Standard name
Human Ortholog
Description Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0 0 0 0 – 0 0 0 0.06 0.09 0.11 0.1 0.13 0.12 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.05 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.11 0.09 0.2 0.23 0.52 0.48 0.47 – 0.57 0.6 0.53 0 0 0 0.08 0.07 0.06 0 0 0 0.14 0.18 0.19
Nucleus 0 0.05 0 0 0 0 0 0.06 – 0.05 0 0 0 0 0 0.09 0.11 0.06 0 0 0 0 0 0
Nuclear Periphery 0.8 0.8 0.83 0.73 0.67 0.63 0.58 0.49 – 0.53 0.53 0.59 0.84 0.79 0.73 0.63 0.65 0.63 0.88 0.82 0.89 0.72 0.67 0.61
Nucleolus 0.06 0.06 0.13 0.18 0.18 0.22 0.28 0.27 – 0.33 0.27 0.32 0.06 0.1 0.06 0.08 0.11 0.18 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.39 0.28 0.19 0.13 0.19 0.08 0.05 0 – 0.08 0.05 0 0.23 0.19 0.29 0.27 0.27 0.24 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 1 0 0 0 – 0 0 0 1 0 0 0 0 0 4 1 1 0 6 4
Bud 0 0 1 0 1 1 3 9 – 2 1 2 0 0 0 0 1 0 7 4 0 6 4 5
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 2 5 0 – 2 10 3 2 2 1 1 1 0 – – – – – –
Cell Periphery 3 0 1 1 1 1 0 0 – 0 0 0 0 1 0 3 0 0 0 0 0 0 0 0
Cytoplasm 5 4 12 18 13 4 16 15 – 5 9 4 17 36 48 54 51 35 0 0 0 0 0 0
Endoplasmic Reticulum 5 0 10 4 5 9 7 4 – 2 5 3 1 0 0 14 3 9 1 0 1 3 3 3
Endosome 3 0 24 3 12 1 10 14 – 1 4 5 3 6 4 17 12 9 8 5 5 15 22 50
Golgi 0 0 2 0 0 0 0 0 – 0 0 0 0 0 2 3 0 3 2 2 2 7 12 5
Mitochondria 11 35 43 73 89 232 313 326 – 322 283 332 2 3 3 44 26 17 24 15 21 73 100 129
Nucleus 24 16 8 7 9 11 20 40 – 28 17 24 5 14 10 50 45 17 10 5 3 3 1 6
Nuclear Periphery 547 257 405 261 261 280 380 342 – 303 250 368 234 313 317 352 257 181 658 296 473 372 377 422
Nucleolus 39 20 62 64 69 100 184 190 – 186 129 201 18 41 27 45 44 51 8 5 3 7 2 9
Peroxisomes 0 0 0 0 2 0 0 6 – 0 0 0 1 1 3 0 0 0 0 0 0 6 7 10
SpindlePole 1 0 3 0 6 1 2 7 – 0 3 1 3 8 16 5 1 2 1 1 1 4 3 6
Vac/Vac Membrane 265 89 94 46 74 35 34 29 – 46 26 27 64 76 126 149 106 69 19 18 11 15 14 30
Unique Cell Count 683 321 490 359 391 447 653 695 568 475 627 279 398 437 561 394 289 752 360 533 521 559 697
Labelled Cell Count 904 421 665 477 543 677 974 982 897 737 970 351 501 558 737 547 393 752 360 533 521 559 697


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.7 11.6 11.1 9.5 8.6 7.2 7.3 7.6 – 6.9 7.1 6.9 12.7 11.7 12.1 9.4 9.7 10.7 12.7 13.7 14.2
Std Deviation (1e-4) 4.0 2.8 3.6 3.0 2.8 2.5 2.5 2.4 – 2.2 2.3 2.2 2.8 3.3 3.5 2.4 2.7 2.9 2.8 2.2 2.6
Intensity Change (Log2) – – – -0.23 -0.37 -0.64 -0.6 -0.54 – -0.7 -0.64 -0.68 0.19 0.08 0.12 -0.25 -0.2 -0.06 0.19 0.3 0.35

