Standard name
Human Ortholog
Description Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0.06
Bud 0 0 0.08 0.06 0 0 – 0 0 0 0 0.05 0 0 0 0.1 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0.07 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0.08 – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0.05 – 0 0 0 0 0 0 0 0.05 0.05 – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Endosome 0.06 0 0 0 0 0 – 0 0 0 0 0 0 0 0.1 0.1 – – 0.06 0.07 0.05 0.11 0.07 0.07
Golgi 0 0.07 0 0 0 0 – 0 0 0 0 0 0.12 0.17 0.19 0.28 – – 0 0.07 0 0.06 0.12 0.12
Mitochondria 0.84 0.84 0.96 0.98 0.92 0.92 – 0.91 0.91 0.96 0.96 0.95 0.82 0.8 0.66 0.15 – – 0.71 0.73 0.81 0.6 0.58 0.54
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.08 – 0.06 0.05 0 0.05 0 0 0 0 0 – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0.06 0.08 0.05 0.06 0.06 0 0 0 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0.05 0 0.05 0.05
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0.09 – – 0 0 0 0 0 0
Vac/Vac Membrane 0.25 0.15 0.07 0 0.05 0.06 – 0 0.05 0.05 0 0.06 0.12 0.07 0.1 0.25 – – 0.1 0 0 0.07 0.07 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 – 0 0 0 0 0 3 4 0 2 – – 9 10 4 4 5 14
Bud 14 2 17 10 5 7 – 5 8 16 11 17 1 3 3 8 – – 3 1 0 2 4 2
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 5 1 0 0 2 1
Bud Site 2 0 3 0 0 0 – 3 4 7 3 4 1 0 0 0 – – – – – – – –
Cell Periphery 18 17 9 2 0 3 – 2 1 3 4 1 6 7 11 6 – – 1 0 0 0 0 1
Cytoplasm 26 4 7 4 9 11 – 7 12 5 4 6 5 10 10 4 – – 2 0 0 2 0 0
Endoplasmic Reticulum 9 5 5 1 1 4 – 0 2 0 2 2 3 5 3 2 – – 3 1 1 1 2 2
Endosome 42 8 1 0 4 1 – 4 0 1 1 1 4 12 21 8 – – 48 18 9 16 16 16
Golgi 2 16 0 0 0 0 – 0 0 0 0 0 21 47 42 22 – – 33 18 4 9 26 26
Mitochondria 597 201 201 157 204 220 – 308 249 356 243 321 140 217 144 12 – – 536 193 172 93 127 121
Nucleus 8 0 2 1 0 3 – 6 2 6 0 3 0 2 1 2 – – 3 0 0 1 1 1
Nuclear Periphery 3 1 2 1 8 19 – 22 13 14 12 14 4 6 1 1 – – 5 1 1 0 2 3
Nucleolus 6 2 0 3 6 10 – 21 22 19 15 19 1 0 0 0 – – 2 0 0 1 1 1
Peroxisomes 20 1 1 2 3 3 – 0 1 1 0 0 2 5 8 2 – – 12 5 9 5 11 11
SpindlePole 7 0 3 2 1 1 – 5 4 6 1 6 4 5 10 7 – – 4 0 0 2 1 1
Vac/Vac Membrane 177 37 15 1 11 14 – 15 13 19 10 19 21 20 21 20 – – 76 11 4 11 14 12
Unique Cell Count 707 239 210 161 221 238 340 273 372 254 337 171 272 219 79 753 264 213 155 222 225
Labelled Cell Count 931 294 267 184 252 296 398 331 453 306 413 216 343 275 96 753 264 213 155 222 225


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.4 6.9 4.2 4.6 5.8 4.9 – 4.9 4.6 4.7 4.6 4.8 6.7 6.8 7.2 7.2 – – 6.3 6.9 7.2
