Standard name
Human Ortholog
Description Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0 0 0.05 0.05 0.06 0 0 0 0.06 0 0 0 0 0.1 0.16 0 0 – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.07 0 0.06 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleus 0.94 0.9 0.94 0.93 0.91 0.91 0.88 0.89 0.83 0.87 0.83 0.84 0.94 0.86 0.74 0.95 0.95 – 0.93 0.91 0.9 0.92 0.77 0.63
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.06 0.11 0.06 0.12 0.16 0.18 0.17 0 0 0.07 0 0.05 – 0 0 0 0 0 0.09
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0.14 0.2
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 1 1 0 0 0
Bud 0 1 0 0 0 0 0 0 1 1 2 0 0 0 0 0 0 – 0 2 0 1 0 4
Bud Neck 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 – 0 0 0 0 0 0
Bud Site 0 1 0 0 0 2 2 0 3 3 1 4 0 0 0 0 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0
Cytoplasm 0 5 16 17 24 18 21 28 23 11 14 12 10 30 48 0 0 – 0 1 1 2 3 2
Endoplasmic Reticulum 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 1 0 1 0
Endosome 0 1 1 1 0 0 1 0 0 2 0 1 1 0 4 0 0 – 0 1 4 0 2 3
Golgi 0 0 0 1 1 0 0 0 0 0 0 0 0 1 1 0 0 – 0 1 3 0 0 0
Mitochondria 1 5 0 2 0 7 4 4 29 11 24 7 0 2 0 0 0 – 1 3 2 0 2 5
Nucleus 67 183 298 299 364 534 679 578 327 390 352 350 213 256 220 20 37 – 82 189 296 139 213 220
Nuclear Periphery 2 1 0 0 0 4 9 2 2 8 4 9 1 3 4 0 0 – 0 0 1 0 0 5
Nucleolus 3 3 0 4 4 36 86 39 48 72 75 69 2 11 20 0 2 – 0 0 1 2 10 30
Peroxisomes 0 1 0 0 0 0 0 0 0 0 0 0 0 0 4 1 0 – 0 0 0 0 0 1
SpindlePole 0 2 0 0 0 0 1 3 0 1 0 1 1 2 8 0 0 – 0 0 0 0 0 2
Vac/Vac Membrane 0 7 3 4 10 9 8 14 5 2 7 7 1 2 4 0 0 – 1 6 10 3 38 70
Unique Cell Count 71 203 316 323 398 587 770 648 395 448 426 415 227 297 297 21 39 89 209 330 152 276 350
Labelled Cell Count 73 210 318 328 404 610 811 669 438 502 479 461 229 307 313 21 39 89 209 330 152 276 350


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.6 8.5 10.2 10.0 11.0 9.3 8.9 9.0 8.0 8.0 8.0 8.4 10.9 10.7 10.1 9.4 10.5 – 10.1 10.5 10.5
Std Deviation (1e-4) 1.8 1.9 1.9 2.3 2.5 2.0 2.2 3.8 2.1 1.8 2.0 2.1 2.0 3.2 2.9 2.1 2.2 – 2.0 1.9 2.0
Intensity Change (Log2) – – – -0.04 0.1 -0.14 -0.21 -0.18 -0.35 -0.35 -0.36 -0.29 0.09 0.06 -0.03 -0.12 0.03 – -0.02 0.04 0.04


