Standard name
Human Ortholog
Description C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.07 0.12 0.1 0.08 0.06 0.05 0.11 0.11 0.07 0.14 0.05 0.05 0 0.11 0.09 0.07 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.09 0.05 0.05 0.07 0.05 0 0.09 0.08 0.08 0.12 0.12 0.18 0.19 0.17 0.16 0.21 0 0 0 0 0 0
Cytoplasm 0.08 0.08 0.08 0.08 0.08 0.1 0.12 0.12 0.14 0.11 0.21 0.17 0.07 0.09 0.23 0.38 0.34 0.34 0 0 0 0 0 0
Endoplasmic Reticulum 0.83 0.92 0.84 0.81 0.71 0.75 0.66 0.63 0.66 0.59 0.46 0.56 0.81 0.81 0.72 0 0 0 0.93 0.92 0.89 0.87 0.9 0.83
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0.17 0.16 0 0 0 0 0 0
Mitochondria 0 0 0 0.11 0.08 0.08 0.09 0.09 0.13 0.17 0.17 0.21 0 0 0 0.05 0 0.05 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0.05 0 0 0 0 0.07 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.15 0 0 0.06 0.13 0.05 0.1 0.17 0 0.11 0.13 0.06 0.06 0 0 0.26 0.28 0.26 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 8 3 16 23 28 14 21 12 33 40 8 22 8 15 3 23 14 8 4 3 5 2 2 5
Bud 0 0 2 3 5 2 8 4 5 11 2 3 1 0 1 2 1 2 3 1 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 – – – – – –
Cell Periphery 3 12 21 9 15 13 18 10 27 27 9 19 19 55 43 34 26 23 1 0 1 1 3 3
Cytoplasm 20 21 20 15 21 18 41 27 41 40 24 27 11 26 54 78 54 37 3 8 2 5 6 4
Endoplasmic Reticulum 216 253 200 162 198 138 229 142 196 210 52 90 125 246 166 6 3 1 267 270 230 163 199 188
Endosome 0 0 0 2 1 0 0 1 0 0 0 0 0 0 0 8 4 0 0 0 1 0 0 2
Golgi 4 1 1 9 15 3 5 0 0 3 0 0 0 0 0 8 27 18 0 0 2 2 2 2
Mitochondria 5 1 6 21 22 14 30 20 37 60 19 34 4 0 0 10 2 5 0 1 5 2 1 4
Nucleus 1 1 0 0 0 0 2 2 0 1 1 1 2 0 0 5 2 0 0 0 0 0 0 0
Nuclear Periphery 4 5 7 9 10 7 12 4 20 25 4 7 1 4 1 1 0 0 2 1 3 1 0 0
Nucleolus 0 0 0 0 0 0 1 0 0 0 1 1 0 0 0 2 1 3 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 2 2 0 0 0 0 0 0
Vac/Vac Membrane 39 4 6 12 35 10 35 39 12 38 15 9 10 4 5 53 44 29 1 2 1 1 2 8
Unique Cell Count 261 274 237 199 277 184 345 225 295 353 112 162 155 302 232 203 160 110 289 293 258 187 222 226
Labelled Cell Count 300 301 279 265 350 219 402 261 371 455 135 213 181 350 273 237 180 128 289 293 258 187 222 226


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 22.1 24.0 14.1 14.9 16.3 14.5 12.1 12.2 12.1 11.8 10.9 11.2 16.5 15.5 10.7 12.2 15.1 16.5 19.1 20.7 21.6
Std Deviation (1e-4) 4.9 5.2 2.9 3.9 4.0 3.0 3.0 2.9 2.7 2.7 2.9 2.5 6.1 3.1 2.2 3.1 3.6 4.0 5.3 4.7 4.9
Intensity Change (Log2) – – – 0.08 0.21 0.04 -0.22 -0.21 -0.22 -0.26 -0.38 -0.33 0.23 0.13 -0.4 -0.21 0.09 0.23 0.43 0.55 0.61


