Standard name
Human Ortholog
Description Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.09 0.07 0.14 0.13 0.11 0.1 – 0.08 0.05 0.1 0.1 0.1 0.06 0.09 0.09 0.22 0.16 0.17 0 0 0 0 0.05 0.05
Bud 0 0 0.07 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0.06 0.1 0.09 0.08 – 0.07 0.12 0.11 0.13 0.08 0.18 0.23 0.23 0.47 0.38 0.24 0 0 0 0 0.05 0.08
Cytoplasm 0.2 0.12 0.16 0.1 0.15 0.12 – 0.18 0.15 0.16 0.13 0.15 0.07 0.08 0.1 0.32 0.4 0.52 0 0 0 0 0 0
Endoplasmic Reticulum 0.65 0.79 0.53 0.64 0.44 0.6 – 0.44 0.43 0.45 0.52 0.48 0.82 0.79 0.79 0 0 0 0.84 0.88 0.87 0.83 0.8 0.74
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.26 0.43 0.19 0.29 – 0.26 0.35 0.27 0.36 0.33 0 0 0 0.07 0.09 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0.06 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.16 0.07 0.08 0 0.18 0.09 – 0.16 0.12 0.13 0 0.08 0 0 0 0 0.07 0.1 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 28 20 47 43 32 34 – 34 18 49 34 35 21 25 28 15 7 5 7 7 8 5 15 14
Bud 6 3 25 5 12 3 – 5 8 16 9 9 2 1 0 2 1 3 0 1 0 1 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 7 1 3 1 1 5
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 11 18 21 34 28 29 – 30 43 57 43 29 61 64 71 32 17 7 2 4 12 5 15 23
Cytoplasm 64 33 56 33 43 41 – 75 51 81 45 56 23 24 30 22 18 15 11 4 2 4 6 6
Endoplasmic Reticulum 209 222 183 207 131 205 – 184 148 228 176 177 274 223 247 0 2 1 323 266 347 160 232 227
Endosome 1 0 0 1 13 1 – 4 2 2 0 1 1 1 1 0 0 1 1 1 2 0 3 4
Golgi 1 4 0 3 15 1 – 2 3 1 3 1 3 4 0 1 0 0 4 1 3 0 4 3
Mitochondria 9 2 90 140 56 99 – 108 120 138 122 120 6 4 2 5 4 0 7 2 9 3 2 4
Nucleus 3 1 2 1 1 0 – 3 2 7 2 8 0 0 3 1 1 2 0 0 0 0 0 0
Nuclear Periphery 0 5 6 11 7 14 – 16 20 19 21 16 2 2 4 0 0 0 2 2 5 2 0 0
Nucleolus 0 0 0 0 1 0 – 5 2 1 1 5 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 1 3 0 – 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 52 21 29 10 53 32 – 66 43 68 13 31 4 2 7 2 3 3 13 6 3 3 8 12
Unique Cell Count 324 280 348 325 296 342 418 345 507 339 366 333 283 314 68 45 29 384 302 401 193 292 306
Labelled Cell Count 384 329 459 489 396 459 533 460 668 470 488 397 350 393 80 53 37 384 302 401 193 292 306


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 9.2 11.4 7.6 9.2 10.7 9.6 – 9.6 9.5 9.7 9.6 9.6 11.2 11.0 10.9 11.0 10.4 10.0 10.6 10.8 10.7
Std Deviation (1e-4) 1.4 1.8 1.6 1.5 1.8 2.0 – 1.7 1.9 1.7 1.9 2.2 1.5 1.7 1.6 2.0 1.5 1.6 1.6 1.8 1.7
Intensity Change (Log2) – – – 0.29 0.5 0.35 – 0.34 0.33 0.37 0.34 0.35 0.57 0.54 0.53 0.54 0.46 0.4 0.49 0.51 0.51