Std Deviation (1e-4) 0.8 1.1 1.1 1.4 1.6 1.2 – 1.2 1.7 1.2 1.5 1.3 1.1 1.1 6.6 1.4 – – 1.7 1.4 1.7
Intensity Change (Log2) – – – 0.13 0.46 0.22 – 0.23 0.14 0.17 0.14 0.18 0.67 0.69 0.78 0.79 – – 0.6 0.73 0.79


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Bud 0 -2.8 0 – -3.9 0 0 0 0 -3.4 -3.8 -3.3 0.5 – –
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Cell Periphery 0 0 0 – 0 0 0 0 0 -0.4 -1.0 0.4 0 – –
Cytoplasm 0 0.4 0.7 – -0.9 0.6 0 0 0 -0.2 0.2 0.7 0 – –
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Endosome 0 0 0 – 0 0 0 0 0 0 2.6 4.3 0 – –
Golgi 0 0 0 – 0 0 0 0 0 5.2 6.3 6.7 8.0 – –
Mitochondria 0 -1.5 0 – -2.2 0 0 0 0 -4.4 -5.1 -7.8 -13.9 – –
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Nuclear Periphery 0 0 0 – 3.1 0 0 0 0 0 0 0 0 – –
Nucleolus 0 0 0 – 3.7 0 0 0 0 0 0 0 0 – –
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 1.9 0 – –
Vacuole -3.1 -0.9 -0.5 – -1.4 -1.1 -1.0 -1.5 -0.7 1.7 0.1 0.9 4.2 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.6822 2.5481 2.1982 1.5312 1.818 2.4383 1.5597 1.488 1.4681 1.2691 1.4398 1.3455 3.8025 3.9762 3.4291 3.2718 3.0997 4.0008
Actin 0.0312 0.0371 0.021 0.0171 0.0654 0.0007 0.0431 0.0365 0.0238 0.0431 0.0205 0.0036 0.0598 0.0323 0.0161 0.001 0.0081 0.0037
Bud 0.001 0.003 0.0032 0.0008 0.0047 0.0002 0.0019 0.0029 0.0025 0.0006 0.0028 0.0003 0.0014 0.0027 0.0015 0.0002 0.0003 0.0004
Bud Neck 0.0009 0.001 0.0007 0.0005 0.0011 0.0002 0.0041 0.0051 0.001 0.0002 0.0024 0.0003 0.0018 0.0006 0.0018 0.0001 0.0005 0.0001
Bud Periphery 0.002 0.0043 0.0025 0.0041 0.0154 0.0005 0.0029 0.005 0.008 0.0014 0.0049 0.0008 0.0026 0.0047 0.0035 0.0006 0.0009 0.001
Bud Site 0.003 0.0223 0.0168 0.0021 0.0044 0.0001 0.0109 0.0462 0.0184 0.0006 0.0147 0.0003 0.0065 0.0138 0.0097 0.0001 0.0003 0.0004
Cell Periphery 0.0007 0.0011 0.0008 0.0323 0.0004 0.0004 0.0011 0.0026 0.0009 0.0001 0.0006 0.0003 0.0025 0.003 0.0026 0.0001 0.0001 0.0003
Cytoplasm 0.0061 0.0074 0.0012 0.0058 0.0013 0.0005 0.0064 0.0084 0.0027 0.0003 0.0027 0.0007 0.0051 0.0132 0.0047 0.0001 0.0022 0.0005
Cytoplasmic Foci 0.0231 0.0228 0.0191 0.0097 0.042 0.0116 0.0506 0.0447 0.034 0.0449 0.0249 0.0103 0.029 0.022 0.0252 0.001 0.0201 0.0054
Eisosomes 0.0008 0.0012 0.0004 0.0012 0.0004 0.0001 0.0008 0.0011 0.0006 0.0003 0.0003 0.0002 0.0008 0.0022 0.0011 0.0001 0.0002 0.0006
Endoplasmic Reticulum 0.0028 0.0007 0.0005 0.0038 0.0008 0.0003 0.0028 0.0015 0.0005 0.0001 0.0004 0.0005 0.0038 0.0019 0.0012 0.0001 0.0096 0.0012
