Standard name
Human Ortholog
Description Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.99 0.99 0.97 0.99 – 0.83 0.89 0.91 0.83 0.85 0.99 0.97 0.97 0.98 0.98 0.99 0.95 0.92 0.91 0.93 0.87 0.82
Endoplasmic Reticulum 0 0 0 0 0 0 – 0.06 0.06 0.05 0.07 0.06 0 0 0 0.07 0.05 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0.1
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 – 0.09 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 – 4 3 5 4 2 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 5 1 0 0 – 1 0 1 0 6 0 1 1 0 1 0 2 3 0 0 2 3
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 2 1 1 6 – 14 14 15 7 11 1 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 538 363 160 259 411 369 – 466 488 405 304 335 171 309 342 105 119 83 507 326 137 82 189 173
Endoplasmic Reticulum 0 2 0 0 2 0 – 33 31 22 27 23 0 4 6 7 6 6 0 2 0 0 1 1
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Golgi 1 0 0 0 0 0 – 3 3 1 2 4 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 1 1 0 0 0 – 1 2 4 11 10 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 4 3 2 1 8 0 0 1 0 0 0 10 12 9 3 13 20
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 – 2 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 1 0 0 1 9 4 – 52 16 7 20 14 2 6 8 1 2 1 3 3 1 0 5 8
Unique Cell Count 540 366 162 261 422 374 564 549 443 368 396 172 320 354 107 121 84 532 354 152 89 217 213
Labelled Cell Count 542 366 168 262 423 380 580 560 462 376 416 174 321 359 113 128 90 532 354 152 89 217 213


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 63.8 74.7 32.5 49.4 49.5 38.1 – 31.7 31.5 29.5 26.8 26.6 70.5 71.4 63.4 125.4 100.2 116.9 66.8 72.8 68.1
Std Deviation (1e-4) 13.2 14.5 8.4 12.7 12.6 9.5 – 8.7 8.1 7.3 7.4 8.2 17.6 18.9 19.0 44.0 40.1 39.5 17.6 17.1 20.4
Intensity Change (Log2) – – – 0.61 0.61 0.23 – -0.03 -0.04 -0.14 -0.27 -0.29 1.12 1.14 0.97 1.95 1.63 1.85 1.04 1.17 1.07


