ORF
Human Ortholog
Description Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.07 0.08 0.24 0.28 0.06 0 0 0.11 0.05 0 0.05 0.07 0.3 0.2 0.18 0.08 0.11 0.14 0 0.06 0.15 0.16 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.23 0.21 0.1 0.25 0.31 0.45 0.27 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.75 0.41 0.4 0.44 0.87 0.82 0.78 0.72 0.75 0.74 0.67 0.69 0.36 0.62 0.74 0.69 0.6 0.57 0.82 0.79 0.62 0.44 0.59 0.47
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0.09 0.05 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.29 0.59 0.49 0.33 0.05 0 0 0.11 0.05 0.06 0.06 0.1 0.48 0.2 0.07 0.22 0.35 0.34 0.06 0.06 0.1 0.24 0.25 0.3
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 1
Bud 0 0 0 1 0 2 5 7 12 14 15 13 0 0 0 0 0 0 8 7 13 11 10 10
Bud Neck 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 1 0 0 2 0 0
Bud Site 0 0 0 0 5 18 12 14 13 14 9 18 0 1 0 0 0 0 – – – – – –
Cell Periphery 0 0 3 1 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 18 13 155 152 38 39 32 104 37 36 43 67 26 47 41 9 15 17 13 10 109 30 6 6
Endoplasmic Reticulum 0 0 1 0 1 0 0 0 1 0 0 0 1 0 1 3 0 3 0 0 9 2 0 3
Endosome 2 5 21 24 8 2 8 12 4 5 0 17 0 4 1 1 2 0 5 2 25 2 2 5
Golgi 0 0 1 1 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 3 0 0 0
Mitochondria 8 0 9 16 11 198 211 94 201 290 394 273 0 1 0 2 1 0 1 0 3 1 3 3
Nucleus 204 66 255 238 596 713 796 675 610 688 582 695 32 146 169 73 84 71 252 142 439 85 129 112
Nuclear Periphery 0 0 1 1 10 7 33 28 15 17 6 18 0 0 6 1 0 0 0 0 5 0 0 5
Nucleolus 0 1 0 2 17 42 95 47 25 46 44 38 0 2 1 2 3 1 0 2 5 3 5 9
Peroxisomes 0 0 0 0 0 0 2 0 0 0 0 1 0 1 0 0 0 0 0 0 1 0 0 0
SpindlePole 0 0 0 0 2 0 2 0 1 0 1 1 0 2 2 0 0 0 2 2 11 2 1 4
Vac/Vac Membrane 79 95 308 180 35 27 35 99 39 54 50 101 42 47 16 23 48 43 19 11 71 45 55 72
Unique Cell Count 273 162 635 540 686 873 1018 938 810 933 872 1011 88 237 227 106 139 125 308 181 712 192 220 240
Labelled Cell Count 311 180 754 616 724 1048 1232 1080 958 1166 1145 1243 101 251 238 114 153 135 308 181 712 192 220 240


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.6 7.8 7.8 7.2 6.8 5.3 5.6 6.6 5.6 5.4 5.1 5.4 8.5 8.6 8.4 11.2 11.7 11.7 7.9 8.1 8.3
Std Deviation (1e-4) 1.2 1.5 1.3 1.4 1.9 1.7 1.6 2.0 1.4 1.2 1.2 1.3 1.4 1.8 1.7 2.9 2.8 3.0 1.6 1.5 1.6
Intensity Change (Log2) – – – -0.13 -0.2 -0.57 -0.49 -0.25 -0.48 -0.54 -0.62 -0.54 0.12 0.13 0.1 0.52 0.58 0.58 0.01 0.06 0.09


