Standard name
Human Ortholog
Description Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0.11 0.07 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0.09 0.06 0 0 0 0 0 0.06 0.06 0.08 0.11 0.16 0.16 0.22 0.29 0 0 0 0 0 0
Cytoplasm 0.21 0.21 0.36 0.41 0.38 0.4 0.44 0.44 0.38 0.33 0.36 0.32 0.3 0.19 0.28 0.62 0.61 0.61 0.07 0.05 0 0 0 0
Endoplasmic Reticulum 0.7 0.79 0.54 0.46 0.45 0.41 0.34 0.21 0.25 0.27 0.3 0.31 0.61 0.77 0.61 0 0 0 0.8 0.81 0.84 0.85 0.85 0.86
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.08 0.15 0.15 0.17 0.22 0.19 0.3 0.26 0.33 0.34 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.13 0 0.07 0.06 0.08 0.05 0.08 0.18 0.14 0.16 0.1 0.08 0.13 0.06 0.11 0.15 0.09 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 4 3 7 2 12 26 9 13 16 9 10 17 4 11 15 6 14 8 5 4 8 9 10 9
Bud 1 1 3 0 9 13 18 16 14 14 12 20 0 2 2 3 2 1 5 0 0 2 3 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 1
Bud Site 0 0 0 0 0 2 0 1 4 1 1 1 0 0 0 0 0 0
Cell Periphery 4 5 3 20 23 16 15 9 19 15 25 31 27 54 100 33 28 35 0 1 2 2 2 4
Cytoplasm 47 35 106 94 138 189 202 223 170 146 150 156 106 97 170 127 78 74 17 9 14 8 11 17
Endoplasmic Reticulum 154 128 158 106 162 191 154 104 112 119 128 151 220 392 374 3 3 2 209 146 301 295 389 461
Endosome 0 1 3 1 5 2 2 5 1 4 1 2 5 1 1 3 0 1 3 0 0 1 2 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 6 0 1 1 1 0 1 6 0
Mitochondria 3 0 25 34 53 80 100 95 136 115 139 164 1 1 1 7 3 0 4 4 10 8 11 7
Nucleus 2 0 2 2 1 6 2 4 6 6 3 6 0 0 2 3 1 0 0 0 0 0 0 0
Nuclear Periphery 2 3 4 8 1 6 6 16 5 12 9 10 1 4 7 2 1 0 1 0 6 1 2 1
Nucleolus 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 28 3 22 13 29 24 35 91 65 72 41 41 48 30 68 31 11 6 7 4 7 11 15 18
Unique Cell Count 221 163 295 232 361 469 455 503 452 443 421 486 358 512 614 205 128 121 261 180 357 348 459 535
Labelled Cell Count 245 179 333 280 433 555 543 579 548 515 519 599 413 593 742 224 141 128 261 180 357 348 459 535


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.0 8.7 6.6 6.8 6.4 6.3 5.9 6.2 6.2 6.2 6.3 6.4 10.6 10.2 9.6 10.8 11.0 11.5 11.7 13.2 13.8
Std Deviation (1e-4) 1.6 1.5 1.1 1.9 1.4 1.4 1.4 1.5 1.6 1.6 1.8 1.7 2.2 2.0 1.6 1.8 2.0 2.0 2.6 2.7 2.8
Intensity Change (Log2) 0.05 -0.04 -0.06 -0.16 -0.09 -0.09 -0.09 -0.05 -0.04 0.68 0.63 0.55 0.72 0.74 0.8 0.83 1.0 1.07