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 -1.0 -0.1 – -5.3 -3.9 -3.2 -5.2 -4.8 0.6 -1.4 -1.4 -0.4 -0.3 0
Endoplasmic Reticulum 0 0 0 – 3.2 3.1 2.9 3.5 3.1 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 – 4.0 0 0 3.0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 70.5503 86.5009 73.4151 70.4774 87.8241 86.7633 71.3411 93.2722 72.7693 80.0655 83.8213 98.5792 84.7476 103.3714 85.5354 94.9664 73.2005 118.1652
Actin 0.0061 0.0013 0.0015 0.0043 0.0002 0.0022 0.0038 0.0004 0.0017 0.0057 0.0001 0 0.0068 0.0001 0.004 0.0002 0.0007 0
Bud 0.0005 0.0001 0.0002 0.0012 0.0004 0.0002 0.0019 0.0007 0.0009 0.0008 0.0002 0 0.0022 0.0001 0.0003 0 0.0004 0
Bud Neck 0.0002 0.0002 0.0007 0.0004 0.0003 0.0005 0.0023 0.0002 0.0002 0.0002 0.0003 0.0004 0.002 0.0001 0.0001 0.0001 0.0002 0.0002
Bud Periphery 0.0003 0.0001 0.0001 0.0008 0.0004 0.0001 0.0012 0.0006 0.0007 0.0031 0.0001 0 0.0011 0 0.0001 0 0.0004 0
Bud Site 0.0004 0.0002 0.0003 0.0017 0.0001 0.0001 0.0026 0.0005 0.0051 0.0003 0.0001 0 0.0021 0 0.0001 0 0.0004 0
Cell Periphery 0.0003 0.0002 0.0002 0.0002 0.0021 0.0001 0.0004 0.0002 0.0004 0.0001 0.0001 0 0.0005 0 0.0001 0 0.0005 0
Cytoplasm 0.8564 0.9654 0.9221 0.8795 0.9505 0.8985 0.855 0.964 0.8816 0.8843 0.9525 0.9577 0.8766 0.9884 0.9283 0.9368 0.7646 0.9819
Cytoplasmic Foci 0.012 0.0003 0.0094 0.0081 0.0052 0.0014 0.0054 0.0012 0.0143 0.0032 0.0042 0.0001 0.0124 0.0001 0.0022 0.0041 0.0789 0.0001
Eisosomes 0.0002 0.0002 0.0001 0.0002 0 0 0.0001 0 0.0002 0 0 0 0.0003 0 0.0001 0 0.0002 0
Endoplasmic Reticulum 0.0032 0.0014 0.0008 0.0044 0.0002 0.0004 0.001 0.0001 0.001 0.0014 0.0006 0.0001 0.0009 0 0.0004 0 0.0046 0
Endosome 0.0082 0.0006 0.0019 0.0021 0.0005 0.0049 0.0056 0.0001 0.0036 0.0238 0.0001 0 0.0042 0 0.0027 0.0003 0.0115 0
Golgi 0.0044 0.0006 0.0004 0.0006 0.0001 0.0085 0.0015 0 0.0021 0.0124 0 0 0.0024 0 0.0033 0.0006 0.001 0
Lipid Particles 0.0095 0.0006 0.0028 0.0024 0.0045 0.0044 0.003 0.0002 0.007 0.0075 0.0001 0 0.0043 0 0.0079 0.0029 0.0314 0
Mitochondria 0.0032 0.0067 0.0009 0.0041 0.0016 0.0019 0.008 0.001 0.0145 0.0114 0.0004 0 0.0053 0.0001 0.0031 0.0007 0.0186 0
None 0.0071 0.0004 0.0035 0.0081 0.0004 0.0018 0.0028 0.0002 0.0047 0.0003 0.0087 0.0001 0.0047 0.0001 0.0012 0.0001 0.0154 0
Nuclear Periphery 0.016 0.0021 0.0047 0.0167 0.0032 0.0069 0.0104 0.0023 0.0055 0.0047 0.0046 0.0037 0.0063 0.0009 0.0031 0.0019 0.0122 0.001
Nucleolus 0.002 0 0.0012 0.0023 0.0011 0.0023 0.0018 0.0003 0.0037 0.0001 0.0004 0 0.0032 0.0001 0.0009 0 0.0051 0
Nucleus 0.0599 0.0184 0.0456 0.0404 0.018 0.0634 0.0834 0.0267 0.0434 0.0181 0.0261 0.0375 0.0467 0.0098 0.034 0.024 0.0162 0.0166
Peroxisomes 0.0016 0.0005 0.0003 0.0006 0.0004 0.0002 0.0009 0.0002 0.002 0.0011 0 0 0.009 0 0.0036 0.0281 0.003 0
Punctate Nuclear 0.004 0.0002 0.0009 0.0181 0.0001 0.0009 0.0033 0.0001 0.0027 0.0004 0.0003 0.0001 0.0019 0.0001 0.0004 0.0001 0.0031 0
Vacuole 0.0027 0.0003 0.0018 0.0024 0.0093 0.0009 0.0042 0.0007 0.0029 0.0102 0.0009 0.0001 0.0048 0.0001 0.0029 0 0.0196 0.0001
Vacuole Periphery 0.0019 0.0002 0.0006 0.0015 0.0016 0.0004 0.0013 0.0002 0.0018 0.0107 0.0001 0.0001 0.0021 0.0001 0.0011 0 0.0121 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 182.1493 657.5841 550.693 282.6025 143.0612 203.0541 683.0877 550.2542 363.0787 196.2865
Translational Efficiency 3.1444 3.5942 3.1034 4.3525 4.1961 3.4862 3.09 4.4725 3.4488 3.1036

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
186 1259 1709 698 939 1626 2585 455 1125 2885 4294 1153

