Standard name
Human Ortholog
Description Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.12 0.05 – 0 0 0 0 0 0
Cytoplasm 0.98 0.96 0.95 0.98 0.97 0.88 – 0.75 0.67 0.64 0.65 0.62 0.97 0.99 0.98 1.0 0.75 – 0.93 0.86 0.9 0.81 0.86 0.82
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0.05 – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 – 0 0 0 0.05 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0.05 0 0
Mitochondria 0 0 0.1 0.18 0.05 0.29 – 0.39 0.56 0.54 0.63 0.64 0 0 0 0 0 – 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0.05 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0.15 – 0 0.06 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 – 2 1 0 0 0 2
Bud 1 2 7 2 0 0 – 8 7 5 9 11 0 0 0 0 0 – 0 1 1 1 6 10
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 1 1
Bud Site 0 0 0 0 0 0 – 0 0 1 1 5 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 1 1 1 1 – 5 2 0 4 3 1 0 1 2 1 – 0 0 0 0 0 0
Cytoplasm 180 188 187 235 260 243 – 299 253 243 171 204 209 222 325 16 15 – 177 191 173 99 225 233
Endoplasmic Reticulum 1 0 0 0 0 0 – 0 1 1 0 0 2 3 1 1 1 – 0 1 2 0 1 0
Endosome 0 0 0 1 7 4 – 4 0 2 0 1 0 0 1 0 1 – 1 1 0 5 3 5
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 0 – 1 0 0 5 6 4
Mitochondria 3 8 20 43 13 81 – 155 212 207 167 210 3 0 1 0 0 – 0 6 6 0 3 3
Nucleus 0 0 0 0 0 0 – 3 2 6 1 1 1 0 1 1 1 – 0 0 0 0 0 2
Nuclear Periphery 1 1 0 0 0 0 – 1 2 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 1 1 1 2 0 0 1 0 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 1 – 2 0 1 0 1 0 0 1 0 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 4 0 3 5 3 0 0 0 0 0 – 0 0 1 2 1 3
Vac/Vac Membrane 1 1 1 0 1 7 – 19 12 5 4 5 0 0 0 0 3 – 1 13 0 4 5 6
Unique Cell Count 184 195 196 241 269 277 397 377 382 263 329 216 225 331 16 20 190 222 192 124 263 284
Labelled Cell Count 187 201 216 282 282 337 500 492 475 363 446 216 226 334 20 22 190 222 192 124 263 284


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 4.7 4.0 3.9 4.7 3.5 – 4.0 3.1 3.6 3.3 3.3 5.3 5.2 5.1 6.6 7.5 – 5.7 5.4 5.3
Std Deviation (1e-4) 1.4 0.9 1.8 1.7 2.0 1.2 – 1.9 1.1 0.9 1.0 1.0 1.7 1.4 1.6 1.4 1.8 – 2.8 2.1 2.0
Intensity Change (Log2) – – – -0.01 0.24 -0.19 – -0.0 -0.37 -0.15 -0.29 -0.28 0.42 0.38 0.35 0.74 0.91 – 0.51 0.45 0.42

