Standard name
Human Ortholog
Description Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0.06 0 – 0.07 0.09 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0 – 0 0 0 0 0.07 0.05 0.12 0.11 0.08 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.67 0.43 0.7 0.58 0.7 0.32 0.3 0.26 – 0.19 0.12 0.15 0.73 0.67 0.76 0.68 0.64 0.65 0.84 0.76 0.77 0.83 0.76 0.81
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0.06 0.06
Mitochondria 0.18 0.34 0.08 0.23 0.19 0.49 0.46 0.43 – 0.59 0.69 0.63 0 0.05 0 0.08 0.11 0.08 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.31 0.29 0.2 0.24 0.14 0.14 0.14 0.16 – 0.11 0.1 0.09 0.19 0.15 0.13 0.14 0.16 0.15 0 0 0 0 0 0
Peroxisomes 0.06 0 0.3 0.17 0.16 0.13 0.18 0.18 – 0.15 0.09 0.09 0.05 0.05 0 0 0 0 0 0 0.05 0 0.05 0
SpindlePole 0.18 0.12 0.39 0.35 0.21 0.18 0.22 0.22 – 0.18 0.15 0.19 0.24 0.24 0.19 0.25 0.22 0.23 0.06 0.05 0.12 0.06 0 0
Vac/Vac Membrane 0.16 0.19 0 0 0.07 0 0 0 – 0 0 0.06 0.21 0.18 0.2 0.07 0.12 0.15 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 4 – 2 5 3 0 2 0 3 2 1 1 3 2 1 6 5
Bud 1 4 3 9 9 15 32 22 – 39 45 27 0 3 0 6 1 0 2 3 1 0 2 0
Bud Neck 0 0 1 3 0 0 0 1 – 2 0 2 0 0 0 0 0 0 0 2 0 0 1 0
Bud Site 0 0 1 0 0 2 0 4 – 1 9 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 2 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Cytoplasm 6 10 10 6 20 19 23 13 – 9 14 10 4 15 11 25 32 20 1 3 1 0 0 1
Endoplasmic Reticulum 1 0 1 0 0 0 4 2 – 0 1 2 0 2 1 5 6 4 0 0 0 0 5 2
Endosome 267 172 347 142 306 152 164 136 – 113 55 67 113 146 172 147 180 154 356 355 392 255 342 285
Golgi 3 0 1 0 1 0 0 0 – 2 0 4 0 8 3 10 9 15 10 8 10 7 25 22
Mitochondria 73 137 41 56 83 233 246 225 – 344 330 274 1 10 1 18 32 20 6 11 4 4 14 7
Nucleus 3 1 3 3 0 2 1 3 – 1 1 2 3 1 0 1 0 1 0 2 0 0 0 0
Nuclear Periphery 1 8 2 0 4 0 2 1 – 6 0 5 4 3 2 0 1 2 1 2 1 2 4 1
Nucleolus 122 115 98 58 62 68 78 84 – 65 46 39 30 33 29 30 46 35 1 9 2 2 1 0
Peroxisomes 24 6 150 43 69 63 96 93 – 87 44 38 7 11 6 8 12 7 7 8 26 9 22 13
SpindlePole 70 47 194 85 92 87 116 113 – 105 73 82 37 53 43 54 62 55 24 24 60 18 9 2
Vac/Vac Membrane 65 74 20 5 30 20 11 21 – 11 7 28 33 40 46 16 34 35 8 22 2 4 11 4
Unique Cell Count 397 398 498 246 435 471 538 518 585 475 438 154 218 225 217 281 238 426 466 510 310 453 352
Labelled Cell Count 636 574 873 410 676 661 773 722 789 630 584 232 327 314 324 418 349 426 466 510 310 453 352


Endosome

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.3 7.6 7.0 6.6 6.6 5.7 5.5 6.1 – 5.5 5.6 6.9 8.8 8.9 9.1 7.6 8.2 9.4 8.7 9.7 10.6
Std Deviation (1e-4) 1.6 1.6 1.2 1.3 1.6 1.4 1.2 1.2 – 1.1 1.1 3.3 1.7 2.0 1.7 1.6 1.9 2.1 1.8 2.4 2.8
Intensity Change (Log2) – – – -0.1 -0.09 -0.3 -0.35 -0.22 – -0.35 -0.34 -0.03 0.32 0.34 0.37 0.12 0.23 0.41 0.31 0.47 0.6


