Standard name
Human Ortholog
Description Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0
Bud 0.05 0 0 0 0 0 0.05 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0.05 0.06 0 0 0 0 0 0
Cytoplasm 0.18 0.18 0.44 0.31 0.26 0.12 0.12 – 0.07 0.06 0 0 0.38 0.72 0.66 0.32 0.22 0.31 0 0 0 0.05 0.08 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0.08 0 0 0.06 0.06 0.06 0 0 0 0 0 0
Endosome 0 0.11 0.12 0.1 0.18 0.06 0.1 – 0 0 0 0 0.11 0.12 0.14 0.14 0.24 0.21 0.08 0.09 0.07 0.05 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0.07 0 0 0 0 0 0
Mitochondria 0.79 0.54 0.13 0.41 0.36 0.73 0.74 – 0.85 0.86 0.99 0.93 0.24 0 0 0.07 0.08 0.12 0.71 0.7 0.69 0.66 0.67 0.7
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0.08 0.11 0.18 0 0 – 0 0 0 0 0 0 0.05 0.12 0.13 0.07 0 0 0 0 0 0
SpindlePole 0.05 0.08 0.16 0.13 0.14 0.09 0.13 – 0.08 0.08 0 0.09 0.08 0.05 0 0.16 0.13 0.12 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0.14 0.1 0 0.12 0.05 0.07 – 0.09 0.06 0 0 0.11 0 0.1 0.1 0.18 0.18 0 0.06 0.05 0.09 0.09 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 7 2 0 1 2 1 – 0 1 1 2 3 6 0 5 0 0 5 12 3 1 4 4
Bud 14 7 2 3 3 3 17 – 2 4 7 9 1 4 0 8 3 0 1 2 1 0 2 2
Bud Neck 1 0 2 3 0 0 0 – 0 2 0 0 0 1 1 0 1 0 3 4 3 1 2 4
Bud Site 4 1 0 0 0 2 2 – 1 5 2 4 0 0 0 1 0 0 – – – – – –
Cell Periphery 0 12 3 4 3 2 2 – 1 1 1 3 2 4 3 8 6 4 0 0 2 0 0 0
Cytoplasm 50 56 51 54 57 28 42 – 19 16 4 11 25 127 90 53 26 22 6 3 6 6 20 11
Endoplasmic Reticulum 1 11 4 3 4 5 4 – 1 5 3 2 5 6 4 10 7 4 0 6 1 1 3 2
Endosome 6 33 14 18 39 14 33 – 3 5 0 3 7 21 19 23 29 15 25 43 16 5 6 9
Golgi 0 2 0 1 2 2 1 – 1 1 0 0 1 1 0 9 5 5 3 13 2 0 1 3
Mitochondria 222 167 15 72 79 169 252 – 219 235 245 243 16 3 1 11 10 9 228 323 166 84 177 184
Nucleus 1 2 2 0 1 4 7 – 6 10 2 5 0 1 2 2 3 0 0 1 0 1 1 0
Nuclear Periphery 0 1 0 0 0 1 1 – 3 3 2 1 0 0 0 0 1 0 1 1 0 0 1 1
Nucleolus 0 0 0 0 0 0 3 – 1 1 0 2 0 0 1 1 1 1 2 1 0 0 1 2
Peroxisomes 2 12 9 19 39 6 11 – 3 5 1 5 2 7 7 20 15 5 11 11 6 1 3 7
SpindlePole 13 26 19 23 32 21 43 – 21 23 6 23 5 8 3 26 15 9 10 5 8 3 7 7
Vac/Vac Membrane 18 45 12 4 27 12 24 – 22 16 9 10 7 5 14 16 21 13 13 27 12 11 23 17
Unique Cell Count 282 312 116 175 221 230 340 258 274 248 262 66 176 137 167 119 72 322 465 240 128 264 262
Labelled Cell Count 332 382 135 204 287 271 443 303 333 283 323 74 194 145 193 143 87 322 465 240 128 264 262


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 4.9 5.4 5.1 5.8 4.6 4.9 – 4.2 4.4 3.8 4.1 5.6 5.5 5.4 7.4 7.7 7.1 5.1 5.1 5.2
Std Deviation (1e-4) 0.6 0.9 1.3 1.4 2.1 1.5 1.6 – 1.0 0.8 0.6 0.6 2.1 1.2 1.3 2.8 3.2 2.6 1.2 1.0 1.3
Intensity Change (Log2) – – – -0.08 0.09 -0.23 -0.16 – -0.37 -0.3 -0.51 -0.41 0.05 0.03 0.0 0.44 0.52 0.39 -0.1 -0.09 -0.05


