Standard name
Human Ortholog
Description Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.12 0.08 0.14 0.1 0.07 0 0 0 0 0 0 0 0.13 0 0 0.24 0.12 0.08 0 0 0 0.06 0.08 0
Bud 0 0 0 0 0 0 0 0 0.06 0.05 0 0.05 0 0 0 0 0.05 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.15 0.09 0.12 0.05 0 0 0 0 0 0 0.08 0.09 0.09 0.42 0.34 0.29 0 0 0 0 0.06 0.07
Cytoplasm 0.18 0.25 0.21 0.4 0.47 0.49 0.47 0.47 0.43 0.47 0.42 0.47 0.23 0.35 0.49 0.18 0.24 0.21 0 0.08 0 0 0 0
Endoplasmic Reticulum 0.69 0.65 0.55 0.37 0.29 0.23 0.27 0.22 0.07 0.11 0.07 0.16 0.64 0.6 0.43 0.06 0.05 0 0.76 0.69 0.63 0.74 0.64 0.64
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Mitochondria 0.06 0 0 0.11 0.07 0.23 0.23 0.13 0.5 0.43 0.5 0.25 0.05 0 0 0 0 0.12 0.05 0.07 0.15 0 0.1 0.08
Nucleus 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.05 0.06 0.09 0.11 0.08 0.16 0.11 0.09 0.13 0.13 0 0 0.07 0.16 0.22 0.25 0.05 0.06 0.05 0.07 0 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 46 23 49 30 25 10 15 15 5 5 4 13 31 9 6 12 5 2 18 10 24 6 21 10
Bud 14 9 13 9 3 9 13 7 23 20 13 22 7 3 1 2 2 1 4 1 3 1 1 0
Bud Neck 1 0 0 0 1 1 0 3 2 0 0 1 0 0 0 0 0 0 4 4 6 0 2 2
Bud Site 0 0 0 0 0 0 3 0 4 0 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 14 12 52 26 42 22 13 10 12 8 5 12 19 20 24 21 14 7 5 6 17 1 16 15
Cytoplasm 68 74 74 115 161 213 262 198 174 175 139 204 57 77 129 9 10 5 14 28 22 3 7 3
Endoplasmic Reticulum 255 194 193 108 100 101 149 93 27 39 22 68 159 130 113 3 2 1 329 250 342 78 174 153
Endosome 0 1 0 3 3 3 4 2 0 0 0 4 0 0 10 0 0 0 3 1 4 1 2 4
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 3 0 4 3 4 0 2 3
Mitochondria 24 13 6 33 23 101 126 53 204 158 166 110 13 3 4 2 1 3 20 25 81 4 26 19
Nucleus 0 0 5 1 4 5 9 19 1 7 3 7 1 1 0 2 2 0 0 2 0 0 0 0
Nuclear Periphery 2 1 0 0 0 0 0 1 0 0 2 0 1 1 0 0 0 0 0 0 0 0 4 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 1 1 1 0 1 3 4 0 0 1 0 0 0 1 0 0 0 0 0 0 0 0
Vac/Vac Membrane 14 8 18 17 31 47 46 69 45 33 42 58 4 1 18 8 9 6 20 21 25 7 9 18
Unique Cell Count 372 300 349 289 342 436 555 421 406 370 331 434 247 218 264 50 41 24 432 362 541 106 274 240
Labelled Cell Count 439 335 411 343 394 512 641 473 501 445 397 502 292 245 307 62 48 25 432 362 541 106 274 240


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.3 7.2 7.1 6.4 6.5 5.3 5.3 5.6 4.6 4.6 4.4 5.0 7.4 7.6 7.9 10.2 10.1 10.3 7.2 7.2 8.0
Std Deviation (1e-4) 1.0 1.0 0.7 0.9 1.1 1.1 0.8 0.9 0.8 0.9 0.9 0.7 1.1 1.0 1.2 1.4 1.4 1.1 1.2 1.4 1.8
Intensity Change (Log2) – – – -0.15 -0.12 -0.42 -0.41 -0.33 -0.63 -0.64 -0.68 -0.49 0.07 0.1 0.16 0.53 0.51 0.54 0.02 0.01 0.17

