Standard name
Human Ortholog
Description Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0.05 0.06 0.06 – 0.07 0.06 0.1 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.66 0.68 0.57 0.53 0.35 0.33 0.4 – 0.42 0.41 0.31 0.32 0.56 0.65 0.54 0.33 0.33 0.44 0.27 0.42 0.41 0.37 0.4 0.4
Endoplasmic Reticulum 0.23 0.14 0.23 0.22 0.2 0.19 0.24 – 0.27 0.2 0.16 0.25 0.33 0.19 0.18 0 0 0 0.3 0.06 0.23 0.33 0.31 0.26
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0.07
Golgi 0 0 0 0.1 0.26 0.31 0.17 – 0.16 0.16 0.11 0.21 0.07 0.09 0.11 0.39 0.37 0.28 0 0 0 0 0.06 0.08
Mitochondria 0 0 0 0 0 0 0 – 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.23 0.14 0.1 0.06 0 0
Nucleolus 0 0 0 0 0 0.05 0.06 – 0 0 0 0 0 0 0.05 0.06 0.08 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.11 0.16 0.23 0.19 0.25 0.19 0.18 – 0.13 0.19 0.3 0.22 0.08 0.1 0.14 0.32 0.35 0.36 0.09 0.18 0.13 0.06 0.08 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 1 0 1 13 22 20 – 19 20 21 33 5 3 3 4 1 0 2 3 3 1 1 2
Bud 1 5 2 1 2 3 7 – 0 8 1 3 7 0 2 1 3 1 3 7 5 2 1 2
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 3 0 0 0 2 – 3 4 3 5 0 0 0 2 0 0 0 0 0 0 0 0
Cytoplasm 215 179 144 95 93 112 147 – 110 134 63 94 144 191 218 83 62 78 118 160 130 67 115 142
Endoplasmic Reticulum 74 38 59 40 53 63 88 – 71 65 32 74 84 57 74 4 3 3 129 22 74 59 88 93
Endosome 0 0 1 0 2 8 5 – 0 1 0 2 1 0 10 0 2 2 12 26 12 7 12 24
Golgi 12 1 6 18 71 105 61 – 42 52 23 63 19 26 46 98 69 51 6 1 1 4 16 29
Mitochondria 0 2 0 0 1 2 2 – 13 6 13 8 0 1 0 7 1 1 1 1 1 0 2 2
Nucleus 1 1 1 1 0 0 0 – 1 0 3 1 0 0 0 0 0 0 2 17 4 0 1 1
Nuclear Periphery 0 0 0 0 0 0 0 – 0 1 2 0 0 0 0 0 0 0 100 51 33 11 10 13
Nucleolus 8 4 3 0 11 17 21 – 10 11 8 10 5 5 19 16 15 6 1 2 0 1 0 0
Peroxisomes 0 0 1 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 1
SpindlePole 0 0 2 1 1 2 1 – 0 0 1 0 0 0 1 4 1 0 7 5 3 3 5 5
Vac/Vac Membrane 37 42 58 33 68 64 64 – 33 62 62 66 21 28 56 80 66 65 40 68 42 10 22 31
Unique Cell Count 326 264 253 178 268 340 363 263 329 206 295 258 293 401 252 186 179 438 380 322 181 289 358
Labelled Cell Count 349 273 280 190 316 398 418 302 364 232 359 286 311 429 299 223 207 438 380 322 181 289 358


Cytoplasm, Nuclear Periphery, Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 39.8 31.1 32.9 30.9 31.5 31.3 28.8 – 27.8 26.4 24.2 27.0 34.8 37.5 34.3 47.0 52.1 45.6 34.0 34.8 35.5
Std Deviation (1e-4) 8.5 8.4 8.1 5.8 5.8 6.5 6.9 – 6.6 6.3 6.7 7.1 7.2 8.1 8.1 15.6 15.6 15.0 6.9 7.1 8.3
Intensity Change (Log2) – – – -0.09 -0.06 -0.07 -0.19 – -0.25 -0.32 -0.44 -0.28 0.08 0.19 0.06 0.52 0.66 0.47 0.05 0.08 0.11


