Standard name
Human Ortholog
Description Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.1 0.1 0.08 0.1 0.14 0.07 0.06 0.09 0.07 0.14 0.17 0.18 0.07 0.05 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.09 0.11 0.06 0.24 0.23 0.19 0.24 0.25 0.33 0.3 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.91 0.92 0.87 0.84 0.85 0.75 0.72 0.77 0.73 0.79 0.73 0.72 0.81 0.76 0.76 0.9 0.9 0.87 0.81 0.89 0.91 0.88 0.61 0.48
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0.06 0.05 0.05 0.09 0.07 0.15 0.17 0.15 0.2 0 0 0 0 0 0 0 0 0 0 0.05 0.06
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.05 0.08 0.27 0.31
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 1 0 1 0 0 0 0 1 1 0 1 0 0 0 0 0 0 0 0 1 0 0 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 1 1 0 1 3 1 2 4 5 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 3 4 10 11 8 16 28 7 7 10 11 17 41 42 23 15 17 1 1 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 4 0 2 2 0 0 0 0 3
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 2 5 0 2 1 3 1 0 0 1 5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 0 0 0 0 2
Mitochondria 3 6 7 11 7 23 37 39 23 31 37 49 1 1 1 6 2 1 0 0 0 0 2 3
Nucleus 87 130 68 81 95 72 116 157 70 96 83 118 99 184 179 302 268 264 78 131 85 96 121 99
Nuclear Periphery 1 0 0 1 0 2 2 1 1 3 3 3 0 2 0 0 0 0 1 0 0 0 0 4
Nucleolus 0 3 3 6 6 5 15 14 14 21 17 32 5 6 8 5 3 4 1 2 0 2 10 13
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 2 6 4 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 4 3 2 0 0 0 0 0 0 0 3 3
Vac/Vac Membrane 6 3 2 1 2 4 3 4 2 2 1 3 0 7 9 9 12 16 4 6 4 8 53 63
Unique Cell Count 96 141 78 96 112 96 161 204 96 122 113 164 122 242 236 336 298 303 97 147 94 110 199 207
Labelled Cell Count 100 146 84 112 122 114 190 246 119 163 155 222 130 253 250 349 303 308 97 147 94 110 199 207


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.0 7.5 7.0 6.2 7.0 7.0 5.8 6.2 6.5 5.6 6.1 5.7 7.8 8.5 9.1 10.1 11.9 12.2 7.2 7.6 8.7
Std Deviation (1e-4) 2.2 1.5 2.2 1.5 2.0 3.0 2.1 2.4 2.6 1.6 2.5 2.5 2.4 3.3 3.8 2.4 2.5 2.8 1.9 1.9 2.0
Intensity Change (Log2) – – – -0.17 -0.0 0.01 -0.27 -0.17 -0.11 -0.32 -0.19 -0.28 0.17 0.29 0.38 0.54 0.77 0.81 0.05 0.12 0.32

