Standard name
Human Ortholog
Description Mitochondrial protein of unknown function involved in lipid homeostasis; associates with mitochondrial ribosome; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0 0.05 0 0 0 0 0 0 0 0 0.06 0 0 0.12 0.13 0.09 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.06 0 0.05 0.05 0.05 0 0 0 0.06 0.06 0.08 0.05 0.05 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0.07 0.08 0.08 0.06 0 0 0 0 0.05 0.08 0.13 0.07 0.09 0.12 0 0 0 0.05 0 0
Golgi 0 0.07 0.41 0.18 0.26 0 0 0 0 0 0 0 0.34 0.41 0.33 0.4 0.48 0.22 0 0.09 0 0.1 0.1 0.12
Mitochondria 0.95 0.85 0.51 0.79 0.6 0.75 0.73 0.72 0.84 0.83 0.92 0.84 0.68 0.58 0.48 0.1 0.09 0.13 0.84 0.77 0.81 0.65 0.68 0.65
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.06 0 0 0 0 0.06 0 0.06 0.07 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0 0 0 0 0.05 0.05 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 0.05 0.09 0 0 0 0.05 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0.18 0.33 0.08 0.17 0.17 0.17 0.11 0.1 0.11 0.05 0.08 0.24 0.15 0.17 0.29 0.17 0.25 0 0 0 0.06 0.07 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 2 3 2 0 1 0 2 0 0 1 5 3 4 1 5 1 4 1 1 3 7
Bud 3 7 1 5 0 3 3 7 4 5 8 10 1 3 3 6 6 10 2 1 0 0 0 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1
Bud Site 1 0 0 0 1 0 2 3 3 1 2 0 0 0 0 1 1 2 – – – – – –
Cell Periphery 4 17 4 10 4 2 0 1 0 5 5 1 14 7 7 18 16 12 0 1 0 0 0 0
Cytoplasm 2 8 3 9 12 14 18 26 16 9 13 14 13 16 25 8 6 10 0 1 0 5 0 1
Endoplasmic Reticulum 3 3 0 1 3 3 1 1 3 1 8 1 4 8 3 6 2 7 0 1 0 0 1 3
Endosome 2 8 3 8 14 26 28 32 9 13 0 11 11 21 41 11 11 16 11 10 6 8 7 9
Golgi 3 22 46 40 51 4 4 10 5 7 4 3 75 113 108 59 59 31 9 28 6 16 23 37
Mitochondria 280 253 57 174 119 253 243 356 277 268 357 311 150 160 156 14 11 18 250 244 129 109 158 207
Nucleus 1 1 2 2 1 5 14 15 8 7 6 8 1 1 1 4 4 4 0 1 2 1 2 1
Nuclear Periphery 17 10 1 1 4 20 11 32 22 10 23 12 0 2 1 3 2 1 4 2 0 2 1 2
Nucleolus 16 4 0 2 4 18 17 29 15 13 10 16 2 2 2 1 1 3 0 0 0 1 2 1
Peroxisomes 1 10 4 7 1 4 7 8 2 5 0 3 3 6 27 8 6 12 7 4 5 9 9 9
SpindlePole 1 3 3 4 7 6 9 21 5 8 3 15 1 5 7 7 2 17 1 0 0 0 0 1
Vac/Vac Membrane 29 53 37 18 33 56 57 56 33 35 19 31 54 42 57 42 21 34 8 13 3 10 16 28
Unique Cell Count 294 299 111 219 199 337 335 497 328 321 386 370 221 277 326 147 122 138 299 319 160 170 232 320
Labelled Cell Count 363 399 162 283 257 416 414 598 402 389 458 436 330 391 441 192 149 182 299 319 160 170 232 320