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – -0.2 1.6 1.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.056 -0.6857 -0.552 -0.9392 -1.0776 -0.7273 0.7854 0.3411 0.4777 0.206 1.2161 0.3536 0.6409 -0.2383 0.087 0.0032 -0.2085 -0.3464
Actin 0.1097 0.0208 0.0054 0.0088 0.0025 0.0174 0.0417 0.0069 0.0044 0.0376 0.0373 0.0127 0.075 0.0195 0.0535 0.0861 0.0909 0.0147
Bud 0.0024 0.0037 0.0069 0.0055 0.0016 0.0033 0.0014 0.0045 0.002 0.0034 0.0016 0.0019 0.0033 0.0041 0.003 0.0052 0.0029 0.0014
Bud Neck 0.0119 0.0027 0.006 0.0218 0.0027 0.0235 0.0023 0.0014 0.0041 0.001 0.0293 0.006 0.0112 0.0013 0.0064 0.0196 0.0022 0.0083
Bud Periphery 0.0051 0.0072 0.0067 0.0181 0.0031 0.0047 0.0032 0.0106 0.0065 0.0075 0.0038 0.0071 0.0046 0.0044 0.0087 0.009 0.006 0.0048
Bud Site 0.0317 0.0473 0.0167 0.0127 0.0094 0.0018 0.0075 0.025 0.0154 0.0043 0.0072 0.0023 0.0218 0.0298 0.0132 0.0122 0.0199 0.0033
Cell Periphery 0.003 0.0033 0.0022 0.0084 0.0007 0.0018 0.0031 0.0028 0.0018 0.0006 0.0008 0.0012 0.0013 0.0019 0.0046 0.0038 0.0007 0.0015
Cytoplasm 0.0317 0.0896 0.0731 0.0478 0.0328 0.066 0.0425 0.0689 0.06 0.0248 0.0194 0.0668 0.0394 0.0802 0.1355 0.1917 0.1993 0.1308
Cytoplasmic Foci 0.0931 0.1352 0.087 0.0874 0.0965 0.1494 0.1056 0.1171 0.1053 0.1214 0.1229 0.1182 0.13 0.1145 0.1062 0.0923 0.1371 0.1634
Eisosomes 0.0012 0.0018 0.0011 0.0044 0.0004 0.0014 0.0031 0.0009 0.0009 0.0006 0.0003 0.0007 0.0014 0.0007 0.0016 0.0006 0.0004 0.0002
Endoplasmic Reticulum 0.0139 0.0069 0.0103 0.006 0.0024 0.0087 0.008 0.0062 0.0045 0.0026 0.0013 0.0037 0.0244 0.0141 0.0079 0.019 0.005 0.0072
Endosome 0.2032 0.1287 0.1158 0.135 0.0837 0.0852 0.1099 0.1244 0.0807 0.1413 0.1163 0.0917 0.1421 0.1394 0.1346 0.2029 0.1834 0.2219
Golgi 0.0481 0.0265 0.0267 0.0227 0.0413 0.0218 0.0318 0.0327 0.0199 0.0316 0.0379 0.0236 0.0706 0.0565 0.0715 0.0843 0.0585 0.0744
Lipid Particles 0.0705 0.0316 0.0396 0.01 0.0339 0.0497 0.0567 0.0227 0.0233 0.0384 0.0757 0.0321 0.0857 0.0224 0.0182 0.0232 0.0149 0.0146
Mitochondria 0.1942 0.181 0.2709 0.373 0.3349 0.2484 0.1738 0.1883 0.2692 0.3865 0.2384 0.3113 0.1349 0.2284 0.2208 0.0928 0.1429 0.1728
None 0.0668 0.2334 0.2489 0.1403 0.3174 0.2237 0.2868 0.31 0.3202 0.0868 0.1972 0.2266 0.1119 0.2339 0.1485 0.0879 0.0528 0.1077
Nuclear Periphery 0.0078 0.0024 0.0029 0.0117 0.0007 0.0019 0.012 0.0022 0.0035 0.0051 0.0015 0.0033 0.0333 0.0024 0.0039 0.0034 0.0014 0.0063
Nucleolus 0.0027 0.0024 0.0025 0.0025 0.0009 0.0017 0.0069 0.0028 0.0047 0.0031 0.0039 0.0021 0.0026 0.0009 0.0011 0.0015 0.0004 0.0013
Nucleus 0.0045 0.0028 0.0037 0.0063 0.0009 0.0029 0.0181 0.0042 0.0048 0.0045 0.0021 0.0035 0.0321 0.0018 0.0023 0.0037 0.001 0.0059
Peroxisomes 0.0394 0.0396 0.0477 0.0521 0.0231 0.0695 0.0521 0.0453 0.046 0.0627 0.0831 0.0648 0.0433 0.0255 0.0244 0.0116 0.0517 0.0393
Punctate Nuclear 0.0102 0.0021 0.002 0.0017 0.0013 0.0034 0.0155 0.003 0.006 0.0018 0.0035 0.0084 0.0146 0.001 0.0064 0.0013 0.0016 0.0054
Vacuole 0.0391 0.0253 0.0183 0.015 0.0073 0.0095 0.0142 0.0159 0.0131 0.0225 0.0118 0.0079 0.0109 0.0137 0.0189 0.0394 0.0114 0.0097
Vacuole Periphery 0.0098 0.0057 0.0056 0.0088 0.0025 0.0043 0.0037 0.0043 0.0038 0.0118 0.0048 0.004 0.0058 0.0037 0.0088 0.0085 0.0155 0.0048

