Standard name
Human Ortholog
Description GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.11 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 0.97 0.99 0.98 1.0 0.98 0.94 0.94 0.95 0.89 0.87 0.8 0.79 0.99 1.0 1.0 0.98 0.98 0.99 0.93 0.9 0.97 0.95 0.92 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.14 0 0.07 0.13 0.16 0.28 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 1 0 1 0 2 1 2 0 0 0 0 0 0 0 0 0 0 1 3 3
Bud 0 0 0 0 0 0 1 2 3 3 10 6 0 1 0 0 0 0 0 0 0 5 11 20
Bud Neck 0 0 0 0 2 1 2 3 8 3 1 1 0 0 0 0 0 0 0 0 0 1 1 2
Bud Site 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 14 6 3 2 2 1 1 2 3 6 0 4 2 5 3 9 0 0 0 0 0 0
Cytoplasm 137 156 122 355 507 171 385 479 511 617 354 396 393 764 934 241 223 188 135 156 131 446 547 699
Endoplasmic Reticulum 3 0 0 1 1 0 0 0 0 1 0 1 0 0 0 7 11 9 0 0 0 2 3 4
Endosome 0 0 0 0 2 0 1 3 6 8 4 3 1 1 1 1 1 0 2 0 0 2 1 3
Golgi 0 0 0 0 2 0 1 0 0 0 0 0 0 0 0 2 0 1 0 0 0 1 2 2
Mitochondria 3 2 0 0 5 26 16 33 74 114 123 125 1 0 2 2 3 2 2 1 0 3 6 4
Nucleus 0 1 1 0 0 2 1 2 3 5 3 3 0 0 3 2 2 0 0 1 0 0 0 2
Nuclear Periphery 0 2 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 0 1 0 2 0 1 0 0 0 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 1 0 1 0 0 1 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 1 0 6 4 4 10 4 5 0 0 0 0 0 0 0 0 0 0 7 4
Vac/Vac Membrane 0 0 0 2 7 0 19 9 19 21 11 17 0 1 1 4 2 0 1 9 0 0 2 3
Unique Cell Count 141 158 124 356 518 181 411 504 575 708 440 500 395 765 938 247 227 190 146 174 135 469 596 760
Labelled Cell Count 144 162 138 364 531 202 435 537 631 789 516 567 395 772 945 264 245 209 146 174 135 469 596 760


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.6 5.1 6.0 5.9 6.3 4.0 5.3 5.0 4.5 4.6 4.4 4.6 5.8 5.8 6.0 7.7 7.4 7.8 5.2 5.2 5.5
Std Deviation (1e-4) 0.6 0.6 0.7 1.4 1.7 1.1 1.8 1.1 1.4 1.4 1.1 1.5 1.1 1.2 1.6 1.3 0.9 1.2 1.1 1.5 1.6
Intensity Change (Log2) – – – -0.01 0.08 -0.57 -0.18 -0.25 -0.4 -0.37 -0.45 -0.38 -0.05 -0.03 0.01 0.36 0.3 0.38 -0.21 -0.19 -0.11


