| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Bud Neck | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 42 | 41 | 22 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | 17 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 235 | 204 | 145 | 40 | 36 | 0 | 2 | 0 | 5 |
| Endoplasmic Reticulum | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 12 | 9 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Endosome | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Golgi | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mitochondria | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleus | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Peroxisomes | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vac/Vac Membrane | 0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Unique Cell Count | 17 | 244 | 207 | 150 | 43 | 37 | 2 | 5 | 4 | 9 | ||||||||||||||
| Labelled Cell Count | 17 | 290 | 254 | 175 | 43 | 37 | 2 | 5 | 4 | 9 | ||||||||||||||
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 314.6 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 456.4 | 480.9 | 453.9 | – | – | – |
| Std Deviation (1e-4) | 96.0 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | 119.1 | 90.9 | 94.1 | – | – | – |
| Intensity Change (Log2) | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | 0.0147 | 0.0029 | 0.0638 | 0.0006 | 0.002 | 0.0065 | 0.0036 | 0.0007 | 0.0123 | 0.0002 | 0 | 0.0096 | 0.0177 | 0.0002 | 0.0092 | 0.0003 | 0.0154 | 0.0047 |
| Bud | 0.0023 | 0.0017 | 0.0048 | 0.003 | 0.008 | 0.0044 | 0.0019 | 0.0026 | 0.0016 | 0.0001 | 0.0006 | 0.01 | 0.0022 | 0.0002 | 0.0118 | 0.0004 | 0.0006 | 0.001 |
| Bud Neck | 0.0013 | 0.0005 | 0.0017 | 0.0004 | 0.0006 | 0.0016 | 0.0004 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0019 | 0.0009 | 0.0001 | 0.0003 | 0.0003 | 0.0015 | 0.0011 |
| Bud Periphery | 0.0022 | 0.0013 | 0.0033 | 0.0003 | 0.0017 | 0.0009 | 0.001 | 0.0004 | 0.0012 | 0 | 0.0001 | 0.0034 | 0.001 | 0 | 0.0239 | 0 | 0.0003 | 0.0003 |
| Bud Site | 0.0037 | 0.0061 | 0.0054 | 0.0003 | 0.0009 | 0.0005 | 0.0014 | 0.0005 | 0.0008 | 0 | 0 | 0.0004 | 0.0036 | 0.0001 | 0.0029 | 0 | 0.0001 | 0.0001 |
| Cell Periphery | 0.0052 | 0.0032 | 0.001 | 0.0007 | 0.0026 | 0.0004 | 0.0021 | 0.0014 | 0.0009 | 0 | 0.0004 | 0.0003 | 0.0019 | 0.0001 | 0.0015 | 0.0003 | 0.0002 | 0.0001 |
| Cytoplasm | 0.7445 | 0.9592 | 0.8591 | 0.643 | 0.8684 | 0.8781 | 0.6247 | 0.9528 | 0.7931 | 0.9928 | 0.9314 | 0.9126 | 0.7051 | 0.9914 | 0.7789 | 0.8129 | 0.6136 | 0.8395 |