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.3 1.2 0.8 1.3 2.0 0 0 1.0 0 2.0 2.6 2.7 0.6 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.5 -0.7 2.6 2.6 2.1 2.6 2.9 3.8 3.6 0 0 0 0 0 0
Nucleus -0.5 -0.5 -2.0 -2.6 -1.9 -2.3 -1.5 -2.3 -2.6 -1.1 -2.1 -2.1 0.7 0.7 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1.5 0 2.4 2.8 2.5 3.2 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.0291 4.3639 3.6149 3.6967 2.4272 3.3798 4.2783 4.6129 4.8327 4.8198 3.9127 4.3905 6.1645 6.2195 6.181 5.5867 5.5644 5.7521
Actin 0.0213 0 0.0115 0 0.008 0.0071 0.0027 0 0.0085 0.0135 0.0084 0.0017 0.0075 0 0.0031 0.0001 0.0053 0
Bud 0.0003 0.0011 0.0001 0 0 0.0015 0.0002 0 0.0003 0.001 0.0004 0.0001 0.0004 0 0.0001 0 0.0002 0
Bud Neck 0.0032 0.0001 0.0053 0 0.0003 0.0008 0.001 0 0.001 0.0048 0.0004 0.0012 0.0006 0 0.0002 0.0009 0.0002 0.0003
Bud Periphery 0.0004 0.0003 0.0001 0 0.0001 0.0011 0.0008 0 0.0007 0.0019 0.0008 0.0003 0.0014 0 0.0002 0 0.0002 0
Bud Site 0.0045 0.0002 0.0009 0 0.0003 0.0002 0.0008 0 0.0046 0.0123 0.0044 0.0001 0.0006 0 0.0003 0.0005 0.0002 0
Cell Periphery 0.0002 0 0.0001 0 0 0.0007 0.0004 0 0.0005 0.0007 0.0001 0.0001 0.0002 0 0.0001 0.0001 0 0
Cytoplasm 0.0084 0.007 0.0001 0 0.0006 0.0078 0.0021 0.0001 0.0007 0.0402 0.0003 0.0003 0.0006 0.0001 0.0003 0.0022 0.0002 0.0001
Cytoplasmic Foci 0.0252 0.0001 0.0011 0 0.014 0.0033 0.0083 0.0001 0.001 0.0129 0.0109 0.0004 0.0107 0 0.0013 0.0039 0.0013 0
Eisosomes 0.0002 0 0.0001 0 0.0034 0.0001 0.0001 0 0.0002 0.0001 0.0001 0 0.0001 0 0.0003 0 0.0001 0
Endoplasmic Reticulum 0.0017 0 0.0001 0 0.0001 0.0007 0.0028 0.0001 0.0004 0.0061 0.002 0.0011 0.0006 0 0.0009 0.0003 0.0002 0
Endosome 0.0105 0.0001 0.0013 0 0.0041 0.0038 0.0093 0.0018 0.0037 0.0121 0.0126 0.0025 0.0021 0 0.0038 0.0109 0.0066 0
Golgi 0.0042 0 0.0019 0 0.0031 0.0011 0.0019 0 0.0022 0.0055 0.0216 0.0005 0.0007 0 0.0011 0.0016 0.0116 0
Lipid Particles 0.0042 0 0.0019 0 0.0538 0.0077 0.0092 0.0003 0.0024 0.0055 0.0113 0.0019 0.0015 0 0.0031 0.0042 0.0009 0
Mitochondria 0.0028 0.0004 0.0006 0.0001 0.0015 0.0083 0.0126 0.0002 0.0056 0.0099 0.0327 0.0004 0.0055 0.0002 0.0095 0.0005 0.025 0.0001
None 0.0023 0.0009 0.0001 0 0.0493 0.0018 0.0011 0.0001 0.0003 0.0008 0.0004 0.0002 0.0003 0.0001 0.0004 0.0191 0.0001 0
Nuclear Periphery 0.0064 0.0016 0.0018 0.0006 0.001 0.0021 0.0111 0.0091 0.0053 0.0266 0.0059 0.0024 0.0211 0.0041 0.0098 0.0013 0.0011 0.0012
Nucleolus 0.0132 0.0108 0.0116 0.0053 0.0305 0.0294 0.0155 0.0116 0.0058 0.0077 0.0072 0.0168 0.0189 0.0057 0.0081 0.0045 0.018 0.0214
Nucleus 0.8729 0.9736 0.9549 0.9937 0.7827 0.9152 0.8883 0.9703 0.9533 0.8279 0.8514 0.9667 0.9051 0.9879 0.9469 0.9391 0.9273 0.9757
Peroxisomes 0.002 0 0.0012 0 0.0417 0.0029 0.0037 0 0.0015 0.0031 0.0226 0.0023 0.0009 0 0.0011 0.0006 0.0004 0
Punctate Nuclear 0.014 0.002 0.0048 0.0002 0.0051 0.0035 0.0241 0.0004 0.0009 0.0026 0.0023 0.0009 0.018 0.0016 0.0083 0.0023 0.0006 0.0012
Vacuole 0.0014 0.0011 0.0002 0 0.0002 0.0006 0.0027 0.0031 0.0008 0.0039 0.0017 0.0002 0.0017 0.0001 0.0006 0.007 0.0003 0.0001
Vacuole Periphery 0.0007 0.0005 0.0001 0 0.0001 0.0003 0.0014 0.0026 0.0004 0.001 0.0023 0.0001 0.0016 0.0002 0.0006 0.0007 0.0003 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.8794 12.6189 14.0456 17.2264 19.3189 21.1624 12.7589 10.0467 16.3571 21.2219
Translational Efficiency 0.9678 0.8179 0.8665 1.3634 1.1325 1.2071 1.0264 1.0953 0.9456 0.8308

