Standard name
Human Ortholog
Description Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.08 0.06 0.06 0 0 0 0 0.05 0 0.05 0.12 0.16 0.18 0.05 0 0.07 0 0 0 0.05 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.18 0 0 0.06 0.06 0.2 0.32 0.2 0.42 0.29 0.56 0.34 0 0 0 0 0 0 0 0 0 0.08 0.07 0.07
Nucleus 0.91 0.91 0.89 0.91 0.88 0.88 0.81 0.82 0.75 0.77 0.71 0.77 0.87 0.83 0.79 0.88 0.86 0.9 0.85 0.82 0.75 0.5 0.44 0.42
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0 0.08 0.09 0.14 0.26 0.3 0.29
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 1 1 2
Bud 0 0 0 1 2 3 9 8 7 10 7 8 0 0 0 0 0 1 6 11 8 2 10 13
Bud Neck 0 0 0 0 0 0 0 0 0 1 1 2 0 1 1 0 1 0 0 0 0 1 4 5
Bud Site 0 0 1 0 3 9 7 2 14 14 18 13 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 0 0 0 0
Cytoplasm 11 30 30 20 35 13 26 28 29 29 18 27 24 42 64 15 12 20 3 6 6 15 17 14
Endoplasmic Reticulum 0 2 2 0 1 0 0 1 0 0 0 0 0 0 0 10 4 3 1 1 1 0 2 4
Endosome 0 6 0 1 5 0 0 2 2 0 0 0 0 2 2 2 5 0 2 5 2 3 8 12
Golgi 0 2 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 1 1 6 1 0 1 1
Mitochondria 92 6 11 19 33 86 226 134 296 186 252 170 1 1 0 13 13 12 7 3 13 27 33 34
Nucleus 469 578 332 302 497 384 561 555 524 486 322 391 175 222 278 260 304 257 454 545 310 167 223 210
Nuclear Periphery 1 1 0 2 3 1 3 0 15 1 4 3 0 0 0 7 1 1 0 2 1 1 3 3
Nucleolus 1 0 0 0 5 1 30 15 18 25 10 3 0 0 0 2 4 0 1 3 1 8 14 16
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 3 3 3 4 3 9 3 10 3 3 3 2 7 0 4 1 8 11 5 8 16 18
Vac/Vac Membrane 21 35 4 6 24 6 9 18 13 27 14 18 4 8 11 14 27 5 44 56 57 85 152 146
Unique Cell Count 518 636 374 333 567 436 696 673 698 634 451 506 202 269 352 294 353 285 534 663 416 335 502 500
Labelled Cell Count 595 660 383 354 611 507 874 772 921 789 649 638 209 278 364 326 376 301 534 663 416 335 502 500


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 6.9 5.8 5.6 6.0 5.2 4.9 5.6 4.5 5.0 4.5 4.9 6.0 6.2 6.1 7.9 8.5 8.3 5.8 6.0 6.3
Std Deviation (1e-4) 0.7 1.4 1.2 1.5 1.6 1.4 1.2 1.3 1.1 1.3 1.3 1.3 1.1 1.3 1.2 1.7 1.9 1.9 1.6 1.5 1.7
Intensity Change (Log2) -0.06 0.05 -0.17 -0.25 -0.05 -0.38 -0.23 -0.38 -0.24 0.05 0.1 0.07 0.44 0.55 0.52 -0.01 0.04 0.11


