Standard name
Human Ortholog
Description ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0.1 0.14 0.15 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0.05 0.13 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0.06 0.07 0 0 0 0.06 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.95 0.95 0.9 0.9 0.83 0.8 0.64 0.61 – 0.52 0.5 0.71 0.63 0.54 0.94 0.91 0.87 0.93 0.92 0.9 0.83 0.78 0.71
Endoplasmic Reticulum 0 0.06 0 0 0.05 0 0.09 0.05 0 – 0 0.05 0.1 0 0 0 0 0.05 0 0 0.05 0.1 0.11 0.22
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0.05 0.06 0.15 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0.08 0.16 0.1 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.14 0 0.22 0.2 0.4 0.53 – 0.58 0.6 0 0 0.1 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 2 2 4 4 6 1 – 4 3 15 37 38 0 1 1 0 0 0 0 0 1
Bud 0 0 2 1 1 1 1 3 9 – 7 5 7 14 34 0 0 0 0 0 0 0 2 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 2 5 5 3 6 12 11 11 – 15 15 1 2 3 23 7 8 0 0 0 0 0 0
Cytoplasm 87 148 167 172 178 185 281 259 167 – 126 116 109 166 139 336 155 187 99 146 172 107 133 165
Endoplasmic Reticulum 4 9 5 8 9 6 33 22 6 – 10 12 15 11 4 14 5 11 3 4 10 13 18 51
Endosome 0 0 0 0 1 1 0 1 1 – 0 0 7 17 38 0 0 1 0 0 0 0 2 1
Golgi 0 0 0 0 1 0 0 0 0 – 0 0 13 42 25 4 2 3 0 1 0 0 1 2
Mitochondria 0 1 0 26 8 50 69 161 145 – 142 137 2 5 25 6 0 3 0 0 1 1 3 1
Nucleus 0 0 1 0 0 0 0 3 0 – 0 1 1 1 1 4 3 5 0 0 0 2 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 1 – 3 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 0 – 1 0 0 5 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 3 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 2 4 5 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 2 1 5 3 4 11 5 – 5 3 2 4 5 8 10 15 0 3 5 2 5 2
Unique Cell Count 90 156 176 191 198 224 353 404 274 244 230 153 265 257 359 171 216 107 160 192 130 171 233
Labelled Cell Count 92 161 182 215 208 256 404 477 346 313 292 174 308 321 395 183 234 107 160 192 130 171 233


