Standard name
Human Ortholog
Description Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.59 0.6 0.71 0.73 0.68 0.6 0.57 – 0.46 0.51 0.45 0.51 0.56 0.54 0.55 0.52 0.31 0.53 0.25 0.35 0.27 0.32 0.32 0.34
Bud 0.07 0.06 0.07 0.12 0.06 0.08 0.1 – 0 0.07 0.12 0.07 0.07 0.08 0.07 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.57 0.55 0.58 0.62 0.52 0.43 0.36 – 0.35 0.36 0.31 0.36 0.68 0.69 0.66 0.52 0.75 0.54 0.67 0.55 0.58 0.62 0.6 0.55
Cytoplasm 0.07 0.06 0.08 0 0.1 0.08 0.05 – 0 0 0.06 0 0.14 0.07 0.05 0.11 0.11 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0.05 0.12 0.06 0.08 0.08 0.16 0.12 – 0.11 0.16 0.12 0.11 0.12 0.13 0.12 0 0.06 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0.07 0.22 0 0.14 0.16 0.12 – 0.07 0.07 0.08 0.15 0 0 0 0.37 0.46 0.3 0 0 0 0 0 0
Mitochondria 0.54 0.24 0.21 0.2 0.17 0.32 0.37 – 0.63 0.61 0.69 0.62 0 0 0.09 0.08 0.06 0.11 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.1 0 0.12 0.15 0.11 0.09 0.1 – 0.06 0 0 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 161 296 208 94 74 193 171 – 136 157 118 128 291 338 301 208 71 106 71 211 91 137 202 243
Bud 18 29 20 15 6 27 30 – 8 22 31 17 38 53 36 7 1 6 0 2 1 0 0 2
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 2 2 2 3 7
Bud Site 0 0 0 1 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 156 271 170 79 57 139 108 – 104 109 80 91 351 432 364 207 174 107 192 331 194 264 381 399
Cytoplasm 19 31 22 4 11 25 16 – 10 7 15 10 72 41 29 44 25 12 3 5 1 1 4 11
Endoplasmic Reticulum 15 57 19 10 9 52 36 – 32 48 31 27 60 85 68 13 15 10 5 13 8 6 17 20
Endosome 1 0 0 0 0 0 1 – 2 1 0 1 1 0 0 0 0 2 1 2 7 1 0 5
Golgi 7 35 65 3 15 51 36 – 22 21 20 37 7 11 9 147 106 61 5 9 5 4 5 8
Mitochondria 147 119 61 26 19 104 111 – 186 187 180 155 15 6 51 32 13 22 2 11 6 5 10 7
Nucleus 0 1 0 0 1 0 0 – 0 1 3 1 0 0 0 1 1 0 0 0 2 0 1 0
Nuclear Periphery 0 0 0 0 0 1 0 – 0 1 0 0 0 0 1 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Peroxisomes 26 20 35 19 12 29 31 – 17 10 4 12 23 17 31 1 0 1 0 0 3 1 0 5
SpindlePole 0 0 2 0 0 0 0 – 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0
Vac/Vac Membrane 0 1 3 0 2 0 0 – 0 0 2 1 0 2 0 2 2 0 3 4 3 0 2 0
Unique Cell Count 273 490 293 128 109 322 298 295 307 261 251 520 630 551 397 232 200 289 602 334 430 639 721
Labelled Cell Count 550 860 605 251 206 621 540 517 564 484 480 858 985 890 663 408 327 289 602 334 430 639 721


Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.6 13.3 10.5 10.0 10.8 11.0 11.1 – 11.4 11.1 11.0 12.0 17.1 18.7 18.4 19.0 21.7 19.9 11.7 12.5 12.6
Std Deviation (1e-4) 1.7 2.6 1.5 1.6 1.6 1.9 1.6 – 2.1 2.1 2.5 2.4 3.6 4.3 4.3 5.0 7.6 5.4 2.2 2.8 2.1
Intensity Change (Log2) – – – -0.07 0.05 0.07 0.07 – 0.12 0.08 0.07 0.2 0.7 0.83 0.81 0.86 1.05 0.92 0.16 0.26 0.26


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.5 -0.6 -2.9 -3.4 – -6.1 -5.0 -6.2 -4.8 -4.2 -5.0 -4.6 -4.9 -9.2 -4.1
Bud 1.7 -0.5 0.7 1.4 – -2.3 0.2 2.1 0 0.3 0.8 -0.2 -3.4 -3.7 -1.9
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.7 -1.0 -3.7 -5.3 – -5.5 -5.5 -6.5 -5.1 2.7 3.1 2.3 -1.5 4.1 -1.0
Cytoplasm -1.7 0.8 0.1 -1.1 – -2.2 -3.0 -0.8 -1.7 2.7 -0.6 -1.3 1.6 1.3 -0.6
Endoplasmic Reticulum 0.5 0.6 3.7 2.3 – 1.9 3.6 2.2 1.8 2.3 3.1 2.7 -2.0 0 -0.7
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi -5.1 -1.9 -2.0 -3.3 – -5.0 -5.4 -4.7 -2.2 -10.0 -10.5 -10.0 4.2 5.7 2.1
Mitochondria -0.1 -0.8 3.2 4.4 – 10.4 10.0 11.4 9.7 -8.4 -10.8 -4.7 -4.9 -5.0 -2.9
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.8 -0.3 -1.2 -0.6 – -2.6 -4.0 -4.8 -3.0 -4.0 -5.7 -3.3 -6.8 -5.4 -4.8
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 13.4464 17.292 15.3559 14.984 14.3439 16.2924 14.5043 19.6563 15.8383 14.314 15.3094 17.8246 15.5591 16.4867 13.9498 15.2904 14.2186 15.7704
Actin 0.0956 0.0689 0.0279 0.0337 0.0054 0.0186 0.082 0.0322 0.0399 0.0662 0.0828 0.0215 0.0108 0.0105 0.0039 0.0008 0.0008 0.0048
Bud 0.0007 0.0002 0.0002 0.0013 0.0001 0.0001 0.0011 0.0002 0.0004 0.0021 0.0008 0.0003 0.0001 0.0001 0.0001 0 0 0.0002
Bud Neck 0.0022 0.0032 0.0031 0.0064 0.0013 0.003 0.0024 0.003 0.004 0.0076 0.0065 0.0014 0.0007 0.0008 0.0008 0.0005 0.0008 0.0016
Bud Periphery 0.0048 0.0008 0.0014 0.0099 0.0014 0.0015 0.0054 0.001 0.0031 0.0114 0.0043 0.0037 0.0005 0.0003 0.0005 0.0004 0.0007 0.0011
Bud Site 0.0083 0.0156 0.0083 0.0066 0.0007 0.0003 0.0084 0.039 0.0143 0.015 0.0072 0.0007 0.0014 0.0042 0.0027 0.0002 0.0001 0.0021
Cell Periphery 0.1083 0.1111 0.1945 0.203 0.1616 0.1454 0.1031 0.192 0.2338 0.1462 0.2799 0.2151 0.0802 0.092 0.1063 0.0778 0.1392 0.137
Cytoplasm 0.0043 0.0056 0.0045 0.0148 0.0028 0.0012 0.0073 0.0054 0.0094 0.0128 0.0048 0.0032 0.0012 0.0023 0.0019 0.0013 0.0031 0.0027
Cytoplasmic Foci 0.0104 0.0005 0.0008 0.0003 0.0056 0.0001 0.0062 0.0002 0.0068 0.0056 0.0026 0.0019 0.0001 0.0001 0 0 0.0001 0.0001
Eisosomes 0.7095 0.7754 0.733 0.6914 0.7375 0.8098 0.6976 0.7156 0.6523 0.6598 0.5179 0.7132 0.9009 0.8835 0.877 0.9078 0.8247 0.8374
