Standard name
Human Ortholog
Description Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.09 0 0 0.06 0 0 0 0 0.08 0.14 0.17 0.09 0.07 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0 0.17 0 0.08 0.24 0.2 0.22 0.25 0.3 0.26 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.87 0.88 0.8 0.8 0.71 0.71 0.66 0.58 0.62 0.62 0.62 0.62 0.85 0.71 0.68 0.77 0.82 0.83 0.8 0.78 0.74 0.64 0.57 0.47
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.26 0.19 0.19 0.24 0.23 0.33 0.39 0.39 0.39 0.4 0.48 0.47 0.18 0.22 0.19 0.11 0.09 0.1 0.12 0.11 0.12 0.24 0.27 0.23
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0.05 0.05 0.05 0.06 0.14
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 2 0 1
Bud 0 0 0 1 0 1 0 1 0 1 2 1 0 1 0 0 0 1 3 0 3 1 3 4
Bud Neck 0 0 0 0 0 0 0 1 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 1 1 0 2 4 2 7 6 4 14 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 1 6 6 15 8 12 16 4 5 4 8 22 53 63 24 11 10 0 0 0 0 1 3
Endoplasmic Reticulum 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 4 6 2 0 0 1 0 0 1
Endosome 0 0 0 0 0 0 2 0 0 0 0 0 0 5 9 4 2 1 5 0 2 1 8 9
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 5 1 0 0 1 2
Mitochondria 23 4 29 6 12 54 63 63 55 83 58 71 1 4 3 10 5 2 1 1 4 1 4 4
Nucleus 306 99 140 110 112 158 210 166 136 171 140 176 249 266 257 197 136 136 291 94 138 126 201 129
Nuclear Periphery 1 0 0 2 2 2 8 5 3 9 3 8 1 2 1 4 4 0 1 0 0 0 3 0
Nucleolus 92 21 33 33 37 73 126 111 85 110 110 132 52 82 71 27 15 17 42 13 22 46 95 62
Peroxisomes 0 0 0 1 0 0 0 0 0 0 0 0 0 1 6 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 2 2 1 0 1 0 0 1 0 2 1 1 1 2 1 1 3 8 10
Vac/Vac Membrane 6 2 4 2 2 1 1 1 2 2 0 1 5 8 10 13 4 5 6 5 9 9 22 37
Unique Cell Count 350 112 174 137 158 222 319 285 220 276 227 282 293 374 379 257 166 164 366 120 188 199 354 276
Labelled Cell Count 434 127 213 162 181 301 428 367 293 389 321 412 332 422 423 285 185 175 366 120 188 199 354 276


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 8.4 6.8 6.8 7.0 6.0 5.3 5.8 5.6 5.2 5.5 5.5 8.3 8.0 7.6 8.8 9.7 10.5 7.3 7.4 8.1
Std Deviation (1e-4) 1.3 1.6 1.4 1.6 2.2 2.0 1.5 1.7 1.5 1.3 1.4 1.5 1.7 2.3 1.9 2.0 2.2 2.2 1.5 1.3 1.6
Intensity Change (Log2) – – – -0.0 0.04 -0.18 -0.34 -0.22 -0.27 -0.37 -0.31 -0.31 0.29 0.24 0.17 0.38 0.51 0.63 0.11 0.12 0.25