Cytoplasm, Punctate Nuclear

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.2 12.7 10.4 9.7 10.2 8.8 8.0 7.3 6.9 – 6.6 6.4 12.8 12.5 10.6 14.8 15.5 16.1 13.5 13.0 14.4
Std Deviation (1e-4) 2.3 2.1 1.3 1.3 1.3 1.3 1.2 1.1 1.2 – 1.3 1.1 1.9 1.8 1.6 2.9 3.2 3.4 2.5 2.9 2.7
Intensity Change (Log2) – – – -0.09 -0.04 -0.24 -0.37 -0.51 -0.58 – -0.65 -0.7 0.3 0.27 0.02 0.51 0.58 0.63 0.38 0.32 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 4.3 5.2 5.3 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 2.3 4.5 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0.3 0 0.7 – 1.6 1.7 0 0 0 1.7 0.6 0.5
Cytoplasm -1.7 -1.8 -3.8 -4.6 -7.7 -8.0 – -9.5 -9.7 -5.8 -7.7 -9.2 -0.6 -1.5 -2.8
Endoplasmic Reticulum 0.7 0.9 0 2.7 1.4 0 – 0.7 1.2 2.6 0.7 0 0.6 0 1.1
Endosome 0 0 0 0 0 0 – 0 0 0 3.4 5.3 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 3.9 5.6 4.3 0 0 0
Mitochondria 5.1 0 6.7 6.3 9.9 11.7 – 12.4 12.6 0 0 4.3 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 2.4 2.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.2963 12.8828 12.4265 11.188 11.8564 12.8528 9.7926 14.6495 13.311 12.5983 11.8316 12.8864 10.7791 15.1521 12.9451 13.7431 13.8091 13.8686
Actin 0.0184 0.0011 0.0126 0.0191 0.0051 0.0025 0.0533 0.0007 0.0159 0.0046 0.0061 0.0091 0.0734 0.0017 0.028 0.0022 0.0039 0.0023
Bud 0.0005 0.0004 0.001 0.001 0.004 0.0006 0.0021 0.0002 0.0004 0.001 0.0003 0.0003 0.0014 0.0004 0.0038 0.0011 0.0006 0.0004
Bud Neck 0.0064 0.0005 0.0009 0.0022 0.0015 0.0029 0.002 0.0003 0.0007 0.0009 0.0006 0.0027 0.0099 0.0002 0.0008 0.0007 0.0007 0.0017
Bud Periphery 0.0005 0.0002 0.0007 0.0006 0.0067 0.0009 0.002 0.0002 0.0003 0.0008 0.0002 0.0003 0.0018 0.0001 0.0017 0.0009 0.0001 0.0002
Bud Site 0.0071 0.0025 0.001 0.0011 0.0005 0.0002 0.0051 0.0021 0.0013 0.0019 0.0002 0.0004 0.0081 0.0029 0.0044 0.0003 0.0002 0.0001
Cell Periphery 0.0008 0.0009 0.0008 0.0003 0.0005 0.0007 0.0008 0.0007 0.0005 0.0004 0.0001 0.0003 0.0011 0.0001 0.0006 0.0011 0 0.0002
Cytoplasm 0.5549 0.8949 0.8046 0.7171 0.7464 0.7531 0.5009 0.9329 0.8625 0.7372 0.8335 0.8355 0.5273 0.9554 0.7499 0.7347 0.8119 0.7949
Cytoplasmic Foci 0.0089 0.0066 0.0081 0.0182 0.0126 0.0133 0.0629 0.0053 0.0251 0.0222 0.0213 0.0188 0.0345 0.012 0.0241 0.0238 0.0349 0.0251
Eisosomes 0.0006 0 0 0.0001 0 0 0.0003 0 0.0001 0.0002 0.0001 0.0001 0.0006 0 0.0003 0.0005 0 0
Endoplasmic Reticulum 0.2319 0.0526 0.1055 0.0693 0.1079 0.1325 0.071 0.0364 0.0301 0.0349 0.0194 0.0445 0.1309 0.0043 0.0401 0.0362 0.0162 0.0853
Endosome 0.0453 0.0183 0.0256 0.0761 0.0589 0.051 0.1226 0.0093 0.0296 0.0979 0.0377 0.0547 0.0824 0.0127 0.0667 0.1326 0.0939 0.0575
Golgi 0.0044 0.0024 0.0032 0.0105 0.005 0.0059 0.0303 0.0015 0.0059 0.0063 0.0099 0.0091 0.0255 0.0046 0.0161 0.0123 0.0223 0.0121
Lipid Particles 0.0045 0.0004 0.0006 0.0053 0.0011 0.001 0.0211 0.0004 0.0039 0.0032 0.0021 0.0029 0.0189 0.0001 0.0086 0.0004 0 0.0008
Mitochondria 0.0052 0.0012 0.006 0.0044 0.0048 0.0062 0.0161 0.0004 0.0022 0.0159 0.0484 0.0048 0.0084 0.0004 0.0237 0.0106 0.0051 0.0063
None 0.0118 0.0013 0.0028 0.0028 0.0019 0.0009 0.006 0.0007 0.0009 0.0072 0.0019 0.0008 0.0072 0.0006 0.0048 0.0012 0.0006 0.0008
Nuclear Periphery 0.0321 0.0033 0.0074 0.0156 0.0138 0.0053 0.0207 0.0022 0.0016 0.0038 0.0038 0.0041 0.0154 0.0007 0.0041 0.0044 0.0015 0.0023
Nucleolus 0.0011 0 0.0001 0.0004 0.0001 0.0001 0.0019 0.0001 0.0001 0.0001 0.0001 0.0001 0.0041 0 0.0002 0 0 0
Nucleus 0.0081 0.0017 0.0024 0.0069 0.005 0.0026 0.0156 0.0019 0.0011 0.0024 0.0032 0.002 0.0067 0.0008 0.0018 0.0018 0.0011 0.0012
Peroxisomes 0.0013 0.0001 0.0006 0.0037 0.0004 0.0004 0.0094 0 0.0014 0.0006 0.0024 0.0016 0.013 0.0001 0.0057 0.0002 0.0007 0.0036
Punctate Nuclear 0.0063 0.0001 0.0017 0.0045 0.0032 0.0011 0.0314 0.0001 0.0079 0.0004 0.005 0.0007 0.0171 0.0001 0.001 0.0002 0.0001 0.0008
Vacuole 0.0429 0.0101 0.011 0.0311 0.0155 0.0139 0.0205 0.0041 0.0071 0.0478 0.0022 0.0048 0.0093 0.0022 0.0099 0.0256 0.0033 0.0027
Vacuole Periphery 0.0071 0.0015 0.0034 0.0097 0.005 0.0052 0.004 0.0005 0.0012 0.0102 0.0014 0.0024 0.003 0.0004 0.0035 0.0092 0.0028 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 67.1654 45.3273 45.4321 54.24 55.684 59.7536 55.8344 59.3256 49.2829 63.6315
Translational Efficiency 0.7227 0.8903 0.8506 0.6103 0.5841 0.6534 0.6668 0.479 0.5723 0.5363