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 3.5 4.1 3.8 – 4.4 4.0 5.2 5.5 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.7 -5.1 -5.8 -4.0 – -3.4 -3.9 -5.6 -5.9 -0.3 2.0 -0.6 -5.4 -4.9 -2.7
Endoplasmic Reticulum -0.2 -1.0 -1.4 0.3 – 1.0 -1.0 -2.1 0.5 2.3 -1.1 -1.5 -7.4 -6.5 -6.3
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 3.5 7.8 8.8 5.7 – 5.3 5.4 3.9 6.7 2.6 3.2 4.2 10.1 9.6 7.9
Mitochondria 0 0 0 0 – 3.6 0 4.1 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 2.1 2.5 2.9 – 1.9 1.7 0 1.7 0 0 2.5 3.0 3.6 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -1.1 0.7 -1.2 -1.6 – -3.1 -1.2 1.7 -0.2 -4.6 -4.3 -2.9 2.2 2.9 3.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 27.268 40.2542 33.4087 32.715 34.5504 35.6133 30.698 43.6043 38.6632 34.8645 37.6641 38.5315 31.3159 45.3247 39.8152 37.5641 29.9672 40.6356
Actin 0.019 0.0103 0.009 0.0011 0.0016 0.0005 0.0219 0.0005 0.004 0.0137 0.0006 0.0086 0.0159 0.0003 0.0162 0.0039 0.0231 0.0016
Bud 0.0001 0 0.0001 0.0001 0.0001 0 0.0003 0 0.0001 0.0006 0.0001 0.0001 0.0002 0 0.0002 0.0001 0.0002 0.0001
Bud Neck 0.0007 0.0001 0.0002 0.0002 0.0002 0.0001 0.0002 0.0001 0.0001 0.0002 0.0001 0.0004 0.0053 0.0001 0.0003 0.0001 0.0003 0.0005
Bud Periphery 0.0002 0.0001 0.0001 0.0001 0 0 0.0003 0 0.0001 0.0009 0.0001 0.0001 0.0002 0 0.0004 0.0002 0.0002 0
Bud Site 0.0014 0.0004 0.0008 0.0001 0.0001 0 0.0015 0 0.0004 0.0008 0 0.0001 0.0027 0 0.0009 0.0002 0.0006 0
Cell Periphery 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0002 0.0001
Cytoplasm 0.0567 0.0709 0.0499 0.1523 0.0627 0.0367 0.0397 0.1138 0.0611 0.0945 0.1073 0.0711 0.0449 0.0836 0.0917 0.2052 0.0597 0.1315
Cytoplasmic Foci 0.0156 0.0104 0.0121 0.0485 0.0357 0.0208 0.0136 0.0104 0.013 0.015 0.0342 0.0145 0.0161 0.0063 0.0157 0.0093 0.0551 0.0071
Eisosomes 0.0003 0 0.0001 0 0 0 0.0001 0 0 0.0001 0 0 0.0002 0 0.0004 0 0.0006 0
Endoplasmic Reticulum 0.0469 0.0351 0.0293 0.0819 0.054 0.0261 0.0163 0.0205 0.0148 0.0501 0.0093 0.0292 0.0092 0.0142 0.0093 0.0175 0.0121 0.0159
Endosome 0.0239 0.0353 0.0312 0.0672 0.0599 0.0395 0.0202 0.0127 0.0233 0.1043 0.1266 0.0305 0.0146 0.0087 0.02 0.0239 0.0523 0.0184
Golgi 0.0057 0.004 0.0057 0.0086 0.0038 0.0089 0.007 0.0035 0.0061 0.0171 0.0138 0.0089 0.0058 0.0007 0.0033 0.0144 0.0314 0.0012
Lipid Particles 0.0313 0.0431 0.0332 0.0659 0.0171 0.0418 0.0149 0.0265 0.0586 0.0348 0.0219 0.0144 0.028 0.0123 0.0101 0.0275 0.1461 0.0067
Mitochondria 0.005 0.0002 0.0014 0.0011 0.0025 0.0003 0.0037 0.0002 0.0029 0.0377 0.0009 0.0009 0.0055 0.0001 0.0029 0.0253 0.0245 0.0003
None 0.0127 0.0002 0.0013 0.003 0.0005 0.0003 0.0008 0.0003 0.0003 0.0005 0.0003 0.0003 0.0027 0.0002 0.0026 0.0005 0.0052 0.0003
Nuclear Periphery 0.6786 0.7282 0.7574 0.4888 0.6852 0.7514 0.7843 0.7456 0.7431 0.5567 0.6179 0.757 0.7692 0.7749 0.7458 0.6264 0.4826 0.6986
Nucleolus 0.0028 0.0004 0.0009 0.0016 0.0137 0.0006 0.0007 0.0025 0.0076 0.0003 0.0007 0.0004 0.0013 0.0034 0.0007 0.0004 0.0014 0.0002
Nucleus 0.0384 0.0251 0.0282 0.0196 0.024 0.0351 0.0373 0.0373 0.0288 0.0173 0.0282 0.0283 0.0533 0.0735 0.0427 0.02 0.0698 0.0908
Peroxisomes 0.0193 0.0002 0.0021 0.0003 0.0013 0.0002 0.0042 0.0001 0.0004 0.0006 0.0001 0.0004 0.0033 0.0001 0.0023 0.0008 0.0074 0.0001
Punctate Nuclear 0.0118 0.0044 0.0044 0.0128 0.0034 0.005 0.0106 0.011 0.01 0.0023 0.0029 0.0049 0.01 0.0091 0.0174 0.0033 0.011 0.009
Vacuole 0.0093 0.0087 0.0086 0.0264 0.0096 0.0083 0.0065 0.0033 0.0066 0.0163 0.0096 0.0091 0.0029 0.0025 0.0041 0.0044 0.0028 0.0056
Vacuole Periphery 0.0202 0.0228 0.0235 0.0203 0.0246 0.0243 0.0158 0.0115 0.0184 0.0358 0.0251 0.0206 0.0086 0.0098 0.0131 0.0164 0.0133 0.012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 81.9233 79.3373 75.2878 86.3277 86.8546 66.5258 67.8766 71.3212 70.6537 83.7971
Translational Efficiency 1.2881 1.2735 1.244 1.0377 1.1174 1.3059 1.2378 1.0725 1.0774 1.0035

