Standard name
Human Ortholog
Description Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.16 0.22 0.24 0.23 0.17 0.24 0.16 0.16 – 0.2 0.23 0.22 – 0.22 0.12 0.12 0.21 0.25 0 0 0.07 0 0.09 0.05
Bud 0 0 0.06 0.05 0.05 0.09 0.07 0.05 – 0.06 0.11 0.1 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.07 0 0.06 0.05 0 0 0.05 – 0 0.06 0.05 – 0 0 0.05 0.07 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0.07 0.09 0.06 0.06 0.09 0.12 0.09 0.09 – 0.12 0.06 0.09 – 0.09 0.08 0.05 0 0.08 0 0 0 0 0.05 0.07
Endosome 0 0 0.06 0.12 0.08 0.05 0.07 0.07 – 0.1 0.09 0.05 – 0 0 0 0 0 0.15 0.15 0.15 0.12 0.1 0.11
Golgi 0.8 0.77 0.7 0.59 0.56 0.34 0.22 0.4 – 0.41 0.2 0.27 – 0.9 0.9 0.75 0.82 0.82 0.74 0.65 0.73 0.69 0.61 0.66
Mitochondria 0.18 0.11 0.59 0.51 0.48 0.65 0.63 0.36 – 0.44 0.6 0.62 – 0.11 0.07 0.15 0.16 0.06 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0 0 0 0 0 0.08 0.12 – 0 0 0.05 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.15 0.18 0 0.05 0.05 0 0.05 0.06 – 0.06 0.06 0.05 – 0.1 0.07 0.2 0.06 0.14 0 0.08 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 35 55 38 65 84 143 105 117 – 144 125 170 – 45 24 5 14 21 7 11 11 0 4 5
Bud 6 0 9 13 25 53 46 34 – 44 59 80 – 0 3 0 2 2 0 2 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 2 1 1 – 3 6 6 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 3 1 0 3 1 3 3 – 5 6 9 – 0 1 0 1 1 0 0 0 0 0 0
Cytoplasm 4 16 5 17 27 25 27 35 – 27 33 36 – 5 6 2 5 4 1 3 0 0 0 1
Endoplasmic Reticulum 16 23 9 17 46 74 57 62 – 87 30 71 – 18 16 2 3 7 2 2 0 0 2 8
Endosome 6 1 9 34 42 29 49 47 – 73 49 37 – 2 1 0 0 1 36 40 25 2 4 12
Golgi 177 188 112 168 279 205 149 283 – 304 109 206 – 184 180 30 56 69 175 172 123 16 29 77
Mitochondria 40 26 94 144 237 395 418 259 – 327 326 477 – 22 14 6 11 5 2 5 1 0 2 1
Nucleus 0 0 0 0 1 0 0 3 – 3 2 0 – 0 0 2 0 0 0 0 0 1 0 0
Nuclear Periphery 0 0 0 0 0 3 1 3 – 3 1 1 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 10 4 4 4 16 17 53 87 – 32 13 40 – 3 0 0 1 3 0 0 0 0 0 0
Peroxisomes 0 0 0 2 6 1 3 5 – 3 1 2 – 0 0 0 0 0 2 1 2 0 0 0
SpindlePole 1 0 1 3 4 1 2 12 – 12 9 6 – 0 1 0 0 1 1 0 0 0 0 0
Vac/Vac Membrane 32 45 4 13 26 21 35 40 – 41 31 36 – 21 13 8 4 12 6 21 3 0 2 4
Unique Cell Count 220 245 159 284 498 606 667 711 736 543 774 205 199 40 68 84 237 265 170 24 48 118
Labelled Cell Count 327 361 286 480 796 970 949 991 1108 800 1177 300 259 55 97 126 237 265 170 24 48 118


Late Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 18.2 21.6 12.9 12.9 11.9 11.2 10.9 11.9 – 11.4 11.1 11.5 – 20.3 20.4 24.8 27.7 27.5 – 20.6 21.0