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1557 1493 553 1258 1742 2275 1154 67 3299 3768 1707 1325

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1037.60 1360.78 1409.72 1658.70 1102.79 1275.00 1585.35 1650.18 1072.02 1308.99 1528.45 1658.27
Standard Deviation 182.25 211.44 318.28 232.57 205.81 192.79 224.29 206.40 197.75 204.74 271.26 231.33
Intensity Change Log 2 — 0.391183 0.442158 0.676803 — 0.209339 0.523643 0.581465 — 0.300356 0.484716 0.628469

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000316 0.000603 0.001372 0.003759 0.000313 0.000962 0.000712 0.001072 0.000314 0.000820 0.000926 0.003623
Bud Neck 0.000564 0.000459 0.003354 0.002892 0.000475 0.000464 0.002170 0.002926 0.000517 0.000462 0.002554 0.002894
Bud Site 0.033178 0.038388 0.047378 0.068829 0.023929 0.033854 0.036975 0.067240 0.028294 0.035651 0.040345 0.068749
Cell Periphery 0.000324 0.000642 0.002570 0.002786 0.000461 0.000322 0.001184 0.004283 0.000397 0.000449 0.001633 0.002862
Cytoplasm 0.599235 0.621055 0.566596 0.581413 0.580415 0.638247 0.545850 0.383836 0.589297 0.631435 0.552571 0.571422
Cytoplasmic Foci 0.249895 0.234398 0.080169 0.115019 0.238050 0.215431 0.103430 0.155534 0.243640 0.222947 0.095894 0.117068
Eisosomes 0.000015 0.000010 0.000010 0.000013 0.000011 0.000010 0.000007 0.000011 0.000013 0.000010 0.000008 0.000013
Endoplasmic Reticulum 0.008795 0.008675 0.012453 0.001829 0.012126 0.006790 0.008518 0.006722 0.010554 0.007537 0.009792 0.002077
Endosome 0.013221 0.011603 0.025418 0.020482 0.013939 0.010836 0.028207 0.046110 0.013600 0.011140 0.027304 0.021778
Golgi 0.034657 0.042766 0.057925 0.060219 0.040631 0.040227 0.035410 0.071807 0.037812 0.041233 0.042704 0.060805
Lipid Particles 0.001345 0.001812 0.013151 0.023830 0.001755 0.001080 0.012859 0.015674 0.001562 0.001370 0.012953 0.023418
Mitochondria 0.002151 0.000916 0.000108 0.000262 0.002058 0.001926 0.000157 0.000194 0.002102 0.001526 0.000141 0.000258
Mitotic Spindle 0.000550 0.001833 0.011174 0.015132 0.001285 0.001344 0.010573 0.010481 0.000938 0.001538 0.010768 0.014897
None 0.000487 0.000247 0.000529 0.000119 0.001653 0.000218 0.000206 0.000019 0.001103 0.000230 0.000311 0.000114
Nuclear Periphery 0.000048 0.000024 0.000440 0.000078 0.000154 0.000041 0.000342 0.000067 0.000104 0.000034 0.000374 0.000078
Nuclear Periphery Foci 0.000645 0.000505 0.021957 0.003545 0.001300 0.000446 0.006333 0.002826 0.000991 0.000469 0.011394 0.003508
Nucleolus 0.000084 0.000024 0.000262 0.000085 0.000172 0.000035 0.000078 0.000098 0.000130 0.000031 0.000138 0.000085
Nucleus 0.001527 0.000696 0.006027 0.002366 0.002312 0.001027 0.002673 0.000861 0.001942 0.000896 0.003760 0.002290
Peroxisomes 0.000390 0.000483 0.000284 0.002783 0.000379 0.000828 0.000777 0.002703 0.000384 0.000691 0.000618 0.002779
Vacuole 0.018449 0.012655 0.109363 0.081121 0.032844 0.022006 0.174125 0.200993 0.026050 0.018301 0.153145 0.087182
Vacuole Periphery 0.034123 0.022205 0.039460 0.013437 0.045738 0.023905 0.029414 0.026541 0.040256 0.023231 0.032668 0.014099

