Standard name | |
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Human Ortholog | |
Description | Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | – | 2 | 5 | 3 | 0 | 2 | 0 | 3 | 2 | 1 | 1 | 3 | 2 | 1 | 6 | 5 |
Bud | 1 | 4 | 3 | 9 | 9 | 15 | 32 | 22 | – | 39 | 45 | 27 | 0 | 3 | 0 | 6 | 1 | 0 | 2 | 3 | 1 | 0 | 2 | 0 |
Bud Neck | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 1 | – | 2 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 |
Bud Site | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 4 | – | 1 | 9 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 6 | 10 | 10 | 6 | 20 | 19 | 23 | 13 | – | 9 | 14 | 10 | 4 | 15 | 11 | 25 | 32 | 20 | 1 | 3 | 1 | 0 | 0 | 1 |
Endoplasmic Reticulum | 1 | 0 | 1 | 0 | 0 | 0 | 4 | 2 | – | 0 | 1 | 2 | 0 | 2 | 1 | 5 | 6 | 4 | 0 | 0 | 0 | 0 | 5 | 2 |
Endosome | 267 | 172 | 347 | 142 | 306 | 152 | 164 | 136 | – | 113 | 55 | 67 | 113 | 146 | 172 | 147 | 180 | 154 | 356 | 355 | 392 | 255 | 342 | 285 |
Golgi | 3 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | – | 2 | 0 | 4 | 0 | 8 | 3 | 10 | 9 | 15 | 10 | 8 | 10 | 7 | 25 | 22 |
Mitochondria | 73 | 137 | 41 | 56 | 83 | 233 | 246 | 225 | – | 344 | 330 | 274 | 1 | 10 | 1 | 18 | 32 | 20 | 6 | 11 | 4 | 4 | 14 | 7 |
Nucleus | 3 | 1 | 3 | 3 | 0 | 2 | 1 | 3 | – | 1 | 1 | 2 | 3 | 1 | 0 | 1 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 1 | 8 | 2 | 0 | 4 | 0 | 2 | 1 | – | 6 | 0 | 5 | 4 | 3 | 2 | 0 | 1 | 2 | 1 | 2 | 1 | 2 | 4 | 1 |
Nucleolus | 122 | 115 | 98 | 58 | 62 | 68 | 78 | 84 | – | 65 | 46 | 39 | 30 | 33 | 29 | 30 | 46 | 35 | 1 | 9 | 2 | 2 | 1 | 0 |
Peroxisomes | 24 | 6 | 150 | 43 | 69 | 63 | 96 | 93 | – | 87 | 44 | 38 | 7 | 11 | 6 | 8 | 12 | 7 | 7 | 8 | 26 | 9 | 22 | 13 |
SpindlePole | 70 | 47 | 194 | 85 | 92 | 87 | 116 | 113 | – | 105 | 73 | 82 | 37 | 53 | 43 | 54 | 62 | 55 | 24 | 24 | 60 | 18 | 9 | 2 |
Vac/Vac Membrane | 65 | 74 | 20 | 5 | 30 | 20 | 11 | 21 | – | 11 | 7 | 28 | 33 | 40 | 46 | 16 | 34 | 35 | 8 | 22 | 2 | 4 | 11 | 4 |
Unique Cell Count | 397 | 398 | 498 | 246 | 435 | 471 | 538 | 518 | 585 | 475 | 438 | 154 | 218 | 225 | 217 | 281 | 238 | 426 | 466 | 510 | 310 | 453 | 352 | |
Labelled Cell Count | 636 | 574 | 873 | 410 | 676 | 661 | 773 | 722 | 789 | 630 | 584 | 232 | 327 | 314 | 324 | 418 | 349 | 426 | 466 | 510 | 310 | 453 | 352 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 8.3 | 7.6 | 7.0 | 6.6 | 6.6 | 5.7 | 5.5 | 6.1 | – | 5.5 | 5.6 | 6.9 | 8.8 | 8.9 | 9.1 | 7.6 | 8.2 | 9.4 | 8.7 | 9.7 | 10.6 |
Std Deviation (1e-4) | 1.6 | 1.6 | 1.2 | 1.3 | 1.6 | 1.4 | 1.2 | 1.2 | – | 1.1 | 1.1 | 3.3 | 1.7 | 2.0 | 1.7 | 1.6 | 1.9 | 2.1 | 1.8 | 2.4 | 2.8 |
