Standard name
Human Ortholog
Description Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.99 0.99 1.0 0.97 0.94 0.89 – 0.79 0.82 0.72 0.74 0.99 0.98 0.99 0.89 0.94 0.95 0.93 0.95 0.95 0.97 0.91 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.12 0.05 – 0.22 0.2 0.3 0.27 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.12 – 0.11 0.08 0.1 0.07 0 0 0 0.15 0.18 0.11 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1
Bud 0 1 0 0 0 2 1 – 2 4 5 3 0 0 0 0 0 0 2 0 0 1 2 9
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 3 0 1 3 5 – 6 3 3 1 0 2 1 4 4 5 0 0 0 0 0 0
Cytoplasm 309 191 249 217 332 332 490 – 375 359 238 267 313 386 353 203 189 197 300 189 236 164 325 330
Endoplasmic Reticulum 1 1 0 0 0 0 1 – 0 3 0 2 0 0 3 8 1 5 2 0 1 0 2 1
Endosome 1 0 0 0 1 0 2 – 0 0 1 0 1 0 0 2 0 0 2 1 0 0 1 0
Golgi 2 0 1 1 0 0 0 – 0 0 0 0 0 1 0 0 0 0 3 0 1 0 2 2
Mitochondria 2 2 0 1 2 42 30 – 105 89 101 98 0 0 0 3 2 0 3 0 2 0 4 1
Nucleus 0 2 3 0 1 11 5 – 8 12 9 9 1 0 0 3 1 0 0 2 0 0 1 1
Nuclear Periphery 0 1 0 0 0 1 1 – 2 0 0 4 0 0 0 0 0 0 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 – 0 1 0 0 1 2 0 0 0 0 0 0 0 0 1 1
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 2 – 0 0 1 0 0 0 0 0 0 0 1 0 2 0 4 1
Vac/Vac Membrane 5 0 3 1 14 6 64 – 50 35 32 27 1 4 2 35 37 23 4 2 2 0 2 1
Unique Cell Count 313 193 251 218 343 354 553 475 438 332 360 316 392 356 229 202 208 323 200 250 170 358 357
Labelled Cell Count 320 199 259 220 351 397 601 548 506 390 411 317 395 359 258 234 230 323 200 250 170 358 357


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 6.3 6.7 6.0 7.0 4.8 6.1 – 5.3 5.4 5.3 5.2 6.8 7.2 7.6 9.9 10.5 10.4 6.1 6.1 6.3
Std Deviation (1e-4) 1.0 1.0 1.1 1.6 1.5 1.1 1.8 – 1.2 1.6 1.4 1.3 1.2 1.5 2.0 2.3 2.5 2.3 2.2 1.4 1.5
Intensity Change (Log2) – – – -0.15 0.06 -0.49 -0.14 – -0.34 -0.32 -0.36 -0.37 0.03 0.1 0.18 0.55 0.64 0.63 -0.14 -0.13 -0.09


