Standard name
Human Ortholog
Description Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.16 0.12 0 0 0 0 0 0
Cytoplasm 0.92 0.95 0.95 0.97 0.96 0.91 0.86 0.88 0.81 0.79 0.74 0.77 0.97 0.99 0.99 0.93 0.9 0.95 0.88 0.93 0.86 0.9 0.97 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.12 0.19 0.1 0.24 0.16 0.34 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0.08 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 1 0 0 0 0 1 2 1 1 0 2 2 0 0 0 1 1 1 1 1 0 0 3
Bud 5 1 2 3 0 4 7 5 12 12 10 8 1 1 0 0 0 0 0 0 1 1 2 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 6 6 7 9 10 16 15 13 13 11 18 5 7 10 16 24 14 0 0 0 0 0 1
Cytoplasm 294 250 261 337 515 497 517 466 431 438 358 384 206 417 341 122 131 109 286 241 245 184 426 362
Endoplasmic Reticulum 9 10 4 1 0 4 4 6 2 1 5 15 4 3 4 3 3 6 10 5 11 3 5 7
Endosome 4 0 3 3 2 1 1 0 1 0 0 0 1 0 0 0 3 0 8 2 5 2 1 2
Golgi 3 0 0 1 1 0 0 0 0 0 0 0 0 1 0 1 1 0 3 3 0 0 0 0
Mitochondria 13 4 0 5 7 64 115 54 128 91 166 82 0 0 0 0 1 0 3 0 5 0 0 2
Nucleus 0 1 1 1 4 1 1 1 1 9 2 2 0 0 1 2 3 0 0 1 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 2 2 0 0 1 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 1 0 1 0 0 1 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0
SpindlePole 0 0 3 0 0 1 0 1 1 0 0 1 1 0 0 0 1 0 1 0 1 0 0 1
Vac/Vac Membrane 0 1 4 4 21 18 25 18 15 45 14 42 0 0 1 2 4 0 2 0 2 4 0 2
Unique Cell Count 319 263 275 348 537 549 599 531 532 556 485 500 213 421 345 131 146 115 325 260 286 204 440 394
Labelled Cell Count 332 274 285 362 559 601 687 570 608 611 566 555 220 429 357 146 172 130 325 260 286 204 440 394


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 9.4 7.9 7.7 8.0 6.6 6.4 7.0 6.0 6.4 5.8 6.5 8.5 9.3 9.4 14.3 14.3 14.0 7.7 8.5 9.4
Std Deviation (1e-4) 1.0 1.1 1.1 1.3 1.6 1.4 1.4 1.6 1.2 1.2 1.2 1.2 1.0 1.2 1.3 3.0 2.8 2.5 1.3 1.6 1.7
Intensity Change (Log2) – – – -0.04 0.02 -0.25 -0.31 -0.17 -0.39 -0.29 -0.45 -0.29 0.11 0.24 0.25 0.85 0.86 0.82 -0.03 0.11 0.26