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 3224.95 3907.06 6772.25 9890.04 3291.91 4126.44 8683.80 9051.94 3280.84 4030.70 7923.01 9559.31
Standard Deviation 704.90 1171.67 1542.97 2107.05 765.70 929.61 1626.67 2485.93 756.39 1047.84 1848.23 2300.91
Intensity Change Log 2 — 0.276807 1.070358 1.616700 — 0.325973 1.399402 1.459302 — 0.301852 1.245923 1.539338

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000505 0.000409 0.000061 0.000124 0.000351 0.000155 0.000028 0.004310 0.000376 0.000266 0.000041 0.001776
Bud Neck 0.002227 0.000723 0.000586 0.001426 0.000987 0.000930 0.000385 0.003047 0.001192 0.000840 0.000465 0.002066
Bud Site 0.001966 0.002354 0.000450 0.002129 0.001327 0.000933 0.000383 0.028096 0.001433 0.001553 0.000409 0.012376
Cell Periphery 0.001192 0.000243 0.000308 0.001042 0.000677 0.000299 0.000114 0.001945 0.000762 0.000275 0.000191 0.001398
Cytoplasm 0.514855* 0.489146* 0.405723* 0.389920* 0.553737* 0.439231* 0.518020* 0.454488* 0.547308* 0.461014* 0.473327* 0.415400*
Cytoplasmic Foci 0.025924 0.004512 0.004588 0.007899 0.006278 0.004766 0.001609 0.023595 0.009526 0.004655 0.002795 0.014093
Eisosomes 0.000006 0.000002 0.000001 0.000003 0.000002 0.000002 0.000001 0.000049 0.000003 0.000002 0.000001 0.000021
Endoplasmic Reticulum 0.000224 0.000093 0.000019 0.000038 0.000190 0.000081 0.000012 0.000752 0.000195 0.000086 0.000015 0.000320
Endosome 0.000396 0.000192 0.000009 0.000168 0.000060 0.000472 0.000009 0.007655 0.000115 0.000350 0.000009 0.003123
Golgi 0.002038 0.000666 0.000070 0.004290 0.001111 0.000648 0.000032 0.004127 0.001264 0.000656 0.000047 0.004225
Lipid Particles 0.001692 0.000135 0.000103 0.000497 0.000267 0.000553 0.000053 0.005073 0.000502 0.000370 0.000073 0.002303
Mitochondria 0.000620 0.000270 0.000255 0.000436 0.000517 0.000843 0.000179 0.036677 0.000534 0.000593 0.000209 0.014738
Mitotic Spindle 0.001624 0.002899 0.000492 0.015462 0.000265 0.001824 0.001053 0.039863 0.000489 0.002293 0.000830 0.025091
None 0.007037 0.022521 0.013004 0.016143 0.010158 0.012966 0.016933 0.019565 0.009642 0.017136 0.015369 0.017494
Nuclear Periphery 0.000332 0.000153 0.000196 0.000484 0.000172 0.000156 0.000146 0.000528 0.000199 0.000155 0.000166 0.000502
Nuclear Periphery Foci 0.001995 0.001133 0.000138 0.001100 0.001121 0.000684 0.000080 0.002441 0.001265 0.000880 0.000103 0.001629
Nucleolus 0.000297 0.000322 0.000042 0.000139 0.000167 0.000216 0.000049 0.000793 0.000189 0.000262 0.000047 0.000397
Nucleus 0.425475* 0.471212* 0.571977* 0.538421* 0.416133* 0.531687* 0.458782* 0.356994* 0.417677* 0.505296* 0.503833* 0.466826*
Peroxisomes 0.000166 0.000037 0.000003 0.000024 0.000027 0.000050 0.000002 0.001719 0.000050 0.000044 0.000002 0.000693
Vacuole 0.007891 0.002413 0.001950 0.013361 0.004426 0.003286 0.002116 0.007631 0.004999 0.002905 0.002050 0.011100
Vacuole Periphery 0.003540 0.000564 0.000026 0.006892 0.002028 0.000218 0.000015 0.000651 0.002278 0.000369 0.000019 0.004429