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 -2.0 -3.4 -5.1 – -7.5 -6.8 -8.9 -8.4 -0.2 -0.8 -0.1 -4.9 -3.3 -2.9
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 3.8 – 8.1 7.7 9.6 9.0 0 0 0 0 0 0
Nucleus 0 0 1.5 0 – 0 1.3 1.3 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 2.1 0 4.9 – 4.6 3.8 4.2 3.5 0 0 0 5.7 6.4 4.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.2562 1.6102 1.4451 1.0904 0.7711 1.2382 1.8814 3.0378 2.5736 2.3962 2.2423 2.9231 4.0094 4.9346 4.2033 4.0017 4.4771 4.746
Actin 0.0388 0.0019 0.0209 0.0164 0.0019 0.0026 0.008 0.0031 0.0045 0.0007 0.0042 0.0052 0.0295 0.0002 0.0225 0.0038 0.071 0.0027
Bud 0.001 0.0038 0.0006 0.0006 0.0001 0.0003 0.0009 0.0052 0.0014 0.0016 0.0007 0.0003 0.0004 0.0001 0.0018 0.0003 0.0013 0.0002
Bud Neck 0.0024 0.0007 0.0033 0.0047 0.0002 0.0009 0.0003 0.0002 0.0004 0.0003 0.0009 0.0011 0.0006 0.0001 0.0013 0.0006 0.0006 0.0007
Bud Periphery 0.0021 0.0034 0.0008 0.0011 0 0.0005 0.0012 0.0008 0.0011 0.0008 0.002 0.0004 0.0004 0.0001 0.0035 0.0002 0.0018 0.0006
Bud Site 0.0057 0.0056 0.0015 0.0044 0 0.0001 0.0009 0.0024 0.0019 0.0089 0.0066 0.0002 0.0029 0.0007 0.003 0.0006 0.0026 0.0001
Cell Periphery 0.0003 0.0002 0.0002 0.0023 0 0 0.0001 0.0001 0.0001 0.0001 0.0002 0 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001
Cytoplasm 0.5636 0.7085 0.6637 0.625 0.7207 0.741 0.7497 0.8592 0.8097 0.7794 0.7956 0.8298 0.6702 0.7417 0.7665 0.664 0.676 0.7879
Cytoplasmic Foci 0.0294 0.0065 0.0226 0.0197 0.0119 0.0193 0.0107 0.0102 0.0075 0.0087 0.013 0.0114 0.0217 0.0051 0.0135 0.0255 0.019 0.005
Eisosomes 0.0004 0.0001 0.0003 0.0002 0.0001 0 0.0001 0 0 0 0.0001 0.0001 0.0001 0 0.0003 0 0.0003 0
Endoplasmic Reticulum 0.0073 0.0028 0.0053 0.0034 0.0025 0.0039 0.0033 0.0022 0.0021 0.0014 0.0049 0.0019 0.0082 0.0031 0.0028 0.0058 0.0064 0.0025
Endosome 0.0226 0.0017 0.02 0.0147 0.0028 0.013 0.0061 0.0029 0.004 0.0015 0.0286 0.0052 0.025 0.0021 0.0059 0.0226 0.0115 0.0068
Golgi 0.0129 0.0003 0.0053 0.0124 0.0002 0.0021 0.0009 0.0005 0.0003 0.0002 0.0044 0.0012 0.0054 0.0001 0.0046 0.0021 0.0133 0.0014
Lipid Particles 0.0172 0.0001 0.0086 0.0135 0.0004 0.0044 0.0011 0.0001 0.0002 0.0001 0.0055 0.002 0.0166 0.0002 0.0039 0.0038 0.0076 0.0005
Mitochondria 0.011 0.0003 0.0029 0.0094 0.0002 0.0012 0.001 0.001 0.0004 0.0003 0.0313 0.0027 0.006 0.0001 0.0165 0.0006 0.012 0.0014
None 0.2391 0.2573 0.2031 0.1552 0.2523 0.1846 0.1975 0.1021 0.1531 0.1887 0.0756 0.1197 0.188 0.2393 0.136 0.2287 0.1228 0.1851
Nuclear Periphery 0.0137 0.0012 0.0119 0.0014 0.001 0.0094 0.0053 0.0012 0.0032 0.0008 0.005 0.0018 0.0053 0.0012 0.0015 0.0041 0.013 0.0006
Nucleolus 0.0019 0.0001 0.0005 0.0011 0.0001 0.0002 0.0002 0.0001 0.0002 0.0001 0.0007 0.0001 0.0005 0.0001 0.0002 0.0002 0.0007 0
Nucleus 0.0051 0.0031 0.0064 0.0049 0.0024 0.0054 0.0041 0.0053 0.0059 0.0038 0.0066 0.0108 0.0029 0.003 0.0057 0.0214 0.0247 0.003
Peroxisomes 0.0095 0.0002 0.0138 0.0866 0.0004 0.0053 0.0051 0.001 0.0002 0.0003 0.0053 0.0012 0.0107 0.0001 0.0058 0.0028 0.0091 0.0002
Punctate Nuclear 0.0121 0.0012 0.0053 0.0014 0.0016 0.0035 0.0017 0.0012 0.0025 0.0016 0.0031 0.004 0.0023 0.0015 0.0031 0.0089 0.0034 0.0004
Vacuole 0.0019 0.0009 0.0018 0.0207 0.0011 0.0014 0.0014 0.001 0.0011 0.0007 0.0036 0.0007 0.002 0.0009 0.0008 0.0032 0.0012 0.0005
Vacuole Periphery 0.0019 0.0001 0.0012 0.0011 0.0002 0.0008 0.0004 0.0001 0.0002 0.0001 0.0018 0.0003 0.001 0.0001 0.0004 0.0007 0.0016 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 18.3901 27.3993 23.0424 27.3529 22.5189 16.3377 24.0097 29.2935 28.6299 23.0305
Translational Efficiency 1.9884 1.3315 1.6965 1.4562 1.3223 2.4608 1.6323 1.3434 1.6934 1.6947