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.1 -1.0 -1.5 – -2.4 -3.7 -1.7 -1.4 -1.7 -3.1 -1.8 -1.9 1.8 0.4 0
Bud -3.5 -1.7 -4.2 – -4.3 -3.0 -2.7 -2.7 -3.0 -4.4 -4.3 -4.8 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 2.1 1.6 1.2 – 0.6 2.9 2.6 3.0 1.0 4.9 6.1 6.2 9.3 0 0
Cytoplasm -2.3 -0.5 -1.6 – 0.7 -0.5 0 -1.0 -0.3 -3.7 -2.9 -2.5 3.1 3.9 4.7
Endoplasmic Reticulum 2.9 -2.1 1.9 – -2.4 -2.6 -2.2 -0.2 -1.1 8.2 6.8 7.0 -8.0 -6.1 -5.1
Endosome 0 3.9 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 4.2 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.7 -2.1 0.9 – 0 2.6 0.4 2.9 2.0 -9.0 -8.6 -9.4 -3.3 -2.5 -3.1
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 1.4 0.6 1.9 – 1.7 2.8 1.7 3.0 2.0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.9 3.6 0.5 – 3.1 1.8 2.3 -2.5 0.1 -4.3 -4.4 -3.5 -1.5 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.8569 6.6347 6.3938 5.9513 4.7327 6.0878 5.4483 6.27 5.8439 5.9682 5.8541 5.9662 7.5681 8.7457 8.5461 9.0756 8.6249 8.3002
Actin 0.0197 0.0073 0.0205 0.0033 0.0305 0.0006 0.0259 0.0175 0.0227 0.0003 0.0002 0.007 0.0288 0.0046 0.0079 0.0464 0.0019 0.0005
Bud 0.0009 0.0002 0.0002 0.0003 0.0005 0 0.0005 0.0002 0.0003 0.0001 0 0.0001 0.0003 0.0001 0.0002 0.0002 0 0
Bud Neck 0.0008 0.002 0.0031 0.0008 0.0003 0.0003 0.0011 0.0008 0.0024 0.0001 0.0002 0.0014 0.0013 0.0008 0.0014 0.0001 0.0003 0.001
Bud Periphery 0.0013 0.0004 0.0006 0.0004 0.0004 0 0.001 0.0007 0.0007 0.0003 0.0001 0.0002 0.0005 0.0003 0.0008 0.0003 0.0001 0.0001
Bud Site 0.0078 0.0124 0.0013 0.0012 0.003 0 0.0028 0.0025 0.003 0 0.0001 0.0002 0.0021 0.0076 0.0087 0.0002 0.0001 0
Cell Periphery 0.0025 0.0246 0.0281 0.002 0.0003 0.0012 0.0046 0.0238 0.0096 0.0005 0.0004 0.0011 0.0028 0.0179 0.0184 0.0002 0.001 0.0015
Cytoplasm 0.0323 0.1122 0.0617 0.0197 0.0092 0.0268 0.0554 0.0878 0.0594 0.002 0.0031 0.0356 0.0352 0.1236 0.0821 0.003 0.014 0.0396
Cytoplasmic Foci 0.0095 0.0046 0.0069 0.0112 0.0173 0.001 0.013 0.0059 0.0132 0.0002 0.001 0.0066 0.0098 0.0042 0.0055 0.0012 0.0054 0.0008
Eisosomes 0.0003 0.0009 0.0004 0.0001 0.0001 0 0.0006 0.0015 0.0008 0.0001 0 0.0002 0.0003 0.0002 0.0007 0.0001 0 0
Endoplasmic Reticulum 0.8041 0.7738 0.816 0.8536 0.8164 0.8674 0.7198 0.7602 0.7914 0.9263 0.887 0.84 0.7578 0.7574 0.8245 0.8826 0.888 0.8503
Endosome 0.0261 0.0094 0.0088 0.0325 0.0158 0.0042 0.0481 0.0152 0.0239 0.0093 0.016 0.0186 0.0323 0.0073 0.0102 0.0037 0.0073 0.0067
Golgi 0.0078 0.0059 0.0126 0.0137 0.0126 0.0012 0.0141 0.0122 0.0142 0.0042 0.0047 0.0082 0.011 0.006 0.0079 0.0087 0.0044 0.0007
Lipid Particles 0.0078 0.0286 0.0208 0.0112 0.0452 0.0015 0.0177 0.0326 0.0218 0.0012 0.0107 0.0081 0.0255 0.0335 0.0156 0.0004 0.0211 0.0015
Mitochondria 0.0083 0.0007 0.0011 0.0218 0.0075 0.0002 0.0237 0.0027 0.0118 0.0315 0.0107 0.004 0.0325 0.0006 0.0012 0.0004 0.0016 0.0003
None 0.0043 0.0013 0.0003 0.0009 0.0007 0.0003 0.0078 0.0033 0.0029 0.0002 0.0001 0.004 0.0033 0.0009 0.0016 0.0001 0.0003 0.0006
Nuclear Periphery 0.0346 0.0092 0.0079 0.0091 0.0041 0.0839 0.0376 0.018 0.0074 0.0117 0.0564 0.0526 0.0222 0.0272 0.0066 0.05 0.0215 0.086
Nucleolus 0.0003 0.0001 0.0004 0.0009 0.0002 0 0.0008 0.0001 0.0002 0 0.0001 0.0002 0.0003 0 0.0001 0 0.0001 0
Nucleus 0.0159 0.0008 0.0008 0.0021 0.0004 0.007 0.0065 0.0027 0.0029 0.0003 0.0012 0.0021 0.0038 0.0018 0.0007 0.0008 0.0084 0.0047
Peroxisomes 0.0057 0.0001 0.0033 0.0029 0.0326 0 0.0026 0.0002 0.0058 0 0.0003 0.0017 0.022 0.0001 0.001 0.0001 0.0186 0
Punctate Nuclear 0.0024 0.0004 0.0021 0.0077 0.0011 0.0001 0.0029 0.0004 0.0008 0 0.0001 0.0017 0.0019 0.0002 0.0009 0.0001 0.0012 0.0001
Vacuole 0.0045 0.0046 0.0028 0.0034 0.0015 0.003 0.0096 0.0105 0.004 0.0028 0.0044 0.0032 0.0044 0.0045 0.0035 0.001 0.0043 0.003
Vacuole Periphery 0.0032 0.0006 0.0003 0.0012 0.0004 0.0011 0.004 0.0011 0.0009 0.0088 0.0032 0.0035 0.0018 0.0013 0.0005 0.0004 0.0006 0.0023

