Standard name
Human Ortholog
Description Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.24 0.25 0.17 0.19 0.22 0.18 0.13 0.17 0.17 0.15 0.13 0.11 0.26 0.32 0.38 0.53 0.58 0.46 0.19 0.15 0.14 0.21 0.16 0.11
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 0 0.05 0.05 0 0 0.05 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.27 0.05 0.08 0.23 0.17 0.54 0.6 0.46 0.47 0.63 0.71 0.63 0 0 0 0 0 0.07 0 0 0.06 0 0 0
Nucleus 0.27 0.2 0.35 0.39 0.33 0.25 0.24 0.29 0.28 0.2 0.19 0.24 0.49 0.43 0.45 0.17 0 0.06 0.45 0.49 0.41 0.43 0.39 0.4
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0.06
Vac/Vac Membrane 0.45 0.63 0.45 0.32 0.36 0.27 0.29 0.29 0.3 0.26 0.22 0.28 0.32 0.31 0.29 0.39 0.42 0.53 0.17 0.18 0.23 0.18 0.21 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 1 0 1 0
Bud 0 0 1 0 2 2 8 7 2 15 7 13 0 1 0 0 0 0 3 13 10 20 23 18
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2 1 3 4 8
Bud Site 0 0 0 0 0 0 4 4 3 7 6 6 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 2 1 1 1 0 3 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 59 76 53 38 48 63 58 82 88 88 67 61 102 180 187 52 81 61 60 57 63 107 84 64
Endoplasmic Reticulum 1 1 1 0 1 2 2 0 0 1 2 2 1 3 0 4 7 3 0 2 5 3 1 4
Endosome 0 5 30 9 9 3 4 2 4 1 0 0 11 13 3 8 7 1 15 16 13 12 24 42
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 2 2 0 3 0 2 6
Mitochondria 66 15 25 46 38 189 262 224 247 367 355 342 0 1 0 3 3 9 8 5 25 10 10 13
Nucleus 66 62 107 79 72 88 107 141 149 118 93 129 195 247 223 17 5 8 147 184 182 220 203 237
Nuclear Periphery 0 0 0 0 0 2 0 1 0 1 0 3 0 0 0 0 0 0 4 1 5 1 4 5
Nucleolus 0 0 0 0 2 0 2 9 1 9 5 7 0 1 0 0 0 0 5 5 6 4 9 11
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 11 8 18 25 35 33
Vac/Vac Membrane 111 194 139 65 79 93 128 139 160 148 111 154 127 179 145 39 59 71 55 66 101 95 110 132
Unique Cell Count 249 309 310 204 221 349 438 487 525 578 498 545 394 571 495 99 140 133 324 373 446 516 529 593
Labelled Cell Count 304 353 356 237 251 442 577 610 655 756 646 720 437 627 559 123 162 155 324 373 446 516 529 593


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 6.5 5.8 5.4 5.6 5.1 5.1 5.3 5.4 5.0 4.7 5.1 7.2 7.2 7.1 7.7 7.2 7.6 7.3 7.8 8.3
Std Deviation (1e-4) 0.5 1.1 1.1 1.3 1.4 1.2 1.2 1.4 1.2 1.3 1.1 1.3 1.0 1.0 1.0 1.6 1.5 1.7 1.1 1.4 1.4
Intensity Change (Log2) – – – -0.09 -0.04 -0.18 -0.18 -0.14 -0.11 -0.22 -0.31 -0.19 0.31 0.31 0.3 0.42 0.32 0.39 0.34 0.43 0.52


