84 6.38 3.67 12.04
Nucleus 1.41 -2.34 -5.22 -3.74 -3.29 -1.55 -11.33 -37.84 -30.73 -19.31 1.70 -10.11 -31.51 -26.00 -20.52
Peroxisomes -4.34 4.69 20.61 10.73 18.91* 0.79 24.48 40.83* 31.81* 14.68 -4.14 19.50 44.66* 32.07 27.69*
Vacuole -0.07 1.93 -5.65 -3.16 -6.56 -0.60 -4.09 -9.24 -9.07 -3.46 1.54 -2.79 -10.54 -10.79 -7.80
Vacuole Periphery -1.03 -2.06 -9.93 -0.64 -9.38 0.16 -11.25 -9.64 -9.65 -5.40 -0.40 -10.68 -12.61 -9.04 -9.57
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
Localization
Cell Percentages nucleolus (92%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-2

Nop56

Nop56


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nop56-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available