Standard name
Human Ortholog
Description Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0.05 0 0.06 – 0.09 0.12 0.09 0 0 0 – – 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.05 0.07 0.06 0.1 0.07 0.08 – 0.09 0.13 0.08 0.05 0.05 0.05 – – 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0.05 0 0 0 0 0 0
Endosome 0.58 0.21 0.56 0.51 0.67 0.37 0.34 0.23 – 0.05 0.05 0.08 0.61 0.65 0.59 – – 0.66 0.81 0.77 0.82 0.83 0.85 0.84
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Mitochondria 0.36 0.65 0.33 0.34 0.26 0.48 0.46 0.48 – 0.74 0.71 0.7 0 0 0 – – 0.12 0 0.05 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 0 0 0 0 0 0 0
Nucleolus 0.08 0.05 0.07 0 0 0 0 0.05 – 0 0 0 0 0 0 – – 0.05 0 0 0 0 0 0
Peroxisomes 0 0 0.06 0.15 0.21 0.17 0.22 0.15 – 0.09 0.08 0.1 0 0 0 – – 0 0 0 0 0 0 0
SpindlePole 0.29 0.09 0.3 0.29 0.27 0.26 0.3 0.29 – 0.2 0.26 0.26 0.41 0.4 0.28 – – 0.32 0 0.06 0.06 0.06 0 0
Vac/Vac Membrane 0.15 0.12 0.08 0 0.07 0 0 0 – 0 0 0 0.14 0.14 0.33 – – 0.2 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 1 0 0 0 0 1 1 – 0 0 1 2 1 0 – – 0 1 1 3 0 1 3
Bud 7 5 6 16 19 32 32 55 – 49 54 43 1 1 0 – – 2 0 1 2 1 0 1
Bud Neck 0 0 0 2 1 0 1 2 – 0 0 0 2 1 2 – – 0 0 0 0 0 2 1
Bud Site 1 2 0 1 0 0 1 1 – 9 7 7 0 0 0 – – 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 1 0 0 1 1 0 – – 0 0 0 0 0 0 0
Cytoplasm 5 10 20 32 34 56 55 66 – 53 56 36 14 14 14 – – 20 2 1 3 0 3 1
Endoplasmic Reticulum 1 8 2 4 1 1 0 2 – 1 0 0 2 5 2 – – 12 0 0 1 1 3 2
Endosome 99 42 249 238 368 215 265 198 – 29 22 36 182 195 159 – – 151 172 184 412 234 502 465
Golgi 0 1 0 0 0 0 0 0 – 0 0 0 0 0 0 – – 1 2 2 1 1 7 11
Mitochondria 61 127 145 157 144 283 354 411 – 424 307 317 1 1 3 – – 28 8 11 14 7 14 17
Nucleus 0 0 0 1 4 4 2 5 – 2 4 0 2 2 6 – – 1 0 0 0 0 0 0
Nuclear Periphery 3 4 4 3 0 0 0 0 – 0 1 1 2 2 1 – – 2 1 2 3 1 2 3
Nucleolus 13 10 30 16 13 16 19 39 – 12 7 4 10 10 2 – – 11 1 2 1 1 1 1
Peroxisomes 6 1 26 71 118 100 169 128 – 54 36 47 9 11 3 – – 2 6 2 14 4 10 11
SpindlePole 50 18 135 137 146 151 229 245 – 115 111 116 123 119 76 – – 74 7 13 28 16 20 14
Vac/Vac Membrane 25 24 34 18 37 24 30 17 – 7 3 11 43 43 88 – – 45 4 13 12 6 12 14
Unique Cell Count 170 196 444 465 550 589 774 848 570 432 453 297 301 269 229 212 241 503 282 588 556
Labelled Cell Count 272 253 651 696 885 882 1158 1170 756 608 619 394 406 356 349 212 241 503 282 588 556


Endosome

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.7 4.8 4.2 4.3 4.3 3.9 3.6 3.9 – 3.3 3.4 3.4 6.3 6.3 6.3 3.9 4.7 5.6 6.4 6.3 6.7
Std Deviation (1e-4) 0.7 1.0 0.8 1.2 1.5 1.4 0.8 1.0 – 0.9 1.1 0.8 1.1 1.1 0.8 0.9 1.0 1.2 1.9 1.3 1.5
Intensity Change (Log2) – – – 0.03 0.02 -0.14 -0.25 -0.14 – -0.36 -0.31 -0.31 0.56 0.56 0.58 -0.14 0.14 0.41 0.58 0.57 0.65