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 2.6 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 2.3 0.1 0.2 1.1 0 0 0 -0.4 1.8 3.8 4.4 2.4 1.3 1.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -3.4 -2.5 1.9 0.8 1.4 2.0 3.2 2.1 2.1 -7.0 -7.1 -7.4 -4.5 -4.2 -4.9
Nucleus 0 -2.0 -2.1 -3.4 -4.9 -4.0 -4.1 -4.1 -4.1 1.3 -2.3 -3.1 -0.9 0.3 0.6
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1.1 1.0 3.1 4.7 4.5 4.2 4.6 6.1 6.0 -0.3 0.8 -0.1 -2.5 -2.6 -2.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 1.4 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.7455 5.5483 4.914 4.7779 4.7465 4.9164 5.693 5.9226 5.6164 5.5951 5.1159 5.7463 6.9393 6.6133 6.8453 6.96 6.2648 6.7713
Actin 0.0037 0 0.0134 0.0003 0.0463 0.0001 0.0523 0.0054 0.0038 0.0007 0.0144 0.0007 0.0097 0 0.0001 0 0.0985 0
Bud 0.0005 0 0.0002 0.0001 0.0012 0 0.0008 0.0001 0.0003 0 0.0004 0.0001 0.0006 0 0 0 0.0006 0
Bud Neck 0.0011 0.0001 0.0003 0.0001 0.0015 0.0008 0.0017 0.0002 0.0001 0.0002 0.0016 0.0006 0.0005 0 0.0001 0.0001 0.0007 0.0004
Bud Periphery 0.001 0 0.0003 0.0002 0.0021 0.0001 0.0012 0.0001 0.0002 0.0001 0.001 0.0002 0.0021 0 0 0 0.0011 0
Bud Site 0.0019 0 0.0007 0.0002 0.007 0.0001 0.0094 0.0017 0.0009 0.0002 0.0023 0.0001 0.0011 0 0 0 0.0018 0
Cell Periphery 0.0002 0 0.0001 0.0002 0.0004 0.0001 0.0002 0 0 0 0.0003 0 0.0003 0 0 0 0.0001 0
Cytoplasm 0.0036 0 0.0003 0.0001 0.0085 0 0.0168 0.0001 0.0037 0.0003 0.0021 0.0001 0.0016 0 0.0009 0 0.0006 0
Cytoplasmic Foci 0.0038 0 0.003 0.0008 0.0091 0.0003 0.0467 0.0026 0.0109 0.0028 0.0328 0.0001 0.0136 0 0.0014 0 0.0084 0
Eisosomes 0.0001 0 0.0001 0 0.0013 0 0.0003 0 0 0 0.0001 0 0.0001 0 0 0 0.0002 0
Endoplasmic Reticulum 0.0034 0 0.0002 0.0002 0.0019 0 0.0054 0 0.0006 0.0006 0.0041 0.0003 0.0008 0 0.0001 0 0.0003 0
Endosome 0.0201 0 0.0042 0.0103 0.0155 0.0002 0.0261 0.0008 0.0111 0.0023 0.0257 0.0009 0.006 0 0.0004 0 0.0079 0
Golgi 0.0051 0 0.0049 0.0038 0.0108 0.0002 0.0076 0.0034 0.0169 0.0013 0.0516 0.0006 0.003 0 0 0 0.0046 0
Lipid Particles 0.0088 0 0.0055 0.015 0.0157 0.0036 0.0245 0.0002 0.0013 0.0173 0.0276 0.0009 0.0126 0 0.0006 0 0.0109 0
Mitochondria 0.0073 0.0001 0.0064 0.0157 0.0408 0.0038 0.0061 0.0007 0.0107 0.0005 0.0037 0.0057 0.0136 0.0001 0.0001 0.0001 0.0034 0.0001
None 0.0016 0 0.0002 0.0001 0.0047 0 0.0191 0 0.0155 0.0002 0.0015 0.0001 0.0019 0 0.0003 0 0.001 0
Nuclear Periphery 0.0075 0.0029 0.001 0.0018 0.0077 0.0005 0.0229 0.0008 0.0014 0.0098 0.0071 0.0036 0.005 0.0005 0.0015 0.0007 0.0063 0.0001
Nucleolus 0.0549 0.0318 0.0348 0.042 0.2646 0.1489 0.0215 0.0164 0.0211 0.0338 0.2028 0.1105 0.035 0.0407 0.0328 0.0458 0.2166 0.0824
Nucleus 0.8564 0.9636 0.9187 0.902 0.5363 0.8395 0.6815 0.9659 0.8965 0.919 0.5716 0.8737 0.8165 0.9577 0.9503 0.9524 0.581 0.9165
Peroxisomes 0.0021 0 0.0044 0.0005 0.0067 0.0003 0.0173 0.0012 0.0009 0.0005 0.0387 0.0001 0.0131 0 0.0001 0 0.0196 0
Punctate Nuclear 0.0112 0.0013 0.0007 0.001 0.0143 0.0007 0.0318 0.0004 0.0035 0.0097 0.0082 0.0007 0.0585 0.001 0.0111 0.0008 0.0355 0.0004
Vacuole 0.0037 0.0001 0.0005 0.0024 0.0023 0.0003 0.0044 0 0.0003 0.0003 0.0016 0.0003 0.0025 0 0.0001 0 0.0006 0
Vacuole Periphery 0.002 0 0.0004 0.0031 0.0012 0.0003 0.0024 0 0.0002 0.0004 0.0008 0.0006 0.0017 0 0 0 0.0005 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.9854 12.0535 13.4163 17.2285 16.0252 12.7274 17.9424 18.0506 13.2389 21.5852
Translational Efficiency 1.3121 1.2678 1.0671 0.5863 1.1227 1.5773 0.9403 1.0971 1.2719 0.8939