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 2.5 0 2.7 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.0 -1.1 -3.2 -3.0 -2.6 -2.6 -2.3 -2.5 -1.6 1.5 3.0 4.1 -1.5 -2.7 -0.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 2.8 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.8 2.0 7.3 0 7.6 0 10.2 0 11.1 0 -2.4 -3.2 1.0 0.6 0.9
Nucleus 0.8 -0.5 -0.3 -3.4 -2.7 -5.3 -4.8 -6.1 -4.4 -0.8 -2.3 -3.6 -0.1 -1.1 0.6
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 2.9 0 3.9 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.8 0 0 1.7 1.0 2.8 2.0 2.3 0 1.8 1.9 2.9 4.4 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.8157 2.6661 2.7495 2.5638 1.6364 2.5605 1.5343 2.2582 2.4298 1.6963 1.267 1.8419 2.3618 2.1179 1.9282 2.1485 3.284 1.8049
Actin 0.0365 0.0001 0.0324 0.0214 0.0002 0.0057 0.0082 0 0.0034 0 0.0005 0.0006 0.0127 0.0008 0.0001 0.033 0.0129 0.0025
Bud 0.0006 0.0001 0.0014 0.0032 0 0.0002 0.0001 0 0.0004 0 0.0001 0 0.0009 0 0 0.0004 0.0034 0.0001
Bud Neck 0.0026 0.0004 0.0023 0.0005 0.0004 0.0016 0.0008 0.0002 0.0009 0.0001 0.0018 0.0016 0.007 0.0003 0.0001 0.0017 0.0018 0.0013
Bud Periphery 0.0012 0.0002 0.0028 0.0058 0 0.0007 0.0001 0 0.0006 0 0.0001 0.0001 0.0021 0.0001 0.0001 0.0004 0.0057 0.0001
Bud Site 0.003 0.0018 0.0026 0.002 0 0.0003 0.0003 0.0003 0.0012 0 0.0004 0.0002 0.0114 0.0004 0.0002 0.0018 0.0345 0.0002
Cell Periphery 0.0005 0.0001 0.0004 0.0004 0 0.0002 0 0 0.0001 0 0 0 0.0012 0 0.0001 0.0002 0.0004 0
Cytoplasm 0.0227 0.0122 0.0027 0.0191 0.0068 0.0061 0.004 0.0036 0.0017 0.0003 0.0028 0.0013 0.0162 0.0075 0.0036 0.0047 0.0452 0.0022
Cytoplasmic Foci 0.0129 0.0007 0.0064 0.0034 0.0001 0.0025 0.0007 0.0001 0.002 0 0.0002 0.0003 0.0138 0.0012 0.0059 0.0163 0.0242 0.004
Eisosomes 0.0003 0 0 0.0002 0 0 0.0001 0 0 0 0 0 0.0003 0 0 0.0001 0.0002 0
Endoplasmic Reticulum 0.0034 0.0004 0.0006 0.0048 0.0002 0.0006 0.0006 0.0002 0.0003 0 0.0003 0.0001 0.0103 0.0009 0.0002 0.0004 0.0016 0.0001
Endosome 0.03 0.0008 0.0118 0.023 0.0004 0.0051 0.0036 0.0009 0.0011 0 0.0006 0.0005 0.0306 0.0007 0.0014 0.0136 0.0377 0.0029
Golgi 0.0101 0.0002 0.0045 0.0132 0 0.0055 0.0009 0 0.0005 0 0.0001 0.0003 0.007 0.0002 0.0005 0.007 0.0141 0.003
Lipid Particles 0.0134 0.0009 0.0032 0.018 0 0.0089 0.0034 0 0.0005 0 0.0001 0.0013 0.0225 0.0004 0.0013 0.0026 0.031 0.0114
Mitochondria 0.0111 0.0016 0.0117 0.0393 0.0003 0.0035 0.0016 0.0001 0.0012 0.0001 0.0003 0.0022 0.022 0.0002 0.0055 0.0014 0.0175 0.0038
None 0.0083 0.0197 0.0003 0.0033 0.0022 0.0066 0.0107 0.0031 0.0005 0.0001 0.0669 0.0002 0.0185 0.0064 0.0084 0.0005 0.0027 0.0045
Nuclear Periphery 0.0255 0.0061 0.0078 0.0228 0.0109 0.0045 0.0145 0.0067 0.0041 0.0013 0.0051 0.0034 0.0207 0.0069 0.0033 0.001 0.0194 0.0031
Nucleolus 0.0118 0.0102 0.0044 0.0046 0.0105 0.0119 0.0129 0.0066 0.0053 0.0031 0.0206 0.0139 0.014 0.007 0.0039 0.0039 0.0206 0.0126
Nucleus 0.7798 0.932 0.891 0.801 0.9469 0.93 0.8967 0.9551 0.9655 0.9942 0.8834 0.9662 0.753 0.9581 0.9581 0.9012 0.6879 0.9297
Peroxisomes 0.0034 0.0003 0.0035 0.0024 0 0.0037 0.0009 0 0.001 0 0 0.0031 0.0114 0.0018 0.0018 0.0058 0.0104 0.0051
Punctate Nuclear 0.0089 0.0111 0.0007 0.0055 0.0208 0.001 0.0389 0.0219 0.0092 0.0008 0.0163 0.0043 0.008 0.006 0.0043 0.0027 0.0179 0.0131
Vacuole 0.0102 0.0008 0.0071 0.003 0.0001 0.0008 0.0005 0.0009 0.0005 0 0.0003 0.0003 0.0116 0.0009 0.0007 0.0013 0.0075 0.0003
Vacuole Periphery 0.004 0.0002 0.0022 0.0033 0.0001 0.0006 0.0004 0.0003 0.0002 0 0.0001 0.0002 0.0049 0.0002 0.0002 0.0002 0.0032 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 40.356 21.9195 15.5875 18.1282 27.1551 25.5276 15.9295 13.7118 19.683 31.0694
Translational Efficiency 1.1162 0.8758 0.7812 0.8216 1.2499 2.0212 1.5095 1.1263 0.9861 1.3543