Endoplasmic Reticulum 0.0069 0.0037 0.0033 0.0079 0.0094 0.0054 0.0113 0.006 0.0034 0.0084 0.0106 0.01 0.0015 0.0027 0.0035 0.0078 0.0249 0.0067
Endosome 0.0033 0.0002 0.0045 0.0002 0.0032 0.0003 0.0132 0.0001 0.0041 0.0115 0.0251 0.0029 0 0.0001 0 0 0.0001 0.0001
Golgi 0.0112 0.0122 0.0049 0.0206 0.003 0.0043 0.0161 0.002 0.0024 0.0163 0.0092 0.0098 0.0007 0.0017 0.0004 0.0021 0.0018 0.0026
Lipid Particles 0.0063 0.0006 0.0014 0.0007 0.0291 0.0003 0.0028 0.0002 0.0026 0.0049 0.0026 0.0016 0.0001 0.0002 0.0001 0.0001 0.0012 0.0005
Mitochondria 0.0064 0.0008 0.0021 0.0005 0.0086 0.008 0.0139 0.0015 0.0051 0.021 0.037 0.006 0.0009 0.0004 0.0013 0.0001 0.0002 0.0007
None 0.004 0.0005 0.0012 0.0005 0.0176 0.0006 0.0047 0.0005 0.0031 0.0016 0.001 0.001 0.0005 0.0004 0.0005 0.0005 0.0005 0.0006
Nuclear Periphery 0.009 0.0003 0.0014 0.0005 0.0009 0.0004 0.0112 0.0005 0.0015 0.0032 0.0016 0.0019 0.0002 0.0003 0.0004 0.0002 0.0008 0.0003
Nucleolus 0.0002 0 0.0002 0.0001 0.0004 0 0.0003 0 0.0007 0.0004 0.0001 0.0003 0 0 0 0 0 0.0006
Nucleus 0.0019 0 0.0004 0.0001 0.0002 0.0001 0.0057 0.0001 0.0026 0.0008 0.0005 0.0003 0 0 0 0 0 0.0003
Peroxisomes 0.0031 0.0001 0.0005 0.0001 0.0094 0.0001 0.0011 0.0001 0.0049 0.0011 0.0008 0.0004 0 0 0 0 0 0
Punctate Nuclear 0.0019 0 0.0007 0 0.0007 0 0.003 0 0.0037 0.0009 0.0001 0.004 0 0 0 0 0 0
Vacuole 0.001 0.0002 0.0047 0.0014 0.0009 0.0003 0.0017 0.0006 0.0016 0.0026 0.0035 0.0007 0.0002 0.0003 0.0003 0.0001 0.0009 0.0006
Vacuole Periphery 0.0006 0 0.0009 0.0001 0.0003 0.0001 0.0015 0 0.0003 0.0008 0.0011 0.0002 0 0 0 0 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.6377 17.5304 41.6266 43.7125 12.1478 16.9862 31.511 52.6378 56.6877 16.7971
Translational Efficiency 2.9844 1.9266 2.4399 2.8151 1.9623 2.9567 1.8852 2.0397 1.8844 1.9657

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2544 1467 1915 1555 2157 2480 2510 2706 4701 3947 4425 4261

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1039.74 1042.18 1631.19 1822.72 1022.13 1052.01 1569.11 2001.67 1031.66 1048.36 1595.98 1936.36
Standard Deviation 137.75 182.53 278.72 324.10 163.22 148.11 249.20 348.10 150.23 161.83 264.18 350.29
Intensity Change Log 2 — 0.003382 0.649702 0.809870 — 0.041570 0.618368 0.969625 — 0.022439 0.634254 0.891276

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.066716 0.136463* 0.043584 0.080413 0.065192 0.094117 0.069869 0.030204 0.066017 0.109856* 0.058493 0.048527