Endosome 0.0479 0.0494 0.0391 0.0403 0.0271 0.0174 0.0972 0.0536 0.0683 0.0163 0.0569 0.0559 0.0577 0.0671 0.0425 0.0076 0.0451 0.0313
Golgi 0.0301 0.0583 0.0392 0.0166 0.0329 0.0176 0.0849 0.0458 0.0967 0.0259 0.0549 0.0741 0.057 0.0791 0.0506 0.0097 0.0669 0.0384
Lipid Particles 0.039 0.0058 0.0081 0.0198 0.0447 0.0111 0.0622 0.0119 0.0224 0.0705 0.0048 0.0104 0.03 0.008 0.0091 0.0008 0.0116 0.0101
Mitochondria 0.7441 0.7433 0.8201 0.7973 0.6855 0.9202 0.5413 0.6611 0.6319 0.7364 0.7717 0.7868 0.6798 0.6879 0.7848 0.9747 0.7672 0.8734
None 0.0125 0.003 0.0004 0.0121 0.0009 0.0036 0.012 0.0159 0.018 0.0002 0.0004 0.0099 0.0019 0.009 0.0009 0.0001 0.0009 0.0002
Nuclear Periphery 0.0039 0.0007 0.0003 0.0053 0.0015 0.0005 0.0023 0.0003 0.0014 0 0.0001 0.0005 0.0018 0.0005 0.0003 0.0001 0.0389 0.0046
Nucleolus 0.0012 0.0007 0.0005 0.0004 0.0004 0.0009 0.0014 0.0028 0.0003 0.0001 0.0003 0.0034 0.0006 0.0007 0.0004 0 0.0001 0.0001
Nucleus 0.0016 0.0006 0.0006 0.0011 0.0004 0.0005 0.001 0.0007 0.0002 0.0001 0.0004 0.0021 0.0017 0.0007 0.0017 0.0001 0.0042 0.0003
Peroxisomes 0.0235 0.0217 0.0157 0.0171 0.0626 0.0051 0.0556 0.0454 0.0578 0.0561 0.0294 0.0323 0.0437 0.0383 0.036 0.0011 0.0171 0.0149
Punctate Nuclear 0.0042 0.0002 0.0003 0.0016 0.0017 0 0.004 0.0004 0.0003 0.0006 0.0003 0.0003 0.0011 0.0009 0.0002 0 0.0016 0.0005
Vacuole 0.0117 0.0115 0.0051 0.0065 0.003 0.0042 0.009 0.0062 0.0055 0.0007 0.0033 0.0038 0.0069 0.0079 0.0034 0.0008 0.0014 0.0066
Vacuole Periphery 0.0084 0.004 0.0047 0.0045 0.0034 0.0042 0.0045 0.0021 0.0047 0.0016 0.0033 0.0029 0.0044 0.0033 0.0028 0.0018 0.0025 0.006

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.5395 24.6594 32.0221 26.6415 26.824 32.1648 24.9331 28.7481 50.5089 27.498
Translational Efficiency 2.0187 1.5137 1.4136 2.8003 1.7958 1.7935 1.9957 2.9076 1.4137 1.683

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1386 1106 2307 909 1640 145 2089 1551 3026 1251 4396 2460

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 653.60 822.23 1054.78 923.87 742.48 814.34 977.03 913.20 701.77 821.32 1017.83 917.14
Standard Deviation 86.83 111.37 145.05 130.21 93.92 98.77 122.56 125.11 100.97 110.01 140.31 127.12
Intensity Change Log 2 — 0.331134 0.690462 0.499282 — 0.133279 0.396051 0.298579 — 0.229294 0.541384 0.396025

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000869 0.004372 0.000343 0.015157 0.001027 0.000944 0.003114 0.012149 0.000955 0.003975 0.001660 0.013261