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1814 1485 215 94 1739 2405 208 1207 3553 3890 423 1301

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 758.72 884.60 1039.61 1194.46 734.76 852.68 1176.67 1035.50 746.99 864.87 1107.01 1046.99
Standard Deviation 91.15 115.56 144.18 184.50 91.23 112.78 155.25 181.26 91.97 114.90 164.66 186.10
Intensity Change Log 2 — 0.221458 0.454403 0.654719 — 0.214731 0.679365 0.494983 — 0.218152 0.569462 0.578340

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000129 0.000450 0.000594 0.000519 0.000076 0.000291 0.000779 0.000238 0.000103 0.000351 0.000685 0.000259
Bud Neck 0.009221 0.007047 0.001605 0.002247 0.004410 0.008822 0.005618 0.006252 0.006866 0.008145 0.003578 0.005962
Bud Site 0.003658 0.011626 0.004138 0.017235 0.003839 0.012016 0.029204 0.016438 0.003747 0.011867 0.016463 0.016496
Cell Periphery 0.000128 0.000101 0.000193 0.000303 0.000106 0.000073 0.000221 0.000187 0.000117 0.000084 0.000207 0.000195
Cytoplasm 0.551286* 0.664991* 0.482764* 0.427587* 0.662354* 0.702139* 0.433993* 0.637133* 0.605648* 0.687958* 0.458782* 0.621993*
Cytoplasmic Foci 0.229197* 0.131899 0.017896 0.042827 0.128623 0.081081 0.016203 0.019179 0.179971 0.100480 0.017063 0.020888
Eisosomes 0.000136 0.000047 0.000048 0.000057 0.000055 0.000036 0.000067 0.000036 0.000097 0.000040 0.000057 0.000037
Endoplasmic Reticulum 0.000762 0.001075 0.004576 0.003606 0.000880 0.000402 0.007580 0.000866 0.000820 0.000659 0.006053 0.001064
Endosome 0.010391 0.010112 0.004204 0.014533 0.004496 0.005056 0.004427 0.007902 0.007506 0.006987 0.004314 0.008381
Golgi 0.001966 0.002857 0.000181 0.035603 0.000749 0.001244 0.000167 0.002348 0.001370 0.001860 0.000174 0.004751
Lipid Particles 0.006510 0.002459 0.001793 0.002279 0.002593 0.001375 0.002158 0.003047 0.004593 0.001789 0.001972 0.002991
Mitochondria 0.002627 0.002084 0.000245 0.000267 0.001678 0.002308 0.000286 0.002873 0.002163 0.002222 0.000265 0.002684
Mitotic Spindle 0.000207 0.008051 0.002620 0.018652 0.000605 0.008132 0.009419 0.014440 0.000402 0.008101 0.005963 0.014744
None 0.002402 0.004212 0.003495 0.001899 0.004386 0.003589 0.003785 0.015971 0.003373 0.003827 0.003637 0.014954
Nuclear Periphery 0.000305 0.000209 0.000990 0.001005 0.000228 0.000206 0.001529 0.000494 0.000267 0.000208 0.001255 0.000531
Nuclear Periphery Foci 0.000431 0.001043 0.006529 0.010043 0.000427 0.000375 0.008308 0.002657 0.000429 0.000630 0.007403 0.003190
Nucleolus 0.000651 0.000624 0.000235 0.000141 0.000448 0.000748 0.000288 0.001052 0.000552 0.000701 0.000261 0.000986
Nucleus 0.118081 0.077491 0.334335* 0.155199* 0.150649* 0.121151 0.250226* 0.153476* 0.134021* 0.104484 0.292977* 0.153601*
Peroxisomes 0.003144 0.003607 0.000211 0.000207 0.000935 0.002492 0.000447 0.001952 0.002063 0.002918 0.000327 0.001826
Vacuole 0.057747 0.069049 0.133158 0.264831* 0.031877 0.047802 0.225095* 0.111079 0.045085 0.055913 0.178366 0.122188
Vacuole Periphery 0.001019 0.000964 0.000191 0.000961 0.000586 0.000661 0.000200 0.002381 0.000807 0.000777 0.000195 0.002278