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud 0 2.0 3.0 4.8 3.7 – 5.2 6.4 4.8 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 2.2 1.8 2.1 0.5 – -0.6 0.9 0.3 0 3.3 2.1 5.4 5.6 4.1
Endoplasmic Reticulum 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Endosome -3.2 0.2 -11.6 -12.6 -13.9 – -16.7 -18.4 -16.7 0.9 -0.7 1.9 -0.5 -1.6 -1.4
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 0 0 5.3
Mitochondria 5.5 4.9 14.2 13.5 12.8 – 17.3 19.7 17.6 -3.4 -1.7 -4.1 0 1.5 0.1
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0
Nucleolus 1.2 -2.2 -2.2 -2.2 -1.4 – -3.9 -4.4 -4.7 -0.1 -1.4 -2.2 -1.9 -1.1 -1.6
Peroxisomes -3.7 -5.1 -6.3 -4.6 -4.5 – -6.0 -8.1 -8.2 -6.5 -7.4 -8.3 -7.8 -8.5 -8.4
SpindlePole -1.2 -5.9 -7.0 -6.1 -5.9 – -7.7 -8.2 -6.8 -3.4 -3.8 -5.3 -3.6 -4.8 -4.3
Vacuole -1.4 1.9 0.2 -1.9 0 – -2.1 -2.4 1.6 6.9 6.4 7.1 1.9 4.3 5.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.1836 4.6058 4.5684 3.8162 3.5955 4.2462 5.8519 7.8237 7.0451 6.4777 6.3119 7.3761 5.96 7.5048 6.9596 6.3025 6.4501 7.0853
Actin 0.0126 0.005 0.0345 0.0001 0.0371 0.0053 0.0009 0.0017 0.0002 0 0 0.0001 0.0001 0.0001 0.003 0.0001 0.0001 0.0001
Bud 0.0003 0.0056 0.0012 0.0003 0.0084 0.0002 0 0.0006 0.0001 0 0 0 0 0 0.0001 0 0 0.0001
Bud Neck 0.0011 0.0009 0.0023 0.0001 0.001 0.0014 0.0002 0.0004 0.0003 0.0001 0.0001 0.0002 0.0003 0.0003 0.0002 0.0001 0.0001 0.0002
Bud Periphery 0.0005 0.0012 0.002 0.0003 0.0184 0.0003 0 0.0005 0.0001 0 0 0 0 0 0 0.0001 0 0
Bud Site 0.0017 0.0039 0.0057 0.0002 0.0209 0.0008 0.0001 0.0041 0.0002 0.0001 0 0.0001 0.0003 0.0002 0.0002 0.0001 0 0.0001
Cell Periphery 0.0003 0.0003 0.0007 0 0.0007 0.0002 0 0.0001 0 0 0 0 0 0.0001 0 0 0 0
Cytoplasm 0.01 0.0057 0.0067 0.0022 0.0038 0.0051 0.0006 0.0009 0.0006 0.0004 0.0004 0.0003 0.0007 0.0008 0.0008 0.0005 0.0005 0.0006
Cytoplasmic Foci 0.1444 0.1712 0.1514 0.106 0.1328 0.1286 0.1771 0.1968 0.1878 0.179 0.1777 0.1468 0.1661 0.1986 0.1806 0.1654 0.185 0.1412
Eisosomes 0.0006 0 0.0006 0 0.0002 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0059 0.0008 0.0243 0.0005 0.0026 0.0021 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001
Endosome 0.4069 0.4855 0.3863 0.6737 0.4943 0.4461 0.401 0.3998 0.43 0.531 0.5337 0.3325 0.4485 0.4421 0.4611 0.5305 0.5259 0.3765
Golgi 0.0473 0.0588 0.0953 0.0771 0.0821 0.096 0.0945 0.1202 0.126 0.1027 0.1062 0.1138 0.0995 0.0924 0.1278 0.1445 0.1651 0.124
Lipid Particles 0.1925 0.1167 0.1829 0.0556 0.0897 0.2337 0.2271 0.1834 0.1819 0.1238 0.1141 0.3141 0.2075 0.209 0.1452 0.116 0.094 0.2949
Mitochondria 0.0198 0.0019 0.0081 0.0023 0.0045 0.004 0.0039 0.0142 0.003 0.0023 0.0009 0.0021 0.0012 0.0009 0.0013 0.0091 0.0006 0.0028
None 0.007 0.0002 0.0134 0.0133 0.0017 0.0107 0.0002 0.0003 0.0001 0 0 0 0.0001 0 0.0001 0.0001 0 0
Nuclear Periphery 0.0469 0.0024 0.0015 0.0012 0.0132 0.0023 0.0003 0.0002 0.0001 0.0001 0.0001 0.0001 0.0002 0.0002 0.0002 0.0007 0.0001 0.0002
Nucleolus 0.0051 0.0017 0.0035 0.0016 0.0006 0.0094 0.0002 0.0006 0.0002 0.0004 0 0.0002 0.0014 0.001 0.0001 0.0006 0.0001 0.0004
Nucleus 0.0139 0.0009 0.0008 0.0017 0.0022 0.0016 0.0001 0.0002 0.0001 0 0 0 0.0003 0.0002 0.0001 0.0001 0 0.0001
Peroxisomes 0.0389 0.022 0.0443 0.0035 0.0163 0.0298 0.0884 0.0656 0.0627 0.045 0.0628 0.0847 0.0621 0.0305 0.0633 0.0163 0.0242 0.0486
Punctate Nuclear 0.0105 0.0022 0.0097 0.0346 0.0076 0.0021 0.0014 0.001 0.0009 0.0004 0.0004 0.0008 0.0048 0.0006 0.0024 0.0003 0.0004 0.002
Vacuole 0.0233 0.0938 0.0202 0.0182 0.0433 0.0153 0.0024 0.0066 0.0037 0.0085 0.0019 0.0024 0.0047 0.0175 0.0095 0.0068 0.0022 0.005
Vacuole Periphery 0.0105 0.0194 0.0049 0.0074 0.0185 0.005 0.0015 0.0027 0.0016 0.006 0.0015 0.0017 0.002 0.0053 0.0037 0.0086 0.0017 0.003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 30.5304 22.476 28.1146 22.9434 16.765 25.1288 32.9519 25.8558 25.5061 24.3663
Translational Efficiency 1.0848 1.3538 0.9554 1.2791 1.4236 1.4887 1.0054 1.1708 1.2635 1.2009

