Standard name
Human Ortholog
Description One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.7 0.51 0.67 0.67 0.62 0.49 0.46 0.38 0.36 0.4 0.48 0.37 0.64 0.73 0.7 0.59 0.56 0.62 0.81 0.59 0.72 0.68 0.68 0.72
Bud 0.19 0.18 0.23 0.21 0.27 0.28 0.18 0.2 0.17 0.17 0.22 0.18 0.2 0.2 0.24 0.19 0.17 0.27 0.09 0.13 0 0.2 0.17 0.15
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0.05 0
Bud Site 0 0.06 0.1 0.13 0.14 0.08 0.06 0.05 0 0.06 0.07 0.05 0.06 0 0 0.06 0 0 – – – – – –
Cell Periphery 0.1 0 0 0.11 0.06 0.06 0.06 0 0.05 0.06 0.05 0.08 0.12 0.11 0.16 0.1 0.12 0.05 0 0 0 0 0 0
Cytoplasm 0.1 0.16 0.06 0 0.09 0.08 0.06 0.06 0.09 0.05 0.06 0.08 0.08 0.09 0.08 0.18 0.11 0.14 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.08 0 0 0.05 0.07 0.05 0.06 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0
Golgi 0.22 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.25 0.33 0.25 0 0 0 0 0 0
Mitochondria 0.07 0.45 0.53 0.75 0.31 0.55 0.64 0.63 0.63 0.67 0.71 0.65 0.3 0.28 0.35 0.08 0.09 0.1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.08 0.1 0.27 0.21 0.29 0.16 0.15 0.13 0.16 0.23 0.15 0.14 0.3 0.27 0.25 0 0 0 0 0 0.09 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 201 25 78 80 86 79 93 80 47 71 60 89 87 122 143 185 100 151 299 64 99 56 125 126
Bud 56 9 27 25 38 44 36 41 23 30 28 43 28 34 49 61 31 66 32 13 4 16 31 27
Bud Neck 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 1 0 8 7 3 3 9 6
Bud Site 12 3 12 16 19 13 12 10 5 11 9 12 8 4 2 18 5 10 – – – – – –
Cell Periphery 29 2 4 13 8 10 12 6 7 10 6 18 17 18 32 32 21 12 2 0 1 0 1 0
Cytoplasm 29 8 7 2 12 13 13 13 12 8 7 19 11 15 16 55 20 34 5 2 2 1 3 0
Endoplasmic Reticulum 5 4 4 4 7 12 10 13 5 4 3 5 3 9 6 6 1 5 1 0 1 0 1 0
Endosome 6 3 1 1 6 2 4 5 1 1 3 3 2 5 3 4 0 2 5 9 4 0 2 3
Golgi 65 0 2 2 3 3 8 4 2 4 3 2 5 9 9 79 59 60 1 2 0 0 2 2
Mitochondria 21 22 61 90 43 88 129 132 83 118 89 155 41 46 71 25 16 25 0 2 3 0 0 1
Nucleus 0 0 0 0 0 0 1 2 2 0 0 2 0 1 1 0 1 0 0 0 0 0 0 0
Nuclear Periphery 1 0 0 0 2 0 2 3 0 1 0 4 1 0 1 0 0 0 0 0 0 0 0 0
Nucleolus 2 2 0 3 4 3 1 2 1 3 0 4 2 1 1 4 4 2 0 0 0 0 0 0
Peroxisomes 24 5 31 25 40 25 30 28 21 40 19 33 41 44 51 13 6 8 10 2 12 0 2 4
SpindlePole 13 0 1 1 0 1 3 2 2 1 1 4 2 1 2 9 8 6 1 0 1 0 0 0
Vac/Vac Membrane 5 3 2 1 2 5 4 4 3 2 2 2 0 0 1 12 11 1 0 0 1 0 0 1
Unique Cell Count 289 49 116 120 139 160 202 208 132 177 126 238 137 166 203 313 179 242 372 109 138 83 184 176