| Cytoplasmic Foci | 0.0171 | 0.0008 | 0.0015 | 0.108 | 0.0043 | 0.0116 | 0.0133 | 0.0003 | 0.0005 | 0.0002 | 0.0002 | 0.001 | 0.0205 | 0.0001 | 0.0286 | 0.0002 | 0.001 | 0.0363 |
| Eisosomes | 0.0011 | 0.0002 | 0.0009 | 0.0014 | 0.0001 | 0 | 0.003 | 0.0001 | 0.0008 | 0 | 0 | 0 | 0.002 | 0 | 0.0034 | 0 | 0 | 0 |
| Endoplasmic Reticulum | 0.0078 | 0.002 | 0.0032 | 0.0002 | 0.0003 | 0.0029 | 0.0018 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0014 | 0.0142 | 0.0001 | 0.0045 | 0.0001 | 0.0664 | 0.0035 |
| Endosome | 0.0253 | 0.0006 | 0.0079 | 0.0002 | 0.0015 | 0.0366 | 0.0008 | 0.0001 | 0.0005 | 0 | 0.0005 | 0.001 | 0.0082 | 0 | 0.0241 | 0 | 0.0094 | 0.003 |
| Golgi | 0.0046 | 0.0002 | 0.006 | 0.0002 | 0.0003 | 0.0113 | 0.0004 | 0 | 0.0007 | 0 | 0 | 0.0002 | 0.0014 | 0 | 0.0049 | 0 | 0.0009 | 0.0002 |
| Lipid Particles | 0.0091 | 0.0002 | 0.0021 | 0.0074 | 0.0004 | 0.0039 | 0.0038 | 0 | 0.0002 | 0 | 0 | 0 | 0.0022 | 0 | 0.0041 | 0 | 0.0002 | 0.0006 |
| Mitochondria | 0.0474 | 0.0033 | 0.0083 | 0.0805 | 0.0302 | 0.0102 | 0.0369 | 0.018 | 0.1738 | 0.0001 | 0.0001 | 0.0165 | 0.0244 | 0.0007 | 0.0332 | 0.002 | 0.0083 | 0.0045 |
| None | 0.0113 | 0.0007 | 0.0018 | 0.0806 | 0.0037 | 0.0011 | 0.0368 | 0.0008 | 0.0011 | 0.0002 | 0.0001 | 0.001 | 0.0183 | 0.0003 | 0.0319 | 0.0006 | 0.001 | 0.0064 |
| Nuclear Periphery | 0.0289 | 0.0036 | 0.0056 | 0.0024 | 0.0052 | 0.0037 | 0.0851 | 0.0019 | 0.0014 | 0.0013 | 0.0021 | 0.0117 | 0.0621 | 0.001 | 0.0098 | 0.0081 | 0.2219 | 0.0454 |
| Nucleolus | 0.0258 | 0.0007 | 0.0005 | 0.0286 | 0.0076 | 0.0006 | 0.0209 | 0.0014 | 0.0006 | 0 | 0.0001 | 0.0001 | 0.0067 | 0.0001 | 0.0047 | 0.0017 | 0.0002 | 0.0165 |
| Nucleus | 0.0226 | 0.008 | 0.0085 | 0.0269 | 0.0209 | 0.0117 | 0.1365 | 0.0109 | 0.0045 | 0.0044 | 0.0046 | 0.0249 | 0.094 | 0.0053 | 0.0105 | 0.1701 | 0.0477 | 0.0298 |
| Peroxisomes | 0.0023 | 0.0001 | 0.0006 | 0.0064 | 0.0012 | 0.0022 | 0.0013 | 0.0002 | 0.0008 | 0 | 0 | 0.0003 | 0.0016 | 0 | 0.0018 | 0 | 0.0001 | 0.0002 |
| Punctate Nuclear | 0.0014 | 0.0002 | 0.0006 | 0.0017 | 0.0002 | 0.001 | 0.005 | 0 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0019 | 0 | 0.0006 | 0.0002 | 0.0011 | 0.003 |
| Vacuole | 0.0116 | 0.0035 | 0.0062 | 0.0033 | 0.0179 | 0.0054 | 0.0074 | 0.0045 | 0.0013 | 0.0002 | 0.0468 | 0.002 | 0.0053 | 0.0003 | 0.005 | 0.0014 | 0.0037 | 0.0016 |
| Vacuole Periphery | 0.0099 | 0.0012 | 0.0073 | 0.004 | 0.0219 | 0.0052 | 0.0119 | 0.0031 | 0.0036 | 0.0001 | 0.0129 | 0.0015 | 0.0048 | 0.0001 | 0.0045 | 0.0014 | 0.0064 | 0.0022 |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 146.9965 | 24.9505 | 18.9258 | 21.8991 | 19.7021 | 115.9204 | 35.7388 | 36.7022 | 46.1181 | 51.2101 |