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 2.4 0 2.3 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.4 1.3 0.3 -1.5 -0.1 -0.1 -0.7 -1.4 -2.4 2.8 4.6 6.2 7.0 8.8 6.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -2.2 -2.4 -5.2 -5.7 -6.5 -6.3 -7.4 0 -7.4 -3.9 -4.9 -6.3 -0.5 -1.7 -3.4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.7 3.2 12.6 14.3 11.3 11.6 15.9 0 15.5 -5.7 -6.6 -6.4 -1.7 -2.4 -0.5
Nucleus 1.0 -0.5 -2.6 -3.0 -1.7 -1.9 -4.6 -5.1 -3.4 4.0 2.5 3.0 -3.3 -7.0 -6.3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.9 -2.1 -4.9 -4.4 -4.7 -4.2 -5.8 -6.7 -4.9 -3.4 -4.0 -4.5 -1.0 -0.5 1.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.7419 5.9662 5.84 6.1309 5.1413 5.9689 3.9158 4.1606 4.188 3.0961 3.5396 3.8991 1.6858 2.696 1.8408 1.5684 1.9811 2.3358
Actin 0.0003 0.0004 0.001 0.0006 0.0004 0.0005 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0006 0.0005 0.0005 0.0001 0.0002 0.0004
Bud 0.003 0.0002 0.0005 0.0002 0.0001 0.0002 0.0001 0.0002 0 0 0.0001 0.0001 0.0002 0.0002 0.0003 0.0001 0.0002 0.0002
Bud Neck 0.0008 0.0009 0.002 0.0041 0.0008 0.0036 0.0005 0.0009 0.0004 0.0003 0.0014 0.0026 0.0006 0.0004 0.0013 0.001 0.0013 0.0025
Bud Periphery 0.0008 0.0001 0.0002 0.0001 0 0.0001 0 0.0001 0 0 0 0 0.0001 0.0001 0.0001 0 0.0001 0.0001
Bud Site 0.0011 0.0019 0.0042 0.0006 0.0003 0.0003 0.0002 0.0009 0.0002 0.0001 0.0001 0.0001 0.0004 0.0007 0.0013 0.0002 0.0003 0.0003
Cell Periphery 0.0001 0.0002 0.0001 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2864 0.3339 0.2973 0.3484 0.3593 0.2382 0.0892 0.1395 0.0898 0.0283 0.1051 0.0628 0.2631 0.3493 0.3311 0.18 0.2612 0.2379
Cytoplasmic Foci 0.0041 0.0092 0.0054 0.0052 0.0049 0.0057 0.0007 0.0013 0.0007 0.0006 0.0006 0.0008 0.0057 0.0022 0.0026 0.0006 0.0025 0.0056
Eisosomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0052 0.0047 0.0054 0.0046 0.0044 0.0038 0.0012 0.0016 0.001 0.0003 0.0014 0.001 0.0088 0.0056 0.0046 0.0017 0.0049 0.0036
Endosome 0.0042 0.0057 0.0059 0.0102 0.0053 0.0065 0.0017 0.0028 0.0014 0.0008 0.0019 0.0015 0.0083 0.0035 0.0035 0.001 0.0087 0.007
Golgi 0.0001 0.0002 0.0002 0.0002 0.0001 0.0001 0 0.0001 0 0 0 0 0.0002 0.0001 0.0001 0 0.0001 0.0002
Lipid Particles 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0 0 0 0 0 0 0.0004 0.0001 0.0002 0 0 0.0002
Mitochondria 0.0012 0.0006 0.0011 0.0007 0.0009 0.0007 0.0003 0.0003 0.0002 0.0002 0.0004 0.0002 0.0007 0.0004 0.0005 0.0003 0.0006 0.0004
None 0.0726 0.0475 0.0549 0.0642 0.0964 0.032 0.0049 0.0053 0.006 0.0008 0.0028 0.0017 0.028 0.0435 0.0396 0.0476 0.0033 0.005
Nuclear Periphery 0.0226 0.0217 0.0225 0.0199 0.0139 0.0149 0.013 0.0145 0.0093 0.0087 0.0162 0.0101 0.0392 0.02 0.0218 0.015 0.039 0.0197
Nucleolus 0.002 0.0016 0.0019 0.0022 0.0017 0.0028 0.0018 0.0026 0.0014 0.0014 0.0024 0.0026 0.0011 0.0007 0.0011 0.0031 0.0019 0.0016
Nucleus 0.5774 0.5526 0.5648 0.4946 0.4891 0.6609 0.873 0.8147 0.8778 0.9295 0.8419 0.8923 0.6227 0.5589 0.5667 0.7236 0.6638 0.6968
Peroxisomes 0.0001 0.0004 0.0004 0.0001 0.0002 0.0002 0 0 0 0 0 0 0.0002 0.0001 0.0001 0 0 0.0002
Punctate Nuclear 0.0153 0.0144 0.0286 0.0397 0.0199 0.0269 0.0123 0.013 0.0107 0.0287 0.0243 0.023 0.0161 0.0098 0.0227 0.0244 0.0083 0.0163
Vacuole 0.0023 0.0032 0.0028 0.0034 0.0015 0.0022 0.001 0.0016 0.0007 0.0002 0.001 0.0009 0.0029 0.0032 0.0015 0.0009 0.0027 0.0016
Vacuole Periphery 0.0004 0.0005 0.0005 0.0008 0.0004 0.0004 0.0002 0.0003 0.0001 0.0001 0.0003 0.0002 0.0007 0.0006 0.0003 0.0002 0.0008 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1.2099 2.1631 2.1402 7.2827 7.3204 5.6429 5.65 9.841 10.6591 6.5609
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1003 380 2073 1033 1757 2018 1475 836 2760 2398 3548 1869