Labelled Cell Count 469 86 230 264 271 298 358 345 214 304 230 395 248 309 388 503 284 382 372 109 138 83 184 176


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.6 9.5 8.1 8.7 8.7 8.5 7.8 7.3 7.4 7.4 7.2 7.1 11.8 12.1 10.7 16.3 18.2 18.1 – 12.5 13.4
Std Deviation (1e-4) 3.4 2.5 2.4 2.8 1.9 2.1 1.7 1.5 1.6 1.5 1.5 1.7 2.6 2.7 2.5 5.1 6.0 5.9 – 2.4 2.5
Intensity Change (Log2) – – – 0.1 0.1 0.07 -0.05 -0.15 -0.13 -0.14 -0.17 -0.2 0.54 0.57 0.39 1.01 1.16 1.16 – 0.62 0.72

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.1 -0.9 -3.0 -3.7 -5.0 -5.0 -4.5 -3.1 -5.3 -0.6 1.1 0.6 -1.5 -2.0 -0.9
Bud -0.5 0.7 0.8 -1.2 -0.8 -1.1 -1.3 -0.2 -1.2 -0.5 -0.6 0.2 -0.9 -1.3 0.8
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0.7 0.8 -0.6 -1.4 -1.9 -2.0 -1.3 -0.9 -1.9 -1.3 -2.8 -3.9 -1.7 -2.7 -2.3
Cell Periphery 2.2 0.9 1.0 1.0 0 0.7 0.9 0 1.5 2.6 2.3 3.3 2.2 2.5 0.6
Cytoplasm 0 0.8 0.7 0.1 0.1 0.9 -0.6 -0.2 0.7 0.6 0.9 0.6 3.0 1.5 2.2
Endoplasmic Reticulum 0 0.6 1.4 0.6 1.1 0 0 0 0 0 0.8 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 5.5 6.5 5.4
Mitochondria 3.6 -3.5 0.4 2.0 1.9 1.6 2.4 2.9 2.3 -3.7 -4.2 -3.1 -10.2 -8.3 -8.8
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes -1.1 0.4 -2.3 -2.6 -3.0 -2.1 -0.8 -2.2 -3.0 0.6 0 -0.3 -6.8 -5.9 -6.7
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 1.8 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.8628 11.1831 10.8889 10.4473 9.5316 11.8988 10.2397 11.6589 10.8467 10.2379 10.6233 11.1504 10.4948 10.5893 10.0452 10.1695 10.9663 10.5942
Actin 0.9686 0.8378 0.9116 0.9543 0.938 0.9544 0.7949 0.731 0.9081 0.7978 0.9336 0.8777 0.8024 0.8555 0.8767 0.9227 0.9944 0.9466
Bud 0.0004 0.0018 0.0158 0.001 0.0006 0.0002 0.0095 0.006 0.0052 0.0204 0.0007 0.0016 0.0007 0.0096 0.0138 0.0037 0.0009 0.0003
Bud Neck 0.0032 0.0074 0.0148 0.02 0.0032 0.0277 0.0046 0.0052 0.0077 0.0174 0.0199 0.0691 0.0215 0.0042 0.0035 0.0014 0.0003 0.0325
Bud Periphery 0.0004 0.0019 0.0155 0.0021 0.001 0.0002 0.0115 0.0055 0.0071 0.0689 0.0012 0.0038 0.0007 0.0091 0.0207 0.0069 0.0014 0.0004
Bud Site 0.0163 0.1089 0.0368 0.0109 0.0013 0.0007 0.031 0.2329 0.0287 0.0044 0.0013 0.0008 0.0366 0.1126 0.0291 0.0051 0.0017 0.0017
Cell Periphery 0.0002 0.0013 0.0005 0.0009 0.0009 0.0001 0.0008 0.0006 0.0008 0.0012 0.0002 0.0002 0.0003 0.0005 0.0003 0.0002 0 0.0001
Cytoplasm 0.0002 0.0125 0.0018 0.001 0.0256 0.0001 0.01 0.0018 0.0046 0.0084 0.0004 0.0005 0.0043 0.0003 0.0006 0.0004 0 0.0005