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -4.6 0 0 0 0 0 0 0 0 0 0 0 -3.8 -4.2 -2.2
Cytoplasm 1.6 -0.4 -1.7 -2.1 -1.6 -3.3 -3.7 -4.9 -5.1 1.2 2.6 1.7 -0.5 -0.1 0.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 2.9 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.7717 0.2122 -0.1421 -0.1826 0.4578 -0.2919 -0.1507 0.4813 0.2828 0.0655 0.461 0.074 1.987 1.768 2.0423 1.9328 1.78 2.0813
Actin 0.0565 0.0024 0.0128 0.0532 0.0208 0.0043 0.0332 0.0008 0.0126 0.0087 0.0496 0.0014 0.0675 0.0003 0.0007 0.0001 0.0001 0.0001
Bud 0.005 0.0087 0.0061 0.0027 0.0095 0.0011 0.0008 0.0008 0.0005 0.0004 0.0045 0.0002 0.0004 0.0001 0.0002 0.0001 0 0
Bud Neck 0.0071 0.0007 0.0068 0.0052 0.0258 0.001 0.0028 0.0002 0.0091 0.0047 0.0017 0.0019 0.0039 0 0.0003 0 0 0.0001
Bud Periphery 0.0114 0.0066 0.0083 0.0072 0.0438 0.0035 0.0016 0.0009 0.0006 0.0005 0.0053 0.0003 0.0007 0.0002 0.0002 0 0 0
Bud Site 0.0147 0.0107 0.015 0.0046 0.0597 0.0009 0.0047 0.0058 0.0023 0.003 0.0439 0.0001 0.0027 0.0001 0.0013 0 0 0
Cell Periphery 0.0009 0.0006 0.0005 0.0004 0.0014 0.0001 0.0004 0.0002 0.0002 0.0002 0.0005 0 0.0003 0.0001 0.0001 0 0 0
Cytoplasm 0.1227 0.2558 0.2309 0.1617 0.1831 0.4125 0.3089 0.3979 0.401 0.5208 0.4274 0.5235 0.1234 0.1675 0.2879 0.2345 0.3561 0.4017
Cytoplasmic Foci 0.0192 0.0112 0.017 0.0103 0.0314 0.0189 0.0143 0.0067 0.0096 0.0136 0.0504 0.0126 0.0231 0.0035 0.0104 0.0043 0.005 0.0028
Eisosomes 0.0006 0.0002 0.0002 0.0011 0.0004 0.0001 0.0004 0.0001 0.0002 0.0001 0.0005 0 0.0007 0.0003 0.0001 0 0 0
Endoplasmic Reticulum 0.008 0.0024 0.0022 0.0082 0.0028 0.003 0.0067 0.0023 0.0025 0.003 0.0017 0.0021 0.0018 0.0008 0.0011 0.0026 0.0014 0.0004
Endosome 0.0222 0.0016 0.0049 0.0123 0.0213 0.0103 0.0233 0.002 0.0092 0.0131 0.028 0.0082 0.0167 0.0006 0.0021 0.0011 0.0014 0.0005
Golgi 0.0059 0.0003 0.0013 0.0019 0.0059 0.0015 0.0047 0.0002 0.0031 0.0038 0.006 0.0002 0.0087 0.0001 0.0004 0.0001 0.0001 0
Lipid Particles 0.0123 0.0008 0.0039 0.0021 0.0111 0.0018 0.006 0.0003 0.0038 0.007 0.0026 0.0002 0.0234 0.0003 0.0005 0.0003 0 0
Mitochondria 0.0077 0.0015 0.0011 0.0028 0.0742 0.0023 0.0028 0.0003 0.0025 0.0007 0.0101 0.0002 0.0031 0.0004 0.0003 0.0002 0.0001 0
None 0.607 0.6861 0.67 0.6825 0.3993 0.5169 0.5534 0.5776 0.5349 0.4108 0.3528 0.4453 0.6618 0.8243 0.6908 0.7545 0.6346 0.5935
Nuclear Periphery 0.0378 0.0008 0.0067 0.0159 0.011 0.0094 0.0183 0.0007 0.0009 0.0013 0.0013 0.0007 0.0039 0.0002 0.0003 0.0005 0.0002 0.0001
Nucleolus 0.0051 0.0009 0.0005 0.0017 0.0075 0.0008 0.0006 0.0001 0.0002 0.0005 0.0008 0 0.0029 0.0001 0.0002 0.0001 0 0
Nucleus 0.0198 0.0038 0.002 0.0073 0.018 0.0034 0.0036 0.0011 0.0009 0.0012 0.0021 0.0011 0.0043 0.0003 0.0006 0.0005 0.0003 0.0003
Peroxisomes 0.0107 0.001 0.0032 0.0015 0.0141 0.0019 0.0031 0.0001 0.0024 0.0017 0.0027 0.0001 0.0318 0.0003 0.0008 0.0001 0 0
Punctate Nuclear 0.0156 0.0017 0.0046 0.0148 0.0495 0.0039 0.0059 0.0006 0.0014 0.0021 0.003 0.0007 0.0172 0.0002 0.001 0.0002 0.0001 0.0001
Vacuole 0.0063 0.0019 0.0015 0.0017 0.0083 0.0015 0.0028 0.0013 0.0015 0.0024 0.004 0.0008 0.0013 0.0003 0.0005 0.0006 0.0003 0.0002
Vacuole Periphery 0.0034 0.0002 0.0003 0.0008 0.0011 0.0011 0.0016 0.0001 0.0005 0.0004 0.001 0.0002 0.0007 0 0.0001 0.0001 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.5782 11.9872 6.3536 9.7238 6.2093 3.8291 5.1944 9.349 9.7602 8.3513
Translational Efficiency 0.7733 0.7633 1.2285 0.8485 1.3727 1.7995 1.8016 0.8853 0.8614 0.8075