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 52.9883 61.3002 37.217 44.525 38.3921 37.3828 52.12 38.9805 50.6206 49.0511
Translational Efficiency 1.1648 0.7286 1.228 1.4317 1.4916 1.8948 0.9967 1.9575 1.2837 0.8688

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
241 1399 1147 127 1576 1022 244 1291 1817 2421 1391 1418

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 816.86 995.15 1189.81 1264.52 958.03 1034.17 1390.45 1083.25 939.31 1011.62 1225.00 1099.49
Standard Deviation 196.65 153.68 176.37 167.93 132.38 146.27 166.59 152.52 150.41 151.82 190.64 162.43
Intensity Change Log 2 — 0.284825 0.542570 0.630429 — 0.110331 0.537409 0.177223 — 0.193267 0.539787 0.403561

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003728 0.005110 0.002476 0.014557 0.001579 0.002920 0.010276 0.016114 0.001864 0.004186 0.003844 0.015974
Bud Neck 0.006491 0.001763 0.003845 0.006665 0.000746 0.001540 0.001506 0.014663 0.001508 0.001669 0.003435 0.013947
Bud Site 0.009267 0.015681 0.019490 0.025738 0.002667 0.006816 0.012483 0.052827 0.003542 0.011939 0.018261 0.050401
Cell Periphery 0.013390 0.006257 0.004971 0.024565 0.007149 0.005980 0.010339 0.003424 0.007976 0.006140 0.005912 0.005317
Cytoplasm 0.076857 0.063078 0.045013 0.031625 0.045078 0.077848 0.013144 0.150513 0.049293 0.069313 0.039422 0.139865
Cytoplasmic Foci 0.047926 0.026683 0.005078 0.012236 0.006971 0.020599 0.003368 0.087418 0.012403 0.024115 0.004779 0.080684
Eisosomes 0.001415 0.000990 0.000164 0.001285 0.001077 0.001490 0.000510 0.001785 0.001122 0.001201 0.000225 0.001740
Endoplasmic Reticulum 0.633405 0.800940 0.841204 0.760378 0.873863 0.799355 0.895122 0.340848 0.841969 0.800271 0.850662 0.378423
Endosome 0.024408 0.010155 0.012941 0.012865 0.004435 0.008726 0.009545 0.043334 0.007084 0.009552 0.012346 0.040605
Golgi 0.033537 0.016379 0.003310 0.003672 0.011781 0.018223 0.002580 0.023581 0.014667 0.017157 0.003182 0.021798
Lipid Particles 0.066780 0.016392 0.005200 0.040313 0.015454 0.020612 0.018664 0.086855 0.022261 0.018173 0.007561 0.082687
Mitochondria 0.005162 0.007436 0.000780 0.000059 0.003223 0.006782 0.000477 0.005225 0.003480 0.007160 0.000727 0.004763
Mitotic Spindle 0.000185 0.000403 0.000590 0.002134 0.000107 0.000379 0.000627 0.010496 0.000118 0.000392 0.000597 0.009747
None 0.014476 0.002497 0.001669 0.000043 0.002907 0.003338 0.000085 0.001941 0.004442 0.002852 0.001391 0.001771
Nuclear Periphery 0.004469 0.001326 0.005869 0.000320 0.003025 0.001588 0.000676 0.002315 0.003216 0.001436 0.004958 0.002136
Nuclear Periphery Foci 0.014859 0.006896 0.033316 0.010274 0.008969 0.005852 0.011275 0.025456 0.009750 0.006456 0.029450 0.024096
Nucleolus 0.001300 0.000482 0.000029 0.000017 0.000107 0.000040 0.000004 0.000250 0.000265 0.000295 0.000025 0.000230
Nucleus 0.018309 0.002054 0.002600 0.002844 0.001154 0.002567 0.000677 0.018898 0.003430 0.002271 0.002263 0.017460
Peroxisomes 0.008183 0.006506 0.000240 0.001075 0.006774 0.007424 0.000696 0.007551 0.006961 0.006893 0.000320 0.006971
Vacuole 0.011537 0.005884 0.010304 0.049026 0.002100 0.005857 0.007716 0.103004 0.003352 0.005873 0.009850 0.098170
Vacuole Periphery 0.004315 0.003088 0.000913 0.000310 0.000837 0.002066 0.000230 0.003502 0.001298 0.002657 0.000793 0.003216