Cytoplasmic Foci 0.0017 0.01 0.0006 0.0018 0.0017 0.002 0.0181 0.0083 0.0116 0.0134 0.0016 0.0022 0.0227 0.0012 0.0227 0.0049 0.0001 0.0058
Eisosomes 0.002 0.0009 0.0006 0.0009 0.0008 0.0037 0.0019 0.001 0.0005 0.0005 0.0005 0.0012 0.0054 0.0013 0.0006 0.0007 0.0003 0.0011
Endoplasmic Reticulum 0.0001 0.0001 0 0.0002 0.0129 0.0001 0.0187 0.0001 0.0005 0.0028 0.0001 0.0005 0.0011 0 0.0003 0.0001 0 0.0003
Endosome 0.0003 0.0014 0.0001 0.0004 0.0043 0.0008 0.0297 0.0004 0.0075 0.0228 0.0052 0.016 0.0071 0 0.0035 0.004 0 0.002
Golgi 0.0022 0.0059 0.0008 0.0041 0.0017 0.0057 0.0121 0.0006 0.0038 0.0172 0.0113 0.0109 0.0071 0.0007 0.004 0.0121 0.0002 0.0019
Lipid Particles 0.0004 0.002 0.0001 0.0002 0.0013 0.0011 0.0075 0.0004 0.0007 0.0035 0.0001 0.0008 0.0125 0.0001 0.0044 0.0012 0 0.0008
Mitochondria 0.0006 0.0022 0.0002 0.0002 0.0002 0.0004 0.011 0.0002 0.0046 0.002 0.0227 0.0098 0.0051 0.0001 0.0043 0.034 0.0001 0.0012
None 0 0.0001 0 0 0.0001 0.0001 0.0018 0.0027 0.0002 0.0015 0 0.0001 0.013 0.0001 0.0005 0 0 0.0002
Nuclear Periphery 0 0 0 0.0001 0.0006 0 0.02 0 0.0005 0.0031 0 0.0004 0.0142 0 0.0008 0 0 0.0002
Nucleolus 0 0.0001 0 0 0 0 0.0003 0 0.0002 0.0002 0 0 0.0014 0 0.0004 0 0 0
Nucleus 0 0.0001 0 0.0001 0.0003 0 0.002 0.0001 0.0008 0.0007 0 0.0001 0.0052 0 0.0005 0 0 0.0001
Peroxisomes 0.0034 0.0051 0.0008 0.0018 0.0028 0.0024 0.0073 0.0019 0.0031 0.001 0.0007 0.0025 0.0317 0.0045 0.0112 0.0021 0.0004 0.0016
Punctate Nuclear 0 0.0001 0 0.0001 0.0001 0.0001 0.0014 0.0011 0.001 0.0007 0 0.0001 0.0055 0.0001 0.0015 0.0001 0 0.0025
Vacuole 0 0.0004 0.0001 0.0001 0.0025 0 0.0032 0.0001 0.0024 0.0084 0.0001 0.0012 0.0007 0 0.0004 0.0002 0 0.0001
Vacuole Periphery 0 0 0 0 0.0002 0 0.0027 0 0.0004 0.0037 0.0002 0.0007 0.0008 0 0.0002 0.0001 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 43.5634 35.0352 43.996 55.0367 40.4558 41.2794 52.3868 58.6687 58.4171 56.5468
Translational Efficiency 0.6713 0.7051 0.6011 0.5741 0.5754 0.6955 0.5872 0.4862 0.5201 0.5387

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1519 36 158 1255 2144 2280 123 2302 3663 2316 281 3557

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1114.49 321.03 2052.24 1568.34 975.49 1137.00 1687.57 1579.04 1033.13 1124.32 1892.62 1575.26
Standard Deviation 206.80 4.05 283.93 264.14 190.78 202.22 186.82 264.67 209.11 224.61 305.51 264.53
Intensity Change Log 2 — -1.795604 0.880816 0.492855 — 0.221033 0.790748 0.694849 — -0.519469 0.839476 0.590662

