Standard name
Human Ortholog
Description Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.17 0.11 0 0 0 0 0 0 0 – 0 0.11 0.11 0.05 0 0.25 0.28 0.35 0 0 0 0 0 0
Cytoplasm 0.95 0.91 0.97 1.0 1.0 1.0 0.96 0.9 0.94 – 0.88 0.83 0.97 0.97 0.99 0.87 0.84 0.79 0.96 0.95 0.94 0.89 0.92 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 0.07 0 – 0.06 0.1 0 0 0 0 0 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 1 0 1 1 – 1 2 0 0 1 1 0 0 0 0 0 0 2 2
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 19 16 1 2 2 1 5 11 3 – 5 18 15 13 5 117 57 139 2 0 0 0 0 2
Cytoplasm 106 132 76 121 217 162 243 234 121 – 103 134 135 267 291 402 172 316 109 147 88 105 260 320
Endoplasmic Reticulum 0 0 1 0 0 0 6 19 4 – 7 16 0 0 1 11 9 30 0 1 0 1 4 11
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Nucleus 0 3 0 0 1 0 0 0 0 – 0 0 0 0 1 0 0 1 0 0 0 1 1 0
Nuclear Periphery 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 2 1 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 2 0 0 0 0 0 2 3 2
Unique Cell Count 112 145 78 121 217 162 252 260 129 117 162 139 274 294 464 204 402 114 155 95 119 283 352
Labelled Cell Count 125 153 78 123 220 164 254 265 129 119 171 150 280 299 535 238 486 114 155 95 119 283 352


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 491.5 448.9 333.0 348.8 313.8 245.6 220.8 197.9 177.5 – 166.0 159.4 477.6 455.0 375.2 488.2 484.5 543.3 425.5 433.9 458.5
Std Deviation (1e-4) 84.1 100.5 88.7 85.5 62.7 60.0 52.1 50.7 53.0 – 54.2 45.5 106.4 87.1 91.9 121.8 154.6 117.6 144.1 130.2 126.7
Intensity Change (Log2) – – – 0.07 -0.09 -0.44 -0.59 -0.75 -0.91 – -1.0 -1.06 0.52 0.45 0.17 0.55 0.54 0.71 0.35 0.38 0.46