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1196 1450 2082 1224 1673 1274 1561 2170 2869 2724 3643 3394

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1997.31 2689.78 4746.60 4664.92 2185.45 2458.99 3263.39 4259.17 2107.02 2581.84 4111.05 4405.50
Standard Deviation 342.94 525.05 871.76 920.08 451.63 541.34 955.96 1035.12 420.21 545.03 1168.18 1014.06
Intensity Change Log 2 — 0.429430 1.248836 1.223794 — 0.170135 0.578441 0.962642 — 0.299773 0.937345 1.093250

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000106 0.000073 0.000663 0.000423 0.000206 0.000224 0.000108 0.000198 0.000164 0.000144 0.000425 0.000279
Bud Neck 0.004520 0.001820 0.008574 0.007346 0.003089 0.003407 0.004948 0.004577 0.003686 0.002562 0.007020 0.005575
Bud Site 0.002350 0.000610 0.004551 0.009123 0.001351 0.002214 0.002580 0.006618 0.001768 0.001360 0.003706 0.007521
Cell Periphery 0.000122 0.000095 0.000238 0.001493 0.000177 0.000203 0.000161 0.000460 0.000154 0.000146 0.000205 0.000833
Cytoplasm 0.066470 0.079223 0.047309 0.190808* 0.114129* 0.090327 0.207788* 0.243611* 0.094261 0.084416 0.116073* 0.224569*
Cytoplasmic Foci 0.017112 0.002499 0.018736 0.026552 0.006871 0.004808 0.003553 0.014194 0.011140 0.003579 0.012230 0.018651
Eisosomes 0.000004 0.000001 0.000006 0.000004 0.000002 0.000002 0.000001 0.000004 0.000003 0.000001 0.000004 0.000004
Endoplasmic Reticulum 0.009711 0.003369 0.004262 0.003143 0.009280 0.005342 0.003157 0.005238 0.009460 0.004292 0.003788 0.004483
Endosome 0.011476 0.003277 0.016187 0.010998 0.007446 0.006961 0.003625 0.009483 0.009126 0.005000 0.010804 0.010029
Golgi 0.005082 0.002853 0.017455 0.028205 0.006287 0.005070 0.002408 0.019844 0.005785 0.003890 0.011007 0.022859
Lipid Particles 0.006164 0.002770 0.033329 0.050541 0.006901 0.005431 0.004023 0.023738 0.006593 0.004014 0.020772 0.033404
Mitochondria 0.000404 0.000521 0.000814 0.000493 0.000451 0.000839 0.000654 0.000770 0.000432 0.000670 0.000745 0.000670
Mitotic Spindle 0.049078 0.056882 0.150802* 0.134086* 0.033237 0.062740 0.082071 0.117754* 0.039841 0.059622 0.121351* 0.123644*
None 0.001289 0.001673 0.000854 0.002371 0.002086 0.003808 0.001152 0.002281 0.001754 0.002672 0.000982 0.002313
Nuclear Periphery 0.083504 0.165224* 0.105601* 0.021543 0.071959 0.149801* 0.180360* 0.036712 0.076772 0.158011* 0.137635* 0.031242
Nuclear Periphery Foci 0.714618* 0.653394* 0.539441* 0.351796* 0.710950* 0.622334* 0.432649* 0.403947* 0.712479* 0.638867* 0.493681* 0.385140*
Nucleolus 0.003655 0.000239 0.000209 0.000256 0.000701 0.000840 0.000276 0.000449 0.001932 0.000520 0.000237 0.000379
Nucleus 0.007616 0.010902 0.004200 0.009814 0.008330 0.012504 0.025807 0.025582 0.008032 0.011651 0.013458 0.019896
Peroxisomes 0.000577 0.000010 0.000354 0.000241 0.000134 0.000119 0.000041 0.000200 0.000318 0.000061 0.000220 0.000215
Vacuole 0.012193 0.010172 0.038899 0.140797 0.013040 0.017805 0.041343 0.077538 0.012687 0.013742 0.039946 0.100352
Vacuole Periphery 0.003949 0.004394 0.007517 0.009966 0.003372 0.005220 0.003294 0.006804 0.003612 0.004780 0.005708 0.007944