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Cytoplasm 0.1 0.6 -1.5 -1.9 -0.5 0.4 -1.9 -1.2 -1.5 -0.4 2.4 4.5 0 0 –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Mitochondria 0 0 0 0 0 4.9 0 4.3 0 0 0 0 0 0 –
Nucleus -0.9 -1.5 -1.8 -3.0 -2.6 -4.7 -3.3 -4.8 -4.2 -0.2 -3.4 -6.9 0.2 0.1 –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Nucleolus 0 0 4.5 6.2 4.5 6.4 7.5 7.9 7.6 0 3.5 4.7 0 0 –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 –
Vacuole 0 1.6 0 0 1.3 0 0 0 0 0 0 0 0 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.756 5.4433 5.1263 4.8517 6.1353 5.7744 6.0494 8.2138 6.4352 6.152 5.2402 6.9504 5.3496 8.1774 6.8341 6.2645 6.1864 6.8419
Actin 0.0188 0 0.0089 0.0003 0.0001 0.0097 0.0636 0 0.0024 0 0.0055 0.0005 0.0641 0 0 0.0377 0 0
Bud 0.001 0 0.0007 0.0008 0.0001 0.0001 0.0004 0 0.0001 0 0.0003 0.0001 0.0006 0 0 0.0005 0 0.0001
Bud Neck 0.0028 0.0001 0.0012 0.0001 0.0006 0.0011 0.0006 0 0.0002 0 0.0005 0.0005 0.0017 0 0 0.0005 0 0.0005
Bud Periphery 0.0018 0 0.0013 0.0035 0.0004 0.0004 0.001 0 0.0001 0 0.0005 0.0002 0.001 0 0 0.0004 0 0.0001
Bud Site 0.0053 0.0001 0.0164 0.0002 0.0001 0.0002 0.0011 0 0.0005 0 0.0011 0.0001 0.0013 0 0 0.0046 0 0
Cell Periphery 0.0013 0 0.0006 0.0003 0.0002 0.0002 0.0004 0 0.0001 0 0.0002 0.0001 0.0003 0 0 0 0 0.0001
Cytoplasm 0.0289 0.0061 0.0014 0.0154 0.0001 0.0001 0.0045 0.0001 0.0029 0 0.0008 0.0018 0.0107 0 0 0.0005 0 0
Cytoplasmic Foci 0.0053 0.0001 0.0079 0.0033 0 0.0008 0.0082 0 0.0156 0 0.0171 0.013 0.027 0 0 0.0148 0 0
Eisosomes 0.0002 0 0.0001 0.0001 0 0.0001 0.0004 0 0 0 0.0002 0 0.0004 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0017 0.0002 0.0007 0.0123 0.0001 0.0003 0.0138 0 0.0004 0 0.0015 0.0006 0.0044 0 0 0.0002 0 0
Endosome 0.0105 0.0005 0.0205 0.0584 0.0001 0.0027 0.0108 0 0.0069 0 0.0278 0.007 0.0182 0 0 0.002 0 0
Golgi 0.0033 0 0.006 0.003 0 0.0018 0.0111 0 0.0042 0 0.0623 0.0002 0.0085 0 0 0.0036 0 0
Lipid Particles 0.012 0 0.0239 0.0009 0 0.0079 0.0015 0 0.009 0 0.0246 0.0009 0.0146 0 0 0.004 0 0
Mitochondria 0.0056 0.0003 0.0164 0.0288 0.0012 0.0081 0.0066 0.0004 0.0037 0.0003 0.027 0.0016 0.0204 0.0003 0.0003 0.0005 0.0004 0.0002
None 0.0081 0.0045 0.0005 0.0096 0 0.0002 0.0039 0 0.0013 0 0.0016 0.0004 0.0054 0 0 0.0005 0 0
Nuclear Periphery 0.0109 0.0184 0.0222 0.007 0.0082 0.0059 0.0369 0.0028 0.0029 0.0006 0.0085 0.0093 0.0088 0.0005 0.0011 0.0007 0.0006 0.0004
Nucleolus 0.0304 0.0126 0.0212 0.0193 0.1359 0.0949 0.0122 0.0123 0.0234 0.0085 0.1538 0.038 0.0186 0.008 0.0091 0.01 0.018 0.0394
Nucleus 0.8352 0.953 0.8227 0.8142 0.8495 0.8615 0.8102 0.9836 0.9126 0.9903 0.6508 0.9151 0.7725 0.9907 0.9889 0.8991 0.9808 0.9587
Peroxisomes 0.0036 0 0.0106 0.0001 0 0.0015 0.0013 0 0.0028 0 0.004 0.005 0.0078 0 0 0.0089 0 0
Punctate Nuclear 0.0056 0.0012 0.0082 0.0003 0.0002 0.0008 0.0004 0.0002 0.01 0.0001 0.0073 0.0012 0.0098 0 0 0.0111 0 0
Vacuole 0.0054 0.002 0.0056 0.0129 0.0013 0.0007 0.0053 0.0002 0.0004 0 0.0015 0.0024 0.0015 0.0002 0.0001 0.0001 0 0.0003
Vacuole Periphery 0.0024 0.0009 0.0028 0.009 0.0017 0.001 0.0057 0.0004 0.0005 0 0.003 0.0019 0.0024 0.0002 0.0003 0 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.553 19.0767 29.1441 32.9873 29.2958 31.365 24.3942 33.6946 36.176 27.229
Translational Efficiency 6.662 4.6323 2.5544 2.5735 2.7795 2.7409 3.0548 2.3975 2.2219 2.9763