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000200400600WT3HU80HU120HU1600200400600WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30200400600WT1AF100AF140AF1800200400600
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 2.6 2.6 0 0 4.7 5.0 5.9
Cytoplasm 1.8 2.4 2.0 -0.4 -2.1 -1.2 – -2.3 -3.2 -0.1 0 1.1 -2.7 -3.0 -3.9
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 2.4 0 0 0 0 0 2.0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 284.5818 530.0769 390.9711 383.4574 338.6926 293.5772 380.7081 698.9622 589.9822 409.236 735.6133 598.8029 434.5529 540.0223 351.9235 375.8712 260.6334 432.4719
Actin 0.0145 0.0007 0.0011 0.0011 0.0036 0.0065 0.0092 0.0007 0.0022 0.0012 0.0006 0.0025 0.003 0.0007 0.0025 0.0634 0.0256 0.0043
Bud 0.0121 0.0044 0.0082 0.0059 0.0085 0.0071 0.0027 0.0037 0.0117 0.0061 0.0044 0.0077 0.0067 0.0052 0.0156 0.0082 0.0091 0.0107
Bud Neck 0.0016 0.001 0.0013 0.0028 0.0032 0.0043 0.0012 0.0008 0.0013 0.0012 0.0011 0.0018 0.0012 0.0007 0.0014 0.0029 0.0025 0.0026
Bud Periphery 0.017 0.0019 0.0049 0.0034 0.0095 0.0066 0.0029 0.0013 0.0056 0.0045 0.001 0.0015 0.0049 0.0018 0.0156 0.0093 0.0054 0.0093
Bud Site 0.0051 0.0025 0.0038 0.0083 0.0036 0.0026 0.0028 0.0024 0.0043 0.0009 0.0002 0.0018 0.0025 0.0026 0.0037 0.0026 0.0046 0.0014
Cell Periphery 0.059 0.0613 0.088 0.0973 0.0433 0.0989 0.0746 0.0306 0.0258 0.0178 0.0064 0.0057 0.0677 0.0146 0.0322 0.0206 0.0068 0.0235
Cytoplasm 0.3107 0.7346 0.4591 0.4886 0.1624 0.3045 0.3388 0.8216 0.6961 0.4427 0.648 0.5915 0.4984 0.8582 0.5095 0.3229 0.4127 0.4627
Cytoplasmic Foci 0.0271 0.0008 0.006 0.0037 0.0061 0.0219 0.0174 0.001 0.0044 0.001 0.0004 0.0036 0.001 0.0008 0.1303 0.0007 0.0144 0.0008
Eisosomes 0.0064 0.0002 0.0014 0.0003 0.0005 0.001 0.0171 0.0046 0.0009 0 0 0.0003 0.0083 0 0.0019 0.0057 0.0012 0.0001
Endoplasmic Reticulum 0.0251 0.0014 0.0029 0.0016 0.0007 0.0206 0.0052 0.0006 0.0011 0.0011 0.0003 0.0003 0.0119 0.0007 0.0023 0.0024 0.056 0.0021
Endosome 0.0052 0.0004 0.0039 0.0088 0.0075 0.107 0.0054 0.0001 0.0011 0.0068 0.0004 0.0008 0.0019 0.0005 0.0059 0.0074 0.1446 0.0019
Golgi 0.0013 0.0001 0.0003 0.0009 0.0019 0.0055 0.0022 0.0001 0.0003 0.0002 0 0.0002 0.0004 0.0001 0.0008 0.0155 0.081 0.0003
Lipid Particles 0.0041 0.0008 0.0026 0.0059 0.0091 0.0137 0.0134 0.0005 0.0018 0.0007 0 0.0005 0.0015 0.0002 0.0067 0.0024 0.0191 0.0006
Mitochondria 0.0702 0.0132 0.0388 0.0057 0.2995 0.0383 0.0547 0.0112 0.037 0.0081 0.0016 0.0944 0.0947 0.0058 0.0507 0.1345 0.0406 0.12
None 0.0356 0.0025 0.0264 0.0036 0.0027 0.0425 0.0405 0.0038 0.0064 0.0016 0.0003 0.0051 0.0063 0.0015 0.04 0.0011 0.0017 0.0013
Nuclear Periphery 0.0886 0.0104 0.0171 0.0328 0.0101 0.0789 0.1166 0.0103 0.0163 0.0352 0.0026 0.0183 0.0556 0.0083 0.0105 0.0099 0.0181 0.0157
Nucleolus 0.037 0.0108 0.0406 0.0321 0.0481 0.0302 0.0542 0.0113 0.0204 0.0154 0.0009 0.0387 0.0105 0.0018 0.0468 0.0039 0.0027 0.0092
Nucleus 0.0797 0.056 0.0656 0.0613 0.0552 0.0465 0.1431 0.0603 0.0767 0.1186 0.0268 0.1746 0.0717 0.0374 0.0332 0.0906 0.0384 0.0431
Peroxisomes 0.0022 0.0005 0.0013 0.0005 0.0042 0.0027 0.0024 0.0004 0.0017 0.0004 0.0001 0.003 0.0009 0.0003 0.0039 0.0007 0.0039 0.0013
Punctate Nuclear 0.0013 0.0001 0.0005 0.0003 0.0004 0.0042 0.003 0.0001 0.0003 0.0002 0 0.0005 0.0002 0.0001 0.0015 0.0001 0.0007 0.0002
Vacuole 0.1277 0.0786 0.1663 0.1849 0.1567 0.0978 0.0524 0.028 0.0608 0.1844 0.2384 0.0212 0.0898 0.0449 0.0666 0.2051 0.0638 0.1617
Vacuole Periphery 0.0684 0.0181 0.0599 0.0502 0.1632 0.0588 0.0402 0.0066 0.0236 0.1518 0.0666 0.0261 0.0608 0.0137 0.0184 0.0902 0.047 0.1273

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3181.7468 3635.276 4088.0889 3215.4698 3591.133 2994.2517 2981.1555 2659.0105 2728.8345 2567.3959
Translational Efficiency 1.0346 1.0452 0.9818 1.2487 1.0707 0.923 1.0164 1.0613 0.9376 1.1284