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – 0
Bud Neck – – – – – – – – – – – – – – 0
Bud Site – – – – – – – – – – – – – – 0
Cell Periphery – – – – – – – – – – – – – – 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – 0
Endosome – – – – – – – – – – – – – – 0
Golgi – – – – – – – – – – – – – – 0
Mitochondria – – – – – – – – – – – – – – 0
Nuclear Periphery – – – – – – – – – – – – – – 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – 0
Peroxisomes – – – – – – – – – – – – – – 0
SpindlePole – – – – – – – – – – – – – – 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – 0
Cytoplasm – – – – – – – – – – – – – – 0
Nucleus – – – – – – – – – – – – – – 0
Vacuole – – – – – – – – – – – – – – 4.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.1929 1.037 1.2206 0.8191 0.8441 0.9814 0.3274 1.4156 0.999 0.5532 0.6132 1.0833 -0.0031 1.1326 0.4838 0.6534 0.3336 0.3808
Actin 0.0395 0.0006 0.0297 0.0001 0.0013 0.0032 0.0099 0.0281 0.0158 0.0007 0.0499 0.0022 0.0178 0 0.0001 0.002 0.0008 0.0001
Bud 0.0006 0.0014 0.0002 0 0.0011 0.0002 0.0001 0.0001 0.0003 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0
Bud Neck 0.0055 0.0003 0.0004 0.0004 0.0004 0.0009 0.0069 0.0023 0.0017 0.0002 0.0005 0.0007 0.0015 0.0003 0.0003 0.0002 0.0002 0.0002
Bud Periphery 0.0009 0.0009 0.0002 0 0.002 0.0002 0.0001 0.0001 0.0005 0.0001 0.0001 0.0001 0.0002 0 0.0001 0.0002 0 0
Bud Site 0.0088 0.0064 0.0012 0.0002 0.0018 0.0005 0.0008 0.0007 0.0026 0.0006 0.0012 0.0005 0.001 0.0002 0.0005 0.0003 0.0001 0.0001
Cell Periphery 0.0007 0.0003 0.0001 0 0.0002 0.0001 0.0001 0 0.0003 0 0.0001 0 0.0001 0.0001 0.0002 0.0001 0 0
Cytoplasm 0.021 0.0458 0.0056 0.0018 0.0433 0.0112 0.0059 0.0037 0.0065 0.0017 0.0077 0.0022 0.0069 0.0108 0.0035 0.0058 0.0011 0.0024
Cytoplasmic Foci 0.1993 0.1917 0.1816 0.1317 0.142 0.1906 0.2193 0.1898 0.2005 0.1734 0.1756 0.1756 0.1634 0.1949 0.1934 0.1669 0.1748 0.1706
Eisosomes 0.0005 0.0001 0.0001 0 0 0 0.0002 0 0.0007 0 0.0003 0 0.0005 0 0 0.0007 0 0
Endoplasmic Reticulum 0.012 0.0101 0.0249 0.0002 0.0096 0.0012 0.0013 0.0004 0.0009 0.0001 0.0008 0.0005 0.0015 0.0011 0.0007 0.0004 0.0003 0.0002
Endosome 0.3105 0.3694 0.4143 0.6475 0.5727 0.3971 0.3206 0.4177 0.3532 0.4227 0.3237 0.2797 0.3514 0.4234 0.3827 0.4979 0.5447 0.3462
Golgi 0.0273 0.0223 0.0635 0.0535 0.0342 0.0531 0.046 0.0523 0.0651 0.0657 0.0469 0.039 0.0382 0.0375 0.0487 0.0566 0.0749 0.0514
Lipid Particles 0.2107 0.2027 0.1848 0.1274 0.0713 0.2027 0.2426 0.1911 0.1873 0.1665 0.2295 0.3686 0.2739 0.2005 0.2593 0.1492 0.1046 0.355
Mitochondria 0.0096 0.005 0.0138 0.0024 0.0036 0.0039 0.0053 0.0046 0.0183 0.0082 0.0012 0.0031 0.0042 0.001 0.009 0.0041 0.0086 0.0013
None 0.0321 0.0513 0.0005 0.0002 0.007 0.0072 0.0128 0.0009 0.0306 0.0003 0.0417 0.0158 0.0379 0.0382 0.0086 0.0132 0.0001 0.0009
Nuclear Periphery 0.0162 0.0012 0.0006 0.0001 0.0427 0.007 0.0013 0.0004 0.0009 0.0001 0.0003 0.0011 0.0033 0.0009 0.0009 0.0018 0.0002 0.0003
Nucleolus 0.0091 0.0016 0.0003 0.0005 0.0006 0.001 0.0007 0.0005 0.0013 0.0004 0.0002 0.0003 0.0011 0.0005 0.0011 0.0032 0.0002 0.0002
Nucleus 0.0153 0.001 0.0002 0.0001 0.0238 0.0016 0.0006 0.0003 0.0007 0.0001 0.0001 0.0001 0.0014 0.0006 0.0002 0.0017 0 0.0001
Peroxisomes 0.0481 0.0523 0.0566 0.024 0.0208 0.0945 0.1158 0.0924 0.0994 0.1365 0.1152 0.1046 0.0769 0.0493 0.0709 0.0727 0.0825 0.0626
Punctate Nuclear 0.0142 0.0068 0.0039 0.0017 0.0031 0.0105 0.0045 0.0045 0.0038 0.0005 0.0017 0.0015 0.0094 0.0015 0.0075 0.007 0.0005 0.0038
Vacuole 0.0147 0.0252 0.0153 0.0062 0.0137 0.0095 0.004 0.0077 0.0071 0.0201 0.0021 0.0031 0.0076 0.0358 0.0097 0.0124 0.0039 0.0033
Vacuole Periphery 0.0032 0.0035 0.0023 0.0021 0.005 0.0038 0.0012 0.0022 0.0026 0.0021 0.0009 0.0013 0.0018 0.0034 0.0027 0.0034 0.0024 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.7771 11.2088 8.3174 11.7155 7.5866 3.3418 8.8777 14.0235 11.1798 12.2658
Translational Efficiency 0.4366 0.4647 0.6261 0.4527 0.6006 1.1782 0.8398 0.5584 0.4668 0.5236