Bud Neck 0.001865 0.005258 0.008392 0.005834 0.002668 0.002754 0.003571 0.001545 0.002234 0.003685 0.005657 0.003110
Bud Site 0.000500 0.003662 0.003568 0.011235 0.001036 0.002294 0.002473 0.002209 0.000746 0.002802 0.002946 0.005503
Cell Periphery 0.072190 0.171776* 0.333320* 0.497031* 0.202754* 0.339429* 0.206111* 0.751673* 0.132098* 0.277117* 0.261163* 0.658745*
Cytoplasm 0.000082 0.000473 0.000076 0.000846 0.000135 0.000715 0.000349 0.000819 0.000106 0.000625 0.000231 0.000829
Cytoplasmic Foci 0.001601 0.001304 0.000224 0.000576 0.001653 0.001364 0.001341 0.000187 0.001625 0.001342 0.000858 0.000329
Eisosomes 0.841894* 0.624350* 0.591707* 0.383118* 0.705025* 0.508004* 0.580518* 0.207771* 0.779093* 0.551247* 0.585360* 0.271762*
Endoplasmic Reticulum 0.001662 0.017313 0.009790 0.006813 0.003417 0.004688 0.027725 0.000776 0.002468 0.009380 0.019963 0.002979
Endosome 0.001257 0.007601 0.001804 0.002194 0.002691 0.003224 0.008922 0.000732 0.001915 0.004850 0.005841 0.001266
Golgi 0.002971 0.011103 0.000651 0.000946 0.003289 0.002911 0.029002 0.000340 0.003117 0.005956 0.016733 0.000562
Lipid Particles 0.001862 0.007121 0.002663 0.003417 0.002119 0.003879 0.042518 0.000279 0.001980 0.005084 0.025270 0.001424
Mitochondria 0.000504 0.001632 0.000932 0.002500 0.000634 0.001455 0.000600 0.000888 0.000564 0.001521 0.000744 0.001476
Mitotic Spindle 0.000797 0.001365 0.000982 0.001439 0.001298 0.001062 0.000742 0.000270 0.001027 0.001175 0.000846 0.000697
None 0.001314 0.000539 0.000204 0.000173 0.000808 0.000536 0.000278 0.000116 0.001082 0.000537 0.000246 0.000137
Nuclear Periphery 0.000226 0.000371 0.000658 0.000396 0.000402 0.000367 0.000603 0.000198 0.000306 0.000369 0.000627 0.000270
Nuclear Periphery Foci 0.000004 0.000032 0.000035 0.000323 0.000015 0.000015 0.000032 0.000005 0.000009 0.000021 0.000033 0.000121
Nucleolus 0.000003 0.000007 0.000020 0.000026 0.000004 0.000004 0.000005 0.000007 0.000003 0.000005 0.000011 0.000014
Nucleus 0.000084 0.000148 0.000140 0.000166 0.000110 0.000123 0.000103 0.000053 0.000096 0.000132 0.000119 0.000094
Peroxisomes 0.004428 0.009260 0.000691 0.000723 0.006637 0.032953 0.024582 0.001836 0.005442 0.024147 0.014243 0.001430
Vacuole 0.000025 0.000144 0.000508 0.001384 0.000077 0.000065 0.000401 0.000061 0.000049 0.000094 0.000447 0.000543
Vacuole Periphery 0.000013 0.000078 0.000054 0.000446 0.000035 0.000040 0.000254 0.000032 0.000023 0.000054 0.000167 0.000183