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.4 -2.9 -6.2 -6.5 -5.2 0 0 0 -5.7 -0.5 -3.8 -5.0 1.8 -0.3 0
Bud -0.4 -2.5 -1.4 -1.2 -1.8 0 0 0 0.9 -0.6 -1.6 -2.7 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.3 -1.0 -4.7 -7.1 -6.4 0 0 0 -6.2 -2.7 -2.0 -2.2 4.6 3.1 0
Cytoplasm 5.1 7.2 8.0 7.9 7.5 6.3 7.3 5.8 7.5 0.5 3.7 7.2 -0.5 0.5 0
Endoplasmic Reticulum -4.5 -6.9 -9.2 -8.6 -9.5 0 0 0 -11.7 2.2 1.0 -3.1 -6.5 -6.1 -4.9
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 5.1 3.3 8.7 8.7 5.6 0 0 0 9.3 2.4 0 0 0 0 0
Nucleus 0 0 0 0.2 2.4 0 0.5 0 0.2 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.4 2.0 2.8 1.8 4.9 2.9 2.0 3.5 3.9 -2.3 -3.0 0.9 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.1367 3.029 2.7431 2.4045 2.0018 2.6652 3.9377 4.3485 4.13 3.7611 3.4185 3.9505 3.5433 3.5361 3.3499 3.6721 3.0656 3.5917
Actin 0.0487 0.0084 0.0197 0.0142 0.0158 0.0152 0.0352 0.0045 0.0158 0.0054 0.0076 0.0033 0.0115 0.0065 0.0119 0.0023 0.0114 0.0034
Bud 0.001 0.0014 0.007 0.0028 0.0004 0.0005 0.0006 0.0005 0.0013 0.0003 0.0005 0.0001 0.0004 0.0003 0.0033 0.0003 0.0003 0.0001
Bud Neck 0.0029 0.0016 0.0026 0.0004 0.0013 0.0258 0.0014 0.0007 0.0018 0.0008 0.0032 0.0065 0.0033 0.001 0.0007 0.0005 0.0007 0.007
Bud Periphery 0.0015 0.0014 0.0108 0.0079 0.0008 0.001 0.0009 0.0004 0.0034 0.0006 0.0007 0.0003 0.0005 0.0004 0.0078 0.0006 0.0005 0.0003
Bud Site 0.0185 0.0179 0.0237 0.0004 0.0014 0.0009 0.0079 0.02 0.0108 0.001 0.001 0.0001 0.0106 0.0176 0.0016 0.0002 0.0009 0.0002
Cell Periphery 0.0028 0.0048 0.0045 0.0007 0.0007 0.0014 0.002 0.0035 0.0055 0.0009 0.0012 0.0008 0.0011 0.0035 0.0015 0.0016 0.0004 0.0007
Cytoplasm 0.2587 0.3937 0.3227 0.2394 0.1587 0.3751 0.1034 0.2278 0.2089 0.1104 0.1955 0.1757 0.1855 0.3362 0.2117 0.2893 0.2633 0.2664
Cytoplasmic Foci 0.0247 0.019 0.0262 0.0111 0.0124 0.0249 0.0225 0.015 0.0132 0.0094 0.0151 0.0104 0.0221 0.0125 0.0238 0.0039 0.0168 0.0141
Eisosomes 0.0005 0.0002 0.0003 0.0001 0.0001 0.0001 0.0004 0.0001 0.0003 0.0001 0.0002 0.0001 0.0003 0.0004 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.4095 0.4188 0.3879 0.5777 0.5326 0.3966 0.6377 0.6255 0.6192 0.7722 0.6554 0.7019 0.6151 0.5418 0.6234 0.6582 0.5429 0.6238
Endosome 0.0628 0.0549 0.0615 0.0553 0.0989 0.0765 0.0495 0.0461 0.0488 0.028 0.0366 0.0454 0.0406 0.0226 0.0386 0.0089 0.0757 0.0353
Golgi 0.0148 0.0077 0.0256 0.0049 0.0171 0.0141 0.0268 0.0074 0.0142 0.0149 0.0118 0.0079 0.0073 0.0052 0.0082 0.0009 0.0088 0.0091
Lipid Particles 0.0376 0.0115 0.0189 0.0023 0.0089 0.0109 0.0225 0.0174 0.0077 0.0068 0.0043 0.0063 0.019 0.0133 0.0146 0.0022 0.0157 0.0068
Mitochondria 0.0142 0.003 0.0204 0.054 0.0628 0.0102 0.0201 0.0024 0.0124 0.0233 0.0294 0.0148 0.0039 0.0032 0.0028 0.0014 0.0053 0.0019
None 0.0219 0.0145 0.0291 0.0025 0.0052 0.0071 0.0139 0.0033 0.0094 0.0069 0.007 0.0026 0.0327 0.0107 0.0148 0.0054 0.0035 0.0114
Nuclear Periphery 0.0335 0.0165 0.0168 0.0128 0.0461 0.0161 0.0191 0.014 0.0127 0.0106 0.0175 0.014 0.0207 0.0116 0.0175 0.0159 0.0225 0.0091
Nucleolus 0.0016 0.0004 0.0003 0.0001 0.0004 0.0002 0.0002 0.0002 0.0002 0.0001 0.0002 0 0.0013 0.0002 0.0003 0 0.0004 0.0001
Nucleus 0.0086 0.0102 0.0043 0.003 0.0085 0.0053 0.0021 0.0022 0.0037 0.0011 0.0036 0.0024 0.0037 0.004 0.0029 0.0024 0.008 0.0034
Peroxisomes 0.0095 0.0003 0.006 0.0003 0.0043 0.0061 0.0238 0.0003 0.0007 0.0033 0.0006 0.0006 0.0079 0.0007 0.006 0 0.0054 0.0005
Punctate Nuclear 0.0037 0.0012 0.0014 0.0006 0.0015 0.0014 0.001 0.0016 0.0007 0.0003 0.0018 0.0004 0.0065 0.0013 0.0026 0.0003 0.0074 0.0012
Vacuole 0.0187 0.0114 0.0083 0.0076 0.0176 0.0083 0.0061 0.006 0.0077 0.0027 0.0053 0.0048 0.005 0.0064 0.0047 0.0047 0.0082 0.0046
Vacuole Periphery 0.0044 0.0012 0.0019 0.002 0.0046 0.0022 0.0029 0.001 0.0016 0.0008 0.0015 0.0016 0.0011 0.0006 0.0011 0.0009 0.0019 0.0007