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 2.0 0.8 -1.8 0 -0.3 – -2.0 -0.6 -2.5 2.6 4.3 5.3 4.8 6.0 5.5
Endoplasmic Reticulum -1.0 -0.9 0 -1.3 -2.3 – -2.6 -1.2 -2.4 0 0 0 0.5 -1.6 0.9
Endosome -3.3 -1.4 -4.4 -3.3 -2.8 – -5.0 -3.8 -4.3 -2.8 -2.8 -3.5 -1.6 -1.4 -1.2
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Mitochondria 4.8 5.8 14.5 14.1 14.0 – 16.3 16.7 15.5 -4.6 -5.4 -5.7 -0.5 -1.2 -1.5
Nucleus 0.3 0.7 0.9 1.5 3.5 – 2.9 1.9 2.2 0 1.8 0.7 5.2 6.1 3.3
Nuclear Periphery -3.5 -5.5 -6.9 -8.8 -11.7 – -10.1 -10.0 -8.6 0.4 -1.5 -3.7 -7.2 -5.9 -6.3
Nucleolus 2.1 2.1 3.9 6.3 6.1 – 7.7 5.7 7.6 -2.7 -1.1 -3.3 -2.5 -0.7 1.9
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 3.3 0 0 0
Vacuole -2.5 -0.1 -5.0 -7.4 -8.3 – -5.3 -6.5 -7.9 1.2 0 3.4 2.8 2.7 1.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.8283 9.3996 9.8645 9.887 9.6803 9.8387 11.2365 12.1319 11.1918 10.2676 10.7925 11.4691 13.0146 13.2024 12.5887 11.5509 11.7559 12.1403
Actin 0.0037 0.0004 0.0102 0.0124 0.0003 0.0005 0.0016 0.0001 0.0039 0.0005 0.0243 0.0001 0.0057 0.0002 0.0004 0.0435 0.0008 0.0001
Bud 0 0 0.0001 0.0002 0 0 0.0013 0 0 0 0.0001 0 0.0002 0 0 0.0005 0.0002 0
Bud Neck 0.0001 0.0001 0.0002 0.0003 0 0.0001 0.0001 0 0.0005 0 0.0005 0 0.0001 0 0 0.0001 0.0002 0
Bud Periphery 0.0001 0.0001 0.0002 0.0003 0.0001 0.0001 0.0072 0.0001 0.0001 0.0001 0.0002 0 0.0002 0.0001 0.0001 0.0024 0.0009 0
Bud Site 0.0001 0 0.0004 0.0008 0 0.0001 0.0003 0 0.0003 0 0.0007 0 0.0008 0 0 0.0003 0.0002 0
Cell Periphery 0.0001 0.0001 0.0001 0.0001 0 0 0.0002 0 0.0001 0 0.0001 0 0.0001 0 0 0.0001 0.0001 0
Cytoplasm 0.0048 0.0098 0.0012 0.0004 0.0001 0.0001 0.0032 0.0001 0.0015 0 0.001 0 0.0051 0.0001 0.0001 0.0001 0.0003 0
Cytoplasmic Foci 0.0021 0.0003 0.0035 0.0022 0.0001 0.0002 0.0008 0 0.0024 0 0.0086 0 0.003 0.0002 0 0.0012 0.0004 0
Eisosomes 0.0002 0 0.0002 0.0001 0 0 0 0 0.0001 0 0.0001 0 0.0001 0 0 0.0005 0 0
Endoplasmic Reticulum 0.0025 0.0009 0.0031 0.0018 0.0006 0.0003 0.0015 0.0071 0.002 0.0009 0.0013 0.0001 0.0357 0.0008 0.0011 0.003 0.001 0.0002
Endosome 0.0055 0.0011 0.003 0.0045 0.0012 0.0005 0.008 0.0012 0.003 0.0002 0.012 0.0001 0.0251 0.0003 0.0007 0.0106 0.0081 0.0001
Golgi 0.0015 0.0005 0.0012 0.0025 0.0004 0.0001 0.0005 0.0001 0.0009 0.0002 0.0038 0 0.004 0.0001 0.0001 0.0228 0.0011 0.0001
Lipid Particles 0.0101 0.007 0.0031 0.0039 0.0029 0.001 0.0014 0.0008 0.0176 0.0008 0.0239 0.0004 0.0128 0.0027 0.0008 0.0112 0.0057 0.0007
Mitochondria 0.0034 0.0016 0.0025 0.0026 0.0018 0.0034 0.0042 0.0012 0.0058 0.0007 0.002 0.001 0.0044 0.0009 0.0019 0.019 0.0101 0.0019
None 0.0012 0.0003 0.002 0.0005 0.0002 0.0002 0.011 0.0001 0.0015 0.0002 0.002 0 0.0013 0.0001 0.0002 0.001 0.0009 0
Nuclear Periphery 0.8882 0.8176 0.8336 0.85 0.9053 0.9266 0.9113 0.9274 0.899 0.9579 0.8727 0.9828 0.8623 0.8898 0.9553 0.8519 0.9028 0.9603
Nucleolus 0.0014 0.0068 0.0054 0.0019 0.0026 0.0036 0.0005 0.0001 0.0034 0.0003 0.0013 0.0001 0.0005 0.0116 0.0002 0.0004 0.0085 0.0006
Nucleus 0.041 0.1151 0.0958 0.0869 0.0589 0.0409 0.0035 0.0095 0.0057 0.0027 0.0018 0.0011 0.0075 0.0534 0.005 0.0053 0.0169 0.0152
Peroxisomes 0.0002 0 0.0013 0.0015 0 0.0002 0.0002 0 0.0003 0 0.0072 0 0.0005 0 0 0.0013 0.0005 0
Punctate Nuclear 0.0047 0.0027 0.0076 0.0059 0.0022 0.0009 0.003 0.0003 0.0059 0.001 0.0139 0.0003 0.0041 0.0027 0.0004 0.0017 0.0019 0.0004
Vacuole 0.0019 0.0043 0.0011 0.0007 0.0008 0.0023 0.0057 0.0018 0.0013 0.0002 0.0008 0 0.0017 0.0019 0.0004 0.0006 0.0065 0.001
Vacuole Periphery 0.0274 0.0313 0.0242 0.0205 0.0226 0.0188 0.0344 0.0502 0.0447 0.0342 0.0216 0.0139 0.0247 0.0351 0.0332 0.0223 0.0326 0.0192