Bud Neck 0.017214 0.004138 0.001345 0.008102 0.003023 0.007635 0.010926 0.004675 0.009523 0.004544 0.005898 0.005942
Bud Site 0.016182 0.017003 0.010145 0.102208* 0.008332 0.007974 0.055910 0.077024 0.011927 0.015957 0.031893 0.086330
Cell Periphery 0.000383 0.000574 0.000168 0.001721 0.000740 0.000874 0.000298 0.002508 0.000577 0.000609 0.000230 0.002217
Cytoplasm 0.014276 0.004374 0.003247 0.020997 0.001959 0.004580 0.011095 0.015293 0.007600 0.004398 0.006976 0.017401
Cytoplasmic Foci 0.074446 0.045911 0.027242 0.061320 0.015959 0.064537 0.031394 0.030995 0.042748 0.048070 0.029215 0.042200
Eisosomes 0.000154 0.000108 0.000024 0.000134 0.000067 0.000095 0.000069 0.000144 0.000107 0.000107 0.000045 0.000140
Endoplasmic Reticulum 0.001246 0.000395 0.000539 0.002207 0.000379 0.000496 0.001732 0.000927 0.000776 0.000407 0.001106 0.001400
Endosome 0.065341 0.067295 0.041055 0.087781 0.042086 0.126239 0.071843 0.056289 0.052738 0.074127 0.055685 0.067926
Golgi 0.119429* 0.126793* 0.094248 0.111198* 0.058038 0.087894 0.057402 0.098176 0.086157 0.122284* 0.076739 0.102988
Lipid Particles 0.010021 0.001895 0.000369 0.001619 0.001463 0.008875 0.000614 0.000132 0.005383 0.002704 0.000485 0.000681
Mitochondria 0.606302* 0.634559* 0.560609* 0.384746* 0.823826* 0.578064* 0.504018* 0.604620* 0.724193* 0.628011* 0.533717* 0.523374*
Mitotic Spindle 0.003819 0.016957 0.051762 0.061858 0.003901 0.017512 0.090998 0.024653 0.003863 0.017022 0.070407 0.038401
None 0.000809 0.000210 0.000667 0.000378 0.000262 0.000248 0.000482 0.000305 0.000512 0.000215 0.000579 0.000332
Nuclear Periphery 0.000399 0.000053 0.000958 0.000753 0.000053 0.000176 0.000642 0.000041 0.000211 0.000067 0.000808 0.000304
Nuclear Periphery Foci 0.000759 0.000082 0.000993 0.000844 0.000108 0.000245 0.000481 0.000084 0.000406 0.000101 0.000750 0.000365
Nucleolus 0.001430 0.000183 0.000516 0.000631 0.000127 0.002679 0.001198 0.000038 0.000724 0.000472 0.000840 0.000257
Nucleus 0.004104 0.000548 0.000754 0.001389 0.000439 0.010203 0.003697 0.000186 0.002118 0.001667 0.002152 0.000631
Peroxisomes 0.027295 0.044300 0.002977 0.048901 0.016879 0.059121 0.018459 0.032073 0.021650 0.046018 0.010334 0.038291
Vacuole 0.017577 0.016881 0.075157 0.054770 0.009396 0.008357 0.087063 0.020321 0.013143 0.015893 0.080815 0.033050
Vacuole Periphery 0.017944 0.013367 0.126883* 0.033286 0.011937 0.013250 0.048567 0.019366 0.014689 0.013353 0.089667 0.024510