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 1.8 1.4 0.3 -0.3 -0.6 1.8 1.9 0.1 2.3 -0.6 -0.9 -3.0 1.7 0.7 0.2
Bud 0 0 0 0 0 0 1.8 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.8 -1.5 -0.7 -1.7 -1.9 0.1 -0.5 -0.3 0.9 1.1 3.1 3.1 2.5 2.2 3.1
Cytoplasm -0.3 -0.4 0.5 1.3 1.3 2.0 1.1 3.4 2.5 -0.5 0.1 4.4 7.5 6.4 5.9
Endoplasmic Reticulum -0.8 -3.5 -2.4 -4.8 -5.2 -4.7 -6.4 -7.4 -6.3 -1.0 -0.9 -3.4 -17.1 -16.1 -14.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 3.2 0 0 0 0 0 0 0 0 0 0 0 6.3 6.1
Mitochondria 3.5 2.7 2.4 3.0 3.0 4.2 5.5 4.9 6.0 0 0 0 1.3 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0.9 0.4 0.5 0.3 -0.8 2.0 2.2 0 0.7 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 1.8 4.2 1.5 3.5 5.4 1.0 3.7 4.0 1.6 1.9 0 -0.3 7.2 7.4 6.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 20.6955 23.9802 21.4878 21.6558 22.1997 22.063 17.2831 21.655 19.7989 20.1821 19.4634 19.9841 5.68 21.4743 18.7623 19.877 21.6775 20.558
Actin 0.011 0.0027 0.0122 0.0002 0.0001 0.0015 0.0612 0.0003 0.0064 0.0008 0.0253 0.0005 0.2709 0.0001 0.0075 0.0198 0 0.0002
Bud 0.0004 0.0001 0.0002 0 0 0 0.001 0 0 0.0001 0.0003 0 0.0008 0 0.0001 0.0006 0 0
Bud Neck 0.0008 0.0006 0.0005 0.0005 0.0004 0.0008 0.0016 0.0002 0.0002 0.0005 0.0003 0.0006 0.0008 0 0.0006 0.0004 0.0001 0.0002
Bud Periphery 0.0008 0.0002 0.0005 0 0 0.0002 0.001 0.0002 0.0001 0.0004 0.0003 0 0.0014 0 0.0002 0.0016 0 0
Bud Site 0.0022 0.0013 0.001 0 0 0 0.0086 0.0002 0.0002 0 0.0007 0 0.0017 0 0.0005 0.0002 0 0
Cell Periphery 0.0011 0.0064 0.0084 0.0004 0.0015 0.0036 0.0023 0.01 0.0016 0.0016 0.0004 0.0005 0.0007 0.0003 0.0013 0.0035 0.0002 0.0003
Cytoplasm 0.0149 0.049 0.0196 0.0117 0.0021 0.0052 0.0277 0.0374 0.0246 0.0017 0.008 0.0034 0.0115 0.0019 0.0143 0.0068 0.0006 0.0018
Cytoplasmic Foci 0.0139 0.0009 0.0054 0.0001 0.0001 0.0007 0.0044 0.0004 0.0024 0.0001 0.0122 0.0012 0.007 0 0.0049 0.0004 0 0
Eisosomes 0.0004 0.0001 0.0002 0 0 0 0.0006 0 0 0.0003 0.0001 0 0.0025 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.7467 0.855 0.861 0.9706 0.9861 0.9364 0.7286 0.9167 0.9116 0.9708 0.8473 0.96 0.497 0.97 0.8961 0.9098 0.9881 0.9739
Endosome 0.0112 0.0027 0.0111 0.0007 0.0004 0.0025 0.028 0.0012 0.0094 0.0033 0.0294 0.009 0.0717 0.0003 0.0181 0.018 0.0004 0.0007
Golgi 0.0027 0.0011 0.0037 0.0002 0.0001 0.0037 0.0059 0.0003 0.0058 0.0015 0.0284 0.0044 0.024 0 0.002 0.0147 0.0001 0.0001
Lipid Particles 0.0121 0.0098 0.0123 0.0005 0.0006 0.0016 0.0053 0.0065 0.006 0.0011 0.0038 0.0019 0.0325 0.0001 0.0038 0.0008 0.0001 0.0001
Mitochondria 0.0091 0.0005 0.0196 0 0 0.0023 0.0083 0.0007 0.0007 0.002 0.0169 0.0005 0.0064 0.0001 0.0008 0.0083 0 0
None 0.0249 0.0001 0.0019 0 0 0 0.0086 0.0024 0.0014 0.0004 0.0002 0.0001 0.0018 0 0.004 0.0002 0 0
Nuclear Periphery 0.0982 0.0523 0.0274 0.0124 0.006 0.026 0.0802 0.0114 0.0246 0.0109 0.0205 0.0144 0.0449 0.0246 0.0306 0.0102 0.0083 0.0206
Nucleolus 0.0033 0.0001 0.0002 0 0 0 0.0009 0 0 0 0 0 0.0001 0 0.0003 0 0 0
Nucleus 0.0128 0.0065 0.0013 0.0007 0.0002 0.0015 0.0114 0.0004 0.0013 0.0004 0.0005 0.0004 0.0012 0.0006 0.003 0.0005 0.0002 0.0006
Peroxisomes 0.0075 0 0.0008 0 0 0.0003 0.0012 0 0.0004 0 0.0017 0 0.0011 0 0.0008 0 0 0
Punctate Nuclear 0.0134 0.0002 0.0012 0.0001 0 0.0001 0.0037 0.0001 0.0003 0 0.0003 0.0001 0.0009 0 0.007 0.0001 0 0
Vacuole 0.0078 0.0086 0.0092 0.0017 0.0022 0.0129 0.0059 0.0105 0.002 0.0025 0.0018 0.0025 0.0189 0.0012 0.0028 0.0023 0.0014 0.0009
Vacuole Periphery 0.0048 0.0018 0.0023 0.0002 0.0002 0.0007 0.0036 0.0011 0.0011 0.0015 0.0016 0.0005 0.0023 0.0007 0.0011 0.0016 0.0003 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 56.9785 68.9304 88.7192 97.9357 64.5855 36.828 78.0219 81.3829 89.0911 81.8082
Translational Efficiency 1.3728 1.641 1.5258 1.3679 1.5085 1.7026 1.3169 1.3584 1.5064 1.394