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_202468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.4136 0.1836 -0.1488 -0.4315 -0.5659 -0.028 -0.2728 0.0998 0.0943 -0.1137 -0.0706 -0.174 0.9827 1.2203 0.9674 0.8719 0.8572 0.8276
Actin 0.0016 0.0009 0.0007 0.0042 0 0.0033 0.0158 0.0015 0.0076 0.0004 0.0107 0.0012 0.0414 0.0004 0.0169 0.0181 0.0086 0.0007
Bud 0.0003 0.001 0.0018 0.0003 0 0.0001 0.0024 0.005 0.0063 0.0011 0.0017 0.0002 0.0014 0.0121 0.0008 0.0002 0.0006 0.0013
Bud Neck 0.0019 0.0003 0.0002 0.0002 0 0.0013 0.0027 0.0003 0.0005 0.0009 0.0053 0.0004 0.0071 0.0001 0.0037 0.001 0.0004 0.0012
Bud Periphery 0.0005 0.0011 0.0024 0.0005 0 0.0001 0.0073 0.0073 0.0094 0.002 0.0032 0.0002 0.0047 0.0036 0.0013 0.0002 0.0009 0.0013
Bud Site 0.003 0.0044 0.0006 0.0001 0 0.0004 0.0084 0.0075 0.0064 0.0046 0.0148 0.0003 0.0041 0.0021 0.0083 0.0019 0.0016 0.0003
Cell Periphery 0.0004 0.0002 0.0001 0 0 0 0.0013 0.0003 0.0005 0.0004 0.0007 0 0.0008 0.0001 0.0003 0.0001 0.0001 0.0001
Cytoplasm 0.1252 0.1853 0.2133 0.0983 0.176 0.2742 0.2005 0.2843 0.2447 0.3385 0.1982 0.348 0.2407 0.3333 0.2876 0.2993 0.3542 0.4865
Cytoplasmic Foci 0.0033 0.0055 0.0054 0.0047 0.0016 0.0072 0.0222 0.0147 0.0195 0.0153 0.0319 0.0131 0.0206 0.0032 0.0066 0.0071 0.0158 0.0074
Eisosomes 0.0002 0.0002 0.0001 0.0002 0 0.0001 0.0007 0.0003 0.0002 0.0001 0.0002 0 0.0003 0 0.0004 0.0001 0.0002 0
Endoplasmic Reticulum 0.0012 0.0018 0.0011 0.0003 0.0002 0.0009 0.0052 0.0021 0.0039 0.0008 0.0012 0.0012 0.006 0.0006 0.002 0.0034 0.0011 0.0014
Endosome 0.001 0.0014 0.001 0.0004 0.0002 0.0011 0.0175 0.0099 0.0239 0.0266 0.0561 0.006 0.0101 0.0004 0.0095 0.0084 0.0077 0.0022
Golgi 0.0002 0.0002 0.0001 0.0001 0 0.0001 0.0047 0.0019 0.0153 0.0041 0.0354 0.0019 0.0029 0.0001 0.0027 0.0011 0.0054 0.0004
Lipid Particles 0.0005 0.0003 0.0001 0.0002 0 0.0002 0.0086 0.0006 0.0056 0.0015 0.0068 0.0016 0.0103 0.0001 0.0051 0.0005 0.0294 0.0001
Mitochondria 0.0008 0.0003 0.0004 0.0002 0 0.0001 0.0123 0.0008 0.0123 0.0014 0.0303 0.007 0.006 0.0005 0.0138 0.0006 0.0492 0.0097
None 0.8522 0.7924 0.7692 0.8882 0.821 0.7081 0.6546 0.6515 0.6295 0.5781 0.5712 0.6092 0.609 0.6402 0.6247 0.6385 0.4629 0.4807
Nuclear Periphery 0.0048 0.0005 0.0005 0.0003 0.0001 0.0004 0.0052 0.0012 0.002 0.0008 0.0013 0.0011 0.0109 0.0004 0.0017 0.0063 0.0006 0.0007
Nucleolus 0.0002 0.0003 0.0002 0.0001 0 0.0001 0.0008 0.0003 0.0003 0.0007 0.0003 0.0003 0.0006 0.0001 0.0002 0.0003 0.0002 0.0001
Nucleus 0.0014 0.0014 0.0012 0.0005 0.0003 0.001 0.0026 0.0026 0.0021 0.0024 0.0014 0.0027 0.0049 0.0014 0.001 0.0037 0.0023 0.0026
Peroxisomes 0.0002 0.0002 0.0001 0.0004 0 0.0001 0.0168 0.0037 0.0043 0.001 0.0109 0.0027 0.0095 0.0002 0.0099 0.0004 0.0561 0.0013
Punctate Nuclear 0.0006 0.0012 0.0008 0.0006 0.0001 0.0009 0.0026 0.0013 0.0014 0.0009 0.0027 0.0017 0.0055 0.0008 0.0012 0.0043 0.0007 0.001
Vacuole 0.0004 0.0007 0.0004 0.0002 0.0001 0.0003 0.0057 0.0027 0.0035 0.0163 0.0074 0.0009 0.0022 0.0004 0.0017 0.004 0.0015 0.0007
Vacuole Periphery 0.0004 0.0001 0.0001 0.0001 0 0 0.002 0.0003 0.0008 0.0023 0.0083 0.0002 0.001 0.0001 0.0006 0.0005 0.0004 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.0464 8.9671 6.6539 15.0199 8.6704 6.6836 9.8221 11.2188 11.7122 12.2658
Translational Efficiency 1.6675 1.8892 4.1976 2.3201 2.3776 4.1748 2.652 2.4485 2.5257 1.6572