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.6196 11.5772 8.2471 18.1508 16.7912 19.6743 19.1973 18.4873 17.8158 18.5351
Translational Efficiency 1.5062 1.2365 1.7267 0.922 0.771 0.7786 0.9617 0.6847 0.8539 0.9725

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
919 537 1106 1460 1889 524 1149 109 2808 1061 2255 1569

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 824.12 943.99 1123.89 1098.68 874.87 898.03 1108.27 1080.83 858.26 921.29 1115.93 1097.44
Standard Deviation 387.80 135.80 155.37 134.02 124.39 135.38 144.99 122.02 245.35 137.53 150.38 133.30
Intensity Change Log 2 — 0.195917 0.447575 0.414845 — 0.037695 0.341169 0.304999 — 0.116611 0.393763 0.359326

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003950 0.006894 0.004545 0.036743 0.002311 0.005067 0.009539 0.028681 0.002848 0.005992 0.007090 0.036183
Bud Neck 0.005009 0.006739 0.008277 0.019201 0.003078 0.005521 0.011250 0.007165 0.003710 0.006137 0.009792 0.018365
Bud Site 0.018678 0.029657 0.026238 0.094239 0.009814 0.021323 0.033064 0.055822 0.012715 0.025541 0.029716 0.091570
Cell Periphery 0.012634 0.002945 0.000612 0.010111 0.002137 0.006374 0.002617 0.004289 0.005573 0.004639 0.001634 0.009706
Cytoplasm 0.161587 0.112293 0.196290 0.178175 0.182592 0.126023 0.176701 0.114695 0.175717 0.119074 0.186309 0.173765
Cytoplasmic Foci 0.073078 0.110205 0.080359 0.051101 0.091940 0.085038 0.041468 0.094909 0.085767 0.097776 0.060543 0.054144
Eisosomes 0.004094 0.001513 0.000231 0.004192 0.001276 0.001783 0.001040 0.001962 0.002198 0.001646 0.000643 0.004037
Endoplasmic Reticulum 0.491825 0.532286 0.232592 0.356709 0.498106 0.543378 0.468103 0.339401 0.496050 0.537764 0.352593 0.355507
Endosome 0.014368 0.029153 0.041335 0.020564 0.018136 0.026404 0.016993 0.027375 0.016903 0.027796 0.028932 0.021037
Golgi 0.066837 0.052023 0.004115 0.015345 0.056759 0.060419 0.005209 0.005514 0.060058 0.056169 0.004672 0.014662
Lipid Particles 0.063781 0.044665 0.073878 0.065024 0.061625 0.054638 0.049371 0.072299 0.062331 0.049591 0.061390 0.065530
Mitochondria 0.031869 0.016650 0.000739 0.002775 0.020082 0.020465 0.000905 0.000574 0.023940 0.018534 0.000824 0.002622
Mitotic Spindle 0.000163 0.000890 0.008012 0.009735 0.000686 0.000331 0.002630 0.004601 0.000515 0.000614 0.005270 0.009378
None 0.002144 0.000656 0.001584 0.000546 0.005778 0.001424 0.000502 0.000044 0.004588 0.001035 0.001033 0.000511
Nuclear Periphery 0.000386 0.000490 0.022554 0.000639 0.001380 0.000779 0.006052 0.002200 0.001055 0.000633 0.014146 0.000747
Nuclear Periphery Foci 0.001785 0.003477 0.121217 0.013940 0.005066 0.002694 0.056559 0.057855 0.003993 0.003090 0.088272 0.016991
Nucleolus 0.000104 0.000139 0.000558 0.000234 0.000343 0.000160 0.000188 0.000090 0.000265 0.000149 0.000369 0.000224
Nucleus 0.004627 0.003615 0.036393 0.024593 0.010179 0.003567 0.037029 0.010302 0.008362 0.003592 0.036717 0.023600
Peroxisomes 0.029743 0.010456 0.002385 0.006073 0.007728 0.011746 0.002270 0.008942 0.014933 0.011093 0.002327 0.006273
Vacuole 0.006046 0.023252 0.136750 0.087182 0.014409 0.014520 0.077935 0.162289 0.011672 0.018939 0.106781 0.092400
Vacuole Periphery 0.007291 0.012001 0.001335 0.002877 0.006575 0.008345 0.000574 0.000990 0.006809 0.010195 0.000947 0.002746