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 748.44 866.02 883.83 922.28 734.74 799.48 943.05 1295.30 739.72 810.02 908.45 1089.13
Standard Deviation 265.45 188.41 113.88 147.16 126.77 104.99 130.42 208.27 189.42 124.47 124.50 256.46
Intensity Change Log 2 — 0.210514 0.239882 0.301318 — 0.121828 0.360100 0.817981 — 0.167262 0.300688 0.580292

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000583 0.001021 0.000517 0.001272 0.000100 0.000347 0.000596 0.000237 0.000276 0.000454 0.000550 0.000809
Bud Neck 0.003371 0.006962 0.012490 0.011733 0.003334 0.006732 0.010610 0.040561 0.003348 0.006769 0.011709 0.024628
Bud Site 0.004772 0.006087 0.004621 0.008309 0.001579 0.003745 0.005287 0.019899 0.002740 0.004116 0.004898 0.013493
Cell Periphery 0.000301 0.000203 0.000147 0.000303 0.000132 0.000125 0.000128 0.000151 0.000193 0.000138 0.000139 0.000235
Cytoplasm 0.349890* 0.222415* 0.054071 0.097974 0.205890* 0.192471* 0.041123 0.194036* 0.258220* 0.197216* 0.048688 0.140942*
Cytoplasmic Foci 0.040229 0.017697 0.001088 0.003197 0.017984 0.016293 0.000776 0.001038 0.026068 0.016516 0.000958 0.002231
Eisosomes 0.000041 0.000049 0.000023 0.000033 0.000028 0.000025 0.000026 0.000012 0.000033 0.000029 0.000024 0.000024
Endoplasmic Reticulum 0.009208 0.009913 0.006005 0.013832 0.003094 0.003634 0.006882 0.001615 0.005316 0.004629 0.006369 0.008367
Endosome 0.002413 0.003822 0.000791 0.002471 0.001279 0.002381 0.000969 0.000842 0.001691 0.002609 0.000865 0.001743
Golgi 0.001041 0.000740 0.000114 0.001365 0.000157 0.001204 0.000135 0.000179 0.000478 0.001130 0.000123 0.000835
Lipid Particles 0.007363 0.002705 0.000353 0.000873 0.001884 0.002283 0.000538 0.000182 0.003875 0.002350 0.000430 0.000564
Mitochondria 0.004770 0.001603 0.002031 0.005410 0.002301 0.006019 0.001297 0.014306 0.003198 0.005319 0.001726 0.009390
Mitotic Spindle 0.004890 0.008136 0.006268 0.033197 0.002741 0.011092 0.007011 0.021618 0.003522 0.010623 0.006576 0.028018
None 0.017950 0.025058 0.007638 0.012823 0.023682 0.006328 0.005868 0.013996 0.021599 0.009296 0.006902 0.013347
Nuclear Periphery 0.001947 0.003203 0.002630 0.005072 0.003038 0.003263 0.001944 0.003277 0.002642 0.003254 0.002345 0.004269
Nuclear Periphery Foci 0.004447 0.005415 0.000492 0.005156 0.001521 0.001460 0.000687 0.000175 0.002584 0.002086 0.000573 0.002928
Nucleolus 0.004046 0.004756 0.002388 0.004946 0.003094 0.003282 0.004012 0.002610 0.003440 0.003515 0.003063 0.003901
Nucleus 0.530940* 0.655445* 0.890515* 0.766753* 0.721911* 0.727922* 0.903515* 0.667834* 0.652511* 0.716437* 0.895919* 0.722507*
Peroxisomes 0.001314 0.003494 0.000287 0.000943 0.000716 0.001842 0.000285 0.000236 0.000933 0.002104 0.000286 0.000627
Vacuole 0.008968 0.020586 0.007063 0.023110 0.005134 0.008907 0.008028 0.016522 0.006527 0.010758 0.007464 0.020163
Vacuole Periphery 0.001514 0.000690 0.000469 0.001229 0.000402 0.000648 0.000283 0.000673 0.000806 0.000654 0.000392 0.000980