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.37 -6.36 -5.45 -4.99 -3.60 -1.49 -2.81 -3.57 -0.13 -1.23 -1.91 -5.62 -5.51 -4.29 -4.38
Bud Neck 1.75 -10.45 -14.24 -14.66 1.00 0.12 -10.61 -5.81 -5.93 -1.49 0.96 -15.02 -14.85 -15.54 -2.06
Bud Site -2.30 -3.87 -11.18 -9.14 -4.88 -5.35 -5.37 -2.71 -2.05 -1.82 -5.11 -5.97 -13.50 -10.92 -8.44
Cell Periphery -6.79 -6.55 -9.09 -7.74 -0.17 3.01 -5.40 -2.31 -2.40 -1.84 -1.59 -8.62 -9.09 -8.87 -3.80
Cytoplasm -1.98 2.23 2.13 3.90 -0.59 -6.02 3.10 4.94 6.51 3.92 -5.85 4.17 2.36 6.53 -1.24
Cytoplasmic Foci 1.93 24.65 18.98 17.00 -6.62 3.33 21.81 4.53 3.44 -2.22 3.99 31.80 22.68 19.87 -4.88
Eisosomes 1.68 1.68 0.61 -2.83 -2.44 0.91 3.25 0.13 -0.38 -1.69 1.90 3.15 0.02 -3.02 -4.94
Endoplasmic Reticulum 0.08 -1.65 7.22 6.41 5.41 3.89 2.55 1.30 0.12 0.44 3.08 0.79 10.90 7.49 7.48
Endosome 1.66 -6.63 -5.89 -7.65 2.55 3.73 -9.74 -3.96 -4.40 -2.01 3.91 -11.95 -7.08 -9.70 3.88
Golgi -4.48 -6.19 -7.01 -4.36 0.05 0.20 2.94 -1.66 -1.69 -2.10 -2.53 -1.96 -6.42 -5.25 -4.73
Lipid Particles -2.69 -8.75 -14.37 -14.06 -4.99 4.32 -9.28 -3.50 -3.68 -0.58 1.68 -12.46 -14.57 -14.71 -5.98
Mitochondria 7.13 13.20 9.96 4.85 -1.22 0.48 8.97 7.12 7.54 -0.14 3.40 14.56 10.90 8.52 -0.95
Mitotic Spindle -3.64 -7.82 -8.02 -7.31 -2.47 -0.14 -5.84 -1.10 -1.09 -0.08 -2.05 -8.30 -7.82 -7.55 -2.24
None 3.05 -0.31 6.96 1.95 4.37 2.82 2.82 3.20 7.16 2.17 3.22 2.89 3.64 3.55 2.92
Nuclear Periphery 1.56 -3.85 -2.05 -4.44 3.49 2.10 -2.19 1.57 -1.24 3.52 2.35 -4.07 0.65 -3.27 4.66
Nuclear Periphery Foci 1.50 -9.20 -9.93 -10.58 7.79 3.38 -10.58 -3.14 -4.77 5.67 3.44 -12.58 -8.97 -10.35 8.87
Nucleolus 3.76 -0.98 -0.34 -5.52 0.94 3.01 2.02 1.32 -1.83 -0.51 3.96 -0.10 1.44 -5.23 0.79
Nucleus 4.88 -2.53 -1.84 -2.83 1.45 2.82 -1.15 2.76 0.08 4.52 4.09 -2.99 -1.28 -2.60 0.90
Peroxisomes -2.21 2.96 -7.88 -7.55 -8.19 -2.94 -2.47 -3.38 -2.62 -2.61 -3.28 -2.17 -8.22 -6.88 -6.84
Vacuole 3.77 -12.09 -16.52 -18.22 3.11 4.73 -21.18 -6.47 -6.86 -1.23 5.36 -24.75 -15.74 -17.94 9.97
Vacuole Periphery 5.34 -1.06 10.63 6.14 6.38 9.32 6.27 3.29 -0.07 0.59 10.40 3.75 16.74 7.84 8.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Nam7

Nam7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nam7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available