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.1 -0.5 -0.4 0.4 0.5 0.2 0.1 0.1 1.1 0 -0.5 0.6 4.2 5.4 4.1
Cytoplasm 1.2 0.7 -2.2 -3.8 -3.2 -5.4 -6.0 -7.2 -6.5 1.0 3.4 2.9 -0.7 -2.0 -0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 1.3 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 5.9 7.8 5.5 8.9 7.1 11.0 7.1 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 1.9 1.5 2.1 1.6 1.2 3.8 1.2 3.9 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.9247 6.3067 5.8197 5.3179 5.0372 5.8238 4.6825 5.5129 5.0124 4.5125 4.1773 5.2283 4.496 5.547 4.8286 4.7066 4.1145 5.091
Actin 0.0205 0.002 0.0103 0.0004 0.0001 0.0037 0.0123 0.0002 0.0102 0.0011 0.0005 0.0024 0.0429 0.0006 0.0299 0.0002 0.0316 0.0104
Bud 0.0047 0.0068 0.0073 0.0003 0.0001 0.0007 0.0049 0.0002 0.0042 0.0043 0.0009 0.0001 0.0035 0.0005 0.0099 0.0006 0.0009 0.0041
Bud Neck 0.0038 0.0003 0.0006 0.0005 0.0004 0.0047 0.0033 0.0003 0.0037 0.0005 0.0013 0.0012 0.0033 0.0003 0.0056 0.0003 0.0009 0.0016
Bud Periphery 0.003 0.0031 0.0035 0.0001 0 0.0005 0.0026 0.0001 0.0025 0.0015 0.001 0.0002 0.002 0.0001 0.0045 0.0002 0.0009 0.0021
Bud Site 0.0073 0.0188 0.003 0.0003 0 0.0003 0.0082 0.0011 0.0172 0.0013 0.0141 0.0002 0.0056 0.014 0.0166 0.0003 0.0013 0.0008
Cell Periphery 0.0007 0.0006 0.0003 0.0001 0 0.0001 0.0005 0.0001 0.0003 0.0004 0.0001 0.0001 0.0006 0.0004 0.0004 0.0001 0.0001 0.0003
Cytoplasm 0.6047 0.8249 0.8734 0.8695 0.9748 0.7004 0.6486 0.9023 0.7962 0.8568 0.7921 0.7194 0.6169 0.8888 0.8015 0.9502 0.7977 0.6405
Cytoplasmic Foci 0.1082 0.0597 0.0247 0.0455 0.007 0.1056 0.0911 0.0308 0.0482 0.0267 0.048 0.1152 0.0781 0.0325 0.028 0.0113 0.0482 0.116
Eisosomes 0.0003 0 0 0 0 0.0001 0.0001 0 0.0001 0 0 0 0.0004 0 0.0002 0 0.0001 0
Endoplasmic Reticulum 0.0269 0.0105 0.004 0.0046 0.0009 0.0182 0.0177 0.004 0.0045 0.004 0.017 0.0114 0.0422 0.0081 0.0265 0.0034 0.0035 0.0257
Endosome 0.1438 0.0493 0.0337 0.0634 0.007 0.1257 0.1344 0.0407 0.0512 0.066 0.0712 0.1101 0.108 0.038 0.0458 0.0154 0.0547 0.1501
Golgi 0.0076 0.0016 0.0034 0.0014 0.0002 0.0074 0.0102 0.0015 0.0038 0.0071 0.0053 0.007 0.0139 0.0036 0.0064 0.0003 0.02 0.0107
Lipid Particles 0.0186 0.0022 0.0037 0.0011 0 0.0157 0.0111 0.0002 0.0017 0.0034 0.0047 0.0085 0.011 0.0031 0.0021 0.0002 0.0062 0.0083
Mitochondria 0.0054 0.0012 0.0013 0.0002 0.0001 0.0012 0.0091 0.0003 0.0078 0.0036 0.0077 0.0015 0.0046 0.0002 0.0022 0.0001 0.0065 0.0017
None 0.0137 0.0091 0.0115 0.0052 0.0063 0.0061 0.0169 0.013 0.0226 0.0105 0.0136 0.0074 0.0278 0.005 0.0042 0.0054 0.0115 0.004
Nuclear Periphery 0.0036 0.0009 0.0008 0.0011 0.0002 0.0018 0.0036 0.0005 0.0045 0.0012 0.0018 0.0024 0.0106 0.0006 0.0057 0.0015 0.0018 0.0021
Nucleolus 0.0005 0.0007 0.0003 0 0 0.0001 0.0009 0 0.0005 0.0002 0.0011 0.0002 0.0008 0 0.0002 0 0.0001 0.0003
Nucleus 0.002 0.0016 0.0012 0.0008 0.0004 0.0008 0.0035 0.0012 0.0038 0.0019 0.0028 0.0014 0.0038 0.0007 0.0025 0.0015 0.0012 0.0043
Peroxisomes 0.0081 0.0005 0.01 0.0003 0 0.0011 0.006 0.0001 0.0056 0.0006 0.0047 0.0019 0.007 0.0002 0.0013 0.0001 0.0054 0.005
Punctate Nuclear 0.0046 0.0012 0.0038 0.0004 0 0.0013 0.0027 0.0003 0.0039 0.0009 0.0045 0.0047 0.0071 0.0002 0.0013 0.0008 0.0027 0.0023
Vacuole 0.0108 0.0042 0.0027 0.004 0.0022 0.0038 0.0109 0.0027 0.0065 0.0067 0.0062 0.0041 0.0084 0.0028 0.0042 0.0072 0.0033 0.0082
Vacuole Periphery 0.0013 0.0007 0.0005 0.0008 0.0003 0.0009 0.0015 0.0004 0.0012 0.0013 0.0014 0.0008 0.0015 0.0003 0.001 0.0009 0.0013 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 17.8448 11.521 26.9625 23.2019 10.9256 12.8808 19.4895 23.5866 22.2564 23.0328
Translational Efficiency 0.8254 1.3048 0.5442 0.8321 1.33 1.6316 0.9968 0.7649 1.0208 0.7196