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.799610 0.000020 0.727839 0.668525 0.779523 0.772952 0.620068 0.690167 0.787852 0.760938 0.680665 0.682532
Bud Neck 0.014027 0.000004 0.029253 0.012920 0.005888 0.013238 0.026666 0.013627 0.009263 0.013033 0.028121 0.013378
Bud Site 0.087334 0.000009 0.152336 0.205350 0.060176 0.120361 0.304335 0.215271 0.071438 0.118490 0.218869 0.211771
Cell Periphery 0.005868 0.000036 0.003469 0.022721 0.003077 0.006521 0.002537 0.018093 0.004234 0.006420 0.003061 0.019726
Cytoplasm 0.006817 0.000021 0.005554 0.006492 0.008618 0.010298 0.005110 0.016259 0.007871 0.010138 0.005360 0.012813
Cytoplasmic Foci 0.020916 0.000012 0.009139 0.002018 0.029935 0.017398 0.007157 0.001898 0.026195 0.017127 0.008271 0.001940
Eisosomes 0.006938 0.000032 0.043850 0.067744 0.003574 0.004696 0.006505 0.030949 0.004969 0.004624 0.027503 0.043931
Endoplasmic Reticulum 0.000256 0.000000 0.004556 0.002378 0.000102 0.000345 0.001635 0.000509 0.000166 0.000339 0.003277 0.001168
Endosome 0.005599 0.000001 0.003429 0.002392 0.005874 0.004898 0.004198 0.001673 0.005760 0.004822 0.003766 0.001927
Golgi 0.003936 0.000004 0.004594 0.002074 0.004556 0.003445 0.001226 0.002259 0.004299 0.003392 0.003120 0.002194
Lipid Particles 0.004763 0.000019 0.005237 0.001553 0.005397 0.000617 0.002402 0.000285 0.005134 0.000608 0.003996 0.000732
Mitochondria 0.002628 0.000007 0.000442 0.001986 0.003519 0.003332 0.000883 0.003655 0.003150 0.003281 0.000635 0.003066
Mitotic Spindle 0.000214 0.000310 0.001249 0.000561 0.000279 0.001354 0.000227 0.000955 0.000252 0.001338 0.000802 0.000816
None 0.000102 0.999403 0.000023 0.000032 0.000162 0.000119 0.000013 0.000036 0.000138 0.015651 0.000019 0.000034
Nuclear Periphery 0.000004 0.000000 0.000045 0.000023 0.000002 0.000006 0.000018 0.000014 0.000003 0.000006 0.000033 0.000017
Nuclear Periphery Foci 0.000044 0.000028 0.000341 0.000027 0.000011 0.000063 0.000277 0.000037 0.000025 0.000063 0.000313 0.000034
Nucleolus 0.000013 0.000026 0.000005 0.000004 0.000011 0.000088 0.000004 0.000005 0.000012 0.000087 0.000005 0.000004
Nucleus 0.000378 0.000008 0.000253 0.000079 0.000485 0.000162 0.000059 0.000049 0.000440 0.000159 0.000168 0.000060
Peroxisomes 0.040406 0.000058 0.004159 0.001649 0.088726 0.039035 0.009733 0.002446 0.068688 0.038429 0.006599 0.002165
Vacuole 0.000118 0.000001 0.004129 0.001072 0.000068 0.000676 0.006918 0.001183 0.000089 0.000666 0.005350 0.001144