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 7.5 8.4 8.0 8.4 7.2 7.2 7.4 6.3 6.6 5.9 6.2 8.4 8.4 8.1 8.4 8.3 7.5 8.1 8.4 8.9
Std Deviation (1e-4) 0.8 1.2 1.3 1.7 1.6 1.5 1.8 1.7 1.4 1.5 1.5 1.5 1.1 1.2 1.3 1.8 1.8 1.3 1.9 1.4 1.5
Intensity Change (Log2) – – – -0.07 -0.0 -0.22 -0.22 -0.19 -0.42 -0.34 -0.51 -0.43 0.0 0.0 -0.05 0.01 -0.01 -0.15 -0.05 0.0 0.09

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 1.0 0 0 2.5 2.6 1.6
Cytoplasm 0 1.3 0 1.2 1.1 0 0 0 0 1.3 1.3 1.8 0 0 1.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 1.6 1.9 2.0 1.5 0 0 0 0 0 1.8 3.0 1.7 2.0 2.6
Golgi -4.5 -2.9 -11.7 -11.6 -13.0 -11.3 -10.9 -12.5 -12.4 -1.3 -0.1 -1.6 -0.2 1.1 -3.2
Mitochondria 5.3 1.4 4.7 4.1 4.1 7.1 6.8 10.2 7.1 2.9 1.1 -0.6 -7.4 -7.1 -6.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 2.2 0 2.3 2.4 0 2.2 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 2.6 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 1.7 0.7 0 1.6
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.8
Vacuole -5.8 -3.4 -3.8 -3.7 -5.8 -5.8 -5.5 -8.3 -6.6 -1.7 -4.0 -3.5 -0.8 -2.8 -1.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.7267 2.8116 3.0177 3.0051 2.5713 3.0606 2.7518 2.6295 2.3566 2.1649 3.2916 2.9821 2.7761 2.8519 2.9088 2.8119 2.3325 2.5124
Actin 0.0017 0.0029 0.0006 0.0007 0.0004 0.0006 0.0149 0.0104 0.018 0.0082 0.0708 0.0249 0.0127 0.0171 0.0049 0.0114 0.0023 0.0106
Bud 0.0003 0.0006 0.004 0.0003 0.0002 0.0001 0.0008 0.0028 0.0006 0.0008 0.0019 0.0024 0.0013 0.0019 0.0017 0.0005 0.0014 0.0007
Bud Neck 0.0003 0.0002 0.0001 0.0001 0 0.0004 0.0021 0.0014 0.0011 0.0007 0.0028 0.0014 0.0011 0.0018 0.0011 0.0005 0.0002 0.0008
Bud Periphery 0.0014 0.0014 0.0015 0.001 0.0006 0.0005 0.0016 0.0059 0.0009 0.0028 0.0041 0.0078 0.0021 0.0028 0.0028 0.0011 0.0026 0.0026
Bud Site 0.0005 0.0013 0.0004 0.0002 0.0002 0.0001 0.0058 0.019 0.0055 0.0069 0.0138 0.0015 0.0043 0.0312 0.0168 0.0017 0.0011 0.0009
Cell Periphery 0.0004 0.0006 0.0002 0.0002 0.0002 0.0002 0.0012 0.0065 0.0006 0.0005 0.0012 0.0005 0.0008 0.0022 0.0011 0.0002 0.0002 0.0012
Cytoplasm 0.001 0.001 0.001 0.0003 0.0001 0.0003 0.0047 0.0048 0.0149 0.0004 0.0048 0.0141 0.0114 0.0056 0.0089 0.0011 0.0066 0.0007
Cytoplasmic Foci 0.0097 0.006 0.0037 0.0055 0.0034 0.0025 0.0205 0.0294 0.0202 0.0051 0.0228 0.0134 0.0333 0.0276 0.0131 0.0122 0.0151 0.003
Eisosomes 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0006 0.0022 0.0003 0.0003 0.0007 0.0003 0.0015 0.0003 0.0003 0.0002 0.0001 0.0006