Std Deviation (1e-4) 3.5 3.5 1.9 2.1 1.9 1.8 1.8 2.4 – 2.4 2.3 2.5 – 4.4 4.8 7.8 7.7 7.3 – 3.8 4.0
Intensity Change (Log2) – – – -0.01 -0.12 -0.21 -0.25 -0.12 – -0.18 -0.22 -0.17 – 0.65 0.66 0.94 1.1 1.09 – 0.67 0.7

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000102030WT3HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.2 -2.0 -0.1 -2.4 -2.2 – -1.2 -0.2 -0.5 – -0.4 -2.9 -1.6 -0.5 0.2
Bud -0.5 -0.3 1.3 0.6 -0.5 – 0.2 2.0 1.8 – 0 -2.2 0 0 0
Bud Neck 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
Bud Site 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
Cell Periphery 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
Cytoplasm 1.3 1.2 0.6 0.5 1.0 – 0.3 1.4 0.8 – 0 0 0 0 0
Endoplasmic Reticulum 0.1 1.4 2.4 1.2 1.3 – 2.3 -0.1 1.4 – 1.1 0.9 0 0 0.8
Endosome 2.2 1.1 -0.5 0.7 0.4 – 1.7 1.4 -0.5 – 0 0 0 0 0
Golgi -2.4 -3.2 -8.3 -11.7 -7.0 – -6.7 -12.0 -10.6 – 4.7 4.9 0.6 1.9 2.0
Mitochondria -1.7 -2.5 1.4 0.8 -5.3 – -3.4 0.2 0.6 – -9.8 -10.7 -5.0 -5.9 -8.0
Nucleus 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
Nucleolus 0 0 0 2.4 3.6 – 1.1 0 1.4 – 0 0 0 0 0
Peroxisomes 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
SpindlePole 0 0 0 0 0 – 0 0 0 – 0 0 0 0 0
Vacuole 1.1 1.4 0.6 1.5 1.6 – 1.6 1.6 1.2 – 2.9 1.8 0 0 3.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 15.7137 15.7868 15.227 14.1487 13.8695 15.8306 10.5128 14.9753 13.3803 11.9341 12.8518 13.9872 14.3351 15.9359 14.71 12.7302 14.237 14.1709
Actin 0.0063 0.0089 0.0088 0.0104 0.0026 0.0089 0.0448 0.0312 0.0279 0.0244 0.0086 0.0183 0.0357 0.0135 0.0172 0.0441 0.0149 0.0086
Bud 0.0002 0.0002 0.0001 0.0002 0 0 0.0004 0.0002 0.0002 0.0002 0.0003 0 0.0003 0.0002 0.0004 0.0001 0.0001 0.0001
Bud Neck 0.0003 0.0002 0.0002 0.0002 0.0001 0.0003 0.0006 0.0003 0.0004 0.0003 0.0003 0.0002 0.0005 0.0003 0.0003 0.0003 0.0001 0.0003
Bud Periphery 0.0002 0.0003 0.0001 0.0003 0 0 0.0004 0.0001 0.0001 0.0001 0.0004 0 0.0002 0.0001 0.0002 0.0001 0.0001 0.0001
Bud Site 0.0003 0.0002 0.0001 0.0003 0 0.0001 0.0008 0.0002 0.0003 0.0002 0.0014 0.0001 0.0011 0.0008 0.0003 0.0001 0 0.0001
Cell Periphery 0.0001 0.0001 0.0001 0.0001 0 0 0.0001 0.0001 0 0.0001 0.0001 0 0.0001 0.0001 0 0 0 0
Cytoplasm 0.0013 0.003 0.001 0.0014 0.0006 0.0012 0.0035 0.0024 0.0015 0.0014 0.0007 0.0017 0.002 0.0034 0.0019 0.0008 0.0008 0.0009
Cytoplasmic Foci 0.0433 0.0728 0.0398 0.0376 0.028 0.0342 0.0657 0.0667 0.0496 0.0483 0.039 0.0245 0.0522 0.0633 0.0399 0.0387 0.03 0.0323