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.70 0.66 -1.97 -1.79 -2.32 -1.57 -2.33 -9.04 -7.82 -1.38 -3.16 -2.29 -9.11 -7.50 -7.34
Bud Neck 1.71 0.82 -0.08 -3.08 -1.50 -2.32 -1.99 -10.23 -9.45 -9.27 -0.37 -3.39 -9.58 -9.74 -7.59
Bud Site -2.08 -3.09 -2.38 -1.50 -0.87 -3.02 -2.59 -13.62 -11.92 -7.52 -6.26 -6.99 -13.69 -10.71 -8.00
Cell Periphery 1.48 1.72 -1.27 -2.54 -2.70 0.99 -1.46 3.88 3.00 3.47 1.60 1.52 2.23 1.01 0.65
Cytoplasm 1.55 3.41 4.04 4.05 1.69 -6.85 9.12 -18.29 -10.88 -23.29 -5.92 2.50 -16.67 -12.91 -17.52
Cytoplasmic Foci 3.01 6.28 4.57 3.26 -1.95 -6.17 2.30 -21.23 -15.89 -21.55 -6.06 5.39 -18.82 -15.18 -21.69
Eisosomes 0.74 2.23 0.22 -0.71 -2.94 -1.51 2.82 -2.66 -0.86 -5.45 -0.41 5.48 -2.43 -2.36 -8.08
Endoplasmic Reticulum -6.41 -7.82 -3.06 1.70 2.94 7.19 -1.31 48.23 35.37 33.62 5.01 -0.68 40.82 37.91 40.26
Endosome 4.27 3.35 2.60 -1.03 -0.04 -3.91 -2.01 -17.15 -13.92 -9.81 -3.06 -5.21 -15.66 -14.36 -12.46
Golgi 3.18 5.76 5.66 8.60 -0.34 -3.10 6.94 -5.85 -1.92 -12.01 -1.58 9.15 -3.47 -2.20 -12.43
Lipid Particles 5.56 6.82 2.15 -2.82 -4.14 -2.50 -0.65 -16.82 -14.97 -9.57 2.17 7.28 -14.57 -16.40 -18.84
Mitochondria -1.49 3.83 4.54 7.12 3.92 -2.54 3.88 -1.64 1.15 -4.91 -3.72 4.48 -1.10 2.27 -4.64
Mitotic Spindle -1.17 -2.20 -1.27 -1.13 -1.00 -1.28 -1.33 -5.75 -5.58 -5.30 -1.91 -2.83 -5.83 -5.66 -5.51
None 2.03 2.17 2.46 4.04 3.03 -0.30 3.74 0.89 0.98 -1.99 1.33 2.75 2.10 1.12 -0.34
Nuclear Periphery 2.17 -0.79 2.87 3.39 6.19 1.80 3.36 0.89 -1.26 -3.75 2.71 -1.82 1.51 -1.64 3.44
Nuclear Periphery Foci 2.29 -4.25 0.94 -1.69 6.24 1.88 -0.81 -7.01 -8.53 -4.09 2.43 -7.56 -6.65 -8.93 1.61
Nucleolus 1.41 2.52 2.55 1.54 1.16 0.98 1.48 -2.02 -6.62 -7.73 -0.13 2.65 0.27 0.30 -6.92
Nucleus 3.17 3.00 2.86 -1.16 -0.39 -3.97 1.94 -13.19 -11.98 -13.48 1.59 1.14 -10.13 -12.30 -11.70
Peroxisomes 1.13 6.13 5.31 6.87 -2.45 -0.57 8.47 -0.66 -0.07 -7.26 0.08 10.95 0.02 -0.04 -8.03
Vacuole 2.33 0.32 -3.41 -3.89 -3.51 -4.84 -3.82 -22.89 -21.88 -20.66 -4.11 -7.03 -22.78 -22.18 -20.93
Vacuole Periphery 1.05 3.16 3.75 5.93 4.01 -2.87 3.46 -5.41 -2.17 -6.83 -3.70 2.33 -4.01 -0.86 -5.46
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
Localization
Cell Percentages ER (98%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Cue4

Cue4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cue4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available