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
237 1399 1106 1200 1531 1951 2176 1596 1768 3350 3282 2796

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 663.57 747.80 889.67 958.65 650.51 786.55 884.08 975.11 652.26 770.37 885.96 968.05
Standard Deviation 71.45 399.46 102.36 150.58 71.61 99.77 105.32 150.00 71.73 269.82 104.36 150.47
Intensity Change Log 2 — 0.172404 0.423022 0.530756 — 0.273967 0.442606 0.583994 — 0.223575 0.432750 0.557356

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000445 0.000451 0.000193 0.004410 0.000170 0.000286 0.000226 0.000829 0.000207 0.000355 0.000215 0.002366
Bud Neck 0.022814 0.032280 0.002999 0.005845 0.017888 0.042277 0.006028 0.006184 0.018549 0.038102 0.005008 0.006038
Bud Site 0.004225 0.017570 0.012238 0.047691 0.003287 0.014210 0.014441 0.046281 0.003413 0.015613 0.013698 0.046886
Cell Periphery 0.000402 0.000138 0.000156 0.000213 0.000111 0.000111 0.000081 0.000134 0.000150 0.000122 0.000107 0.000168
Cytoplasm 0.375659 0.469785 0.438534 0.521009 0.462274 0.433990 0.577876 0.586373 0.450663 0.448938 0.530919 0.558320
Cytoplasmic Foci 0.379165 0.232658 0.014474 0.019586 0.266244 0.243057 0.008686 0.017145 0.281381 0.238714 0.010637 0.018193
Eisosomes 0.000395 0.000119 0.000042 0.000048 0.000181 0.000138 0.000022 0.000036 0.000210 0.000130 0.000029 0.000041
Endoplasmic Reticulum 0.000276 0.000658 0.002252 0.002709 0.000519 0.000490 0.001120 0.001361 0.000487 0.000560 0.001501 0.001940
Endosome 0.014576 0.024734 0.002625 0.006777 0.014664 0.027128 0.002704 0.008088 0.014653 0.026128 0.002678 0.007525
Golgi 0.003977 0.004643 0.000079 0.004834 0.001876 0.004778 0.000283 0.003396 0.002157 0.004721 0.000214 0.004013
Lipid Particles 0.010956 0.005936 0.001936 0.001267 0.012134 0.005091 0.000681 0.001007 0.011976 0.005444 0.001104 0.001119
Mitochondria 0.005757 0.008475 0.001299 0.004418 0.010514 0.009263 0.001681 0.006405 0.009877 0.008934 0.001552 0.005552
Mitotic Spindle 0.000077 0.004119 0.005877 0.048208 0.001340 0.007361 0.014562 0.035926 0.001170 0.006007 0.011635 0.041198
None 0.001834 0.003395 0.006135 0.006209 0.002137 0.001143 0.004841 0.004173 0.002097 0.002084 0.005277 0.005047
Nuclear Periphery 0.000283 0.000425 0.001621 0.001151 0.000513 0.000321 0.001242 0.000685 0.000483 0.000364 0.001369 0.000885
Nuclear Periphery Foci 0.000183 0.001209 0.001184 0.001982 0.000229 0.000243 0.000818 0.001144 0.000223 0.000647 0.000941 0.001504
Nucleolus 0.000655 0.001811 0.000595 0.000257 0.001135 0.001145 0.000271 0.000297 0.001070 0.001423 0.000381 0.000280
Nucleus 0.129474 0.085155 0.449487 0.150385 0.147257 0.086396 0.307427 0.120056 0.144873 0.085878 0.355299 0.133073
Peroxisomes 0.012360 0.017173 0.000398 0.001469 0.008091 0.014522 0.000416 0.003622 0.008664 0.015629 0.000410 0.002698
Vacuole 0.035787 0.087170 0.057668 0.169603 0.048629 0.105954 0.056234 0.150231 0.046908 0.098109 0.056717 0.158545
Vacuole Periphery 0.000700 0.002096 0.000206 0.001926 0.000805 0.002099 0.000360 0.006626 0.000791 0.002098 0.000308 0.004609