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -9.69 5.16 -2.44 7.14 -6.75 -5.18 -0.91 7.95 13.73 9.58 -10.17 2.18 5.25 14.77 3.07
Bud Neck -11.46 -14.24 -11.97 -1.39 4.70 -0.43 -3.27 5.81 6.71 7.75 -8.97 -13.54 -5.22 2.95 9.26
Bud Site -5.05 -6.95 -7.42 -4.83 -5.10 -3.01 -3.09 -2.58 0.15 0.45 -6.00 -6.87 -7.93 -4.00 -3.85
Cell Periphery -14.40 -34.50* -46.71* -30.49* -14.73 -16.45 -0.43 -69.52* -50.15* -70.88* -25.70 -23.80 -88.05 -55.39* -59.25*
Cytoplasm -2.83 0.16 -4.34 -1.70 -4.36 -5.32 -2.55 -3.00 -0.42 -1.95 -6.08 -2.52 -4.58 -1.16 -3.66
Cytoplasmic Foci 0.95 6.51 3.23 2.27 -1.55 0.87 0.87 4.58 11.84 7.08 1.33 3.71 6.32 7.61 4.12
Eisosomes 22.27* 29.87 50.06* 20.46 19.57 21.75* 13.37 61.23* 37.64* 45.06* 34.87* 30.83 85.12* 40.91* 47.56*
Endoplasmic Reticulum -8.90 -8.55 -6.18 5.53 2.49 -2.07 -12.92 6.11 7.62 14.57 -9.14 -15.24 -1.30 8.19 14.58
Endosome -9.66 -3.80 -3.12 7.57 -1.31 -1.73 -10.08 6.92 16.19 14.66 -10.04 -11.22 3.60 12.63 13.34
Golgi -5.72 4.28 3.30 7.52 -1.00 0.65 -12.68 5.93 5.32 14.32 -4.33 -11.37 6.36 9.14 13.91
Lipid Particles -5.95 -1.27 -1.78 3.16 -0.77 -2.63 -16.26 4.20 6.97 17.25 -6.03 -15.93 1.38 6.77 16.20
Mitochondria -3.40 -6.46 -3.61 -1.35 -2.83 -2.46 0.27 -1.45 1.58 -1.55 -3.97 -2.46 -3.99 0.13 -3.14
Mitotic Spindle -4.12 -2.92 -1.25 -0.34 -0.96 2.62 6.48 13.20 16.30* 11.64 -2.07 3.46 1.20 1.81 0.42
None 7.50 11.54 11.85 9.43 2.93 5.40 11.52 16.55 14.36 7.91 9.08 14.75 17.00 17.14 8.76
Nuclear Periphery -6.96 -15.71 -7.83 -0.99 8.05 1.41 -5.88 9.56 9.06 13.30 -3.96 -14.44 2.51 6.32 16.17
Nuclear Periphery Foci -7.28 -8.71 -1.33 -1.24 -1.23 -0.14 -5.14 3.73 9.44 12.76 -6.24 -10.63 -1.29 -1.17 -1.06
Nucleolus -1.91 -2.11 -2.52 -2.01 -0.48 -0.28 -2.46 -7.58 -7.17 -5.80 -2.13 -2.26 -3.09 -2.49 -0.49
Nucleus -8.13 -8.76 -3.38 -0.73 -1.09 -2.31 1.31 11.95 16.47 13.52 -8.24 -5.87 0.13 3.90 2.59
Peroxisomes -4.36 7.39 8.25 8.32 -0.11 -12.57 -10.39 6.23 15.55 14.11 -13.67 -8.78 8.91 17.13 13.57
Vacuole -6.88 -10.71 -3.02 -2.76 -1.96 0.99 -2.69 0.97 0.31 2.83 -5.02 -5.62 -3.00 -2.73 -0.58
Vacuole Periphery -4.03 -7.82 -2.05 -1.74 -1.86 -0.51 -1.68 0.19 0.75 1.70 -3.92 -1.96 -2.07 -1.67 -0.15
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication
Localization
Cell Percentages cell periphery (56%)
Cell Cycle Regulation No
Subcompartmental Group cell periphery-2

Eis1

Eis1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Eis1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available