Intensity Change (Log2) | – | – | – | -0.1 | -0.09 | -0.3 | -0.35 | -0.22 | – | -0.35 | -0.34 | -0.03 | 0.32 | 0.34 | 0.37 | 0.12 | 0.23 | 0.41 | 0.31 | 0.47 | 0.6 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 2.0 | 3.0 | 4.8 | 3.7 | – | 5.2 | 6.4 | 4.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.4 | 2.2 | 1.8 | 2.1 | 0.5 | – | -0.6 | 0.9 | 0.3 | 0 | 3.3 | 2.1 | 5.4 | 5.6 | 4.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | -3.2 | 0.2 | -11.6 | -12.6 | -13.9 | – | -16.7 | -18.4 | -16.7 | 0.9 | -0.7 | 1.9 | -0.5 | -1.6 | -1.4 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.3 |
Mitochondria | 5.5 | 4.9 | 14.2 | 13.5 | 12.8 | – | 17.3 | 19.7 | 17.6 | -3.4 | -1.7 | -4.1 | 0 | 1.5 | 0.1 |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 1.2 | -2.2 | -2.2 | -2.2 | -1.4 | – | -3.9 | -4.4 | -4.7 | -0.1 | -1.4 | -2.2 | -1.9 | -1.1 | -1.6 |
Peroxisomes | -3.7 | -5.1 | -6.3 | -4.6 | -4.5 | – | -6.0 | -8.1 | -8.2 | -6.5 | -7.4 | -8.3 | -7.8 | -8.5 | -8.4 |
SpindlePole | -1.2 | -5.9 | -7.0 | -6.1 | -5.9 | – | -7.7 | -8.2 | -6.8 | -3.4 | -3.8 | -5.3 | -3.6 | -4.8 | -4.3 |
Vacuole | -1.4 | 1.9 | 0.2 | -1.9 | 0 | – | -2.1 | -2.4 | 1.6 | 6.9 | 6.4 | 7.1 | 1.9 | 4.3 | 5.2 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.1836 | 4.6058 | 4.5684 | 3.8162 | 3.5955 | 4.2462 | 5.8519 | 7.8237 | 7.0451 | 6.4777 | 6.3119 | 7.3761 | 5.96 | 7.5048 | 6.9596 | 6.3025 | 6.4501 | 7.0853 |
Actin | 0.0126 | 0.005 | 0.0345 | 0.0001 | 0.0371 | 0.0053 | 0.0009 | 0.0017 | 0.0002 | 0 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.003 | 0.0001 | 0.0001 | 0.0001 |
Bud | 0.0003 | 0.0056 | 0.0012 | 0.0003 | 0.0084 | 0.0002 | 0 | 0.0006 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 |
Bud Neck | 0.0011 | 0.0009 | 0.0023 | 0.0001 | 0.001 | 0.0014 | 0.0002 | 0.0004 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0002 |
Bud Periphery | 0.0005 | 0.0012 | 0.002 | 0.0003 | 0.0184 | 0.0003 | 0 | 0.0005 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 |
Bud Site | 0.0017 | 0.0039 | 0.0057 | 0.0002 | 0.0209 | 0.0008 | 0.0001 | 0.0041 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0003 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0001 |
Cell Periphery | 0.0003 | 0.0003 | 0.0007 | 0 | 0.0007 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.01 | 0.0057 | 0.0067 | 0.0022 | 0.0038 | 0.0051 | 0.0006 | 0.0009 | 0.0006 | 0.0004 | 0.0004 | 0.0003 | 0.0007 | 0.0008 | 0.0008 | 0.0005 | 0.0005 | 0.0006 |
Cytoplasmic Foci | 0.1444 | 0.1712 | 0.1514 | 0.106 | 0.1328 | 0.1286 | 0.1771 | 0.1968 | 0.1878 | 0.179 | 0.1777 | 0.1468 | 0.1661 | 0.1986 | 0.1806 | 0.1654 | 0.185 | 0.1412 |