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
458 613 232 1735 1343 1415 1913 206 1801 2028 2145 1941

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 606.47 655.23 787.60 777.70 629.81 791.52 794.11 856.73 623.87 750.32 793.41 786.09
Standard Deviation 125.66 159.49 169.15 93.07 74.17 94.58 86.81 125.57 90.67 133.60 99.09 100.05
Intensity Change Log 2 — 0.111565 0.377027 0.358777 — 0.329709 0.334422 0.443924 — 0.226810 0.355480 0.402782

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000101 0.000308 0.000342 0.000325 0.000129 0.000917 0.000101 0.000121 0.000122 0.000733 0.000127 0.000304
Bud Neck 0.018186 0.021552 0.002521 0.006669 0.015375 0.029844 0.003536 0.001020 0.016090 0.027338 0.003427 0.006069
Bud Site 0.003546 0.012712 0.006108 0.021258 0.005264 0.015571 0.004643 0.005979 0.004827 0.014706 0.004801 0.019637
Cell Periphery 0.002054 0.000210 0.000194 0.000141 0.000163 0.000077 0.000051 0.000075 0.000644 0.000117 0.000067 0.000134
Cytoplasm 0.484619* 0.466838* 0.496623* 0.558196* 0.511158* 0.593710* 0.685626* 0.729038* 0.504409* 0.555361* 0.665184* 0.576328*
Cytoplasmic Foci 0.257655* 0.193873* 0.019945 0.028650 0.272065* 0.154156 0.017142 0.036816 0.268400* 0.166161 0.017445 0.029516
Eisosomes 0.011278 0.000162 0.000059 0.000053 0.000224 0.000079 0.000018 0.000035 0.003035 0.000104 0.000023 0.000051
Endoplasmic Reticulum 0.001067 0.001075 0.003039 0.001382 0.000895 0.000583 0.000810 0.000672 0.000939 0.000731 0.001051 0.001306
Endosome 0.011247 0.034770 0.004328 0.005104 0.012710 0.009677 0.001000 0.003066 0.012338 0.017262 0.001360 0.004887
Golgi 0.004781 0.003923 0.000212 0.000880 0.003618 0.003375 0.000060 0.000112 0.003914 0.003541 0.000076 0.000798
Lipid Particles 0.014154 0.007059 0.001755 0.001070 0.010792 0.002315 0.000502 0.000563 0.011647 0.003749 0.000638 0.001016
Mitochondria 0.004763 0.004983 0.000317 0.001556 0.004896 0.004585 0.000371 0.000063 0.004863 0.004705 0.000365 0.001398
Mitotic Spindle 0.000089 0.002721 0.003478 0.017411 0.000270 0.006673 0.005628 0.004085 0.000224 0.005478 0.005395 0.015996
None 0.043434 0.018426 0.019331 0.002999 0.003813 0.002182 0.003263 0.010354 0.013888 0.007092 0.005001 0.003780
Nuclear Periphery 0.000269 0.000540 0.001096 0.001011 0.000380 0.000199 0.000702 0.000290 0.000352 0.000302 0.000745 0.000935
Nuclear Periphery Foci 0.000775 0.001111 0.002493 0.001593 0.000436 0.000137 0.000586 0.004139 0.000523 0.000431 0.000792 0.001863
Nucleolus 0.000810 0.005505 0.000886 0.000369 0.001157 0.000883 0.000151 0.000143 0.001069 0.002280 0.000230 0.000345
Nucleus 0.086575 0.109740 0.366525* 0.203317* 0.101098 0.098809 0.210917* 0.067897 0.097405 0.102113 0.227747* 0.188945*
Peroxisomes 0.013513 0.007884 0.002507 0.000523 0.003567 0.005928 0.000174 0.000158 0.006096 0.006519 0.000427 0.000484
Vacuole 0.040102 0.103282 0.068045 0.145143 0.050694 0.069099 0.064635 0.135275 0.048000 0.079431 0.065003 0.144095
Vacuole Periphery 0.000983 0.003327 0.000198 0.002350 0.001296 0.001200 0.000084 0.000099 0.001216 0.001843 0.000096 0.002111