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
92 1178 246 1314 188 681 1424 1845 280 1859 1670 3159

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1030.45 776.64 975.37 899.67 717.21 747.00 925.11 899.25 820.13 765.78 932.51 899.42
Standard Deviation 189.00 107.75 96.24 118.75 88.39 94.56 105.05 110.99 196.54 104.10 105.32 114.28
Intensity Change Log 2 — -0.407957 -0.079253 -0.195807 — 0.058713 0.367229 0.326327 — -0.197902 0.120939 0.041706

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002764 0.000285 0.001163 0.002005 0.000246 0.000092 0.000141 0.001147 0.001074 0.000214 0.000291 0.001504
Bud Neck 0.004633 0.003449 0.005021 0.004742 0.018698 0.023509 0.008105 0.002994 0.014077 0.010797 0.007651 0.003721
Bud Site 0.026461 0.003856 0.012946 0.010034 0.002703 0.002187 0.003867 0.012656 0.010509 0.003245 0.005205 0.011565
Cell Periphery 0.000241 0.000039 0.000051 0.000058 0.000229 0.000143 0.000023 0.000046 0.000233 0.000077 0.000027 0.000051
Cytoplasm 0.022251 0.007807 0.005247 0.006552 0.033454 0.005917 0.001930 0.009363 0.029773 0.007115 0.002419 0.008194
Cytoplasmic Foci 0.125093 0.150889 0.207294 0.153353 0.164820 0.072279 0.073731 0.169661 0.151767 0.122092 0.093405 0.162878
Eisosomes 0.000064 0.000032 0.000024 0.000028 0.000193 0.000075 0.000019 0.000023 0.000150 0.000048 0.000019 0.000025
Endoplasmic Reticulum 0.002499 0.000182 0.000675 0.000649 0.000535 0.000667 0.000570 0.000336 0.001181 0.000359 0.000585 0.000466
Endosome 0.464822 0.670472 0.487627 0.529323 0.543044 0.634987 0.713827 0.560573 0.517342 0.657473 0.680506 0.547574
Golgi 0.016196 0.070285 0.068858 0.034740 0.046816 0.034068 0.013878 0.067462 0.036755 0.057018 0.021977 0.053851
Lipid Particles 0.008330 0.017900 0.012110 0.012021 0.052124 0.050678 0.007724 0.004556 0.037734 0.029908 0.008370 0.007661
Mitochondria 0.001089 0.010792 0.002563 0.006103 0.017128 0.039821 0.002287 0.008915 0.011858 0.021426 0.002328 0.007745
Mitotic Spindle 0.029024 0.004921 0.068114 0.051455 0.000446 0.004613 0.035988 0.029381 0.009836 0.004808 0.040720 0.038563
None 0.000015 0.000311 0.000052 0.000496 0.000240 0.000488 0.000105 0.000031 0.000166 0.000376 0.000097 0.000225
Nuclear Periphery 0.000264 0.000081 0.000470 0.000839 0.000862 0.001186 0.001175 0.000254 0.000665 0.000486 0.001071 0.000497
Nuclear Periphery Foci 0.005901 0.002843 0.006519 0.008402 0.001674 0.001990 0.013835 0.001065 0.003063 0.002531 0.012758 0.004117
Nucleolus 0.000380 0.000612 0.001029 0.001411 0.004199 0.007034 0.006204 0.000334 0.002945 0.002965 0.005442 0.000782
Nucleus 0.001075 0.000692 0.001745 0.000942 0.012788 0.014323 0.003241 0.000338 0.008940 0.005685 0.003021 0.000589
Peroxisomes 0.042801 0.031010 0.029887 0.036904 0.066974 0.033691 0.020859 0.026681 0.059032 0.031992 0.022189 0.030933
Vacuole 0.228026 0.019064 0.079971 0.129164 0.029051 0.059692 0.085180 0.093897 0.094428 0.033947 0.084412 0.108566
Vacuole Periphery 0.018072 0.004478 0.008634 0.010780 0.003775 0.012561 0.007310 0.010289 0.008472 0.007439 0.007505 0.010493

