Standard name | |
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Human Ortholog | |
Description | Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 11 | 11 | 15 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 1 | 1 | 1 | 0 | 0 | 4 | 1 | 2 | 6 | 0 | 2 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 2 | 3 | 5 | 16 | 31 | 52 | 32 | 34 | 15 | 9 | 6 | 9 | 3 | 8 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 63 | 104 | 216 | 185 | 332 | 431 | 442 | 545 | 331 | 262 | 143 | 172 | 195 | 517 | 430 | 211 | 154 | 107 | 66 | 111 | 200 | 140 | 351 | 317 |
Endoplasmic Reticulum | 0 | 1 | 1 | 1 | 4 | 10 | 43 | 90 | 18 | 29 | 16 | 16 | 5 | 5 | 5 | 5 | 8 | 5 | 0 | 0 | 1 | 1 | 5 | 7 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 4 | 15 | 4 | 12 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 10 | 1 | 4 | 1 | 1 | 2 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 3 |
Unique Cell Count | 63 | 106 | 217 | 185 | 336 | 448 | 493 | 665 | 372 | 328 | 169 | 202 | 202 | 524 | 437 | 212 | 155 | 108 | 67 | 113 | 208 | 148 | 365 | 341 |
Labelled Cell Count | 63 | 107 | 220 | 190 | 343 | 459 | 526 | 715 | 399 | 370 | 183 | 221 | 209 | 535 | 441 | 226 | 168 | 115 | 67 | 113 | 208 | 148 | 365 | 341 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 59.7 | 70.5 | 55.5 | 58.2 | 52.4 | 42.1 | 36.3 | 33.1 | 28.6 | 25.2 | 27.0 | 24.5 | 92.9 | 89.1 | 84.2 | 63.6 | 76.9 | 89.5 | 73.2 | 70.6 | 68.7 |
Std Deviation (1e-4) | 10.0 | 12.4 | 12.6 | 15.7 | 10.7 | 9.0 | 8.9 | 8.7 | 7.2 | 6.8 | 6.9 | 7.2 | 22.0 | 19.1 | 23.7 | 22.6 | 29.0 | 32.5 | 15.8 | 15.9 | 19.6 |
Intensity Change (Log2) | – | – | – | 0.07 | -0.08 | -0.4 | -0.61 | -0.75 | -0.96 | -1.14 | -1.04 | -1.18 | 0.74 | 0.68 | 0.6 | 0.2 | 0.47 | 0.69 | 0.4 | 0.35 | 0.31 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 2.0 | 3.1 | 3.7 | 3.9 | 4.3 | 3.8 | 2.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.9 | -0.9 | -2.5 | -4.7 | -6.5 | -4.8 | -6.8 | -5.7 | -5.6 | -2.2 | -1.0 | -1.2 | 0 | -0.2 | -0.5 |
Endoplasmic Reticulum | 0 | 0 | 0 | 4.2 | 5.5 | 2.9 | 4.2 | 4.3 | 3.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 0 | 3.6 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 64.6397 | 86.5237 | 75.2012 | 74.9448 | 63.9566 | 77.331 | 57.6094 | 74.6557 | 71.046 | 65.9022 | 43.6942 | 74.2644 | 67.157 | 84.6309 | 74.0498 | 81.4252 | 60.5429 | 76.8047 |
Actin | 0.0171 | 0.0001 | 0.0151 | 0.0002 | 0.002 | 0.0039 | 0.0175 | 0.0001 | 0.0117 | 0.0001 | 0.0613 | 0.0001 | 0.0035 | 0.0002 | 0.0118 | 0.0001 | 0.0034 | 0.0004 |
Bud | 0.0013 | 0.0001 | 0.0005 | 0.0005 | 0.0005 | 0.0002 | 0.0002 | 0.0012 | 0.0002 | 0.0001 | 0.0008 | 0 | 0.0012 | 0.0001 | 0.0005 | 0.0001 | 0.0012 | 0.0002 |
Bud Neck | 0.0007 | 0.0003 | 0.0005 | 0.0008 | 0.0004 | 0.0009 | 0.0007 | 0.0001 | 0.0002 | 0.0003 | 0.0004 | 0.0005 | 0.0006 | 0.0001 | 0.0002 | 0.0002 | 0.0005 | 0.0006 |
Bud Periphery | 0.0016 | 0 | 0.0007 | 0.0001 | 0.0007 | 0.0002 | 0.0001 | 0.0006 | 0.0001 | 0 | 0.001 | 0 | 0.0007 | 0 | 0.0003 | 0 | 0.001 | 0 |
Bud Site | 0.0031 | 0.0001 | 0.0017 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0002 | 0.0014 | 0 | 0.002 | 0 | 0.0023 | 0 | 0.0003 | 0 | 0.0019 | 0 |