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 3.1 3.1 3.3 2.9 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 3.6 0 3.1 3.2 3.1 0 3.4 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.5 -9.7 -11.4 -13.3 -7.0 -11.0 -12.2 -11.1 -10.3 1.0 -1.4 -2.0 -3.7 -3.5 -2.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 1.0 -2.7 -4.8 -3.8 -2.8 -4.1 -4.2 -5.4 -2.1 0 -1.3 -2.4 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 1.8 0.3 11.8 11.2 6.8 12.5 14.7 19.0 13.4 0 0 0 0 0 0
Nucleus 1.4 17.7 16.6 15.6 12.6 13.5 13.3 10.3 11.4 -0.7 5.7 8.9 5.5 4.4 3.4
Nuclear Periphery 0 2.6 0 4.3 4.1 3.1 3.0 0 3.0 0 0 0 0 0 0
Nucleolus 0 4.0 5.6 7.9 5.7 4.5 5.7 5.7 4.9 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -5.3 -18.0 -20.9 -22.0 -16.9 -19.3 -19.7 -19.3 -17.6 -0.1 -7.7 -11.1 -5.1 -3.0 -2.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.7244 4.8162 4.2021 3.9813 3.4934 3.7891 5.1497 6.7015 5.9372 5.5802 5.7003 5.8708 4.0764 5.5081 5.1543 4.9497 4.3936 4.8869
Actin 0.0346 0 0.0001 0.0031 0 0.0001 0.0161 0.0043 0.0176 0.0036 0.0666 0.0023 0.0067 0.002 0.0127 0.0203 0 0.0011
Bud 0.0004 0 0 0.0001 0 0.0001 0.0005 0.0002 0.0007 0.0001 0.001 0.0005 0.0001 0.0007 0.0004 0.0007 0 0.0004
Bud Neck 0.0027 0.0001 0.0002 0.0003 0.0002 0.0025 0.0055 0.0004 0.001 0.0004 0.0024 0.0015 0.0002 0.0004 0.0002 0.0008 0.0005 0.0016
Bud Periphery 0.001 0 0 0 0 0.0001 0.0008 0.0001 0.0013 0.0003 0.0023 0.0005 0 0.0005 0.0002 0.0005 0 0.0003
Bud Site 0.0011 0.0002 0.0001 0.0003 0 0.0004 0.0043 0.0012 0.0023 0.001 0.0024 0.0004 0.0001 0.0123 0.0016 0.0009 0 0.0009
Cell Periphery 0.0004 0 0 0 0 0 0.0004 0 0.0002 0.0002 0.0011 0.0001 0.0001 0.0002 0 0.0001 0 0
Cytoplasm 0.021 0.0315 0.0331 0.0271 0.0155 0.0315 0.0135 0.0787 0.0357 0.0109 0.0181 0.0182 0.0189 0.0568 0.0042 0.1358 0.0464 0.0059
Cytoplasmic Foci 0.0056 0.0001 0.0024 0.01 0 0.0011 0.0122 0.0025 0.0035 0.0008 0.0026 0.0022 0.0194 0.0013 0.0145 0.0106 0.0001 0.0117
Eisosomes 0.0004 0 0 0 0 0 0.0008 0 0.0001 0.0001 0.0028 0 0.0001 0.0001 0 0.0001 0 0
Endoplasmic Reticulum 0.0062 0.0003 0.001 0.0004 0.0002 0.0007 0.0055 0.0007 0.0017 0.0061 0.0027 0.0019 0.0063 0.0013 0.0004 0.0056 0.0005 0.0002
Endosome 0.015 0.0003 0.0021 0.0015 0.0001 0.0018 0.0244 0.0011 0.0052 0.0087 0.0079 0.0074 0.0066 0.0028 0.0075 0.072 0.0003 0.0114
Golgi 0.003 0 0.0002 0.0005 0 0.0001 0.0049 0.0011 0.0027 0.0015 0.0055 0.002 0.0029 0.0007 0.0087 0.0728 0 0.0069
Lipid Particles 0.0049 0 0.0023 0.0005 0 0 0.0099 0.0022 0.0027 0.0019 0.0049 0.0054 0.0228 0.0006 0.0004 0.0008 0 0.002
Mitochondria 0.0027 0.0002 0.0002 0.0002 0.0002 0.0002 0.0093 0.001 0.0099 0.042 0.0262 0.0032 0.0005 0.0074 0.002 0.0068 0.0002 0.0016
None 0.0028 0.0002 0.0011 0.001 0.0001 0.0004 0.0133 0.0007 0.002 0.001 0.0016 0.0018 0.007 0.0006 0.0002 0.0006 0.004 0.0002
Nuclear Periphery 0.0322 0.0084 0.016 0.0051 0.0066 0.0091 0.0172 0.0098 0.0103 0.0147 0.0092 0.0074 0.0051 0.0069 0.0014 0.0091 0.0081 0.0021
Nucleolus 0.0071 0.0024 0.0031 0.0015 0.0075 0.0058 0.0076 0.0077 0.0042 0.0015 0.031 0.004 0.0033 0.003 0.0017 0.0004 0.0023 0.0073
Nucleus 0.841 0.9535 0.9309 0.9096 0.9678 0.9316 0.8149 0.8802 0.8834 0.9008 0.7916 0.9269 0.8951 0.8987 0.9395 0.6574 0.9348 0.9362
Peroxisomes 0.0016 0 0.0001 0.0013 0 0.0001 0.0046 0.0037 0.0045 0.0005 0.001 0.0009 0.0025 0.0006 0.0032 0.0004 0 0.0062
Punctate Nuclear 0.0122 0.0022 0.006 0.0371 0.0013 0.0128 0.0276 0.0032 0.0084 0.0016 0.0033 0.0079 0.0018 0.0021 0.001 0.0014 0.0021 0.0035
Vacuole 0.0028 0.0005 0.0006 0.0003 0.0002 0.0012 0.0051 0.001 0.0021 0.0015 0.0125 0.0045 0.0004 0.0009 0.0001 0.0018 0.0004 0.0005
Vacuole Periphery 0.0015 0.0001 0.0002 0.0001 0.0001 0.0003 0.0017 0.0002 0.0006 0.0008 0.003 0.001 0.0002 0.0003 0.0001 0.0012 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.4935 31.0181 34.5252 28.3677 49.4866 31.2111 25.0899 17.9924 28.7281 33.0207
Translational Efficiency 2.4071 2.266 1.5401 2.3043 1.1042 2.0613 2.4541 2.1803 1.3315 1.7543