| Translational Efficiency | 1.5246 | 1.6877 | 1.3421 | 1.6354 | 1.2172 | 2.2643 | 1.2334 | 1.2258 | 1.4781 | 1.2435 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | ✘ |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 431 | 745 | 2312 | 1629 | 1960 | 1490 | 166 | 974 | 2391 | 2235 | 2478 | 2603 |
Protein Abundance
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 7096.52 | 20135.61 | 14949.97 | 11283.88 | 21971.46 | 22198.15 | 14900.06 | 9329.49 | 19290.11 | 21510.64 | 14946.63 | 10552.58 |
| Standard Deviation | 2305.55 | 6290.24 | 3352.68 | 3875.72 | 4353.45 | 5456.05 | 3549.14 | 4006.40 | 7013.53 | 5829.24 | 3366.22 | 4037.46 |
| Intensity Change Log 2 | — | 1.504566 | 1.074959 | 0.669080 | — | 0.014809 | -0.560313 | -1.235761 | — | 0.542378 | 0.038302 | -0.495850 |
Localization Score (DeepLoc)
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000251 | 0.000116 | 0.000021 | 0.000150 | 0.000022 | 0.000052 | 0.000115 | 0.000272 | 0.000064 | 0.000074 | 0.000028 | 0.000196 |
| Bud Neck | 0.001596 | 0.000704 | 0.000239 | 0.001354 | 0.000241 | 0.000431 | 0.002398 | 0.002536 | 0.000485 | 0.000522 | 0.000383 | 0.001796 |
| Bud Site | 0.012973 | 0.003224 | 0.000684 | 0.004886 | 0.000614 | 0.000888 | 0.003240 | 0.009236 | 0.002842 | 0.001666 | 0.000855 | 0.006514 |
| Cell Periphery | 0.028680 | 0.015987 | 0.002020 | 0.009255 | 0.005291 | 0.006222 | 0.044881 | 0.004597 | 0.009507 | 0.009477 | 0.004891 | 0.007512 |
| Cytoplasm | 0.764535* | 0.823898* | 0.928594* | 0.839023* | 0.906822* | 0.873831* | 0.660928* | 0.805855* | 0.881173* | 0.857187* | 0.910663* | 0.826612* |
| Cytoplasmic Foci | 0.014790 | 0.011165 | 0.002879 | 0.005551 | 0.003371 | 0.006756 | 0.024043 | 0.011932 | 0.005429 | 0.008226 | 0.004297 | 0.007938 |
| Eisosomes | 0.000004 | 0.000002 | 0.000000 | 0.000003 | 0.000001 | 0.000001 | 0.000006 | 0.000006 | 0.000001 | 0.000002 | 0.000001 | 0.000004 |
| Endoplasmic Reticulum | 0.000368 | 0.000099 | 0.000022 | 0.000045 | 0.000071 | 0.000031 | 0.000044 | 0.000167 | 0.000124 | 0.000054 | 0.000023 | 0.000091 |
| Endosome | 0.000504 | 0.000147 | 0.000030 | 0.000408 | 0.000068 | 0.000079 | 0.000181 | 0.003839 | 0.000147 | 0.000101 | 0.000040 | 0.001692 |
| Golgi | 0.025065 | 0.012873 | 0.002347 | 0.001638 | 0.006567 | 0.005814 | 0.006959 | 0.004414 | 0.009902 | 0.008167 | 0.002656 | 0.002677 |
| Lipid Particles | 0.015191 | 0.009081 | 0.000812 | 0.008039 | 0.002833 | 0.003497 | 0.020635 | 0.007156 | 0.005061 | 0.005358 | 0.002140 | 0.007708 |