Eisosomes 0 0 0 0.0001 0 0 0.0005 0 0 0 0.0001 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0006 0.0004 0.0004 0.0005 0.0004 0.0005 0.0022 0.0005 0.0005 0.0008 0.0005 0.0005 0.0006 0.0005 0.0005 0.0003 0.0003 0.0005
Endosome 0.1622 0.2009 0.1522 0.1356 0.1083 0.0968 0.1999 0.1459 0.1914 0.2962 0.2352 0.0946 0.1607 0.1845 0.1832 0.2052 0.1774 0.1008
Golgi 0.7546 0.6887 0.7847 0.7785 0.8422 0.846 0.5772 0.7088 0.6932 0.5753 0.6673 0.8542 0.7115 0.7184 0.7412 0.6957 0.7569 0.8383
Lipid Particles 0.0104 0.0078 0.0029 0.0234 0.0057 0.0043 0.0397 0.0097 0.0124 0.0365 0.0086 0.001 0.019 0.0061 0.0042 0.004 0.0024 0.0092
Mitochondria 0.0123 0.0061 0.0046 0.0048 0.0087 0.0033 0.0166 0.0037 0.0096 0.0045 0.0082 0.002 0.0053 0.0035 0.0031 0.0019 0.0096 0.0058
None 0.0001 0.0001 0 0.0005 0 0.0003 0.0015 0 0.0002 0.0003 0.0001 0.0002 0.0001 0 0 0 0 0
Nuclear Periphery 0.0003 0.0001 0.0001 0.0003 0.0002 0.0002 0.0115 0.0001 0.0004 0.0005 0.0002 0.0002 0.0005 0.0001 0.0001 0.0001 0.0001 0.0001
Nucleolus 0 0.0001 0 0.0001 0 0.0001 0.0002 0 0 0 0.0001 0 0.0001 0 0 0 0 0
Nucleus 0.0001 0.0001 0 0.0001 0 0.0001 0.0037 0.0001 0.0001 0 0.0001 0.0001 0.0001 0 0 0 0 0
Peroxisomes 0.0019 0.0014 0.001 0.0033 0.0002 0.0015 0.0208 0.0013 0.0079 0.002 0.0215 0.0004 0.0032 0.0016 0.001 0.0046 0.0002 0.0009
Punctate Nuclear 0.0002 0 0 0.0003 0 0.0002 0.0033 0 0.001 0.0002 0.0007 0.0001 0.0006 0 0 0 0 0
Vacuole 0.0025 0.0056 0.0014 0.001 0.0006 0.0009 0.0033 0.0193 0.0011 0.0028 0.0032 0.0007 0.0038 0.0016 0.0027 0.0014 0.0028 0.0007
Vacuole Periphery 0.0029 0.0032 0.0026 0.0012 0.0023 0.0012 0.0034 0.0094 0.002 0.0058 0.0034 0.001 0.0023 0.0018 0.0036 0.0025 0.0041 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.5555 31.3135 43.5675 52.3192 34.0622 17.5047 41.5552 43.406 54.7267 51.4461
Translational Efficiency 2.7104 2.5187 1.9028 1.6057 2.0859 5.6338 2.9297 2.0156 1.9158 1.925

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
857 1484 2718 1097 2035 1742 1186 1414 2892 3226 3904 2511

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1194.72 1540.55 2036.32 2223.31 1544.46 1459.94 2000.21 2086.45 1440.82 1497.02 2025.35 2146.24
Standard Deviation 210.87 296.02 321.48 436.18 268.95 253.37 292.58 411.18 299.30 276.74 313.42 427.71
Intensity Change Log 2 — 0.366773 0.769292 0.896037 — -0.081193 0.373049 0.433948 — 0.131454 0.559372 0.653863