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.4088 3.5628 4.1544 4.0665 5.5364 3.9833 7.5906 7.2939 4.7139 6.8409
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
925 1599 480 1224 1947 2396 241 47 2872 3995 721 1271

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 561.70 670.54 849.00 801.95 675.97 687.14 850.09 830.12 639.17 680.50 849.36 802.99
Standard Deviation 69.08 84.44 92.22 106.55 80.07 84.46 79.28 99.22 93.45 84.85 88.11 106.42
Intensity Change Log 2 — 0.255524 0.595965 0.513712 — 0.023645 0.330656 0.296361 — 0.133517 0.457136 0.399076

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000475 0.000876 0.003073 0.009488 0.000630 0.001001 0.001642 0.008198 0.000580 0.000951 0.002595 0.009441
Bud Neck 0.040862 0.026063 0.027966 0.038670 0.023283 0.025148 0.028350 0.016328 0.028944 0.025514 0.028094 0.037844
Bud Site 0.012154 0.022398 0.045674 0.098835 0.011353 0.016281 0.018894 0.071210 0.011611 0.018730 0.036723 0.097813
Cell Periphery 0.001431 0.000188 0.000243 0.000463 0.000246 0.000140 0.000234 0.000267 0.000628 0.000159 0.000240 0.000456
Cytoplasm 0.081254 0.043212 0.106129* 0.118718* 0.055388 0.033342 0.157321* 0.073325 0.063719 0.037292 0.123241* 0.117040*
Cytoplasmic Foci 0.175040 0.180598* 0.117769 0.162220 0.247322* 0.172918 0.199999* 0.240480* 0.224042* 0.175992 0.145255 0.165114
Eisosomes 0.000415 0.000144 0.000145 0.000176 0.000197 0.000141 0.000230 0.000228 0.000267 0.000142 0.000173 0.000178
Endoplasmic Reticulum 0.003546 0.000725 0.015426 0.003384 0.001754 0.000527 0.005440 0.003446 0.002331 0.000606 0.012088 0.003386
Endosome 0.032461 0.071079 0.044880 0.041996 0.056123 0.072102 0.062607 0.049707 0.048502 0.071693 0.050805 0.042281
Golgi 0.049230 0.092779 0.016665 0.033928 0.085230 0.102168 0.012327 0.050771 0.073635 0.098410 0.015215 0.034551
Lipid Particles 0.045552 0.010001 0.012759 0.004078 0.026662 0.008796 0.028880 0.006872 0.032746 0.009279 0.018148 0.004182
Mitochondria 0.442335* 0.397624* 0.032600 0.084679 0.347064* 0.431076* 0.013957 0.025657 0.377749* 0.417687* 0.026368 0.082497
Mitotic Spindle 0.001047 0.021474 0.100744* 0.089770 0.012625 0.022067 0.040033 0.099205 0.008896 0.021829 0.080451 0.090119
None 0.008713 0.002165 0.001781 0.001675 0.001588 0.000843 0.003222 0.000356 0.003883 0.001372 0.002262 0.001626
Nuclear Periphery 0.000431 0.000297 0.005567 0.000717 0.000581 0.000201 0.003072 0.000436 0.000533 0.000239 0.004733 0.000706
Nuclear Periphery Foci 0.000276 0.000408 0.006286 0.000921 0.000385 0.000212 0.003188 0.001306 0.000350 0.000291 0.005250 0.000936
Nucleolus 0.003933 0.002619 0.009291 0.001454 0.002841 0.001591 0.011766 0.001607 0.003193 0.002002 0.010118 0.001460
Nucleus 0.027755 0.013525 0.266430* 0.035435 0.023062 0.007684 0.195873* 0.043302 0.024573 0.010022 0.242846* 0.035726
Peroxisomes 0.039488 0.073334 0.054870 0.149040* 0.061337 0.057385 0.072642 0.225688* 0.054300 0.063769 0.060810 0.151875*
Vacuole 0.018962 0.029083 0.120546 0.117165 0.030464 0.034566 0.133404 0.078516 0.026759 0.032372 0.124844 0.115736
Vacuole Periphery 0.014641 0.011408 0.011155 0.007186 0.011866 0.011811 0.006919 0.003094 0.012760 0.011649 0.009739 0.007035