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1973 924 1498 1398 733 1262 443 92 2706 2186 1941 1490

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1535.88 1511.42 2569.54 1801.68 1484.46 1701.38 1930.98 1949.89 1521.95 1621.09 2423.80 1810.83
Standard Deviation 280.74 384.88 759.42 402.31 259.57 338.81 320.61 522.17 276.11 371.07 735.11 412.27
Intensity Change Log 2 — -0.023161 0.742445 0.230277 — 0.196767 0.379395 0.393455 — 0.089120 0.575381 0.312784

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000268 0.000993 0.001377 0.002936 0.001189 0.001336 0.004125 0.005667 0.000517 0.001191 0.002004 0.003104
Bud Neck 0.000191 0.001009 0.008669 0.016489 0.000155 0.000308 0.003469 0.022253 0.000181 0.000604 0.007482 0.016845
Bud Site 0.002431 0.010395 0.012430 0.035124 0.001281 0.005157 0.005613 0.036066 0.002119 0.007371 0.010874 0.035183
Cell Periphery 0.004549 0.006463 0.012739 0.019380 0.001759 0.002116 0.007617 0.012201 0.003793 0.003954 0.011570 0.018937
Cytoplasm 0.003771 0.018817 0.031359 0.019588 0.001233 0.004862 0.006821 0.009681 0.003083 0.010761 0.025758 0.018976
Cytoplasmic Foci 0.000652 0.013501 0.002944 0.010581 0.000157 0.002329 0.001555 0.024537 0.000518 0.007052 0.002627 0.011443
Eisosomes 0.000101 0.000067 0.000236 0.000182 0.000027 0.000055 0.000192 0.000241 0.000081 0.000060 0.000226 0.000186
Endoplasmic Reticulum 0.975892* 0.809088* 0.747500* 0.644699* 0.983627* 0.954391* 0.891176* 0.467846* 0.977987* 0.892973* 0.780291* 0.633779*
Endosome 0.002826 0.026084 0.018565 0.026078 0.002961 0.007550 0.009743 0.041137 0.002862 0.015384 0.016551 0.027008
Golgi 0.000734 0.021773 0.002475 0.006688 0.000433 0.003396 0.001251 0.010989 0.000653 0.011164 0.002196 0.006954
Lipid Particles 0.003078 0.016380 0.019583 0.141791* 0.000780 0.002441 0.021643 0.115677* 0.002455 0.008333 0.020053 0.140179*
Mitochondria 0.000569 0.001577 0.001186 0.000773 0.000147 0.000556 0.000160 0.002313 0.000454 0.000988 0.000952 0.000868
Mitotic Spindle 0.000047 0.000412 0.003674 0.005958 0.000019 0.000554 0.001734 0.054819 0.000039 0.000494 0.003231 0.008975
None 0.001597 0.006193 0.002570 0.001874 0.000195 0.000843 0.000041 0.000055 0.001218 0.003105 0.001993 0.001761
Nuclear Periphery 0.000329 0.002690 0.031626 0.002599 0.001086 0.000837 0.003858 0.009317 0.000534 0.001620 0.025289 0.003014
Nuclear Periphery Foci 0.001363 0.029854 0.072448 0.043624 0.002058 0.005014 0.027704 0.124326 0.001552 0.015514 0.062236 0.048607
Nucleolus 0.000007 0.000218 0.000040 0.000033 0.000002 0.000143 0.000007 0.000127 0.000006 0.000175 0.000032 0.000039
Nucleus 0.000203 0.001194 0.006037 0.001825 0.000072 0.000497 0.000933 0.002081 0.000167 0.000792 0.004872 0.001841
Peroxisomes 0.000258 0.000221 0.000030 0.000288 0.000044 0.000173 0.000029 0.002294 0.000200 0.000193 0.000030 0.000412
Vacuole 0.000878 0.023573 0.023323 0.018192 0.002422 0.005829 0.012141 0.054929 0.001296 0.013330 0.020771 0.020461
Vacuole Periphery 0.000258 0.009499 0.001189 0.001296 0.000352 0.001609 0.000188 0.003443 0.000283 0.004944 0.000961 0.001428