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.010984 0.008598 0.015413 0.084392 0.004582 0.006390 0.025730 0.062966 0.006479 0.007406 0.018547 0.072327
Bud Neck 0.000999 0.000253 0.000689 0.010338 0.000153 0.000285 0.001215 0.005977 0.000404 0.000270 0.000849 0.007883
Bud Site 0.005042 0.001886 0.001134 0.041310 0.000967 0.001654 0.002773 0.026952 0.002175 0.001760 0.001632 0.033224
Cell Periphery 0.000258 0.000135 0.000292 0.096546 0.000112 0.000112 0.000598 0.046179 0.000155 0.000122 0.000385 0.068184
Cytoplasm 0.000909 0.000803 0.000186 0.001927 0.000256 0.000739 0.000236 0.002135 0.000449 0.000768 0.000202 0.002044
Cytoplasmic Foci 0.112880 0.085634 0.030762 0.015885 0.055635 0.102386 0.022979 0.023646 0.072598 0.094680 0.028397 0.020255
Eisosomes 0.000107 0.000082 0.000257 0.013308 0.000074 0.000069 0.000303 0.004808 0.000084 0.000075 0.000271 0.008522
Endoplasmic Reticulum 0.001805 0.001021 0.003675 0.040615 0.000963 0.000946 0.004820 0.031552 0.001212 0.000980 0.004023 0.035511
Endosome 0.107152 0.073325 0.069640 0.073275 0.063296 0.105411 0.055425 0.101224 0.076292 0.090651 0.065322 0.089014
Golgi 0.689940 0.780707 0.769775 0.486509 0.827544 0.725614 0.803809 0.564714 0.786767 0.750957 0.780114 0.530548
Lipid Particles 0.016220 0.018598 0.072516 0.085664 0.008962 0.019230 0.052580 0.091736 0.011113 0.018939 0.066460 0.089083
Mitochondria 0.018532 0.006055 0.005286 0.004544 0.010637 0.009201 0.002299 0.004168 0.012977 0.007754 0.004379 0.004333
Mitotic Spindle 0.001433 0.001414 0.000371 0.001272 0.000197 0.000926 0.000495 0.000802 0.000563 0.001150 0.000409 0.001007
None 0.000083 0.000089 0.000070 0.000351 0.000044 0.000031 0.000071 0.000165 0.000056 0.000058 0.000070 0.000246
Nuclear Periphery 0.000129 0.000113 0.000410 0.000684 0.000079 0.000130 0.000289 0.000306 0.000094 0.000122 0.000373 0.000471
Nuclear Periphery Foci 0.000594 0.000444 0.000761 0.000820 0.000212 0.000679 0.000565 0.000791 0.000326 0.000571 0.000702 0.000804
Nucleolus 0.000082 0.000203 0.000009 0.000044 0.000004 0.000010 0.000008 0.000038 0.000027 0.000099 0.000009 0.000040
Nucleus 0.000048 0.000430 0.000017 0.000169 0.000007 0.000017 0.000020 0.000196 0.000019 0.000207 0.000018 0.000185
Peroxisomes 0.001681 0.000681 0.000176 0.001520 0.000237 0.000855 0.000196 0.001337 0.000665 0.000775 0.000182 0.001417
Vacuole 0.016000 0.009350 0.013034 0.029061 0.009843 0.012596 0.014160 0.019708 0.011668 0.011103 0.013376 0.023794
Vacuole Periphery 0.015122 0.010179 0.015525 0.011764 0.016197 0.012717 0.011430 0.010598 0.015878 0.011550 0.014281 0.011108