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1928 1081 519 1659 1859 1613 615 202 3787 2694 1134 1861

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 759.92 939.86 1115.17 1101.04 806.22 892.85 1139.44 1231.67 782.65 911.71 1128.33 1115.22
Standard Deviation 95.09 145.79 152.68 172.18 110.99 133.72 154.35 162.67 105.77 140.59 154.06 175.93
Intensity Change Log 2 — 0.306598 0.553344 0.534947 — 0.147244 0.499079 0.611370 — 0.226765 0.525665 0.574794

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000335 0.000717 0.001027 0.001965 0.000384 0.000636 0.001001 0.001511 0.000359 0.000669 0.001013 0.001916
Bud Neck 0.004430 0.016042 0.018833 0.041373 0.003818 0.009115 0.019816 0.033660 0.004130 0.011894 0.019366 0.040536
Bud Site 0.001032 0.001760 0.001364 0.014185 0.000402 0.002082 0.001280 0.010169 0.000723 0.001952 0.001318 0.013749
Cell Periphery 0.000104 0.000089 0.000034 0.000530 0.000055 0.000083 0.000042 0.000129 0.000080 0.000085 0.000038 0.000487
Cytoplasm 0.005248 0.001940 0.000170 0.010529 0.002549 0.002597 0.000394 0.002165 0.003923 0.002333 0.000292 0.009621
Cytoplasmic Foci 0.000678 0.000132 0.000022 0.004130 0.000204 0.000828 0.000027 0.000328 0.000445 0.000549 0.000025 0.003717
Eisosomes 0.000025 0.000034 0.000047 0.000047 0.000023 0.000036 0.000041 0.000044 0.000024 0.000035 0.000044 0.000047
Endoplasmic Reticulum 0.002026 0.003039 0.002598 0.003722 0.002056 0.002855 0.002281 0.002274 0.002041 0.002929 0.002426 0.003564
Endosome 0.000753 0.000449 0.000084 0.006771 0.000132 0.001448 0.000083 0.000357 0.000449 0.001047 0.000083 0.006075
Golgi 0.000732 0.000407 0.000130 0.006517 0.000160 0.000719 0.000128 0.000357 0.000451 0.000594 0.000128 0.005848
Lipid Particles 0.000254 0.000088 0.000058 0.000939 0.000108 0.000304 0.000042 0.000140 0.000182 0.000217 0.000049 0.000853
Mitochondria 0.001772 0.001741 0.001177 0.007178 0.000653 0.003337 0.001381 0.003360 0.001223 0.002697 0.001287 0.006763
Mitotic Spindle 0.003964 0.002594 0.000692 0.087538 0.000743 0.004375 0.002652 0.089602 0.002383 0.003660 0.001755 0.087762
None 0.015282 0.003261 0.000994 0.009369 0.006579 0.004651 0.001429 0.005178 0.011010 0.004093 0.001230 0.008914
Nuclear Periphery 0.000252 0.000340 0.000126 0.003910 0.000151 0.000476 0.000211 0.000675 0.000202 0.000421 0.000172 0.003559
Nuclear Periphery Foci 0.001057 0.000364 0.000066 0.003202 0.000721 0.000650 0.000091 0.000214 0.000892 0.000535 0.000080 0.002877
Nucleolus 0.121965 0.101076 0.054369 0.058015 0.107258 0.110730 0.056190 0.109155 0.114745 0.106856 0.055356 0.063566
Nucleus 0.837632* 0.862543* 0.916169* 0.716119* 0.873259* 0.850520* 0.911195* 0.735016* 0.855121* 0.855344* 0.913471* 0.718170*
Peroxisomes 0.000529 0.000615 0.001021 0.001388 0.000424 0.001455 0.000924 0.002481 0.000478 0.001118 0.000968 0.001507
Vacuole 0.001235 0.001305 0.000785 0.014242 0.000171 0.001855 0.000515 0.002667 0.000712 0.001634 0.000639 0.012986
Vacuole Periphery 0.000694 0.001465 0.000236 0.008332 0.000149 0.001248 0.000278 0.000521 0.000426 0.001335 0.000258 0.007484