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1279 2092 2534 1415 1625 2044 2698 2381 2904 4136 5232 3796

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 782.01 987.89 1124.11 1298.26 832.51 929.50 1170.24 1211.47 810.27 959.03 1147.90 1243.82
Standard Deviation 107.70 150.49 176.59 240.52 126.51 142.76 171.78 193.27 121.22 149.60 175.64 216.23
Intensity Change Log 2 — 0.337163 0.523524 0.731320 — 0.158987 0.491265 0.541219 — 0.248039 0.506980 0.636427

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000185 0.000288 0.000347 0.001329 0.000205 0.000245 0.000289 0.000550 0.000196 0.000267 0.000317 0.000841
Bud Neck 0.004635 0.006330 0.014613 0.029383 0.005082 0.010480 0.014437 0.022585 0.004885 0.008381 0.014522 0.025119
Bud Site 0.001490 0.001762 0.001421 0.005796 0.001421 0.003218 0.000877 0.003132 0.001451 0.002481 0.001140 0.004125
Cell Periphery 0.000205 0.000137 0.000117 0.000395 0.000215 0.000231 0.000093 0.000125 0.000210 0.000184 0.000104 0.000226
Cytoplasm 0.042097 0.066518 0.017906 0.011409 0.092865 0.137703* 0.005307 0.009055 0.070506 0.101697* 0.011409 0.009932
Cytoplasmic Foci 0.003799 0.001147 0.000032 0.001795 0.002709 0.004410 0.000026 0.000148 0.003189 0.002760 0.000029 0.000762
Eisosomes 0.000016 0.000011 0.000014 0.000030 0.000014 0.000017 0.000019 0.000021 0.000015 0.000014 0.000017 0.000025
Endoplasmic Reticulum 0.003993 0.003848 0.002376 0.002716 0.003724 0.003298 0.002322 0.003107 0.003843 0.003576 0.002348 0.002961
Endosome 0.000872 0.000559 0.000173 0.003790 0.000619 0.001758 0.000187 0.000573 0.000730 0.001151 0.000180 0.001772
Golgi 0.000486 0.000214 0.000041 0.002401 0.000082 0.000773 0.000030 0.000189 0.000260 0.000490 0.000035 0.001013
Lipid Particles 0.000692 0.000181 0.000051 0.000313 0.000331 0.000640 0.000052 0.000059 0.000490 0.000408 0.000051 0.000154
Mitochondria 0.001204 0.000759 0.001361 0.004713 0.000590 0.003352 0.000961 0.001976 0.000860 0.002041 0.001155 0.002996
Mitotic Spindle 0.001953 0.002038 0.002201 0.008412 0.002086 0.009883 0.000893 0.007858 0.002028 0.005915 0.001526 0.008064
None 0.006703 0.004391 0.004224 0.004939 0.009150 0.010170 0.002039 0.004234 0.008072 0.007247 0.003097 0.004497
Nuclear Periphery 0.001100 0.001349 0.001143 0.001691 0.001066 0.001660 0.000699 0.002056 0.001081 0.001503 0.000914 0.001920
Nuclear Periphery Foci 0.000387 0.000320 0.000058 0.000835 0.000580 0.000678 0.000096 0.000883 0.000495 0.000497 0.000078 0.000865
Nucleolus 0.003306 0.001224 0.000740 0.005570 0.002273 0.003444 0.000624 0.002146 0.002728 0.002321 0.000681 0.003422
Nucleus 0.923459* 0.904526* 0.951369* 0.906226* 0.872954* 0.795482* 0.969955* 0.937359* 0.895197* 0.850637* 0.960954* 0.925754*
Peroxisomes 0.000371 0.000245 0.000026 0.000322 0.000166 0.000578 0.000022 0.000079 0.000256 0.000410 0.000024 0.000170
Vacuole 0.002796 0.003946 0.001716 0.005745 0.003669 0.011175 0.001000 0.002475 0.003284 0.007519 0.001347 0.003694
Vacuole Periphery 0.000252 0.000209 0.000072 0.002189 0.000200 0.000805 0.000072 0.001390 0.000223 0.000503 0.000072 0.001688