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.00 -1.84 -12.73 -13.74 -12.43 -1.55 -7.76 -14.12 -13.51 -7.64 -0.85 -8.39 -19.46 -19.21 -15.29
Bud Neck 3.13 1.11 -11.77 -13.28 -12.55 -3.27 -4.62 -8.61 -8.42 -6.62 1.73 -3.59 -14.59 -14.97 -13.51
Bud Site 3.04 4.60 -12.34 -13.65 -14.19 -2.24 -4.79 -11.63 -11.26 -10.66 0.97 1.65 -17.39 -17.54 -17.81
Cell Periphery 4.23 -1.29 -14.09 -14.10 -14.08 0.01 -4.49 -10.96 -10.96 -10.84 2.56 -6.43 -17.70 -17.71 -17.64
Cytoplasm 0.25 4.14 -2.68 -2.48 -5.08 -2.50 0.56 -3.56 -2.72 -3.59 -1.84 4.41 -4.61 -3.53 -5.25
Cytoplasmic Foci 5.85 20.23 23.81 26.24 10.91 -16.47 19.25 17.92 29.49 -0.50 -9.26 24.99 29.37 39.18 7.88
Eisosomes 1.66 -6.25 -6.95 -6.96 -6.87 0.42 -7.37 -5.28 -5.28 -5.02 0.93 -10.17 -8.65 -8.66 -8.46
Endoplasmic Reticulum 2.22 -4.33 -14.80 -15.22 -14.11 0.11 -7.31 -14.91 -14.91 -12.63 1.60 -10.18 -21.10 -21.27 -19.18
Endosome 7.23 8.34 7.13 -0.01 -1.13 -12.67 2.81 -11.05 1.10 -13.12 -5.49 4.55 -4.72 0.61 -9.42
Golgi -9.35 -8.39 14.70 23.91 23.34 15.70 3.33 27.06 15.64 21.88 6.74 1.35 31.98 27.72 31.18
Lipid Particles -0.88 -14.89 -12.15 -12.09 -2.13 -5.05 -11.33 -16.64 -13.92 -6.36 -5.12 -21.09 -21.01 -18.46 -5.18
Mitochondria 4.63 5.11 5.39 1.23 0.76 0.83 6.34 4.37 3.41 -1.91 3.75 6.94 6.82 3.49 0.06
Mitotic Spindle -0.07 2.91 0.29 0.23 -3.39 -2.72 -0.97 -4.24 0.32 -0.34 -1.65 0.46 -2.73 0.37 -2.71
None -0.24 0.97 -1.70 -1.63 -1.78 3.49 -4.63 -4.46 -4.90 -3.54 -0.20 -2.73 -2.79 -2.70 -2.58
Nuclear Periphery 0.56 -5.53 -7.12 -7.32 -3.04 -2.74 -4.47 -8.83 -5.88 -0.36 -2.01 -7.63 -10.28 -9.15 -1.91
Nuclear Periphery Foci 1.06 -1.32 -1.89 -3.67 -0.43 -1.81 -4.78 -7.88 -0.67 -2.72 -1.68 -4.98 -8.11 -1.79 -1.47
Nucleolus -0.63 1.37 0.68 0.84 -3.26 -2.44 -4.26 -2.40 -1.96 -2.12 -0.82 1.11 -0.89 0.64 -3.32
Nucleus -1.29 1.55 -5.42 0.89 -13.29 -2.37 -9.35 -1.97 -1.91 -1.90 -1.39 0.05 -2.52 -0.44 -2.53
Peroxisomes 2.17 4.34 0.37 -2.06 -5.00 -3.58 0.83 -5.03 -1.76 -5.30 -0.58 4.44 -3.76 -2.70 -7.32
Vacuole 3.20 1.47 -4.86 -8.49 -7.19 -2.35 -3.06 -6.45 -4.43 -3.07 0.53 -1.80 -8.73 -9.30 -7.68
Vacuole Periphery 3.12 -0.27 2.03 -1.46 3.46 2.62 3.74 4.29 1.86 0.79 4.28 1.59 4.65 0.50 4.11
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport
Localization
Cell Percentages Golgi (30%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Tvp18

Tvp18


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tvp18-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available