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 42.4215 36.5325 32.8545 47.4006 38.7313 23.7518 42.7597 40.851 35.0093 52.6522
Translational Efficiency 0.5974 0.5061 0.7155 0.4189 0.4934 0.8236 0.5366 0.4085 0.5282 0.435

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
145 1485 283 1157 1070 1552 995 1957 1215 3037 1278 3114

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1259.61 1109.39 1352.89 1329.34 1022.84 1163.28 1327.83 1328.55 1051.10 1136.93 1333.38 1328.84
Standard Deviation 190.63 211.60 235.00 235.04 1307.74 195.98 233.96 244.42 1231.39 205.54 234.42 240.98
Intensity Change Log 2 — -0.183210 0.103067 0.077733 — 0.185618 0.376490 0.377272 — -0.006195 0.232037 0.219698

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000798 0.000589 0.000727 0.000554 0.001594 0.000388 0.000344 0.000527 0.001499 0.000486 0.000429 0.000537
Bud Neck 0.004263 0.000832 0.000944 0.004625 0.003393 0.000295 0.000833 0.001722 0.003497 0.000558 0.000858 0.002800
Bud Site 0.004306 0.000139 0.000111 0.001267 0.001847 0.000071 0.000048 0.000362 0.002141 0.000104 0.000062 0.000698
Cell Periphery 0.000244 0.000071 0.000033 0.000115 0.000648 0.000035 0.000020 0.000063 0.000600 0.000053 0.000022 0.000082
Cytoplasm 0.000953 0.000265 0.000316 0.001667 0.007163 0.000291 0.000209 0.001332 0.006422 0.000278 0.000233 0.001457
Cytoplasmic Foci 0.009167 0.001328 0.000339 0.003362 0.006178 0.000864 0.000206 0.000840 0.006535 0.001091 0.000236 0.001777
Eisosomes 0.000014 0.000009 0.000017 0.000009 0.000037 0.000008 0.000003 0.000005 0.000034 0.000009 0.000006 0.000007
Endoplasmic Reticulum 0.009586 0.003909 0.005554 0.002058 0.008715 0.002452 0.001151 0.001916 0.008819 0.003164 0.002126 0.001968
Endosome 0.011368 0.001272 0.000283 0.003419 0.003053 0.001338 0.000259 0.001001 0.004045 0.001306 0.000265 0.001899
Golgi 0.011144 0.000708 0.000148 0.001783 0.001663 0.000586 0.000187 0.000335 0.002794 0.000646 0.000179 0.000873
Lipid Particles 0.007359 0.002572 0.000919 0.001553 0.009447 0.003213 0.000359 0.000896 0.009198 0.002899 0.000483 0.001140
Mitochondria 0.007538 0.006780 0.001871 0.004226 0.018940 0.005511 0.001954 0.004690 0.017579 0.006132 0.001935 0.004518
Mitotic Spindle 0.081088 0.002946 0.005318 0.062918 0.005624 0.002045 0.002718 0.018716 0.014630 0.002485 0.003294 0.035139
None 0.000207 0.001675 0.003451 0.001156 0.022549 0.000717 0.000225 0.001563 0.019883 0.001185 0.000939 0.001412
Nuclear Periphery 0.555648 0.610711 0.524405 0.551259 0.444459 0.692916 0.761438 0.643877 0.457729 0.652720 0.708950 0.609465
Nuclear Periphery Foci 0.220859 0.303449 0.193023 0.272127 0.293076 0.247188 0.169465 0.249323 0.284457 0.274698 0.174682 0.257796
Nucleolus 0.015513 0.020507 0.074361 0.030716 0.060655 0.012325 0.023953 0.022992 0.055268 0.016326 0.035115 0.025862
Nucleus 0.022200 0.022411 0.184060 0.038613 0.089249 0.011624 0.026788 0.037719 0.081247 0.016899 0.061614 0.038051
Peroxisomes 0.000705 0.000504 0.000961 0.000619 0.002191 0.000512 0.000293 0.000386 0.002014 0.000508 0.000441 0.000473
Vacuole 0.015736 0.004433 0.001081 0.006823 0.005757 0.004627 0.001548 0.003190 0.006948 0.004532 0.001444 0.004540
Vacuole Periphery 0.021303 0.014892 0.002080 0.011131 0.013760 0.012992 0.007999 0.008547 0.014661 0.013921 0.006689 0.009507