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.80 -8.56 -10.32 -9.92 -6.49 -2.54 -4.89 -3.65 -3.45 -3.01 -3.12 -10.39 -10.71 -10.17 -7.49
Bud Neck 3.66 2.60 0.67 -4.20 -2.62 -0.87 -0.78 1.78 2.26 1.97 1.68 0.09 -3.25 -4.88 -3.02
Bud Site -4.96 -6.84 -17.25 -14.96 -7.47 -3.91 -2.86 -3.04 -2.77 -2.64 -6.49 -7.55 -18.32 -16.54 -10.34
Cell Periphery 5.15 4.89 3.61 -1.34 -0.95 3.20 0.42 0.10 -1.33 -0.11 5.74 4.66 1.38 -1.55 -0.99
Cytoplasm 6.52 -2.93 -6.77 -14.64 -2.75 6.77 -7.54 -0.94 -2.26 3.89 9.02 -8.59 -11.37 -17.06 -0.67
Cytoplasmic Foci -0.85 7.26 3.02 4.62 -5.31 12.80 4.42 0.73 -2.24 -1.29 10.26 12.35 12.02 4.11 -2.19
Eisosomes 9.26 8.67 8.30 -2.84 -1.31 5.22 -2.68 -0.71 -2.16 0.46 10.46 6.08 7.30 -3.67 1.20
Endoplasmic Reticulum 4.69 -9.14 -0.16 -5.39 9.20 6.06 -6.26 -1.78 -2.85 1.30 7.23 -11.25 -2.38 -5.91 8.85
Endosome -11.26 -2.46 -1.63 9.68 1.24 -5.09 -0.44 0.48 2.01 0.65 -9.67 0.33 4.35 12.71 2.86
Golgi -8.78 8.91 5.47 15.56 -4.60 -3.96 16.12 2.56 3.54 -1.60 -7.40 20.02 14.02 22.28 -5.53
Lipid Particles 10.34 8.76 12.52 5.80 4.90 9.94 -0.11 4.22 -0.31 3.28 14.18 6.47 17.90 7.10 7.47
Mitochondria 3.31 34.21* 29.70* 33.11* -7.42 -8.54 41.85* 28.35* 37.28* -0.85 -4.84 52.00* 39.60* 49.94* -9.03
Mitotic Spindle -11.80 -10.90 -16.53 -11.88 0.89 -4.79 -3.60 -2.41 -2.12 -1.42 -9.02 -10.56 -14.95 -12.32 -1.04
None 3.37 3.75 3.88 1.08 0.80 2.59 -2.18 4.60 2.52 4.21 3.75 2.37 3.30 -0.12 1.73
Nuclear Periphery 1.50 -7.33 -1.94 -2.50 6.32 6.21 -4.39 -0.01 -1.84 4.14 5.76 -8.33 -1.54 -2.86 6.96
Nuclear Periphery Foci -1.12 -5.58 -5.97 -3.86 4.80 4.29 -6.13 -2.93 -3.23 1.80 1.02 -6.70 -5.90 -5.98 5.58
Nucleolus 1.37 -4.45 3.53 2.14 6.95 2.42 -4.84 1.33 -0.41 5.22 2.50 -6.96 3.94 1.41 8.84
Nucleus 4.12 -17.84 -5.06 -10.11 16.25 8.69 -11.40 -1.36 -2.20 6.09 8.86 -21.27 -7.15 -12.30 18.40
Peroxisomes -7.70 -1.88 -14.32 -8.46 -10.08 1.16 -1.13 -3.80 -3.93 -3.42 -3.30 -0.64 -12.96 -11.37 -10.32
Vacuole -4.66 -15.74 -22.90 -21.12 -3.02 -1.86 -10.44 -3.53 -3.39 0.04 -3.50 -18.18 -22.23 -21.18 -2.74
Vacuole Periphery 2.34 2.61 6.03 4.86 2.14 -0.02 4.44 7.60 8.13 2.25 1.38 3.48 6.85 6.34 1.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor
Localization
Cell Percentages mitochondrion (79%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Guf1

Guf1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Guf1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available