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
32 1416 2246 1524 1434 2187 2335 119 1466 3603 4581 1643

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1229.87 929.35 1102.05 1018.27 877.71 963.07 1000.95 1170.84 885.40 949.82 1050.52 1029.32
Standard Deviation 203.24 164.02 141.91 169.20 117.93 127.63 161.32 253.94 130.97 143.99 160.29 181.08
Intensity Change Log 2 — -0.404212 -0.158316 -0.272386 — 0.133896 0.189554 0.415728 — -0.155355 -0.003139 0.054757

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001988 0.000459 0.000237 0.000849 0.000323 0.000370 0.000446 0.001146 0.000360 0.000405 0.000343 0.000870
Bud Neck 0.003333 0.006021 0.003796 0.003968 0.007559 0.006942 0.003684 0.002581 0.007466 0.006580 0.003739 0.003868
Bud Site 0.082992 0.026177 0.009806 0.037782 0.014788 0.018316 0.014745 0.019111 0.016276 0.021405 0.012323 0.036429
Cell Periphery 0.001104 0.000553 0.000117 0.000115 0.000197 0.000071 0.000071 0.000131 0.000217 0.000260 0.000094 0.000116
Cytoplasm 0.404148 0.419834 0.690038 0.738699 0.487864 0.392990 0.734235 0.544851 0.486037 0.403540 0.712566 0.724658
Cytoplasmic Foci 0.185042 0.304935 0.056033 0.070170 0.288118 0.290116 0.053229 0.105434 0.285868 0.295940 0.054604 0.072724
Eisosomes 0.000039 0.001636 0.000080 0.000015 0.000123 0.000036 0.000015 0.000036 0.000122 0.000665 0.000047 0.000017
Endoplasmic Reticulum 0.013918 0.002960 0.000586 0.000473 0.006381 0.001479 0.000203 0.000375 0.006546 0.002061 0.000390 0.000466
Endosome 0.034767 0.074083 0.007015 0.009343 0.048007 0.103329 0.006312 0.009255 0.047718 0.091835 0.006657 0.009336
Golgi 0.026948 0.022443 0.000295 0.006606 0.013821 0.011648 0.000862 0.000720 0.014108 0.015890 0.000584 0.006179
Lipid Particles 0.007883 0.012480 0.002342 0.001430 0.013670 0.010443 0.001042 0.001541 0.013544 0.011244 0.001679 0.001438
Mitochondria 0.029664 0.002020 0.000179 0.000915 0.002016 0.001571 0.000155 0.010961 0.002619 0.001748 0.000167 0.001643
Mitotic Spindle 0.002285 0.006285 0.009715 0.018603 0.003760 0.019475 0.006589 0.002639 0.003728 0.014291 0.008122 0.017447
None 0.000463 0.007137 0.001096 0.000529 0.001072 0.000444 0.000840 0.001209 0.001058 0.003074 0.000965 0.000578
Nuclear Periphery 0.000967 0.000157 0.000308 0.000132 0.000083 0.000166 0.000106 0.000127 0.000103 0.000163 0.000205 0.000132
Nuclear Periphery Foci 0.046090 0.001830 0.002614 0.002043 0.001239 0.001236 0.000764 0.001276 0.002218 0.001470 0.001671 0.001987
Nucleolus 0.006670 0.000487 0.000273 0.000151 0.000405 0.000478 0.000437 0.000132 0.000542 0.000482 0.000356 0.000149
Nucleus 0.048203 0.007525 0.057518 0.011892 0.011824 0.007600 0.023093 0.009733 0.012618 0.007571 0.039971 0.011736
Peroxisomes 0.002729 0.006372 0.000928 0.003550 0.002444 0.006231 0.002049 0.003225 0.002450 0.006286 0.001500 0.003526
Vacuole 0.088246 0.090660 0.156733 0.089274 0.093399 0.123267 0.150620 0.285098 0.093287 0.110452 0.153617 0.103457
Vacuole Periphery 0.012520 0.005945 0.000291 0.003462 0.002906 0.003791 0.000500 0.000421 0.003116 0.004637 0.000398 0.003242