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.62 -4.97 -6.31 -4.81 -3.56 -0.16 -1.56 -1.90 -1.95 -0.23 -1.82 -3.10 -5.73 -4.54 -2.03
Bud Neck -5.51 -10.95 -13.76 -13.10 -5.07 -2.24 -3.67 -4.70 -4.67 -3.97 -5.28 -11.52 -14.52 -14.18 -6.79
Bud Site -4.72 -6.18 -12.06 -8.82 -7.44 -3.01 -3.13 -4.16 -3.74 -3.64 -4.81 -6.81 -12.84 -10.75 -8.68
Cell Periphery -1.99 -7.19 -10.25 -8.15 -3.08 -0.64 -3.14 -2.29 -2.21 -0.82 -0.28 -7.99 -11.16 -10.96 -3.91
Cytoplasm -7.16 -11.78 -8.37 -0.95 4.35 -4.24 -3.76 -2.25 -1.67 -1.13 -7.15 -12.27 -9.04 -4.75 2.98
Cytoplasmic Foci -7.14 -4.06 -7.05 0.73 -5.04 -4.16 -1.96 -3.97 -3.66 -3.74 -7.88 -4.55 -7.98 -3.30 -6.12
Eisosomes 0.79 -1.59 -1.95 -4.67 0.65 -1.15 -2.68 -2.16 -1.82 -0.16 0.65 -2.21 -3.12 -5.51 0.65
Endoplasmic Reticulum 16.86 27.60 33.63 12.99 7.13 6.36 8.80 12.91 12.19 10.25 16.30 28.46 35.93 24.93 11.63
Endosome -14.85 -17.51 -20.55 -0.11 -4.27 -6.42 -6.32 -6.11 -5.31 -4.86 -15.56 -18.51 -21.46 -8.57 -6.88
Golgi -8.35 -6.78 -10.08 5.85 -6.56 -3.88 -3.43 -3.17 -2.08 -2.88 -8.98 -7.56 -10.76 3.34 -7.62
Lipid Particles -6.42 -8.56 -21.67 -18.87 -17.83 -3.21 -5.26 -5.68 -5.59 -4.46 -5.80 -10.12 -22.49 -21.38 -18.44
Mitochondria -2.04 -4.75 -1.95 1.43 3.46 -3.71 -0.87 -1.50 -1.17 -1.46 -2.33 -5.02 -3.29 0.17 1.47
Mitotic Spindle -3.54 -4.85 -5.57 -5.28 -2.00 -1.84 -2.16 -4.02 -4.00 -3.92 -2.62 -5.28 -6.53 -6.26 -4.25
None -2.80 -1.51 -0.45 2.50 0.87 -2.10 1.21 0.91 2.60 -0.99 -2.50 -1.59 -0.91 1.42 0.36
Nuclear Periphery -3.81 -15.57 -11.71 0.01 14.34 0.65 -3.89 -2.15 -2.23 -1.29 -3.80 -15.66 -8.33 -3.63 13.88
Nuclear Periphery Foci -8.59 -18.45 -16.40 -3.52 6.36 -3.53 -6.05 -4.88 -4.75 -3.67 -9.30 -19.23 -16.41 -10.32 3.54
Nucleolus -1.55 -5.77 -6.98 1.31 1.03 -1.18 -1.57 -2.43 -0.11 -2.33 -1.87 -5.98 -6.94 1.41 -0.99
Nucleus -1.45 -9.03 -5.63 -1.64 5.95 -1.89 -4.43 -1.93 -1.74 -1.47 -1.99 -9.32 -6.02 -3.54 5.05
Peroxisomes 0.42 3.07 -0.43 -0.99 -4.48 -1.73 0.61 -2.04 -1.92 -2.05 0.04 3.11 -2.16 -2.22 -4.34
Vacuole -10.28 -16.98 -14.35 1.47 3.17 -2.79 -4.47 -4.29 -4.03 -3.39 -10.53 -16.89 -13.65 -4.75 0.46
Vacuole Periphery -7.10 -6.66 -6.84 6.26 -0.41 -3.84 1.35 -1.93 -0.98 -2.04 -7.96 -6.14 -6.79 5.86 -2.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
Localization
Cell Percentages ER (100%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Erg5

Erg5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Erg5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available