Eisosomes | 0.0006 | 0 | 0.0006 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0059 | 0.0008 | 0.0243 | 0.0005 | 0.0026 | 0.0021 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0.0001 |
Endosome | 0.4069 | 0.4855 | 0.3863 | 0.6737 | 0.4943 | 0.4461 | 0.401 | 0.3998 | 0.43 | 0.531 | 0.5337 | 0.3325 | 0.4485 | 0.4421 | 0.4611 | 0.5305 | 0.5259 | 0.3765 |
Golgi | 0.0473 | 0.0588 | 0.0953 | 0.0771 | 0.0821 | 0.096 | 0.0945 | 0.1202 | 0.126 | 0.1027 | 0.1062 | 0.1138 | 0.0995 | 0.0924 | 0.1278 | 0.1445 | 0.1651 | 0.124 |
Lipid Particles | 0.1925 | 0.1167 | 0.1829 | 0.0556 | 0.0897 | 0.2337 | 0.2271 | 0.1834 | 0.1819 | 0.1238 | 0.1141 | 0.3141 | 0.2075 | 0.209 | 0.1452 | 0.116 | 0.094 | 0.2949 |
Mitochondria | 0.0198 | 0.0019 | 0.0081 | 0.0023 | 0.0045 | 0.004 | 0.0039 | 0.0142 | 0.003 | 0.0023 | 0.0009 | 0.0021 | 0.0012 | 0.0009 | 0.0013 | 0.0091 | 0.0006 | 0.0028 |
None | 0.007 | 0.0002 | 0.0134 | 0.0133 | 0.0017 | 0.0107 | 0.0002 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0 |
Nuclear Periphery | 0.0469 | 0.0024 | 0.0015 | 0.0012 | 0.0132 | 0.0023 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0007 | 0.0001 | 0.0002 |
Nucleolus | 0.0051 | 0.0017 | 0.0035 | 0.0016 | 0.0006 | 0.0094 | 0.0002 | 0.0006 | 0.0002 | 0.0004 | 0 | 0.0002 | 0.0014 | 0.001 | 0.0001 | 0.0006 | 0.0001 | 0.0004 |
Nucleus | 0.0139 | 0.0009 | 0.0008 | 0.0017 | 0.0022 | 0.0016 | 0.0001 | 0.0002 | 0.0001 | 0 | 0 | 0 | 0.0003 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0001 |
Peroxisomes | 0.0389 | 0.022 | 0.0443 | 0.0035 | 0.0163 | 0.0298 | 0.0884 | 0.0656 | 0.0627 | 0.045 | 0.0628 | 0.0847 | 0.0621 | 0.0305 | 0.0633 | 0.0163 | 0.0242 | 0.0486 |
Punctate Nuclear | 0.0105 | 0.0022 | 0.0097 | 0.0346 | 0.0076 | 0.0021 | 0.0014 | 0.001 | 0.0009 | 0.0004 | 0.0004 | 0.0008 | 0.0048 | 0.0006 | 0.0024 | 0.0003 | 0.0004 | 0.002 |
Vacuole | 0.0233 | 0.0938 | 0.0202 | 0.0182 | 0.0433 | 0.0153 | 0.0024 | 0.0066 | 0.0037 | 0.0085 | 0.0019 | 0.0024 | 0.0047 | 0.0175 | 0.0095 | 0.0068 | 0.0022 | 0.005 |
Vacuole Periphery | 0.0105 | 0.0194 | 0.0049 | 0.0074 | 0.0185 | 0.005 | 0.0015 | 0.0027 | 0.0016 | 0.006 | 0.0015 | 0.0017 | 0.002 | 0.0053 | 0.0037 | 0.0086 | 0.0017 | 0.003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 30.5304 | 22.476 | 28.1146 | 22.9434 | 16.765 | 25.1288 | 32.9519 | 25.8558 | 25.5061 | 24.3663 |
Translational Efficiency | 1.0848 | 1.3538 | 0.9554 | 1.2791 | 1.4236 | 1.4887 | 1.0054 | 1.1708 | 1.2635 | 1.2009 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✔ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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