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1897 1354 2645 921 1467 1952 209 1496 3364 3306 2854 2417

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 724.93 812.08 895.60 943.66 691.07 764.42 967.39 950.92 710.16 783.94 900.86 948.15
Standard Deviation 101.35 121.46 143.01 146.72 93.34 103.56 132.91 147.47 99.37 113.68 143.51 147.23
Intensity Change Log 2 0.163780 0.305013 0.380425 0.145534 0.485266 0.460492 0.154904 0.395799 0.420057

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000105 0.000469 0.000479 0.000872 0.000195 0.000154 0.000585 0.004295 0.000144 0.000283 0.000487 0.002991
Bud Neck 0.003904 0.011769 0.019434 0.015768 0.003598 0.004267 0.003615 0.030796 0.003771 0.007339 0.018275 0.025070
Bud Site 0.000958 0.002974 0.002593 0.004360 0.001184 0.000674 0.000601 0.021878 0.001056 0.001616 0.002447 0.015202
Cell Periphery 0.000183 0.000219 0.000184 0.000181 0.000235 0.000131 0.000065 0.000236 0.000205 0.000167 0.000175 0.000215
Cytoplasm 0.028695 0.026641 0.009763 0.025121 0.038495 0.008231 0.004770 0.063071 0.032969 0.015771 0.009397 0.048610
Cytoplasmic Foci 0.002582 0.002512 0.000266 0.000318 0.004014 0.000344 0.001117 0.002112 0.003207 0.001232 0.000329 0.001428
Eisosomes 0.000014 0.000021 0.000022 0.000029 0.000020 0.000013 0.000041 0.000031 0.000017 0.000016 0.000023 0.000030
Endoplasmic Reticulum 0.003108 0.007944 0.004896 0.009114 0.002410 0.004017 0.005985 0.008274 0.002804 0.005625 0.004976 0.008594
Endosome 0.000463 0.001437 0.000611 0.000695 0.000780 0.000825 0.000269 0.004964 0.000602 0.001076 0.000586 0.003337
Golgi 0.000056 0.000436 0.000117 0.000124 0.000146 0.000036 0.000044 0.001940 0.000095 0.000200 0.000112 0.001248
Lipid Particles 0.000653 0.001165 0.000079 0.000250 0.001026 0.000276 0.000595 0.000461 0.000815 0.000640 0.000117 0.000381
Mitochondria 0.001126 0.001834 0.001920 0.002033 0.001142 0.000925 0.000644 0.008658 0.001133 0.001297 0.001827 0.006133
Mitotic Spindle 0.001026 0.004294 0.003467 0.009268 0.002035 0.000614 0.000239 0.039775 0.001466 0.002121 0.003231 0.028150
None 0.008831 0.007540 0.003090 0.006089 0.013489 0.004699 0.003631 0.007387 0.010862 0.005863 0.003129 0.006892
Nuclear Periphery 0.001570 0.001547 0.001518 0.001546 0.000731 0.001025 0.000556 0.004402 0.001204 0.001239 0.001448 0.003314
Nuclear Periphery Foci 0.000187 0.000677 0.000131 0.000249 0.000378 0.000231 0.000083 0.000812 0.000270 0.000414 0.000127 0.000597
Nucleolus 0.003670 0.006810 0.001358 0.001358 0.007244 0.004606 0.003490 0.001557 0.005228 0.005509 0.001514 0.001481
Nucleus 0.940617* 0.915421* 0.947260* 0.913649* 0.920097* 0.966496* 0.970330* 0.768837* 0.931669* 0.945578* 0.948949* 0.824017*
Peroxisomes 0.000472 0.000656 0.000148 0.000168 0.000760 0.000146 0.000205 0.000769 0.000598 0.000355 0.000152 0.000540
Vacuole 0.001491 0.004862 0.002444 0.008653 0.001742 0.001897 0.003061 0.025636 0.001601 0.003112 0.002489 0.019164
Vacuole Periphery 0.000289 0.000770 0.000221 0.000158 0.000280 0.000392 0.000074 0.004112 0.000285 0.000547 0.000211 0.002605