Cell Periphery | 0.0018 | 0.0004 | 0.0004 | 0.0004 | 0.0009 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0004 | 0 | 0.0003 | 0 | 0.0003 | 0 | 0.0004 | 0 |
Cytoplasm | 0.8558 | 0.9823 | 0.9262 | 0.9234 | 0.8549 | 0.9134 | 0.9131 | 0.9924 | 0.9774 | 0.9942 | 0.6738 | 0.9902 | 0.9023 | 0.9975 | 0.9412 | 0.9951 | 0.813 | 0.9829 |
Cytoplasmic Foci | 0.002 | 0.0002 | 0.0079 | 0.0011 | 0.0024 | 0.0018 | 0.0134 | 0.0003 | 0.0019 | 0.0008 | 0.0347 | 0.0018 | 0.0105 | 0.0002 | 0.007 | 0.0005 | 0.0733 | 0.0021 |
Eisosomes | 0.0002 | 0 | 0.0002 | 0 | 0.0008 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0011 | 0 | 0.0001 | 0 | 0 | 0 | 0.0003 | 0 |
Endoplasmic Reticulum | 0.0112 | 0.0041 | 0.0044 | 0.003 | 0.0007 | 0.0162 | 0.011 | 0.0001 | 0.0006 | 0.0003 | 0.0013 | 0.002 | 0.0023 | 0.0005 | 0.0017 | 0.0002 | 0.0041 | 0.0036 |
Endosome | 0.0045 | 0.0003 | 0.0051 | 0.0037 | 0.0031 | 0.0192 | 0.0069 | 0.0001 | 0.0008 | 0.0005 | 0.0097 | 0.0024 | 0.0106 | 0.0001 | 0.0014 | 0.0003 | 0.0039 | 0.0042 |
Golgi | 0.0011 | 0 | 0.0015 | 0.0003 | 0.0004 | 0.0022 | 0.0039 | 0 | 0.0013 | 0 | 0.015 | 0.0001 | 0.0036 | 0 | 0.0005 | 0 | 0.0011 | 0.0002 |
Lipid Particles | 0.0015 | 0 | 0.0023 | 0.0001 | 0.0009 | 0.0007 | 0.0033 | 0 | 0.0001 | 0 | 0.0299 | 0 | 0.0087 | 0 | 0.0009 | 0 | 0.019 | 0 |
Mitochondria | 0.0059 | 0 | 0.0071 | 0.0001 | 0.0681 | 0.0035 | 0.0008 | 0.0001 | 0.0003 | 0 | 0.1012 | 0 | 0.0119 | 0 | 0.0022 | 0 | 0.0106 | 0.0003 |
None | 0.0013 | 0.0001 | 0.0074 | 0.0001 | 0.0031 | 0.0005 | 0.0037 | 0.0001 | 0.0013 | 0.0001 | 0.0226 | 0.0001 | 0.0013 | 0 | 0.0029 | 0.0001 | 0.0271 | 0.0002 |
Nuclear Periphery | 0.0315 | 0.0019 | 0.004 | 0.006 | 0.0041 | 0.0169 | 0.0115 | 0.0002 | 0.0005 | 0.0006 | 0.0043 | 0.001 | 0.0042 | 0.0003 | 0.0024 | 0.0011 | 0.0051 | 0.002 |
Nucleolus | 0.0005 | 0 | 0.0004 | 0 | 0.0026 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0.0054 | 0 | 0.0011 | 0 | 0.0034 | 0 | 0.0047 | 0 |
Nucleus | 0.0154 | 0.0012 | 0.0029 | 0.0036 | 0.0038 | 0.0042 | 0.0058 | 0.0005 | 0.0006 | 0.0009 | 0.0038 | 0.0006 | 0.0047 | 0.0004 | 0.0031 | 0.0011 | 0.0047 | 0.0009 |
Peroxisomes | 0.0013 | 0 | 0.0004 | 0 | 0.0003 | 0.0001 | 0.0028 | 0 | 0.0005 | 0 | 0.0128 | 0 | 0.0032 | 0 | 0.0009 | 0 | 0.004 | 0 |
Punctate Nuclear | 0.0003 | 0 | 0.0013 | 0 | 0.0001 | 0.0007 | 0.0021 | 0 | 0.0002 | 0 | 0.0023 | 0 | 0.0028 | 0 | 0.0016 | 0 | 0.0145 | 0 |
Vacuole | 0.0307 | 0.0075 | 0.0082 | 0.043 | 0.0214 | 0.011 | 0.0015 | 0.0033 | 0.0005 | 0.0014 | 0.0069 | 0.0008 | 0.0143 | 0.0004 | 0.0082 | 0.0009 | 0.0038 | 0.0015 |
Vacuole Periphery | 0.0113 | 0.0011 | 0.0021 | 0.0133 | 0.0287 | 0.0041 | 0.0007 | 0.0006 | 0.0001 | 0.0004 | 0.0093 | 0.0003 | 0.01 | 0.0001 | 0.0091 | 0.0003 | 0.0026 | 0.0007 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 328.8454 | 300.5561 | 356.1891 | 309.375 | 291.6738 | 256.0558 | 281.8455 | 281.7539 | 269.7833 | 274.2061 |
Translational Efficiency | 0.872 | 0.9802 | 0.8625 | 0.8731 | 0.8995 | 1.0429 | 0.962 | 0.8061 | 0.8196 | 0.8373 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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