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0.7 2.1 -0.4 0.2 0.9 -0.3 0 0.9 0 -0.2 0.1 0.4 3.7 0
Bud 0 1.4 1.6 2.4 1.9 1.9 1.9 1.7 2.5 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 4.2 3.5 2.1 2.0 0 2.5 2.0 3.3 3.6 4.0 5.1 6.8 6.4 7.6 9.0
Cytoplasm 1.1 0.6 1.2 2.3 2.3 0.5 -0.8 -0.1 -1.1 -1.7 -5.4 -2.5 5.7 4.8 4.7
Endoplasmic Reticulum -1.8 -2.2 -3.5 -5.4 -9.5 -8.0 -7.3 -6.2 -6.2 2.0 6.8 2.1 -12.3 -10.0 -9.9
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.2 2.4 3.4 4.8 4.0 7.0 5.9 7.7 8.0 -5.3 -6.4 -7.0 -2.3 -2.3 -3.3
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 1.6 0 0 0 1.6 0 1.2 0.8 0.7 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -0.8 0.3 -1.3 0.1 4.2 2.9 3.5 1.1 0.5 2.4 -0.9 1.7 2.7 0.4 -0.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.22 5.365 5.4868 5.2706 5.0482 5.7628 6.7719 7.2229 6.8943 6.6733 7.1353 6.6316 5.5982 4.2918 3.3242 4.1289 4.1431 4.0326
Actin 0.0244 0.0057 0.0208 0.0058 0.0137 0.0009 0.0425 0.0021 0.0129 0.0026 0.0302 0.0007 0.0276 0.0004 0.0003 0.0733 0.0009 0.0111
Bud 0.0006 0.0035 0.0002 0.0003 0.0003 0 0.0004 0.0001 0.0002 0.0009 0.0023 0 0.0004 0 0 0.0002 0 0
Bud Neck 0.0028 0.0008 0.0006 0.0038 0.0008 0.0015 0.0065 0.0004 0.0007 0.0005 0.0093 0.0004 0.0019 0.0001 0.0001 0.001 0.0093 0.0003
Bud Periphery 0.0011 0.0027 0.0002 0.0006 0.0007 0.0001 0.0014 0.0003 0.0005 0.0011 0.0028 0 0.0008 0 0 0.0003 0.0001 0.0001
Bud Site 0.0051 0.0113 0.0011 0.0019 0.0005 0 0.0016 0.0029 0.0048 0.0009 0.0121 0 0.002 0.0004 0 0.0013 0.0002 0.0001
Cell Periphery 0.0017 0.0024 0.001 0.0007 0.0005 0.0002 0.0035 0.0086 0.001 0.0009 0.0009 0.0006 0.0011 0.0012 0.0005 0.0003 0.0027 0.0001
Cytoplasm 0.1325 0.3432 0.1667 0.225 0.126 0.1108 0.0818 0.1808 0.1732 0.1914 0.2806 0.1309 0.1065 0.2314 0.0992 0.078 0.3547 0.124
Cytoplasmic Foci 0.0243 0.0095 0.0179 0.0043 0.0057 0.0089 0.0168 0.0057 0.0058 0.0048 0.0155 0.0024 0.001 0.0022 0.0023 0.0014 0.005 0.0026
Eisosomes 0.0003 0.0002 0.0004 0.0003 0.0002 0 0.0007 0.0001 0.0004 0 0.0001 0 0.0005 0 0 0.0001 0 0.0001
Endoplasmic Reticulum 0.5295 0.4664 0.6621 0.672 0.5469 0.8125 0.7108 0.7257 0.7353 0.707 0.5675 0.8122 0.8094 0.7149 0.8783 0.8331 0.6096 0.8088
Endosome 0.0813 0.0193 0.035 0.0254 0.0567 0.0113 0.0193 0.0136 0.0186 0.0096 0.0352 0.0112 0.0042 0.0033 0.0039 0.0016 0.0041 0.0048
Golgi 0.012 0.0024 0.0067 0.0069 0.0093 0.0009 0.0098 0.0013 0.0044 0.0011 0.0126 0.0008 0.0015 0.0003 0.0005 0.0029 0.0005 0.0095
Lipid Particles 0.0321 0.0057 0.0125 0.0051 0.0179 0.0016 0.0258 0.0076 0.0062 0.0013 0.0038 0.0019 0.0013 0.0063 0.0044 0.0008 0.0034 0.0178
Mitochondria 0.0041 0.0012 0.0031 0.0087 0.0034 0.0006 0.0075 0.0005 0.0052 0.0006 0.0025 0.0007 0.0006 0.0001 0.0001 0.0003 0.0001 0.0014
None 0.0258 0.0445 0.0245 0.0058 0.0121 0.0093 0.0037 0.0191 0.0115 0.0593 0.0034 0.0192 0.0264 0.0271 0.0022 0.0005 0.001 0.0004
Nuclear Periphery 0.0546 0.0312 0.0258 0.0174 0.1069 0.0255 0.0203 0.017 0.0102 0.0103 0.0066 0.0143 0.0104 0.0073 0.0059 0.0031 0.0032 0.0072
Nucleolus 0.0019 0.0016 0.0012 0.0004 0.0014 0.0003 0.0007 0.0002 0.0003 0 0.0002 0 0.0001 0 0 0 0 0
Nucleus 0.0167 0.0256 0.0053 0.0052 0.0607 0.0069 0.0112 0.0029 0.0017 0.0024 0.0054 0.0018 0.0016 0.0015 0.0006 0.0003 0.0015 0.0033
Peroxisomes 0.0045 0.0002 0.0023 0.0014 0.0013 0.0002 0.013 0.0001 0.0013 0.0002 0.0021 0 0 0 0 0.0006 0 0.0063
Punctate Nuclear 0.0241 0.0094 0.006 0.0009 0.0213 0.0058 0.002 0.0013 0.0015 0.0005 0.0016 0.0004 0.0003 0.0004 0.0002 0.0001 0.0005 0.0004
Vacuole 0.017 0.0121 0.005 0.0066 0.0087 0.0021 0.0191 0.0093 0.0034 0.004 0.0049 0.002 0.0019 0.003 0.0014 0.0007 0.003 0.0015
Vacuole Periphery 0.0034 0.001 0.0016 0.0015 0.0049 0.0005 0.0017 0.0005 0.0007 0.0005 0.0007 0.0004 0.0005 0.0001 0.0001 0.0001 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 40.6785 37.8793 33.7297 32.5108 32.9634 37.268 41.3637 29.9857 32.9237 36.8555
Translational Efficiency 1.7477 1.6075 1.4622 2.1575 1.8546 2.4587 1.5094 2.2699 1.9398 1.8098