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.96 3.05 2.73 1.45 -4.54 2.26 4.36 -0.44 -1.15 -1.75 1.46 4.98 0.99 -0.13 -2.15
Bud Neck 4.34 3.95 -0.24 -7.38 -6.95 -0.98 2.39 -5.61 -4.76 -8.15 1.18 3.24 -6.27 -8.15 -10.88
Bud Site 0.29 5.21 -1.17 -1.10 -7.82 0.53 1.92 -3.05 -3.24 -3.55 -0.23 2.54 -3.72 -3.76 -5.28
Cell Periphery 5.16 3.94 1.86 -7.41 -4.45 4.27 8.42 -1.79 -4.58 -6.85 6.92 7.80 -1.24 -8.21 -9.07
Cytoplasm 0.98 7.00 6.74 10.19 0.38 14.11 8.40 7.44 -1.91 2.33 11.83 13.77 14.43 5.72 4.44
Cytoplasmic Foci 4.69 3.98 2.22 -6.02 -4.16 0.31 5.54 -8.11 -8.26 -9.89 3.59 4.69 -6.55 -10.06 -10.91
Eisosomes 2.64 2.77 0.66 -5.17 -8.30 0.21 4.07 -2.93 -2.98 -3.60 1.89 4.23 -3.80 -4.94 -6.03
Endoplasmic Reticulum 1.51 2.32 2.11 1.51 -6.00 1.32 2.19 0.87 -0.36 -1.52 1.59 2.63 1.81 0.66 -2.12
Endosome 1.31 2.51 2.08 1.37 -3.09 -1.74 3.63 -1.19 -0.68 -1.27 -1.56 3.84 -1.00 -0.31 -1.42
Golgi 1.77 2.55 1.70 0.13 -1.19 1.02 2.22 0.90 0.04 -1.49 1.46 2.81 1.36 0.12 -1.85
Lipid Particles 2.86 2.73 1.14 -7.44 -6.89 -1.15 4.57 -3.74 -2.99 -4.30 1.39 3.90 -4.15 -5.19 -7.11
Mitochondria 1.54 1.25 1.08 -2.01 -1.27 -0.43 1.94 -1.38 -1.29 -1.50 0.00 1.97 -1.28 -1.26 -1.54
Mitotic Spindle -1.17 0.45 -3.45 -2.95 -3.65 -2.79 -3.70 -4.54 -3.83 -4.23 -3.49 -2.77 -5.82 -4.72 -5.47
None -8.70 -7.15 -7.02 3.28 -2.05 -3.69 -8.44 -5.27 -3.56 -0.83 -8.08 -9.04 -7.12 0.33 -1.40
Nuclear Periphery 2.38 -0.48 -6.67 -12.42 -9.45 -0.62 -2.02 -10.29 -11.93 -11.05 0.26 -2.59 -12.70 -17.34 -14.93
Nuclear Periphery Foci 1.86 3.72 2.68 0.69 -4.75 2.10 5.64 -0.16 -2.11 -5.24 2.03 6.60 1.95 -0.48 -7.30
Nucleolus -0.42 2.40 0.09 0.54 -3.56 -0.42 1.65 -1.23 -0.62 -2.84 -0.94 2.46 -1.30 -0.01 -4.43
Nucleus -2.84 -9.52 -4.31 -2.66 7.60 -13.64 -8.80 4.53 14.35 10.93 -11.95 -15.04 -2.86 7.41 9.91
Peroxisomes 0.99 1.52 1.18 0.74 -2.19 -0.47 1.53 -1.09 -0.99 -1.24 0.01 2.12 -0.82 -0.83 -1.52
Vacuole 3.43 2.96 -8.90 -13.27 -12.97 -1.36 -2.25 -12.47 -12.25 -12.21 1.09 0.06 -16.99 -17.44 -17.26
Vacuole Periphery 0.99 1.18 0.85 -0.37 -1.05 1.46 1.61 1.52 0.99 -2.87 1.65 1.93 1.37 -0.44 -1.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Sml1

Sml1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sml1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available