Vacuole Periphery 0.000030 0.000000 0.000097 0.000400 0.000016 0.000394 0.000030 0.000629 0.000022 0.000388 0.000068 0.000548

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 108.00 3.24 10.79 -68.67 1.77 0.70 4.76 9.09 8.46 -2.09 3.19 5.49 13.81 8.80 -0.42
Bud Neck 10.36 -3.29 0.68 -14.00 3.61 -6.09 -3.60 -7.25 -0.28 2.24 -3.07 -5.24 -4.39 -0.27 4.11
Bud Site 18.00 -3.46 -12.14 -24.33 -2.38 -10.11 -7.97 -21.65 -12.07 2.88 -8.49 -8.35 -24.25 -13.55 0.50
Cell Periphery 7.26 2.44 -8.22 -12.04 -9.82 -5.00 0.94 -10.84 -7.85 -10.93 -3.09 2.16 -13.33 -10.67 -14.44
Cytoplasm 6.69 -0.52 -0.03 -6.81 0.51 -1.30 1.81 -4.37 -3.37 -4.97 -1.96 0.20 -4.11 -2.07 -2.15
Cytoplasmic Foci 9.77 2.30 8.50 -3.58 2.59 4.60 6.73 12.56 9.36 2.05 4.08 5.99 15.17 9.39 3.28
Eisosomes 8.82 -4.21 -12.86 -14.53 -2.55 -1.74 -1.59 -11.99 -11.38 -8.52 0.54 -4.42 -17.30 -17.30 -3.12
Endoplasmic Reticulum 8.22 -1.95 -4.30 -4.83 0.96 -2.28 -1.78 -4.72 -1.19 1.30 -1.65 -2.41 -5.47 -3.93 1.61
Endosome 6.10 1.44 2.89 -3.95 0.99 0.82 0.98 4.40 3.89 1.73 0.93 1.76 5.35 3.56 2.13
Golgi 7.00 -0.27 2.22 -3.40 0.97 1.35 4.49 2.69 1.58 -1.60 1.36 0.76 3.43 1.84 0.62
Lipid Particles 4.29 -0.61 2.66 -3.47 2.56 5.00 2.33 5.37 2.66 2.56 6.21 0.57 5.94 -0.68 3.62
Mitochondria 5.41 4.40 0.77 -2.95 -2.28 0.23 3.93 -0.18 -0.41 -3.88 -0.21 5.93 0.12 0.30 -4.90
Mitotic Spindle -1.61 -1.48 -1.74 -1.26 1.10 -2.40 0.55 -2.02 0.70 -2.21 -2.48 -1.42 -2.49 1.04 0.36
None -11505.74 5.19 4.80 11663.24 -1.45 0.64 5.73 4.84 1.31 -7.77 -6.04 7.12 6.26 6.08 -5.17
Nuclear Periphery 5.05 -3.59 -4.46 -5.41 2.13 -2.31 -3.08 -4.56 -2.70 0.71 -1.80 -4.29 -6.31 -4.23 2.48
Nuclear Periphery Foci 0.70 -1.52 0.71 0.05 1.58 -2.28 -1.09 -1.73 0.93 0.98 -1.49 -1.88 -0.56 1.17 1.84
Nucleolus -1.09 0.65 0.95 4.17 1.19 -1.30 0.98 0.83 1.42 -0.81 -1.29 1.07 1.25 1.43 0.64
Nucleus 1.11 -0.11 0.89 -4.34 2.01 0.70 0.94 0.96 1.14 0.83 0.91 0.56 1.28 1.01 2.11
Peroxisomes 12.65 10.33 12.00 -3.43 1.66 10.08 12.73 20.60 13.67 1.58 7.92 17.50 23.58 13.83 2.03
Vacuole 5.83 -2.99 -2.12 -2.36 2.41 -3.16 -1.20 -3.58 -1.46 1.00 -3.04 -2.35 -4.09 -1.63 1.94
Vacuole Periphery 3.71 -1.80 -1.66 -1.79 -1.31 -3.04 -1.28 -2.92 -0.98 -2.85 -2.99 -2.10 -3.35 -0.85 -2.99
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication
Localization
Cell Percentages actin (95%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Myo5

Myo5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Myo5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available