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.91 3.25 2.47 -2.12 -3.95 -0.85 -0.38 -1.09 -1.01 -1.03 -0.97 0.87 -3.27 -2.86 -3.52
Bud Neck -1.43 0.50 0.63 5.32 0.32 0.86 7.03 8.32 9.57 1.84 1.46 7.37 7.43 8.82 0.40
Bud Site 2.55 3.35 2.36 -1.55 -9.34 -2.65 2.26 -0.93 0.00 -1.70 -4.12 5.12 -5.96 -3.73 -8.99
Cell Periphery 1.50 3.00 2.97 3.88 -0.60 12.94 13.21 4.89 -2.83 -3.27 -0.89 10.97 8.21 3.41 -2.49
Cytoplasm -0.61 -4.73 -5.49 -26.74 -4.97 9.59 -24.85 -0.91 -3.96 6.35 9.25 -24.61 -20.72 -33.26 -0.68
Cytoplasmic Foci -3.89 3.55 3.43 36.68 -1.16 -0.14 41.42 16.96 17.44 -4.23 -1.45 41.60 37.51 51.11 -3.75
Eisosomes -2.52 -0.10 2.61 2.57 1.97 12.34 15.72 8.95 0.26 -2.65 -2.18 7.67 15.50 2.62 1.81
Endoplasmic Reticulum 1.68 2.04 2.06 4.59 1.90 4.27 5.45 5.29 4.68 -1.15 3.93 5.53 5.50 6.50 -0.54
Endosome -4.17 3.20 3.12 21.38 -0.90 -13.42 18.69 16.27 27.09 -2.58 -13.34 18.81 17.67 34.37 -2.12
Golgi 0.38 2.77 2.33 11.13 -3.93 2.68 19.86 20.40 15.46 0.19 -1.67 20.63 8.84 10.19 -3.75
Lipid Particles -1.82 2.52 2.89 9.34 2.23 2.55 11.60 10.96 12.98 -1.09 1.90 10.95 10.67 14.64 0.05
Mitochondria 0.95 1.02 1.00 1.95 -1.41 0.67 2.91 -0.73 -0.79 -0.98 0.93 2.79 1.40 0.93 -1.55
Mitotic Spindle -2.88 -4.90 -4.90 -2.75 -1.43 -6.67 -0.88 -0.82 1.50 -0.61 -6.11 -2.66 -4.07 0.56 -2.59
None -3.57 -2.34 0.34 3.63 6.73 3.01 1.38 -0.05 -1.20 -0.57 -2.68 0.84 2.94 3.51 4.59
Nuclear Periphery 1.81 1.34 1.85 0.48 9.64 -4.15 -3.63 -0.90 0.91 0.26 -2.76 -7.78 -1.65 1.08 6.19
Nuclear Periphery Foci 2.30 2.25 2.29 -0.60 2.38 -0.37 3.11 -0.70 -0.34 -3.33 1.60 0.96 0.68 -1.72 -0.45
Nucleolus 1.95 1.99 2.02 4.72 6.21 -1.98 0.40 6.96 6.79 1.67 0.85 2.09 4.05 8.31 2.61
Nucleus 1.81 -0.04 1.52 -6.53 18.89 6.14 -14.91 0.64 -0.89 6.06 6.13 -21.40 -1.65 -8.03 20.04
Peroxisomes -2.74 2.11 0.20 3.46 -2.89 -8.64 3.16 -0.23 2.62 -0.87 -8.32 6.76 -0.27 5.21 -2.39
Vacuole 0.33 -3.52 -1.91 -9.53 6.08 -6.91 -16.24 -8.16 -7.05 -5.12 -4.67 -20.97 -11.41 -8.59 3.88
Vacuole Periphery 2.42 4.65 3.79 5.29 -3.82 -2.01 10.01 9.93 10.31 0.19 -4.09 11.37 1.83 4.44 -3.69
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-4

Rim11

Rim11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rim11-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available