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.32 -6.90 -6.41 -1.27 1.55 -2.13 -10.59 -6.54 0.70 8.05 -3.41 -11.69 -5.83 1.41 8.90
Bud Neck 2.25 9.11 5.46 3.23 -2.32 -5.04 -0.28 -0.21 3.67 0.11 -1.83 4.22 2.47 3.66 -0.96
Bud Site -6.63 -2.23 -1.90 -0.33 -1.60 -6.15 -2.16 -4.14 0.32 0.40 -8.89 -2.48 -4.72 0.20 -0.90
Cell Periphery 2.97 -4.05 -1.66 -2.21 -0.03 4.35 -6.55 -1.16 -4.17 5.07 5.75 -7.28 -0.85 -3.97 5.30
Cytoplasm -11.82 8.91 8.88 12.90 2.01 -5.06 18.05 7.98 12.17 -12.90 -13.54 18.59 4.49 13.32 -13.75
Cytoplasmic Foci 15.64 38.20 34.31 20.19 -0.08 11.00 31.20 29.58 22.45 -3.49 20.90 47.57 48.94 32.62 -1.84
Eisosomes 9.15 7.32 7.37 -2.07 -0.02 4.91 -2.68 8.05 1.77 7.44 10.50 5.20 12.44 2.80 8.04
Endoplasmic Reticulum -1.83 -8.33 -5.30 -4.48 2.89 2.35 -6.46 0.15 -5.50 6.69 1.20 -10.31 -1.85 -3.68 9.95
Endosome 0.50 8.01 3.71 3.05 -0.30 -0.82 0.87 -0.14 0.41 -0.68 1.16 7.06 3.51 2.57 -0.55
Golgi -1.47 8.11 -0.67 -0.51 -1.00 -1.75 5.45 -0.92 0.16 -2.29 -1.62 9.60 -0.16 0.62 -2.33
Lipid Particles 6.12 8.96 6.89 -0.43 -1.68 3.59 0.75 1.01 -0.86 0.67 7.89 8.19 4.23 -0.37 0.31
Mitochondria 0.89 5.41 5.30 3.18 -0.22 -1.16 4.30 0.41 1.32 -2.28 -0.04 6.89 1.56 1.49 -2.35
Mitotic Spindle -4.60 -1.86 -2.82 -2.39 -2.71 -5.39 -2.12 -6.08 -3.14 -2.09 -7.15 -2.56 -6.76 -3.94 -4.36
None -1.68 -0.25 -0.34 1.34 -0.18 1.37 1.49 -3.72 -4.36 -4.37 -0.70 0.92 -4.42 -4.13 -4.79
Nuclear Periphery 3.51 -11.84 -5.97 -6.25 -2.36 0.59 -14.20 -8.35 -8.32 9.45 2.59 -18.14 -9.35 -10.18 9.03
Nuclear Periphery Foci -5.44 -9.76 -5.25 -4.78 -0.08 0.42 -10.67 -6.66 -6.65 6.43 -3.30 -14.44 -7.81 -7.13 7.27
Nucleolus 0.53 3.95 0.71 0.46 -1.00 -2.25 1.34 -2.34 -0.39 -2.88 -1.20 3.87 -1.44 -0.61 -3.47
Nucleus 9.76 -12.28 -2.86 -5.25 7.37 6.21 -8.37 0.31 -4.98 8.37 9.08 -14.67 -3.19 -9.13 12.88
Peroxisomes -0.63 9.45 9.11 6.14 -0.57 -4.24 5.53 -0.59 3.12 -3.02 -2.40 10.71 3.40 4.76 -3.14
Vacuole -4.74 -9.85 -11.61 -10.99 -5.30 -7.80 -14.59 -22.11 -19.29 5.50 -7.09 -17.18 -22.53 -20.22 3.78
Vacuole Periphery 0.49 7.29 4.60 4.23 -0.62 -0.70 5.30 -1.35 -1.18 -2.34 0.46 8.98 -0.71 -0.82 -2.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant
Localization
Cell Percentages cytoplasm (71%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Adi1

Adi1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Adi1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available