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.39 -5.70 -3.19 0.42 2.57 -1.22 -0.20 -3.16 1.08 -3.56 -1.37 -2.35 -3.02 1.03 -2.01
Bud Neck -0.80 5.53 4.59 6.36 -3.02 -6.60 9.91 11.84 14.31 2.56 -6.01 10.92 9.23 13.65 -2.24
Bud Site -6.14 -1.56 -5.70 -0.18 -2.91 -7.27 1.02 -0.85 3.52 -1.25 -9.06 0.37 -5.23 1.27 -4.99
Cell Periphery 4.58 4.63 4.84 3.44 3.80 9.72 12.92 8.97 0.20 -3.84 5.05 5.53 5.18 1.05 -3.77
Cytoplasm 1.09 3.12 -0.45 -1.91 -3.81 -8.24 -11.02 0.71 4.24 5.06 -5.71 -9.99 1.61 7.18 11.43
Cytoplasmic Foci 5.32 22.61 22.37 22.65 -2.79 15.69 43.56 38.62 23.60 -2.50 15.97 49.00 47.50 34.43 -5.22
Eisosomes 4.09 4.13 4.13 2.77 2.53 8.02 11.40 9.76 5.19 -5.80 4.19 4.30 4.27 4.31 -10.49
Endoplasmic Reticulum -0.08 -6.52 -1.87 -3.58 6.30 1.51 -2.47 -2.24 -2.90 -0.94 1.20 -4.88 -5.10 -5.38 -0.41
Endosome -7.30 4.74 6.29 10.68 0.95 2.71 13.47 11.40 9.59 -4.49 -3.72 15.15 11.70 12.90 -5.12
Golgi 0.98 6.42 5.89 4.97 -1.42 0.47 11.08 10.87 6.32 -6.62 0.85 12.78 10.32 7.05 -2.14
Lipid Particles 3.95 7.19 7.73 7.23 3.51 7.99 9.84 9.63 5.50 -2.71 8.58 12.33 11.98 8.49 -5.79
Mitochondria 0.05 2.99 2.56 4.16 -3.36 0.30 4.65 4.96 7.90 7.95 0.28 5.51 4.81 7.41 -3.04
Mitotic Spindle -3.53 -2.42 -6.47 -4.62 -3.87 -3.87 -3.91 -2.17 -1.00 -1.32 -4.50 -4.23 -6.76 -3.22 -3.65
None 2.88 3.38 4.96 4.76 2.16 2.50 1.04 -1.94 -3.47 -2.69 2.88 4.39 4.91 3.66 1.77
Nuclear Periphery -4.14 -10.65 -13.42 -9.25 1.56 2.91 -10.57 -4.78 -8.51 3.67 0.98 -14.74 -12.01 -13.64 -3.48
Nuclear Periphery Foci -1.50 -5.74 -2.13 -1.01 4.49 4.42 -3.13 -5.85 -6.46 -5.33 0.85 -4.51 -5.86 -6.59 -3.50
Nucleolus -6.52 0.91 4.91 7.32 2.38 0.92 3.64 3.74 5.92 1.25 -3.82 4.15 3.80 8.41 -2.34
Nucleus -2.51 -15.17 -19.58 -14.57 8.58 0.51 -26.79 -0.93 -1.17 14.11 -1.00 -30.91 -22.28 -20.69 8.07
Peroxisomes 2.21 4.68 5.64 7.47 1.17 -3.67 12.12 12.22 9.87 0.61 -0.54 8.94 9.06 12.12 -0.03
Vacuole -10.13 -6.80 -26.38 -11.95 -6.55 -5.98 -12.72 -13.20 -12.20 -10.66 -11.00 -14.85 -30.43 -22.89 -18.44
Vacuole Periphery -3.97 2.91 -0.37 3.37 -2.63 0.40 12.54 12.33 4.46 -1.93 -2.32 11.33 0.55 1.93 -2.94
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
Localization
Cell Percentages cytoplasm (59%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Cin4

Cin4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cin4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available