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.01 -13.28 -14.72 -8.28 -8.80 1.16 -6.78 -2.89 -2.96 -1.87 -4.94 -12.13 -3.85 -3.55 -2.98
Bud Neck -7.25 -16.60 -12.38 -5.07 0.71 -1.04 -2.59 -15.65 -15.67 -13.98 -6.15 -17.42 -19.40 -15.76 -4.79
Bud Site -4.53 -3.83 -6.01 -2.91 -3.51 1.50 0.11 -7.60 -8.09 -7.76 -2.07 -3.58 -8.95 -8.48 -7.45
Cell Periphery -1.43 0.77 0.50 2.01 -0.34 1.99 3.01 1.05 -2.82 -6.61 1.49 1.66 1.11 -0.76 -1.06
Cytoplasm 0.33 8.61 1.67 1.23 -5.09 10.06 10.83 -3.74 -14.95 -15.52 8.24 12.60 -3.49 -11.08 -14.88
Cytoplasmic Foci 0.09 4.54 4.39 4.10 -0.88 6.03 4.11 4.54 -3.42 -0.41 4.29 7.31 5.81 1.65 -3.46
Eisosomes -4.30 -7.55 -14.11 -9.34 -10.15 5.22 -6.92 -8.94 -14.36 2.72 0.66 -7.54 -16.19 -16.74 -10.49
Endoplasmic Reticulum -11.41 -8.93 -15.60 -5.53 -11.45 -5.37 -8.29 -17.17 -11.94 -1.43 -11.17 -13.27 -22.55 -12.37 -13.45
Endosome -3.44 -0.32 -2.80 2.34 -1.39 -0.12 3.11 -3.59 -3.31 -4.40 -2.54 0.43 -4.13 -2.39 -3.96
Golgi -1.47 -0.90 -3.19 1.16 -0.55 2.84 2.05 -2.56 -3.03 -2.91 -0.94 -0.07 -2.85 -1.89 -2.74
Lipid Particles -1.23 6.33 2.54 1.84 -8.79 4.52 2.39 2.73 -4.68 -0.03 1.06 7.89 3.30 0.60 -12.79
Mitochondria -2.21 -3.13 -4.23 -2.32 -1.52 0.74 1.12 -4.67 -4.89 -5.03 -0.71 -3.82 -5.35 -5.13 -4.03
Mitotic Spindle -2.74 -3.17 -4.38 -2.70 -3.21 1.72 1.15 -8.26 -8.95 -8.71 -1.04 -2.45 -9.50 -9.09 -8.38
None 0.93 5.80 3.39 2.35 -2.52 6.45 7.11 5.39 -1.77 -3.14 5.33 9.82 5.86 0.32 -5.34
Nuclear Periphery -0.06 -0.81 -4.94 -5.40 -4.03 -1.98 -1.56 -6.97 -6.23 -6.56 -0.46 -2.88 -7.33 -7.08 -5.81
Nuclear Periphery Foci -3.49 0.80 -4.03 1.69 -4.58 1.15 1.60 -2.04 -4.73 -5.79 -1.50 1.79 -3.99 -2.19 -7.14
Nucleolus -3.63 5.74 3.51 5.68 -1.29 3.40 4.78 9.64 6.52 2.63 -0.74 10.37 9.78 8.55 -0.38
Nucleus 4.82 -0.89 8.04 3.37 9.22 -9.31 -7.26 16.48 25.13 22.86 -3.67 -4.10 19.31 22.23 22.93
Peroxisomes -0.90 1.64 1.48 3.33 -0.62 2.51 2.17 1.34 -2.22 -1.48 1.38 2.78 1.67 0.56 -1.88
Vacuole -4.92 -3.55 -9.66 -7.82 -8.95 -0.47 -3.99 -14.67 -14.42 -12.42 -3.48 -4.40 -17.30 -16.24 -16.40
Vacuole Periphery -2.45 0.69 1.10 3.67 0.58 -0.83 4.24 -3.06 -2.77 -3.45 -2.19 1.05 -2.86 -1.97 -3.16
Standard name
Human Ortholog
Description Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus
Localization
Cell Percentages nucleus (87%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Ung1

Ung1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ung1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available