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.89 -2.95 -3.00 -3.16 1.34 -0.95 0.39 -0.25 1.02 -1.25 -0.45 -2.49 -2.13 -1.87 1.50
Bud Neck 4.26 -6.51 -6.80 -12.05 0.35 -1.41 -6.34 -8.19 -7.01 -1.10 2.00 -9.41 -10.43 -13.39 0.27
Bud Site 3.44 -3.97 -6.36 -8.16 -4.17 -2.06 -2.92 -8.76 -6.25 -4.51 0.53 -5.39 -10.61 -10.97 -6.00
Cell Periphery 1.18 -8.51 -12.25 -12.40 -10.75 -1.12 -2.27 -7.62 -4.98 -5.78 -0.10 -6.77 -14.29 -13.67 -11.90
Cytoplasm -2.09 2.86 -14.87 -13.24 -18.34 2.45 -12.73 -18.16 -20.85 -3.78 1.26 -6.15 -23.84 -25.61 -18.47
Cytoplasmic Foci 6.46 -1.25 -3.07 -10.29 -2.26 1.34 1.53 -5.10 -6.76 -7.32 6.12 -1.80 -5.20 -12.58 -3.75
Eisosomes 4.45 -1.92 0.12 -9.74 2.71 -1.43 0.47 -4.53 -2.45 -6.72 2.64 -2.54 -2.79 -7.33 0.28
Endoplasmic Reticulum 5.06 4.22 5.82 1.52 2.76 4.09 7.72 5.36 1.74 -2.19 6.85 7.84 7.68 1.58 0.17
Endosome 8.74 -3.18 1.82 -9.27 5.36 0.29 6.36 -1.92 -1.90 -8.26 7.07 -2.23 0.19 -7.66 2.53
Golgi 2.52 -8.98 -9.69 -11.72 -2.41 1.27 5.41 -6.44 -7.26 -10.83 2.92 -6.12 -11.07 -13.47 -5.70
Lipid Particles 3.77 -11.80 -15.98 -17.12 -5.08 1.01 1.37 -9.37 -9.77 -10.39 3.34 -10.73 -17.69 -19.19 -5.92
Mitochondria -1.41 -4.01 -0.20 0.88 3.13 -3.58 -3.48 -1.49 0.68 0.42 -3.48 -5.02 -1.52 0.47 1.46
Mitotic Spindle -1.70 -15.31 -10.91 -9.58 2.06 -6.16 -10.46 -14.99 -7.40 -3.08 -5.82 -19.60 -18.20 -12.05 0.85
None -1.32 1.86 -1.69 -0.83 -2.49 -1.88 2.25 -1.11 1.44 -3.60 -2.02 3.39 -2.13 0.60 -4.79
Nuclear Periphery -13.43* -3.93 17.20 29.62* 24.96 -13.27 -14.42 14.25 22.28* 23.70* -19.47 -13.34 21.64 35.95* 32.67*
Nuclear Periphery Foci 5.68 17.69 34.77* 30.31* 19.43 8.77 30.49* 38.18* 25.33* 5.66 10.10 32.50 51.26 39.41* 18.77
Nucleolus 3.62 3.62 3.51 -1.43 -1.44 -0.66 0.87 -1.12 -0.51 -3.45 3.12 3.73 2.56 -1.59 -4.02
Nucleus -2.32 1.37 -4.32 -1.69 -6.18 -3.31 -11.24 -14.04 -10.95 -3.03 -3.92 -8.44 -14.57 -11.26 -7.89
Peroxisomes 3.12 1.16 2.03 -3.70 1.48 -0.11 0.86 -1.15 -1.59 -3.92 2.56 0.93 0.88 -3.77 -0.18
Vacuole 0.73 -13.52 -25.65 -25.96 -19.33 -3.63 -14.42 -26.61 -22.68 -11.45 -2.15 -19.79 -36.59 -34.98 -22.27
Vacuole Periphery -0.46 -4.79 -4.78 -3.64 -0.46 -2.23 0.32 -3.99 -0.46 -4.78 -1.83 -4.90 -5.99 -2.65 -1.39
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
Localization
Cell Percentages cytoplasm (21%), ER (9%), mixed (46%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Kap95

Kap95


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Kap95-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available