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.03 0.49 -1.21 -1.34 -1.66 -1.94 -0.72 -3.36 -1.75 -2.88 -1.86 -0.39 -2.18 -1.62 -2.13
Bud Neck -2.24 5.36 5.00 12.45 -1.74 -9.61 8.50 10.26 17.12 1.73 -9.86 10.62 11.40 21.13 0.88
Bud Site -6.65 -2.19 -5.16 0.04 -2.78 -9.79 -4.89 -7.39 -1.88 -3.84 -12.98 -5.50 -9.58 -1.43 -4.78
Cell Periphery 1.81 1.71 1.91 1.08 2.26 0.25 6.98 3.14 2.22 -3.14 1.42 2.41 2.19 2.18 -0.72
Cytoplasm -5.36 -0.20 -1.37 6.22 -1.77 2.95 -2.76 -1.75 -4.67 0.83 0.19 0.03 0.70 0.58 0.77
Cytoplasmic Foci 8.75 23.01 22.98 38.13 -0.46 3.53 47.09 46.05 47.91 -6.73 6.97 51.37 50.64 61.17 -5.35
Eisosomes 5.66 7.10 7.22 7.41 1.77 4.52 18.47 16.91 16.67 -7.41 7.40 17.69 16.99 16.44 -4.55
Endoplasmic Reticulum -4.65 -15.52 -15.28 -11.71 4.45 0.33 -12.27 -9.32 -9.50 3.41 -1.04 -18.01 -15.11 -14.99 4.52
Endosome -3.99 5.59 5.58 14.39 0.37 -6.93 10.53 9.33 17.49 -1.22 -7.77 11.52 10.75 22.66 -1.08
Golgi -0.33 2.20 1.52 4.41 -1.51 -5.68 8.40 3.29 7.45 -2.64 -5.76 6.87 2.81 8.22 -2.51
Lipid Particles 3.51 6.75 7.30 6.77 2.37 6.75 11.40 11.14 11.53 -3.76 7.01 12.20 12.24 12.29 -0.14
Mitochondria -0.88 1.72 1.59 5.83 -0.60 0.65 5.15 4.63 6.03 -0.97 0.60 5.44 5.05 8.30 -1.11
Mitotic Spindle -4.91 -3.98 -8.72 -7.25 -6.30 -4.16 -6.24 -7.38 -3.80 -0.98 -5.08 -6.95 -11.02 -7.91 -4.84
None -1.13 -2.79 -2.39 -1.55 0.66 2.75 -5.73 -5.99 -13.09 0.04 0.06 -6.69 -6.22 -6.35 0.42
Nuclear Periphery -2.12 -19.81 -18.14 -14.76 1.07 2.49 -15.14 -11.09 -16.56 6.52 1.66 -19.73 -16.37 -21.83 4.84
Nuclear Periphery Foci -2.14 -9.03 -13.95 -1.59 -1.98 -0.44 -5.64 -13.25 -12.33 -2.76 -2.11 -9.69 -18.91 -4.31 -3.93
Nucleolus -4.55 1.04 4.96 6.18 3.75 -0.24 6.55 6.99 9.10 1.25 -2.40 6.11 7.37 9.79 3.50
Nucleus 4.24 -25.10 -4.45 -15.67 28.09 12.84 -32.69 -4.31 -16.98 28.09 14.07 -42.79 -6.40 -23.10 38.82
Peroxisomes -1.76 5.66 5.61 11.48 -0.84 -4.97 11.09 8.96 12.17 -1.88 -6.21 12.42 11.21 16.75 -2.06
Vacuole -11.31 -10.60 -32.89 -26.85 -24.04 -15.76 -12.54 -32.77 -22.87 -24.10 -18.26 -15.54 -45.81 -34.78 -34.16
Vacuole Periphery -5.28 4.75 0.78 4.62 -1.22 -4.66 6.92 -1.27 0.80 -2.25 -6.62 8.29 -0.86 2.44 -2.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic
Localization
Cell Percentages cytoplasm (16%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Grx8

Grx8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Grx8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available