Endoplasmic Reticulum 0.0012 0.0008 0.001 0.0001 0.0001 0.0003 0.0145 0.0027 0.0012 0.0006 0.0047 0.0013 0.0052 0.0014 0.0036 0.0003 0.002 0.0008
Endosome 0.0478 0.0418 0.0168 0.0216 0.0136 0.0156 0.0449 0.1049 0.0314 0.0323 0.1464 0.0419 0.0701 0.0639 0.0319 0.0216 0.0468 0.0285
Golgi 0.0316 0.0355 0.0143 0.0192 0.0223 0.0185 0.0334 0.0655 0.0264 0.0106 0.0443 0.0484 0.0414 0.0405 0.0221 0.0317 0.0126 0.0393
Lipid Particles 0.0227 0.0175 0.0067 0.0011 0.001 0.0123 0.0435 0.0157 0.017 0.0293 0.0203 0.0179 0.0382 0.0145 0.0056 0.0119 0.012 0.005
Mitochondria 0.8306 0.8608 0.9316 0.9103 0.9407 0.9303 0.7449 0.6521 0.8282 0.8602 0.5329 0.7827 0.7234 0.7326 0.8496 0.8825 0.8458 0.8879
None 0.0007 0.0003 0.0004 0.0001 0.0001 0.0006 0.015 0.0029 0.0004 0.0004 0.0031 0.0022 0.0045 0.0039 0.0011 0.0009 0.009 0.0003
Nuclear Periphery 0.0017 0.0005 0.0006 0 0 0.0003 0.0121 0.002 0.0002 0.0008 0.0459 0.0107 0.0126 0.0015 0.0009 0.0001 0.004 0.0014
Nucleolus 0.0026 0.0006 0.0004 0 0.0001 0.0004 0.002 0.0022 0.0033 0.001 0.0013 0.0006 0.0019 0.0027 0.0007 0.0001 0.0007 0.0002
Nucleus 0.0007 0.0004 0.001 0 0.0001 0.0004 0.0058 0.0015 0.0006 0.0007 0.02 0.0016 0.0019 0.0015 0.0006 0.0001 0.0013 0.0003
Peroxisomes 0.024 0.007 0.0103 0.0358 0.0138 0.0105 0.012 0.0294 0.0216 0.0049 0.0339 0.0162 0.0154 0.0139 0.0108 0.0166 0.0162 0.0032
Punctate Nuclear 0.0004 0.0001 0.0001 0 0 0.0002 0.005 0.0003 0.0006 0.0005 0.005 0.0008 0.0014 0.0005 0.0003 0.0002 0.0091 0.0002
Vacuole 0.009 0.0109 0.0019 0.0011 0.0011 0.0021 0.0089 0.0265 0.0033 0.0122 0.0086 0.0033 0.0091 0.0216 0.0117 0.0021 0.0067 0.0059
Vacuole Periphery 0.0118 0.0097 0.0035 0.0022 0.002 0.0038 0.0059 0.0119 0.0034 0.0207 0.0106 0.0061 0.0064 0.011 0.0102 0.0029 0.0041 0.006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.26 10.3829 15.8372 15.0146 12.9675 18.0574 16.9137 18.5011 19.7258 19.6228
Translational Efficiency 0.5618 0.7062 0.4371 0.6015 0.4919 0.431 0.6505 0.4234 0.4488 0.4223

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
847 1380 192 269 2141 1530 319 1883 2988 2910 511 2152

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 611.74 873.23 1020.31 943.75 792.56 841.52 1044.33 822.48 741.30 856.56 1035.30 837.64
Standard Deviation 74.26 152.42 111.35 115.23 116.67 116.87 120.61 100.56 134.01 135.83 117.79 110.07
Intensity Change Log 2 — 0.513443 0.738017 0.625486 — 0.086477 0.397986 0.053460 — 0.288147 0.556039 0.330822

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000387 0.000897 0.003569 0.012800 0.000505 0.000583 0.006830 0.000252 0.000471 0.000732 0.005604 0.001821