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.61 0.95 0.41 -2.05 -0.82 1.75 0.92 -3.91 -4.94 -4.56 1.68 1.47 -0.75 -3.54 -3.21
Bud Neck 1.60 -0.12 -0.35 -2.72 -0.18 -0.89 1.91 3.21 6.30 6.23 0.94 1.63 3.08 5.30 5.37
Bud Site 2.70 1.52 1.88 -5.61 1.15 0.71 -2.21 -8.24 -9.25 -7.59 2.53 1.69 -0.55 -10.04 -7.22
Cell Periphery 1.48 1.38 1.33 -1.17 -0.34 1.34 3.44 3.04 3.38 -2.04 2.59 3.46 3.05 1.98 -2.48
Cytoplasm 1.93 2.22 1.92 -0.08 -1.57 4.88 5.54 4.12 -3.21 -7.24 4.92 5.93 4.51 -1.79 -7.98
Cytoplasmic Foci -1.95 -4.61 -1.96 -0.00 4.72 8.30 8.54 -0.13 -18.47 -22.07 3.15 6.39 -1.02 -9.19 -17.43
Eisosomes 1.05 1.32 1.16 0.76 -1.01 4.61 6.82 6.72 8.45 -1.13 5.16 6.51 6.29 6.73 -1.92
Endoplasmic Reticulum 1.60 1.26 1.26 -6.47 -0.10 -0.34 -0.63 0.78 2.73 3.24 1.65 0.94 1.38 -2.54 2.17
Endosome -6.81 -1.32 -2.27 13.95 -1.55 -3.74 -6.70 -0.72 5.88 15.18 -7.53 -8.05 -1.70 14.32 15.45
Golgi -9.61 -6.44 -3.52 10.51 5.08 1.83 5.46 -3.14 -8.24 -19.99 -4.29 3.15 -3.56 1.60 -14.64
Lipid Particles -2.47 -0.78 -1.04 2.38 -0.04 0.27 6.33 6.81 9.11 3.28 1.54 5.84 6.01 9.53 0.61
Mitochondria -6.40 -1.24 -3.77 2.71 -2.07 -3.39 2.75 1.51 7.23 -7.12 -2.42 2.59 1.12 7.13 -6.97
Mitotic Spindle 2.40 -1.60 -0.92 -11.01 1.29 -4.36 -11.09 -12.78 -10.26 1.96 1.74 -5.07 -5.01 -14.88 0.77
None -1.46 -1.11 -1.14 -0.33 -1.06 -0.88 1.76 2.48 3.58 2.23 -0.94 1.48 0.12 0.81 -0.67
Nuclear Periphery 1.48 0.33 -0.78 -8.77 -2.55 -0.83 -1.74 1.98 3.48 5.70 1.25 -1.87 0.97 -0.79 4.22
Nuclear Periphery Foci 1.01 0.05 -0.51 -3.86 -1.20 0.32 -6.59 0.76 0.89 8.23 0.83 -4.95 -0.50 -2.63 6.05
Nucleolus -0.63 -2.08 -3.42 -2.52 -1.59 -1.08 -1.30 2.54 4.82 6.78 0.25 -2.14 1.96 3.40 6.02
Nucleus 1.85 -0.00 0.63 -2.25 0.43 -0.15 2.64 4.10 4.74 4.40 1.69 2.32 4.05 4.37 4.01
Peroxisomes 0.98 1.06 0.46 -1.45 -1.36 4.21 6.26 5.45 2.05 -2.51 4.31 6.07 4.64 0.65 -4.14
Vacuole 6.98 4.96 3.23 -20.39 -6.06 -4.47 -9.81 -11.44 -6.40 -1.67 5.23 1.02 -1.11 -21.26 -5.83
Vacuole Periphery 1.93 1.26 0.98 -5.41 -1.23 -5.98 -4.77 -7.84 1.55 -3.71 0.25 0.25 -1.05 -3.56 -3.99
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
Localization
Cell Percentages endosome (30%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Vps38

Vps38


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vps38-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available