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
815 1605 2005 256 1952 1949 2105 1828 2767 3554 4110 2084

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 874.97 955.22 1342.25 2497.25 880.37 875.65 1495.32 2291.84 878.78 911.58 1420.65 2317.07
Standard Deviation 165.48 153.70 228.46 525.21 119.05 146.32 228.08 478.74 134.42 154.85 240.75 489.36
Intensity Change Log 2 0.126599 0.617348 1.513035 -0.007756 0.764272 1.380324 0.060779 0.692905 1.448001

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001879 0.001011 0.001357 0.000798 0.000327 0.000632 0.001059 0.004172 0.000784 0.000803 0.001204 0.003757
Bud Neck 0.002136 0.001662 0.002063 0.002605 0.001698 0.002902 0.001272 0.003613 0.001827 0.002342 0.001658 0.003489
Bud Site 0.014673 0.007150 0.008260 0.004410 0.001548 0.005628 0.005461 0.013575 0.005414 0.006316 0.006827 0.012449
Cell Periphery 0.007761 0.001687 0.002388 0.040888 0.000673 0.000995 0.002879 0.012930 0.002760 0.001308 0.002639 0.016365
Cytoplasm 0.038677 0.122483 0.046272 0.002126 0.162163 0.156325 0.027674 0.006006 0.125791 0.141042 0.036747 0.005529
Cytoplasmic Foci 0.017395 0.023353 0.001731 0.000768 0.024245 0.033297 0.001406 0.004615 0.022228 0.028806 0.001565 0.004142
Eisosomes 0.000582 0.000453 0.000138 0.001189 0.000468 0.000430 0.000140 0.000354 0.000502 0.000441 0.000139 0.000456
Endoplasmic Reticulum 0.861882 0.756469 0.888936 0.839180 0.713732 0.687560 0.931114 0.824810 0.757369 0.718680 0.910538 0.826575
Endosome 0.005477 0.006612 0.007003 0.011930 0.004613 0.008353 0.004343 0.021497 0.004868 0.007567 0.005641 0.020321
Golgi 0.006367 0.011401 0.001017 0.009963 0.009138 0.012189 0.001354 0.020785 0.008322 0.011833 0.001190 0.019456
Lipid Particles 0.006797 0.016693 0.006834 0.033703 0.026384 0.026627 0.005114 0.047696 0.020615 0.022141 0.005953 0.045977
Mitochondria 0.004927 0.005277 0.000626 0.000845 0.003656 0.009192 0.001312 0.002400 0.004030 0.007424 0.000977 0.002209
Mitotic Spindle 0.000184 0.001436 0.000335 0.001166 0.000071 0.000485 0.000111 0.001956 0.000104 0.000914 0.000221 0.001859
None 0.006927 0.005286 0.002101 0.000220 0.003522 0.005576 0.003462 0.001975 0.004525 0.005445 0.002798 0.001759
Nuclear Periphery 0.000622 0.002442 0.002156 0.004579 0.006356 0.002907 0.000985 0.001357 0.004667 0.002697 0.001556 0.001753
Nuclear Periphery Foci 0.004581 0.006085 0.013898 0.008441 0.005284 0.006247 0.005214 0.008535 0.005077 0.006174 0.009451 0.008523
Nucleolus 0.001672 0.000505 0.000017 0.000026 0.000168 0.000213 0.000026 0.000085 0.000611 0.000345 0.000022 0.000077
Nucleus 0.006655 0.012708 0.003269 0.000364 0.018670 0.015136 0.001856 0.000558 0.015131 0.014039 0.002545 0.000534
Peroxisomes 0.004076 0.001485 0.000079 0.000115 0.001415 0.002092 0.000320 0.000564 0.002199 0.001818 0.000202 0.000508
Vacuole 0.004992 0.013894 0.010996 0.027831 0.014884 0.019945 0.004468 0.018078 0.011970 0.017212 0.007653 0.019276
Vacuole Periphery 0.001737 0.001907 0.000524 0.008854 0.000987 0.003269 0.000431 0.004440 0.001208 0.002654 0.000476 0.004983