Bud Neck 0.028186 0.002071 0.019027 0.016947 0.001995 0.000947 0.006076 0.030404 0.009420 0.001480 0.010942 0.028722
Bud Site 0.028507 0.009735 0.033762 0.092181 0.005114 0.003927 0.047825 0.038126 0.011745 0.006681 0.042541 0.044883
Cell Periphery 0.001604 0.000631 0.000501 0.000953 0.000777 0.000371 0.000411 0.000781 0.001012 0.000494 0.000445 0.000802
Cytoplasm 0.018897 0.001978 0.003142 0.011013 0.000940 0.000839 0.007633 0.014049 0.006030 0.001379 0.005945 0.013669
Cytoplasmic Foci 0.044064 0.017991 0.065633 0.041842 0.011188 0.017601 0.090726 0.023141 0.020508 0.017786 0.081298 0.025479
Eisosomes 0.000129 0.000046 0.000099 0.000121 0.000037 0.000037 0.000093 0.000096 0.000063 0.000041 0.000096 0.000099
Endoplasmic Reticulum 0.000868 0.000363 0.003836 0.001311 0.000354 0.000254 0.001966 0.001550 0.000500 0.000306 0.002669 0.001520
Endosome 0.072833 0.052059 0.147476 0.092771 0.036354 0.051310 0.130202 0.145388 0.046695 0.051665 0.136692 0.138811
Golgi 0.059456 0.043160 0.080759 0.073835 0.029253 0.049940 0.158509 0.034391 0.037814 0.046724 0.129296 0.039321
Lipid Particles 0.006597 0.001208 0.004102 0.000509 0.002084 0.002271 0.001093 0.002519 0.003363 0.001767 0.002224 0.002268
Mitochondria 0.627005 0.819861 0.373944 0.418483 0.867407 0.819190 0.302849 0.424460 0.799261 0.819509 0.329562 0.423713
Mitotic Spindle 0.006989 0.005962 0.089061 0.074496 0.002693 0.003986 0.097221 0.034028 0.003911 0.004923 0.094155 0.039087
None 0.007760 0.000371 0.000331 0.000509 0.000281 0.000285 0.000270 0.002645 0.002401 0.000325 0.000293 0.002378
Nuclear Periphery 0.000356 0.000204 0.003221 0.000495 0.000095 0.000113 0.000261 0.000697 0.000169 0.000156 0.001373 0.000672
Nuclear Periphery Foci 0.000213 0.000315 0.005777 0.001481 0.000144 0.000157 0.000868 0.000750 0.000163 0.000232 0.002713 0.000841
Nucleolus 0.003457 0.000110 0.005585 0.001412 0.000177 0.000411 0.000374 0.006633 0.001107 0.000268 0.002332 0.005980
Nucleus 0.005389 0.000185 0.009530 0.002864 0.000176 0.000206 0.001311 0.008922 0.001653 0.000196 0.004399 0.008164
Peroxisomes 0.027483 0.015360 0.066938 0.046324 0.010204 0.010653 0.048457 0.019351 0.015102 0.012885 0.055401 0.022723
Vacuole 0.026275 0.013113 0.047265 0.065350 0.011583 0.016197 0.051095 0.137688 0.015748 0.014734 0.049656 0.128645
Vacuole Periphery 0.033544 0.014379 0.036441 0.044302 0.018639 0.020724 0.045929 0.074130 0.022864 0.017715 0.042364 0.070401

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.25 -4.29 -3.02 -2.90 -2.22 -0.41 -3.80 1.60 2.90 3.96 -1.60 -4.74 -2.55 -2.06 3.19