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.44 -0.49 -8.79 -2.06 -12.74 -5.53 -16.86 -7.20 2.14 12.38 -3.84 -9.31 -13.08 -8.04 -6.38
Bud Neck -4.61 -10.14 -14.17 -6.68 -3.04 -3.99 -7.56 -11.60 -10.29 -8.23 -5.19 -12.44 -16.01 -12.71 -8.55
Bud Site -1.89 0.30 -3.15 -0.91 -3.37 -3.20 -3.11 -5.95 -4.56 -3.43 -2.61 -2.87 -7.30 -5.41 -4.81
Cell Periphery 2.66 7.96 1.45 -0.95 -4.92 0.25 0.37 2.54 0.86 2.64 1.98 5.48 0.44 -1.59 -3.68
Cytoplasm 9.26 33.94 29.09 10.62 -5.10 2.06 28.76 6.26 4.67 -17.01 9.67 42.24 24.42 14.55 -15.73
Cytoplasmic Foci 5.98 15.77 15.16 6.60 -1.52 0.42 14.17 14.18 13.23 0.40 5.12 20.76 19.99 13.97 -1.32
Eisosomes -3.23 5.33 -3.41 1.69 -9.92 0.52 -2.73 7.21 9.35 13.97 0.20 1.31 -0.54 -0.77 -2.19
Endoplasmic Reticulum -2.20 1.83 -7.44 -3.61 -12.91 -2.47 -14.85 4.48 6.71 18.12 0.35 -7.16 -9.58 -10.59 -4.54
Endosome -2.12 8.05 0.74 2.36 -6.75 -3.20 0.64 3.74 5.18 2.83 -3.08 5.23 1.05 3.60 -4.04
Golgi 0.92 4.05 1.18 0.47 -1.50 -2.31 0.84 1.07 2.40 0.21 -1.63 4.15 0.54 1.77 -1.48
Lipid Particles 3.54 6.47 5.63 3.97 -7.30 -2.23 7.34 10.56 9.41 6.05 2.66 8.29 7.50 8.05 -3.96
Mitochondria 4.95 4.08 0.88 -3.26 -2.46 -3.49 1.23 -4.33 -2.09 -5.11 -2.48 2.72 -3.60 -1.17 -5.62
Mitotic Spindle -1.20 -1.75 -6.95 -5.44 -6.24 -4.40 -2.52 -5.58 -2.82 -4.11 -4.23 -3.47 -9.14 -6.01 -7.43
None -0.81 6.51 5.03 2.73 -1.41 6.67 7.20 3.67 -7.70 -9.18 6.48 8.88 5.88 -1.51 -6.14
Nuclear Periphery -3.88 -7.63 -10.19 -6.10 -6.94 -0.91 1.53 -3.76 -3.38 -4.41 -2.86 -3.09 -8.99 -7.16 -7.89
Nuclear Periphery Foci -0.87 5.63 -1.00 -0.05 -4.76 -0.90 1.12 5.99 5.48 2.98 0.55 5.66 -1.14 -1.46 -4.04
Nucleolus -1.05 3.07 0.72 1.34 -0.97 -0.41 -1.48 -1.20 -0.99 -0.19 -0.53 0.50 -0.56 -0.16 -0.87
Nucleus -6.17 -33.50 -17.09 -5.89 15.12 -0.40 -21.62 0.43 0.77 17.35 -7.31 -36.55 -9.82 -2.72 22.82
Peroxisomes -1.76 6.37 3.35 2.30 -1.56 -3.07 2.13 2.58 5.73 1.76 -3.41 4.33 3.20 5.26 -1.09
Vacuole -5.31 -0.47 -12.23 -3.69 -12.09 -5.72 -6.12 -6.19 -3.72 -1.12 -6.74 -5.87 -13.91 -10.15 -11.08
Vacuole Periphery 2.19 3.43 2.26 0.28 -0.80 -1.51 1.18 -0.01 2.06 -2.00 0.96 3.29 1.53 0.87 -1.21
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START
Localization
Cell Percentages nucleus (43%), cytoplasm (18%), mixed (37%)
Cell Cycle Regulation Yes
cytoplasm - S/G2 (0.00011)
nucleus - T/G1 (0.00011)
Subcompartmental Group N/A

Gid8

Gid8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Gid8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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