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.29 2.90 -6.40 -4.37 -6.66 0.17 -3.55 -7.04 -7.16 -5.59 -3.16 -2.33 -9.55 -5.89 -8.97
Bud Neck 6.76 8.73 4.36 -3.27 -6.54 -1.74 -8.50 -2.27 1.10 6.67 4.46 3.57 3.48 -1.69 0.13
Bud Site -0.36 3.54 -14.26 -13.88 -15.52 0.20 -16.96 -17.11 -16.51 -4.39 -2.17 -12.49 -21.98 -19.31 -15.28
Cell Periphery -1.72 6.21 -1.72 -1.46 -2.00 -0.21 3.12 -2.74 -1.86 -3.51 -0.22 4.41 -3.31 -3.19 -4.06
Cytoplasm 5.90 6.95 -2.94 -8.02 -8.82 -1.55 -10.94 -11.29 -4.41 -2.62 3.19 0.33 -7.94 -10.90 -9.26
Cytoplasmic Foci 7.77 14.39 3.10 -4.20 -10.42 -5.22 -9.61 -8.55 3.64 0.28 -2.00 7.49 0.32 2.31 -7.50
Eisosomes 2.42 7.22 1.08 -2.63 -15.39 -1.80 -0.51 -5.47 -2.29 -5.51 0.03 7.02 -2.70 -3.10 -10.58
Endoplasmic Reticulum 3.27 2.69 -2.37 -5.65 -5.18 -0.85 -4.86 -3.63 -2.34 2.84 2.79 -2.04 -3.30 -6.63 -1.24
Endosome -0.45 7.25 -4.17 -3.74 -9.95 -5.07 -8.75 -4.21 4.20 4.22 -5.54 -1.19 -5.13 1.52 -4.49
Golgi -1.01 4.27 1.20 2.11 -2.51 -2.74 0.31 -8.10 -0.95 -8.82 -6.37 2.78 -3.82 3.32 -6.77
Lipid Particles 5.44 6.87 5.61 0.34 -2.34 -1.63 2.08 3.56 1.93 5.73 2.74 7.16 6.67 2.74 -0.85
Mitochondria -2.10 3.97 15.16 16.48 13.05 7.88 32.82* 20.32 -0.90 -9.01 8.62 24.78 21.67 8.75 0.98
Mitotic Spindle -7.21 -17.80 -12.43 -9.05 -1.94 -2.32 -21.97* -10.36 -1.18 15.29 -7.50 -27.99 -15.97 -7.87 10.12
None 6.23 1.53 2.85 -2.38 2.43 0.06 -1.83 -0.15 -0.31 6.17 4.18 -0.71 2.20 -3.40 5.89
Nuclear Periphery 1.99 -2.08 -0.85 -1.86 0.48 -1.70 -6.06 0.95 1.89 6.23 1.79 -4.24 -0.57 -1.70 2.80
Nuclear Periphery Foci 1.79 -0.54 -0.34 -2.88 0.19 -1.85 -5.38 0.79 2.31 6.30 1.74 -1.72 0.07 -2.66 2.40
Nucleolus 3.33 2.26 0.45 -1.39 -0.84 -1.08 -4.49 1.30 1.11 5.09 0.40 -0.60 1.01 0.31 1.54
Nucleus 4.16 3.55 2.65 -1.98 -1.07 -1.62 -5.08 1.32 1.67 5.71 0.50 -0.69 3.29 1.34 4.40
Peroxisomes -3.97 11.43 -4.49 -0.80 -10.61 -4.11 -0.81 -4.90 2.60 -4.55 -6.51 7.33 -6.27 1.87 -11.66
Vacuole 0.23 -22.19 -9.81 -9.42 4.55 0.64 -25.26 -6.64 -6.26 20.61 -1.59 -34.05 -11.16 -7.51 19.38
Vacuole Periphery 2.68 -27.76* -5.12 -6.80 20.50* -0.34 -16.71 -4.76 -1.60 12.17 1.01 -31.60 -6.55 -6.60 25.15*
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast
Localization
Cell Percentages mitochondrion (94%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Rcf1

Rcf1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rcf1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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Images are not yet available