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1531 451 2452 1320 257 1966 1844 1725 1788 2417 4296 3045

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 884.67 1080.04 1172.18 1460.75 917.37 1031.34 1028.76 1465.30 889.37 1040.43 1110.62 1463.33
Standard Deviation 142.09 167.09 180.83 288.62 121.23 154.34 219.67 317.40 139.75 157.94 210.75 305.27
Intensity Change Log 2 — 0.287873 0.405983 0.723498 — 0.168944 0.165331 0.675620 — 0.228555 0.288489 0.699323

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000344 0.000533 0.000432 0.000504 0.000337 0.000388 0.000455 0.000449 0.000343 0.000415 0.000442 0.000473
Bud Neck 0.005153 0.009633 0.011765 0.008616 0.002130 0.008427 0.008331 0.008995 0.004718 0.008652 0.010291 0.008831
Bud Site 0.000565 0.001914 0.000655 0.000842 0.001388 0.001784 0.000988 0.000742 0.000683 0.001808 0.000798 0.000786
Cell Periphery 0.000160 0.000071 0.000085 0.000123 0.000021 0.000215 0.000348 0.000126 0.000140 0.000188 0.000198 0.000124
Cytoplasm 0.001055 0.000238 0.000106 0.000453 0.003073 0.002259 0.003027 0.000340 0.001345 0.001882 0.001360 0.000389
Cytoplasmic Foci 0.000079 0.000035 0.000035 0.000615 0.000548 0.000499 0.000306 0.000037 0.000146 0.000412 0.000151 0.000288
Eisosomes 0.000036 0.000043 0.000067 0.000041 0.000018 0.000042 0.000042 0.000051 0.000034 0.000042 0.000056 0.000047
Endoplasmic Reticulum 0.005536 0.004009 0.001778 0.000962 0.002804 0.006270 0.002163 0.000987 0.005144 0.005848 0.001943 0.000976
Endosome 0.000284 0.000340 0.000134 0.000600 0.000209 0.000804 0.000230 0.000071 0.000273 0.000718 0.000175 0.000300
Golgi 0.000039 0.000056 0.000170 0.001208 0.000037 0.000282 0.000057 0.000063 0.000039 0.000240 0.000121 0.000560
Lipid Particles 0.000041 0.000060 0.000024 0.000134 0.000076 0.000274 0.000075 0.000007 0.000046 0.000234 0.000046 0.000062
Mitochondria 0.000706 0.001506 0.001170 0.001627 0.000351 0.002416 0.001314 0.001238 0.000655 0.002246 0.001232 0.001407
Mitotic Spindle 0.000122 0.003609 0.000154 0.001039 0.002188 0.001788 0.001061 0.000655 0.000419 0.002128 0.000543 0.000821
None 0.002498 0.000869 0.000434 0.001153 0.000898 0.003984 0.011119 0.000725 0.002268 0.003403 0.005021 0.000911
Nuclear Periphery 0.000265 0.000243 0.000326 0.000336 0.000079 0.000754 0.000339 0.000211 0.000239 0.000659 0.000332 0.000265
Nuclear Periphery Foci 0.000618 0.000110 0.000061 0.000708 0.000091 0.000333 0.000218 0.000103 0.000542 0.000291 0.000128 0.000366
Nucleolus 0.017177 0.019381 0.006838 0.008820 0.018335 0.015405 0.006081 0.006029 0.017344 0.016147 0.006513 0.007239
Nucleus 0.964171* 0.955898* 0.974566* 0.967862* 0.965721* 0.949907* 0.963004* 0.977819* 0.964394* 0.951025* 0.969603* 0.973503*
Peroxisomes 0.000146 0.000465 0.000135 0.000283 0.000347 0.000271 0.000235 0.000167 0.000175 0.000307 0.000178 0.000217
Vacuole 0.000582 0.000656 0.000672 0.002384 0.001254 0.002507 0.000444 0.000756 0.000679 0.002161 0.000574 0.001462
Vacuole Periphery 0.000422 0.000330 0.000395 0.001688 0.000096 0.001390 0.000162 0.000429 0.000376 0.001192 0.000295 0.000975