| Mitochondria | 0.000320 | 0.000248 | 0.000087 | 0.000126 | 0.000073 | 0.000165 | 0.000073 | 0.001067 | 0.000117 | 0.000193 | 0.000086 | 0.000478 |
| Mitotic Spindle | 0.003422 | 0.000743 | 0.000136 | 0.000424 | 0.000201 | 0.000804 | 0.000718 | 0.004149 | 0.000782 | 0.000784 | 0.000175 | 0.001818 |
| None | 0.004732 | 0.008088 | 0.004017 | 0.003595 | 0.003780 | 0.006067 | 0.004368 | 0.008029 | 0.003952 | 0.006741 | 0.004040 | 0.005254 |
| Nuclear Periphery | 0.000371 | 0.000457 | 0.000240 | 0.000176 | 0.000310 | 0.000348 | 0.001381 | 0.000216 | 0.000321 | 0.000384 | 0.000317 | 0.000191 |
| Nuclear Periphery Foci | 0.005748 | 0.005032 | 0.001208 | 0.001599 | 0.003155 | 0.002516 | 0.006573 | 0.001924 | 0.003622 | 0.003355 | 0.001567 | 0.001720 |
| Nucleolus | 0.000156 | 0.000084 | 0.000033 | 0.000132 | 0.000042 | 0.000057 | 0.000082 | 0.000421 | 0.000062 | 0.000066 | 0.000036 | 0.000240 |
| Nucleus | 0.046771 | 0.063183 | 0.045261 | 0.053293 | 0.034260 | 0.062332 | 0.086621 | 0.066534 | 0.036515 | 0.062616 | 0.048031 | 0.058248 |
| Peroxisomes | 0.000060 | 0.000019 | 0.000005 | 0.000047 | 0.000009 | 0.000009 | 0.000020 | 0.000951 | 0.000018 | 0.000013 | 0.000006 | 0.000385 |
| Vacuole | 0.045762 | 0.036621 | 0.009036 | 0.068402 | 0.025230 | 0.026096 | 0.130662 | 0.064689 | 0.028931 | 0.029604 | 0.017184 | 0.067012 |
| Vacuole Periphery | 0.028704 | 0.008228 | 0.002330 | 0.001855 | 0.007041 | 0.004003 | 0.006073 | 0.002011 | 0.010946 | 0.005412 | 0.002580 | 0.001913 |
Localization Changes (T-score)
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | UBP2_WT | UBP14_WT | UBP2UBP14_WT | UBP2UBP14_UBP2 | UBP2UBP14_UBP14 | |
| Actin | 3.64 | 8.91 | 2.59 | -1.26 | -7.22 | -5.93 | -7.56 | -6.15 | -4.87 | -2.18 | -2.12 | 6.06 | -6.84 | -5.38 | -8.96 |
| Bud Neck | 3.47 | 6.97 | -0.85 | -4.97 | -9.45 | -4.60 | -5.19 | -7.56 | -6.85 | 0.01 | -2.39 | -0.46 | -10.03 | -9.12 | -9.65 |
| Bud Site | 5.00 | 7.21 | 3.85 | -2.41 | -8.63 | -2.34 | -3.94 | -6.74 | -6.40 | -3.21 | 2.16 | 5.51 | -6.20 | -7.93 | -10.19 |
| Cell Periphery | 2.73 | 7.09 | 5.33 | 4.24 | -9.09 | -1.24 | -5.35 | 2.42 | 3.36 | 5.62 | -0.42 | 4.94 | 3.15 | 3.73 | -2.80 |
| Cytoplasm | -3.44 | -12.52 | -2.30 | 2.07 | 21.60 | 6.63 | 12.27 | 18.15 | 12.55 | -4.79 | 5.52 | -4.92 | 17.23 | 11.32 | 22.93 |
| Cytoplasmic Foci | 1.58 | 8.23 | 4.68 | 3.58 | -5.12 | -6.30 | -5.30 | -5.89 | -2.81 | 3.31 | -5.76 | 0.87 | -4.68 | -0.07 | -5.00 |
| Eisosomes | 2.70 | 6.77 | 0.54 | -2.63 | -8.22 | -4.46 | -6.90 | -5.68 | -4.13 | 1.81 | -3.29 | 2.44 | -7.46 | -5.41 | -8.53 |