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.21 -9.93 -7.18 -6.08 -5.51 -1.69 -7.44 -5.74 -4.59 -3.39 -2.71 -12.40 -9.17 -7.37 -6.30
Bud Neck -2.00 -14.14 -15.20 -14.06 -8.14 -5.25 -14.47 -14.94 -9.67 -4.99 -5.17 -20.27 -21.23 -16.97 -9.07
Bud Site -0.50 -0.58 -4.82 -4.87 -5.27 -4.40 1.68 -3.45 0.35 -4.37 -3.20 0.15 -5.69 -3.11 -6.53
Cell Periphery 2.25 3.14 -2.03 -3.79 -4.36 -0.25 5.92 4.56 3.38 -2.92 1.32 6.25 0.84 -0.44 -4.86
Cytoplasm -5.47 7.74 9.63 16.54 4.75 -6.87 19.56 18.25 25.42 -4.42 -7.66 20.33 20.37 29.87 1.28
Cytoplasmic Foci 2.83 4.14 2.73 -0.31 -5.47 -2.56 5.84 5.62 7.84 -2.93 0.59 6.66 5.50 7.32 -5.96
Eisosomes 4.62 -0.60 -8.59 -12.58 -9.22 -2.93 -5.87 -5.64 -2.50 -1.04 0.78 -4.70 -9.74 -10.80 -7.33
Endoplasmic Reticulum -0.09 3.53 3.78 4.03 0.91 1.36 5.72 2.72 1.64 -1.91 0.66 6.38 4.38 3.89 -0.86
Endosome 1.91 4.81 -2.12 -2.62 -3.17 -3.79 5.89 1.93 4.35 -2.63 -2.50 7.40 -1.50 0.12 -3.70
Golgi 0.99 1.78 -1.96 -2.68 -3.14 -2.37 2.82 -1.27 2.12 -2.10 -1.25 1.99 -1.93 -0.57 -3.47
Lipid Particles 2.14 2.59 1.82 -0.49 -1.65 -2.39 6.31 6.55 4.61 -0.70 0.64 3.96 3.23 3.98 -1.75
Mitochondria 1.49 -1.60 -6.47 -8.76 -6.67 -4.44 -8.94 -9.51 1.78 -5.89 -3.47 -4.34 -9.57 -2.96 -8.44
Mitotic Spindle -0.09 -2.39 -3.69 -3.85 -1.97 -4.60 -0.29 -3.68 1.40 -3.69 -4.02 -1.95 -5.13 -1.16 -3.88
None 2.76 3.13 2.11 -0.69 -1.09 -0.55 7.11 4.68 5.18 -3.49 1.22 7.50 5.08 4.21 -2.95
Nuclear Periphery -1.15 -2.61 -2.48 -1.48 -0.96 -3.43 0.90 -2.26 -0.43 -2.53 -3.10 -1.93 -3.04 -1.14 -2.43
Nuclear Periphery Foci 0.59 4.43 -1.13 -1.53 -3.44 -0.82 5.87 -0.31 0.38 -2.77 -0.43 7.41 -0.83 -0.43 -3.88
Nucleolus 4.26 5.08 -4.78 -7.31 -7.69 -2.29 5.03 -0.93 1.50 -5.28 1.32 7.05 -4.36 -5.36 -9.23
Nucleus 3.24 -3.99 2.66 -0.32 7.38 9.88 -16.40 -9.98 -20.30 8.45 8.92 -15.25 -6.27 -16.23 10.40
Peroxisomes 0.90 3.18 0.72 -0.43 -4.90 -2.62 3.04 2.09 3.18 -4.18 -1.68 4.25 1.88 2.76 -5.90
Vacuole -3.02 -1.08 -2.97 -1.43 -2.60 -6.94 4.99 1.33 7.64 -3.50 -7.36 3.39 -1.37 5.54 -3.78
Vacuole Periphery 0.49 2.09 -3.24 -3.42 -3.81 -4.01 2.44 -2.12 -0.50 -2.47 -3.10 3.15 -3.45 -2.41 -4.05
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages nucleus (76%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

YML108W

YML108W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Yml108w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available