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1675 1177 380 1582 1373 1892 216 193 3048 3069 596 1775

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 761.52 885.59 1131.52 1106.01 825.26 856.37 1209.64 1131.73 790.23 867.58 1159.83 1108.81
Standard Deviation 105.51 147.50 147.70 158.53 122.12 156.98 128.09 178.38 117.65 154.07 145.82 161.01
Intensity Change Log 2 — 0.217757 0.571308 0.538411 — 0.053386 0.551657 0.455609 — 0.134609 0.561121 0.495940

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000172 0.000493 0.000650 0.000584 0.000224 0.000340 0.001043 0.000839 0.000195 0.000399 0.000792 0.000612
Bud Neck 0.002229 0.007512 0.008828 0.020702 0.002156 0.006589 0.006197 0.015066 0.002196 0.006943 0.007874 0.020089
Bud Site 0.000465 0.001253 0.000768 0.003840 0.000394 0.001128 0.000840 0.003644 0.000433 0.001176 0.000794 0.003819
Cell Periphery 0.000258 0.000208 0.000037 0.000108 0.000141 0.000241 0.000052 0.000099 0.000206 0.000228 0.000043 0.000107
Cytoplasm 0.003643 0.001890 0.000375 0.002111 0.001184 0.002815 0.001532 0.008575 0.002535 0.002460 0.000794 0.002814
Cytoplasmic Foci 0.000180 0.000131 0.000014 0.000659 0.000040 0.000547 0.000028 0.000094 0.000117 0.000387 0.000019 0.000598
Eisosomes 0.000016 0.000025 0.000035 0.000024 0.000017 0.000026 0.000043 0.000025 0.000016 0.000026 0.000038 0.000024
Endoplasmic Reticulum 0.004339 0.007091 0.004039 0.003632 0.004479 0.007631 0.007033 0.003494 0.004402 0.007424 0.005124 0.003617
Endosome 0.000238 0.000637 0.000079 0.001186 0.000097 0.000574 0.000163 0.001006 0.000174 0.000598 0.000110 0.001166
Golgi 0.000032 0.000116 0.000036 0.002173 0.000027 0.000383 0.000056 0.000127 0.000030 0.000280 0.000043 0.001950
Lipid Particles 0.000056 0.000072 0.000051 0.000053 0.000038 0.000112 0.000128 0.000095 0.000048 0.000097 0.000079 0.000057
Mitochondria 0.000431 0.001408 0.000792 0.002869 0.000298 0.001146 0.000930 0.001605 0.000371 0.001247 0.000842 0.002732
Mitotic Spindle 0.000095 0.001090 0.000043 0.005438 0.000095 0.001485 0.000429 0.009279 0.000095 0.001334 0.000183 0.005856
None 0.007166 0.003696 0.000616 0.001540 0.003698 0.008008 0.001418 0.008973 0.005604 0.006354 0.000906 0.002348
Nuclear Periphery 0.000232 0.000340 0.000175 0.001261 0.000120 0.000628 0.000329 0.001027 0.000181 0.000517 0.000231 0.001236
Nuclear Periphery Foci 0.000194 0.000344 0.000020 0.000429 0.000063 0.000516 0.000075 0.001983 0.000135 0.000450 0.000040 0.000598
Nucleolus 0.007982 0.007515 0.003407 0.002759 0.008222 0.006867 0.002928 0.003608 0.008090 0.007116 0.003234 0.002851
Nucleus 0.971390 0.964612 0.978561 0.947203 0.978256 0.957983 0.973862 0.937494 0.974483 0.960525 0.976858 0.946148
Peroxisomes 0.000092 0.000225 0.000232 0.000173 0.000124 0.000666 0.000231 0.000154 0.000106 0.000497 0.000231 0.000171
Vacuole 0.000643 0.001080 0.001176 0.002523 0.000256 0.001812 0.002598 0.002466 0.000469 0.001531 0.001691 0.002517
Vacuole Periphery 0.000148 0.000263 0.000067 0.000734 0.000070 0.000504 0.000084 0.000347 0.000113 0.000411 0.000073 0.000692