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
208 958 2214 1022 2159 701 874 1190 2367 1659 3088 2212

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1028.36 841.71 1077.36 1111.34 806.01 904.10 1006.29 1085.40 825.55 868.07 1057.24 1097.38
Standard Deviation 154.68 141.18 162.53 171.36 121.71 122.94 142.76 152.77 139.92 137.28 160.41 162.14
Intensity Change Log 2 — -0.288950 0.067155 0.111955 — 0.165685 0.320176 0.429357 — -0.071388 0.183828 0.260079

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000837 0.001228 0.000296 0.000726 0.000562 0.000395 0.000221 0.003273 0.000586 0.000876 0.000275 0.002096
Bud Neck 0.006291 0.004599 0.010577 0.005272 0.015014 0.003661 0.009806 0.002912 0.014248 0.004203 0.010359 0.004002
Bud Site 0.020358 0.008287 0.007448 0.013508 0.016506 0.002519 0.013972 0.018773 0.016844 0.005850 0.009295 0.016340
Cell Periphery 0.000163 0.000152 0.000170 0.000147 0.000398 0.000106 0.000078 0.000177 0.000378 0.000133 0.000144 0.000163
Cytoplasm 0.004629 0.004437 0.001967 0.003668 0.003449 0.000941 0.004805 0.005428 0.003553 0.002960 0.002770 0.004615
Cytoplasmic Foci 0.153031 0.146787 0.117344 0.143210 0.089567 0.100167 0.164170 0.143617 0.095144 0.127088 0.130597 0.143429
Eisosomes 0.000026 0.000046 0.000056 0.000037 0.000100 0.000052 0.000032 0.000041 0.000093 0.000048 0.000049 0.000039
Endoplasmic Reticulum 0.001958 0.000342 0.000771 0.000317 0.000259 0.000288 0.000355 0.000271 0.000408 0.000319 0.000653 0.000292
Endosome 0.504245* 0.616268* 0.425262* 0.421150* 0.672147* 0.694956* 0.544600* 0.435995* 0.657393* 0.649518* 0.459038* 0.429136*
Golgi 0.103426 0.108888 0.051192 0.151757* 0.050941 0.079253 0.052611 0.226532* 0.055554 0.096366 0.051594 0.191984*
Lipid Particles 0.005068 0.031445 0.035154 0.023448 0.029662 0.034596 0.012869 0.006762 0.027501 0.032776 0.028847 0.014471
Mitochondria 0.009016 0.011705 0.026318 0.020509 0.015923 0.016248 0.006559 0.025667 0.015316 0.013624 0.020725 0.023284
Mitotic Spindle 0.023905 0.004190 0.034148 0.015264 0.002457 0.005711 0.024118 0.010690 0.004342 0.004833 0.031309 0.012804
None 0.000051 0.000079 0.000198 0.000079 0.000316 0.000142 0.000073 0.000067 0.000293 0.000106 0.000163 0.000073
Nuclear Periphery 0.000492 0.000117 0.006443 0.001044 0.000132 0.000397 0.001104 0.000326 0.000163 0.000235 0.004932 0.000658
Nuclear Periphery Foci 0.003640 0.005503 0.040352 0.007511 0.008211 0.007222 0.015347 0.001231 0.007810 0.006229 0.033275 0.004133
Nucleolus 0.000287 0.001069 0.012272 0.000870 0.001866 0.000801 0.005655 0.000152 0.001727 0.000956 0.010399 0.000484
Nucleus 0.000171 0.000675 0.004461 0.000279 0.000564 0.000547 0.002421 0.000132 0.000529 0.000621 0.003884 0.000200
Peroxisomes 0.040799 0.027950 0.016465 0.022202 0.071008 0.022366 0.038840 0.020918 0.068353 0.025591 0.022798 0.021511
Vacuole 0.091708 0.019149 0.147069 0.126344 0.016904 0.018656 0.084181 0.069349 0.023477 0.018941 0.129269 0.095682
Vacuole Periphery 0.029901 0.007086 0.062038 0.042658 0.004013 0.010974 0.018181 0.027686 0.006288 0.008729 0.049625 0.034603