| Endoplasmic Reticulum | 3.83 | 5.17 | 4.81 | 2.83 | -2.02 | 2.50 | 1.60 | -1.17 | -2.43 | -2.03 | 3.69 | 5.62 | 2.46 | -0.92 | -3.18 |
| Endosome | 6.28 | 8.93 | 1.19 | -1.29 | -2.20 | -1.31 | -4.57 | -3.03 | -3.01 | -2.80 | 2.40 | 8.03 | -3.18 | -3.31 | -3.54 |
| Golgi | 3.86 | 8.18 | 8.62 | 8.91 | 4.73 | 1.17 | 0.07 | 4.19 | 3.02 | 3.58 | 1.98 | 10.81 | 11.22 | 9.28 | 2.47 |
| Lipid Particles | 2.19 | 6.29 | 2.82 | 0.71 | -9.30 | -1.29 | -6.05 | -5.50 | -4.25 | 4.35 | -0.70 | 4.72 | -4.04 | -3.22 | -9.02 |
| Mitochondria | 0.67 | 3.46 | 2.44 | 0.86 | -2.08 | -3.41 | -0.50 | -2.81 | -2.23 | -2.78 | -1.99 | 2.10 | -2.72 | -1.48 | -3.11 |
| Mitotic Spindle | 1.84 | 2.28 | 1.68 | -0.45 | -2.28 | -2.28 | -1.75 | -3.77 | -2.64 | -3.32 | -0.60 | 2.45 | -2.42 | -1.98 | -4.49 |
| None | -2.17 | 1.03 | 1.80 | 3.37 | 1.43 | -3.11 | -0.11 | -2.16 | -0.28 | -1.85 | -4.06 | -0.32 | -0.70 | 2.70 | -0.55 |
| Nuclear Periphery | -2.28 | 0.67 | 2.83 | 4.77 | 1.50 | -1.15 | -4.69 | 0.57 | 2.07 | 4.86 | -2.00 | -0.96 | 1.87 | 4.81 | 2.65 |
| Nuclear Periphery Foci | 0.58 | 6.08 | 5.41 | 5.47 | -2.51 | 1.62 | -3.46 | 3.56 | 1.32 | 4.69 | 0.67 | 6.66 | 6.40 | 4.77 | -1.10 |
| Nucleolus | 2.54 | 4.66 | 0.73 | -2.69 | -6.34 | -4.03 | -5.24 | -5.52 | -5.13 | -4.69 | -1.24 | 4.61 | -6.38 | -6.11 | -7.67 |
| Nucleus | -2.01 | 0.78 | -3.44 | -1.63 | -7.56 | -9.78 | -7.29 | -12.34 | -4.78 | 0.29 | -10.10 | -4.97 | -14.41 | -3.98 | -9.80 |
| Peroxisomes | 2.51 | 3.99 | 1.04 | -2.16 | -5.11 | -0.33 | -2.11 | -1.30 | -1.29 | -1.27 | 1.04 | 3.43 | -1.37 | -1.40 | -1.45 |
| Vacuole | 0.85 | 8.09 | -7.38 | -9.20 | -20.57 | -0.93 | -7.74 | -13.04 | -12.16 | 2.63 | -1.19 | 4.66 | -17.67 | -16.23 | -21.46 |
| Vacuole Periphery | 4.69 | 6.35 | 6.62 | 5.16 | 1.98 | 3.65 | 1.43 | 7.30 | 4.72 | 3.78 | 5.05 | 8.00 | 9.85 | 7.14 | 2.68 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description | Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine |
| Localization | |
| Cell Percentages | cytoplasm (99%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | cytoplasm-1 |
Ade17
Ade17
Nearest neighbours ( genes)
correlation threshold
0.80
Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)
Endocytosis
| Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
|---|---|---|---|---|
| 37℃ | ||||
| RT |
Cell Cycle Omics
CYCLoPs (Ade17-GFP)
| Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
|---|
| Gene | Images |
|---|
| Gene | Images |
|---|
Images are not yet available
Images are not yet available