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.36 -10.88 -11.72 -9.13 -5.75 -7.06 -15.96 -12.33 -10.57 -7.28 -9.79 -18.42 -13.61 -11.03 -6.90
Bud Neck -10.47 -12.72 -25.67 -15.97 -14.44 -8.23 -12.77 -9.99 -8.43 -3.96 -13.05 -17.56 -27.62 -21.50 -14.20
Bud Site -1.95 -2.68 -9.43 -7.95 -8.83 -4.18 -8.47 -5.27 -4.14 -4.44 -4.29 -7.34 -10.76 -8.67 -9.53
Cell Periphery 0.58 5.12 -1.88 -2.02 -2.82 -1.83 0.46 -4.81 -2.66 -5.36 -0.47 4.41 -2.32 -2.20 -2.87
Cytoplasm 2.93 6.31 -2.28 -5.08 -8.84 -0.12 2.85 0.55 0.66 -2.87 2.20 6.63 -3.67 -5.35 -8.61
Cytoplasmic Foci 2.86 3.34 -0.98 -3.49 -3.86 -2.28 2.01 -0.59 1.44 -1.64 -0.00 3.84 -1.91 -1.89 -3.97
Eisosomes -4.24 -9.05 -12.46 -7.87 -1.04 -7.94 -12.44 -9.07 -6.21 -4.42 -8.50 -14.82 -16.63 -9.34 -3.05
Endoplasmic Reticulum -5.55 -3.37 -9.10 -3.94 -5.29 -5.07 -3.13 -4.73 -3.02 -3.89 -7.46 -4.60 -10.20 -5.40 -7.27
Endosome 1.40 3.10 -3.40 -4.75 -5.94 -3.38 0.82 -4.61 2.43 -5.49 -2.11 3.17 -4.60 -2.65 -6.03
Golgi 0.98 1.86 -2.10 -2.84 -3.37 -2.62 -0.33 -8.98 -0.02 -9.22 -0.52 1.83 -2.78 -2.60 -3.46
Lipid Particles 2.14 2.41 -1.47 -3.71 -3.94 -2.21 1.73 -3.34 0.00 -5.41 -0.48 2.92 -2.51 -2.13 -4.35
Mitochondria 0.04 1.44 -6.97 -6.95 -9.62 -3.13 -13.66 -12.62 -0.58 -7.79 -2.68 -2.15 -9.86 -3.91 -9.66
Mitotic Spindle 0.54 2.45 -13.60 -13.75 -14.56 -3.17 -1.73 -6.21 -5.98 -6.03 -1.54 0.01 -15.42 -14.99 -15.31
None 6.58 8.87 4.70 -3.40 -8.45 1.80 6.02 0.63 -0.85 -3.84 6.55 10.53 3.67 -3.42 -8.57
Nuclear Periphery -1.78 2.07 -6.68 -6.34 -6.92 -2.55 -4.88 -7.46 -4.70 -6.26 -2.83 -2.41 -7.27 -6.36 -7.04
Nuclear Periphery Foci 2.41 3.35 -0.79 -3.05 -3.84 -0.43 2.84 0.77 1.22 -3.78 1.01 4.37 -1.18 -1.92 -3.96
Nucleolus 4.14 10.41 9.03 4.50 -2.75 -0.92 7.92 -1.75 -1.42 -4.93 2.22 12.96 7.54 5.51 -4.53
Nucleus -3.63 -10.10 12.88 15.47 20.35 4.45 -3.23 9.31 8.07 10.07 0.36 -9.41 18.16 17.47 23.03
Peroxisomes 0.51 -2.53 -1.88 -2.95 0.24 -3.58 -6.23 -6.04 -3.36 -4.57 -2.97 -5.33 -4.67 -0.92 -1.35
Vacuole -0.13 0.57 -6.46 -6.43 -6.90 -3.36 -8.19 -4.08 -2.85 -3.73 -2.40 -0.66 -7.52 -6.52 -7.49
Vacuole Periphery -1.03 2.28 -2.59 -1.34 -3.23 -2.57 -1.47 -6.70 1.79 -2.26 -2.31 1.57 -2.98 -1.56 -3.24
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions
Localization
Cell Percentages nucleus (98%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Mot3

Mot3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mot3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available