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1122 776 245 882 1218 1140 1472 237 2340 1916 1717 1119

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 23653.18 24739.94 39112.92 29712.71 23297.32 22536.16 38677.23 33920.55 23467.95 23428.71 38739.40 30603.91
Standard Deviation 4855.99 6325.27 6151.58 7723.48 5754.10 5770.34 6444.73 7537.24 5345.30 6098.00 6405.54 7874.39
Intensity Change Log 2 — 0.064808 0.725611 0.329046 — -0.047922 0.731320 0.541996 — 0.009971 0.728447 0.438641

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000056 0.000107 0.000062 0.000252 0.000041 0.000123 0.000125 0.000149 0.000048 0.000116 0.000116 0.000230
Bud Neck 0.000369 0.000747 0.001344 0.001877 0.000216 0.001026 0.000802 0.000837 0.000289 0.000913 0.000879 0.001657
Bud Site 0.001064 0.003715 0.000338 0.005756 0.001736 0.003230 0.001663 0.002115 0.001414 0.003426 0.001474 0.004985
Cell Periphery 0.031566 0.040495 0.204022 0.064956 0.021569 0.018173 0.153245 0.163836 0.026362 0.027214 0.160490 0.085899
Cytoplasm 0.698132 0.640591 0.130207 0.313737 0.737518 0.701706 0.212559 0.197547 0.718633 0.676954 0.200808 0.289129
Cytoplasmic Foci 0.009447 0.009851 0.004351 0.004332 0.010027 0.017291 0.001003 0.003430 0.009749 0.014278 0.001480 0.004141
Eisosomes 0.000003 0.000003 0.000023 0.000006 0.000002 0.000005 0.000012 0.000007 0.000002 0.000004 0.000013 0.000006
Endoplasmic Reticulum 0.000519 0.000469 0.001853 0.000331 0.000605 0.000247 0.002244 0.000234 0.000564 0.000337 0.002188 0.000311
Endosome 0.000200 0.000422 0.000161 0.000786 0.000312 0.000434 0.000237 0.000256 0.000258 0.000429 0.000226 0.000674
Golgi 0.052031 0.058127 0.031406 0.016122 0.041744 0.043685 0.009480 0.010337 0.046677 0.049534 0.012609 0.014897
Lipid Particles 0.009769 0.022221 0.030113 0.022808 0.008617 0.011626 0.023470 0.034226 0.009170 0.015917 0.024418 0.025227
Mitochondria 0.000142 0.000193 0.000081 0.001584 0.000294 0.000439 0.000107 0.001720 0.000221 0.000340 0.000104 0.001613
Mitotic Spindle 0.000459 0.000994 0.000295 0.000436 0.000460 0.000749 0.000198 0.000238 0.000459 0.000848 0.000212 0.000394
None 0.003154 0.003844 0.000923 0.002062 0.002799 0.003046 0.000316 0.000980 0.002969 0.003369 0.000403 0.001833
Nuclear Periphery 0.001321 0.001247 0.004984 0.000750 0.000757 0.001052 0.002200 0.001014 0.001027 0.001131 0.002597 0.000806
Nuclear Periphery Foci 0.008725 0.013677 0.008316 0.005249 0.007859 0.010159 0.005460 0.004139 0.008274 0.011584 0.005867 0.005014
Nucleolus 0.000093 0.000182 0.000072 0.000241 0.000101 0.000739 0.000077 0.000109 0.000097 0.000513 0.000077 0.000213
Nucleus 0.016837 0.017190 0.010513 0.015523 0.008393 0.021882 0.004706 0.013268 0.012442 0.019982 0.005534 0.015046
Peroxisomes 0.000007 0.000036 0.000016 0.000075 0.000051 0.000045 0.000082 0.000037 0.000030 0.000042 0.000073 0.000067
Vacuole 0.064052 0.116796 0.466326 0.492630 0.070469 0.105488 0.545726 0.532155 0.067392 0.110068 0.534396 0.501001
Vacuole Periphery 0.102053 0.069091 0.104594 0.050485 0.086431 0.058855 0.036288 0.033364 0.093922 0.063001 0.046035 0.046859