Bud Neck 7.63 1.58 2.53 -5.77 0.29 2.20 -4.30 -14.36 -15.18 -11.50 7.44 -0.71 -9.64 -15.64 -6.97
Bud Site 5.95 -0.80 -6.21 -8.21 -5.04 1.27 -7.60 -15.35 -16.30 1.67 4.04 -7.23 -13.87 -16.37 -0.47
Cell Periphery 2.06 2.38 1.28 -1.09 -1.61 1.41 1.37 -0.01 -3.01 -4.20 2.11 2.42 0.89 -2.65 -4.02
Cytoplasm 6.41 5.93 2.35 -4.45 -3.84 0.47 -5.50 -9.15 -9.27 -3.25 5.83 -0.09 -5.17 -9.55 -5.02
Cytoplasmic Foci 8.22 -3.02 0.45 -5.14 3.04 -4.18 -14.94 -8.01 -3.24 12.38 2.06 -14.23 -3.14 -5.14 12.82
Eisosomes 5.62 1.30 0.35 -6.10 -1.03 -0.03 -7.41 -13.47 -14.63 -0.36 4.48 -4.57 -6.38 -15.58 -0.26
Endoplasmic Reticulum 3.90 -3.12 -2.07 -4.62 2.60 1.24 -4.08 -5.18 -5.83 1.00 2.71 -4.99 -5.05 -6.16 2.47
Endosome 3.99 -5.66 -2.11 -4.64 3.70 -4.31 -11.26 -22.55 -18.09 -1.69 -1.77 -12.58 -20.78 -19.47 -0.27
Golgi 3.50 -2.03 -1.51 -3.43 0.55 -6.34 -12.15 -2.13 4.72 11.65 -3.55 -11.66 -0.58 2.80 11.40
Lipid Particles 3.87 1.18 4.32 2.35 3.17 -0.22 1.80 -0.97 -0.41 -3.39 2.56 1.36 1.85 -1.21 0.17
Mitochondria -14.18 8.89 8.34 17.22 -1.26 5.70 30.37 46.93 37.92 -6.23 -2.85 29.73 40.92 44.22 -5.67
Mitotic Spindle 0.74 -6.48 -7.66 -7.78 0.86 -1.84 -9.95 -13.29 -12.52 6.45 -1.54 -11.88 -14.89 -14.31 6.90
None 4.17 4.19 4.09 -1.77 -2.24 -0.24 0.37 -4.09 -4.05 -4.11 4.08 4.16 0.03 -4.04 -4.11
Nuclear Periphery 0.65 -2.06 -0.44 -1.19 1.96 -0.70 -4.11 -3.97 -3.86 -2.82 0.17 -2.31 -3.38 -3.68 1.31
Nuclear Periphery Foci -0.87 -2.26 -1.83 -1.68 1.66 -0.48 -2.27 -7.34 -6.44 0.54 -1.20 -2.70 -5.87 -4.76 1.99
Nucleolus 3.21 -0.92 1.88 -3.25 1.99 -0.84 -1.60 -7.08 -6.14 -6.81 2.20 -1.44 -5.62 -6.84 -3.04
Nucleus 5.08 -1.01 1.89 -3.37 1.63 -0.37 -2.96 -8.79 -8.70 -7.09 4.81 -1.78 -7.02 -9.07 -2.08
Peroxisomes 3.91 -3.64 -2.51 -4.19 1.54 -0.25 -5.89 -5.29 -4.59 4.44 1.45 -7.03 -4.19 -5.35 5.58
Vacuole 5.45 -3.54 -5.30 -7.27 -2.03 -2.98 -7.94 -31.28 -29.41 -13.47 0.83 -8.93 -30.53 -30.86 -15.07
Vacuole Periphery 6.45 -0.53 -1.77 -5.51 -1.13 -1.15 -5.24 -19.54 -18.72 -5.05 3.47 -5.17 -18.13 -21.22 -6.65
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial protein of unknown function involved in lipid homeostasis; associates with mitochondrial ribosome; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1
Localization
Cell Percentages mitochondrion (96%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mcp2

Mcp2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mcp2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available