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.30 0.57 1.31 0.24 1.09 -2.77 -3.06 -5.00 -4.60 -3.85 -0.13 -1.79 -4.30 -4.36 -3.57
Bud Neck 0.97 0.07 -0.50 -1.69 -0.65 -2.04 0.82 -3.82 -1.67 -4.78 -1.09 0.27 -3.74 -2.95 -4.21
Bud Site 2.76 2.12 3.51 1.30 2.33 -4.78 -4.30 -8.50 -5.25 -5.12 -0.83 -1.67 -5.17 -4.73 -4.08
Cell Periphery 4.46 3.93 -5.76 -7.00 -6.87 -2.68 -7.58 -12.50 -12.11 -9.86 3.44 0.20 -11.49 -13.39 -12.11
Cytoplasm -15.52 -2.19 9.67 24.62 13.89 0.88 27.21 33.52 31.74 10.70 -3.18 22.99 33.31 40.51 18.39
Cytoplasmic Foci -1.38 5.63 5.96 13.31 2.51 -3.89 15.28 12.50 15.17 -5.27 -3.37 15.31 12.77 18.42 -4.96
Eisosomes 0.72 2.89 -1.40 -1.75 -2.56 0.53 4.70 1.43 1.12 -3.25 0.78 5.48 0.50 -0.17 -4.24
Endoplasmic Reticulum 8.27 -2.29 1.29 -4.54 2.98 2.48 -26.48 -10.73 -12.90 14.74 4.65 -22.40 -7.56 -12.48 12.71
Endosome -1.34 -2.05 -3.67 -3.20 -2.79 -6.29 0.31 -16.29 -11.88 -16.23 -5.96 -2.25 -16.43 -13.39 -15.38
Golgi -3.47 5.40 -2.33 0.91 -7.49 -2.50 9.44 -6.20 -4.36 -10.91 -3.76 11.35 -6.79 -4.54 -11.77
Lipid Particles -6.85 -0.43 -4.19 -2.64 -4.10 -0.13 13.30 -7.10 -7.06 -15.33 -1.10 11.94 -9.48 -9.09 -15.62
Mitochondria -0.28 4.14 3.69 4.84 -0.57 -4.98 4.34 1.77 6.22 -2.40 -4.20 6.33 2.88 6.74 -3.18
Mitotic Spindle -1.82 -1.21 -1.55 0.26 -1.27 -2.55 -0.92 -3.48 -2.69 -3.39 -2.55 -1.94 -3.62 -1.83 -3.35
None 0.85 2.70 3.89 4.70 3.36 -1.74 0.06 1.68 3.13 1.63 -0.89 2.13 3.15 4.09 1.48
Nuclear Periphery -4.26 -5.27 -6.87 -3.10 -3.87 4.04 6.95 6.53 3.43 -1.72 3.26 5.58 5.24 2.75 -1.07
Nuclear Periphery Foci -1.37 -7.25 -1.56 -1.05 2.08 -1.04 -0.11 -3.97 -2.51 -3.39 -1.60 -6.08 -4.45 -3.09 0.82
Nucleolus 1.53 2.23 2.22 2.75 -0.96 -0.95 3.54 0.94 1.83 -1.54 1.13 2.66 2.29 2.71 -1.64
Nucleus -2.79 2.42 3.58 7.79 2.60 2.55 15.02 16.53 16.43 3.32 1.06 13.74 16.11 17.60 6.17
Peroxisomes 2.49 3.91 3.87 8.15 -0.66 -3.05 8.42 4.32 6.28 -1.44 1.11 6.35 4.95 7.04 -2.14
Vacuole -5.92 -5.16 -5.27 -3.26 -3.70 -2.70 7.96 -2.35 0.34 -9.37 -4.01 3.57 -5.08 -1.84 -8.04
Vacuole Periphery -0.32 2.79 -1.83 -1.79 -2.15 -4.04 3.19 -6.68 -1.64 -7.53 -4.10 4.31 -5.69 -3.26 -6.84
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Componentsactinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication
Localization
Cell Percentages ER (96%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Orm2

Orm2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Orm2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available