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.82 0.23 0.69 -0.48 1.21 8.94 9.94 6.86 -1.72 -2.38 8.56 9.04 7.15 -1.48 -2.15
Bud Neck 2.95 2.79 -0.59 -7.01 -6.61 8.09 6.49 2.88 -6.18 -4.05 8.03 7.05 0.72 -9.04 -7.72
Bud Site 2.01 2.01 1.23 -3.29 -3.29 2.10 2.13 1.61 -2.68 -2.84 2.58 2.63 1.53 -4.13 -4.33
Cell Periphery 1.11 1.34 0.76 -1.58 -2.76 7.60 7.81 7.23 -3.00 -5.42 7.46 7.87 6.94 -2.44 -5.00
Cytoplasm 2.45 2.15 -1.40 -2.98 -2.82 5.94 6.08 4.81 -4.06 -4.97 6.07 6.13 4.58 -5.06 -5.38
Cytoplasmic Foci 2.47 2.81 1.70 -2.46 -3.91 6.08 6.96 5.90 -0.11 -2.30 6.33 7.48 5.22 -1.89 -4.59
Eisosomes 1.23 -0.81 1.07 -0.51 3.17 6.49 8.09 7.44 1.42 -3.27 6.75 7.36 7.24 1.31 -0.65
Endoplasmic Reticulum 1.81 1.25 2.31 3.17 4.64 8.52 10.81 9.48 1.67 -3.87 7.51 8.92 9.05 3.98 0.55
Endosome 3.02 3.33 2.28 -3.10 -4.64 3.49 8.10 5.25 0.78 -4.03 5.04 7.54 3.61 -1.85 -5.89
Golgi 2.42 2.55 2.15 -2.23 -3.70 2.17 3.23 2.90 1.07 -2.63 3.23 4.01 2.86 -1.04 -4.15
Lipid Particles 0.97 1.29 1.18 1.67 -0.93 4.84 8.76 8.25 2.94 -2.13 5.43 8.05 7.44 3.61 -2.57
Mitochondria 0.19 1.61 0.88 2.35 -4.31 5.81 7.84 6.33 0.69 -3.77 5.63 8.01 6.52 1.97 -5.07
Mitotic Spindle 4.73 4.58 1.07 -11.89 -11.16 2.82 2.30 -6.01 -7.78 -7.52 5.16 4.79 -6.49 -13.97 -13.54
None -2.94 -1.63 -2.65 0.78 1.15 7.21 7.39 6.88 -2.34 -4.19 6.98 7.01 6.87 -0.89 -1.09
Nuclear Periphery -2.36 0.73 0.19 6.60 -0.87 -23.36 -27.36 -17.40 6.75 13.13 -20.20 -21.38 -14.16 7.80 11.34
Nuclear Periphery Foci -5.16 1.24 -2.93 4.37 -5.51 5.41 14.64 5.28 -0.05 -12.14 1.14 13.79 3.74 3.91 -13.94
Nucleolus -0.61 -5.71 -2.38 -3.60 4.82 11.38 7.76 8.18 -4.90 0.03 10.28 4.45 6.93 -5.55 2.48
Nucleus 0.50 -8.08 -1.89 -4.68 7.73 12.69 9.38 7.26 -8.62 -3.33 11.83 2.76 6.86 -9.12 3.59
Peroxisomes 0.66 -0.75 0.06 -1.42 1.55 5.22 6.34 5.60 0.48 -1.39 5.52 5.82 5.34 -0.30 -0.94
Vacuole 2.94 3.80 2.14 -2.89 -6.58 1.26 5.69 2.83 1.56 -3.35 2.84 6.89 2.39 -0.53 -6.81
Vacuole Periphery 1.04 3.35 1.73 2.64 -8.14 0.43 3.26 3.57 3.31 -0.37 0.43 4.88 3.57 4.58 -2.52
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
Localization
Cell Percentages nuclear periphery (73%), nucleus (9%), mixed (5%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Nup188

Nup188


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nup188-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available