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.48 -0.43 -2.75 -2.06 -2.70 -3.79 -3.59 -3.21 -1.05 -0.67 -4.46 -3.44 -3.27 -2.07 -1.78
Bud Neck -2.56 -4.35 -8.87 -6.56 -3.92 -5.97 -6.52 -4.79 0.28 -1.00 -6.28 -6.99 -9.95 -5.68 -6.09
Bud Site -3.27 4.15 -4.79 -1.77 -5.50 -2.46 -0.20 -1.61 0.20 -1.39 -4.09 -0.48 -4.77 -1.95 -4.15
Cell Periphery -2.63 -15.58 -5.79 -3.33 13.13 1.61 -31.09 -13.16 -13.54 -0.35 -0.54 -33.76 -12.92 -12.67 15.96
Cytoplasm 3.63 32.53 24.73 18.27 -10.94 3.49 43.85 24.71 22.11 -0.00 4.71 53.38 35.00 29.18 -8.57
Cytoplasmic Foci -0.42 4.15 3.11 3.50 -1.32 -5.13 9.94 4.22 7.97 -3.07 -4.90 12.90 4.71 8.34 -6.36
Eisosomes -0.93 -7.07 -3.97 -3.60 5.50 -3.03 -11.99 -8.09 -1.14 4.85 -3.07 -13.58 -5.84 -2.00 6.41
Endoplasmic Reticulum 0.14 -1.30 0.67 1.81 1.62 3.20 -3.96 3.29 0.47 5.05 1.30 -3.99 1.65 1.15 5.18
Endosome -5.56 1.69 -2.32 -1.29 -2.49 -2.87 1.46 0.60 1.78 -0.07 -5.64 0.77 -2.02 -0.99 -2.16
Golgi -1.55 6.22 15.15 13.56 6.21 -0.50 15.01 12.62 13.63 -0.36 -1.07 20.65 18.75 18.51 -0.85
Lipid Particles -6.11 -6.67 -7.19 0.44 2.86 -2.87 -10.62 -6.02 -5.22 -2.37 -6.40 -12.42 -9.96 -4.85 0.41
Mitochondria -1.49 3.21 -1.43 -1.37 -1.50 -1.26 4.86 -0.93 -0.81 -1.06 -1.68 4.79 -1.61 -1.44 -1.75
Mitotic Spindle -3.39 3.37 0.59 3.32 -1.08 -2.86 3.82 2.60 5.34 -0.68 -4.50 5.93 1.12 4.52 -2.01
None -1.00 6.48 1.65 1.89 -1.67 -0.40 7.22 2.85 2.61 -1.17 -0.85 13.07 2.06 2.26 -2.82
Nuclear Periphery 0.21 -7.69 1.81 5.24 11.94 -3.65 -12.48 -1.82 0.42 6.57 -0.84 -8.36 1.33 4.88 16.16
Nuclear Periphery Foci -4.48 0.31 4.76 8.51 3.50 -2.85 3.56 5.25 8.02 2.76 -5.01 4.52 6.19 10.72 2.33
Nucleolus -1.31 1.20 -5.35 -0.42 -6.86 -1.27 0.98 -0.21 1.26 -3.35 -1.45 1.34 -4.88 0.97 -7.00
Nucleus -0.30 2.68 -3.21 -2.67 -4.99 -7.57 2.17 -2.04 2.13 -2.75 -5.77 5.75 -5.15 -0.77 -8.14
Peroxisomes -3.14 -1.59 -4.50 -1.85 -3.53 0.21 -1.30 0.76 0.53 3.35 -0.83 -2.89 -2.13 -1.21 0.69
Vacuole -7.27 -24.63 -37.88 -29.54 -0.90 -6.10 -57.93 -24.58 -22.03 1.17 -9.46 -66.24 -44.59 -37.81 3.85
Vacuole Periphery 4.95 -0.17 10.02 5.10 6.20 5.47 11.21 9.80 5.34 1.07 7.57 12.37 13.38 6.33 1.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Yef3

Yef3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yef3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available