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.25 -2.62 -4.59 0.37 -1.82 -0.36 -1.43 -1.41 -2.14 -0.04 -2.11 -3.46 -4.64 -2.38 -1.36
Bud Neck -2.46 -8.47 -3.32 0.30 2.62 -8.10 -8.23 -7.63 -1.05 -1.03 -4.89 -8.68 -5.51 -0.76 1.51
Bud Site -1.45 -0.71 -1.45 0.90 -1.12 -0.33 0.41 0.55 1.86 0.85 -2.33 -0.56 -0.87 1.94 -0.58
Cell Periphery 2.40 2.26 0.79 -1.41 -1.17 -5.48 -3.96 -4.09 1.99 2.50 -1.20 -1.18 0.41 1.73 1.63
Cytoplasm 2.20 2.68 -0.18 -1.40 -1.61 0.45 0.17 1.43 3.32 4.23 -0.84 0.16 1.27 2.13 1.47
Cytoplasmic Foci 0.97 0.98 -1.78 -1.99 -2.00 0.22 0.67 1.36 2.32 1.03 -1.48 0.14 -0.92 0.61 -0.94
Eisosomes -1.44 -4.36 -1.42 0.36 3.59 -8.58 -6.81 -8.12 -1.96 -1.94 -2.96 -4.95 -4.10 -1.37 1.97
Endoplasmic Reticulum 2.15 7.07 8.42 6.10 4.82 -6.24 2.40 6.72 10.90 11.40 -1.15 7.04 9.15 11.94 10.21
Endosome -0.29 1.04 -1.17 -0.97 -1.94 -2.71 -0.01 1.09 4.12 2.51 -2.42 0.86 -0.18 2.39 -1.20
Golgi -0.97 -1.10 -2.08 -2.05 -1.81 -1.46 -0.69 -0.64 1.28 -0.33 -1.52 -1.20 -2.14 -1.13 -1.74
Lipid Particles -0.58 0.81 -1.32 -1.01 -1.58 -1.37 0.35 1.86 2.10 2.21 -1.78 0.20 -0.43 1.60 -0.55
Mitochondria -1.48 -2.23 -4.73 -0.32 -1.52 -3.91 -2.92 -11.95 2.16 0.09 -3.50 -2.87 -5.52 1.81 -0.79
Mitotic Spindle -1.47 -0.76 -1.69 0.89 -1.59 0.32 0.65 0.77 1.75 0.59 -2.35 -0.09 -0.79 1.71 -0.93
None 4.26 5.80 2.59 -0.82 -2.03 -3.95 -6.79 0.87 4.39 7.00 -1.67 -3.79 3.90 3.97 6.16
Nuclear Periphery 0.22 -0.40 -0.77 -0.86 -0.07 -4.62 -3.15 -4.11 3.62 1.43 -3.25 -0.91 -0.56 3.08 0.60
Nuclear Periphery Foci 1.42 1.56 -0.13 -1.18 -1.28 -1.56 -0.77 0.07 1.59 0.83 0.79 1.38 0.46 -0.33 -1.13
Nucleolus -0.87 8.12 5.27 4.03 -1.55 1.16 4.07 4.10 7.05 0.12 0.82 9.60 8.48 7.39 -0.84
Nucleus 1.48 -3.77 -0.30 -1.52 2.18 1.95 0.06 -1.96 -7.78 -4.51 4.20 -1.97 -2.88 -6.69 -1.34
Peroxisomes -5.26 0.37 -3.77 2.67 -4.32 1.19 1.54 3.51 1.73 0.81 -2.54 0.03 -1.70 1.73 -1.20
Vacuole -0.37 -0.57 -2.71 -2.55 -2.46 -1.22 0.88 0.48 3.47 -1.41 -3.84 0.43 -2.26 1.48 -2.67
Vacuole Periphery 0.49 0.15 -1.81 -1.95 -1.84 -3.72 -1.17 -1.67 2.34 -1.37 -2.68 0.55 -1.79 0.53 -2.08
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Sub1

Sub1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sub1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available