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.31 -0.54 -13.32 -10.99 -12.40 -2.36 -5.31 -3.04 -2.68 -2.13 -3.62 -4.87 -14.21 -12.21 -11.76
Bud Neck -1.20 -2.78 -10.18 -7.46 -7.22 -2.17 -6.52 -3.79 -1.23 2.71 -2.73 -7.23 -12.68 -9.13 -6.29
Bud Site -2.71 -2.23 -15.06 -11.20 -12.57 -3.61 -7.05 -4.01 -2.95 -1.95 -5.13 -7.38 -17.88 -13.45 -12.74
Cell Periphery 6.67 8.53 1.88 -8.61 -12.98 -3.88 -0.70 -1.28 1.28 -0.98 1.24 6.82 -4.41 -5.45 -10.91
Cytoplasm 6.27 -3.88 -2.57 -8.76 1.71 7.10 0.61 4.46 0.48 3.91 10.20 -1.86 -0.09 -8.62 1.49
Cytoplasmic Foci -5.17 -1.52 5.01 8.85 7.24 1.17 12.35 -0.23 -0.71 -3.84 -2.57 7.64 9.38 9.28 2.29
Eisosomes 3.82 6.26 0.09 -5.48 -10.38 -2.04 1.39 -0.95 -0.13 -1.35 1.96 6.82 -4.14 -5.78 -9.25
Endoplasmic Reticulum -2.16 19.77 10.66 10.88 -9.76 -2.64 3.80 5.23 6.12 3.66 -3.34 16.60 14.57 14.34 -0.19
Endosome -7.07 -14.96 -4.10 3.94 10.54 -3.31 0.79 -2.50 -0.24 -2.77 -6.62 -10.02 -2.91 3.76 5.43
Golgi 2.92 18.03 14.22 9.63 -8.16 -0.75 24.42 22.39 12.09 -0.22 1.14 30.54 21.69 13.62 -7.82
Lipid Particles 4.29 -2.03 -0.35 -4.75 1.74 1.40 3.20 -0.90 -1.45 -1.91 3.86 0.38 -0.98 -4.09 -1.24
Mitochondria 4.10 11.60 10.74 5.41 -4.13 -0.11 16.09 15.93 6.26 1.02 2.29 19.39 16.96 7.74 -3.89
Mitotic Spindle -2.04 -4.94 -5.54 -5.03 -0.69 1.01 -3.26 -1.17 -1.29 -0.44 -0.32 -5.66 -5.40 -5.37 -2.13
None 2.53 0.78 3.05 0.39 1.59 4.48 6.21 6.74 2.78 3.59 5.42 5.39 6.72 1.72 1.50
Nuclear Periphery -0.75 -10.55 -2.00 -1.06 10.40 1.20 -5.85 -1.03 -1.68 3.78 1.49 -11.63 1.35 -0.53 11.99
Nuclear Periphery Foci -2.65 -23.66 -13.10 -9.77 20.77 3.02 -16.23 -4.48 -4.69 -0.07 1.54 -27.68 -10.19 -11.22 21.76
Nucleolus -0.69 -7.53 -2.61 -1.45 3.98 2.55 3.01 5.78 1.17 3.44 2.43 -2.64 0.54 -1.34 2.42
Nucleus 0.90 -13.25 -10.96 -13.93 3.88 9.87 -12.91 -0.34 -4.63 10.69 8.12 -18.33 -10.56 -14.28 5.79
Peroxisomes 8.40 14.18 12.17 3.42 -7.17 -2.89 9.43 -0.33 1.20 -2.59 3.24 16.49 10.32 5.02 -8.09
Vacuole -6.76 -26.19 -21.93 -15.76 6.93 -0.04 -17.49 -7.70 -7.68 -4.02 -4.25 -30.30 -21.89 -19.24 2.36
Vacuole Periphery -2.76 7.97 5.02 5.69 -2.53 -1.43 12.40 10.92 6.35 -1.47 -3.25 14.40 6.59 6.99 -3.26
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope
Localization
Cell Percentages ER (98%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Sec39

Sec39


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sec39-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available