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.45 -12.83 -15.32 -4.21 -0.12 -3.83 -10.93 -7.58 -6.78 -1.30 -7.92 -15.77 -16.56 -9.19 2.07
Bud Neck -6.19 -7.65 -16.89 -11.64 -10.27 -6.42 -8.85 -6.14 -4.70 -4.36 -8.61 -10.51 -18.32 -13.61 -11.99
Bud Site -2.93 -2.05 -4.04 -2.81 -3.53 -3.51 -4.58 -4.15 -3.44 -3.37 -4.57 -4.22 -4.82 -3.57 -3.95
Cell Periphery 0.98 5.21 3.75 3.63 -5.55 -2.20 2.34 0.65 3.58 -3.42 -0.64 5.72 3.69 5.39 -5.39
Cytoplasm 1.97 4.87 1.87 -0.69 -5.70 -2.77 -0.68 -2.56 -1.84 -2.36 0.40 4.00 -0.54 -0.94 -4.86
Cytoplasmic Foci 0.70 2.61 -0.90 -1.26 -1.99 -2.78 0.35 -1.39 1.30 -1.44 -2.07 2.66 -1.40 0.06 -2.10
Eisosomes -5.23 -9.16 -6.70 -0.53 5.15 -4.96 -9.50 -5.49 -3.64 0.58 -6.98 -13.13 -9.31 -1.44 6.79
Endoplasmic Reticulum -6.15 -0.22 1.20 7.83 1.37 -7.34 -5.65 -1.88 2.88 2.78 -9.48 -3.86 1.06 10.48 4.70
Endosome -2.06 3.85 -1.81 -0.43 -2.27 -3.71 -4.20 -2.01 -0.72 -1.70 -3.85 1.48 -2.27 -0.71 -2.39
Golgi -1.65 -1.08 -1.79 -1.66 -1.78 -2.08 -4.64 -5.06 0.89 -3.23 -2.35 -4.44 -1.82 -1.40 -1.78
Lipid Particles -0.69 -0.43 -1.23 -0.19 -0.95 -3.23 -4.72 -4.09 -2.69 -1.97 -3.03 -3.88 -3.73 0.08 0.06
Mitochondria -1.95 -3.21 -4.81 -2.02 -4.10 -4.66 -12.16 -7.82 -3.23 -4.12 -3.93 -7.73 -5.48 -3.02 -4.16
Mitotic Spindle -2.05 -0.08 -4.11 -2.99 -4.11 -2.41 -1.67 -2.42 -2.12 -1.80 -3.08 -1.66 -4.77 -3.46 -3.48
None 2.87 6.91 5.72 2.35 -7.02 -3.06 2.05 -1.61 0.15 -2.37 -0.64 7.12 4.91 4.53 -3.66
Nuclear Periphery -1.76 0.43 -7.10 -6.22 -7.19 -2.92 -6.67 -3.37 -2.07 -2.50 -3.07 -5.00 -8.02 -5.07 -7.16
Nuclear Periphery Foci -0.79 2.35 -0.68 0.14 -2.13 -1.95 -1.38 -1.58 -1.03 -1.52 -1.89 1.90 -1.85 -0.02 -2.49
Nucleolus 0.47 6.26 3.55 2.95 -1.82 1.30 5.18 0.59 -0.07 -1.91 1.35 8.21 3.96 2.74 -2.29
Nucleus 1.97 -2.33 7.99 5.66 10.13 6.91 3.96 5.71 3.88 4.36 6.08 1.20 10.81 6.12 9.81
Peroxisomes -3.16 -4.91 -1.06 1.20 1.43 -1.72 -3.59 -3.93 1.12 -1.07 -1.98 -6.08 -1.36 1.65 1.45
Vacuole -1.35 -2.87 -4.64 -3.89 -2.79 -3.86 -3.86 -3.39 -2.84 -1.99 -3.79 -4.87 -5.95 -4.03 -2.32
Vacuole Periphery -1.50 1.71 -2.22 -1.46 -2.76 -2.45 -2.80 -2.01 1.09 -1.77 -2.62 1.31 -2.59 -0.43 -2.85
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Cac2

Cac2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cac2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available