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.70 1.14 0.21 1.28 -2.08 0.69 2.45 -3.65 -3.79 -4.16 -1.17 2.31 -3.57 -2.67 -4.47
Bud Neck 1.21 -3.48 0.64 -0.89 6.65 7.47 3.09 9.10 0.55 6.61 7.89 2.93 8.47 -0.00 10.73
Bud Site 4.16 4.66 2.03 -2.89 -3.72 9.28 0.86 -1.20 -8.29 -1.88 7.34 4.96 -0.08 -7.48 -5.10
Cell Periphery 0.25 -0.26 0.44 0.20 2.00 4.85 6.31 4.04 -1.79 -4.25 4.91 5.05 4.51 -1.31 -1.34
Cytoplasm 0.52 1.96 0.79 0.34 -2.37 4.15 -1.49 -2.39 -5.88 -0.32 0.76 1.05 -1.71 -2.27 -2.99
Cytoplasmic Foci 0.49 3.16 0.81 0.55 -4.43 -1.97 -11.09 -10.36 -6.75 2.70 -7.20 -9.07 -11.25 -3.34 -2.97
Eisosomes -1.88 -7.12 -2.45 0.85 5.26 1.88 7.22 6.02 0.45 -1.72 3.12 5.17 6.33 0.78 3.45
Endoplasmic Reticulum 1.10 0.79 1.12 0.45 7.22 -0.53 -2.19 -0.21 0.26 1.59 0.66 -1.94 0.87 0.62 7.44
Endosome -5.60 4.17 4.13 16.43 0.29 -1.87 11.85 24.49 20.55 8.87 0.89 25.69 28.01 25.59 3.76
Golgi -0.57 5.39 -4.33 -5.91 -16.47 -6.05 -0.35 -26.36 -18.91 -25.17* -11.53 1.84 -28.35 -17.64 -29.91*
Lipid Particles -7.06 -12.10 -5.90 1.94 3.71 -1.11 6.53 10.29 6.82 3.16 -1.68 -0.48 5.82 6.42 7.52
Mitochondria -0.93 -5.71 -3.56 -3.15 2.00 -0.12 5.49 -3.32 -2.34 -6.70 0.84 -2.90 -3.76 -4.05 -1.19
Mitotic Spindle 2.82 -1.33 1.22 -4.99 6.31 -1.95 -7.05 -5.35 -2.41 3.94 -0.46 -13.81 -5.99 -5.36 8.37
None -1.39 -10.52 -2.42 0.01 9.54 0.88 1.36 1.40 1.01 0.57 1.13 0.79 1.36 0.99 9.50
Nuclear Periphery 1.54 -13.22 -1.98 -6.91 13.47 -2.83 -4.27 -3.94 0.62 3.35 -1.48 -16.82 -6.95 -5.41 14.73
Nuclear Periphery Foci -0.88 -12.86 -1.71 -1.25 14.18 0.51 -3.21 7.76 3.12 6.70 1.22 -14.05 3.87 1.92 17.32
Nucleolus -1.42 -11.74 -2.44 0.32 10.94 1.97 -3.26 3.27 1.89 4.85 1.40 -9.80 2.64 1.16 12.22
Nucleus -1.22 -8.19 -1.71 0.86 7.90 -0.01 -3.51 0.95 0.87 3.73 -0.36 -8.11 1.26 1.13 8.49
Peroxisomes 1.89 3.81 2.79 1.92 -2.57 13.61 8.49 15.08 0.53 5.62 14.10 16.64 16.04 1.97 0.80
Vacuole 8.30 -5.97 -3.48 -20.13 3.28 -0.92 -15.09 -15.05 -13.81 2.94 2.72 -35.71 -21.90 -23.95 8.27
Vacuole Periphery 4.96 -6.31 -2.41 -13.25 5.73 -3.99 -9.74 -12.61 -6.69 -4.18 -2.38 -24.76 -17.18 -14.62 6.57
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages endosome (26%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mvp1

Mvp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mvp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available