Standard name
Human Ortholog
Description Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.11 0.12 0 0 0.05 0 0.05 0
Bud 0 0 0.07 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0 0.08 0 0.07 0.06 0.05 0.07 0.09 0.1 0.09 0.2 0.26 0.33 0.12 0.08 0 0 0 0 0 0 0
Cytoplasm 0.97 0.94 0.84 0.84 0.86 0.9 0.84 0.89 0.75 0.77 0.7 0.68 0.95 0.95 0.96 0.68 0.59 0.71 0.83 0.85 0.68 0.77 0.69 0.57
Endoplasmic Reticulum 0 0.05 0 0 0 0.07 0 0 0.05 0 0.05 0 0 0 0 0 0.05 0 0.06 0.07 0.07 0.09 0.14 0.2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0 0.05 0 0 0.05 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.22 0.07 0.07 0.18 0.09 0.2 0.23 0.25 0.31 0 0 0 0 0.08 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.14 0.09 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 7 0 4 1 1 4 5 4 1 2 3 8 2 6 4 9 4 0 4 4 15 10
Bud 4 4 5 2 2 3 6 6 6 7 6 1 6 6 1 1 0 3 0 0 0 0 3 5
Bud Neck 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 1 4 5 7 12
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 7 8 2 4 3 8 10 8 9 15 8 10 53 84 117 14 3 3 1 0 2 1 2 2
Cytoplasm 252 118 64 41 77 103 152 131 103 132 54 77 251 303 341 81 22 55 223 104 67 116 213 149
Endoplasmic Reticulum 6 6 0 0 3 8 3 3 7 6 4 5 5 7 5 5 2 3 16 8 6 13 43 52
Endosome 1 0 3 0 1 0 3 1 0 3 1 0 2 1 2 12 1 4 3 0 4 3 3 8
Golgi 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 4 0 2 3 0 0 0 3 1
Mitochondria 4 0 3 11 6 8 32 13 27 40 19 35 0 0 2 3 3 1 3 0 2 0 9 5
Nucleus 0 2 1 0 1 0 0 2 1 0 1 0 0 0 0 2 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 1 0 1 0 1 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1 0 1 0 1 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 1 0 0 1 2 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 0 0 1 0 3 2 1 1 0 2 1 0 2 6 5 7 0 0 2 0 1 1
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 7 1 4 3 3 1 2 3 7
Unique Cell Count 261 126 76 49 90 114 180 148 137 171 77 113 265 320 354 119 37 77 269 123 98 152 310 264
Labelled Cell Count 276 140 85 61 98 133 212 174 159 209 97 133 321 409 472 142 41 91 269 123 98 152 310 264


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.1 7.5 5.6 5.3 5.9 5.7 5.0 5.9 5.7 5.5 5.5 5.2 7.7 7.9 8.2 9.9 11.0 11.2 6.6 7.3 8.4
Std Deviation (1e-4) 0.6 1.3 0.8 0.8 1.1 0.9 1.1 1.1 0.8 1.3 1.1 1.1 0.8 0.9 1.0 2.0 2.9 2.3 1.0 1.4 1.5
Intensity Change (Log2) – – – -0.08 0.07 0.03 -0.16 0.06 0.01 -0.03 -0.05 -0.12 0.46 0.5 0.53 0.81 0.96 0.99 0.22 0.37 0.57

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 -1.2 0 0 0 0 0 0 0 0 0 0 -1.1 0 0.5
Bud 0 0 0 0 0 0 0 0.3 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 1.8 0 0 3.6 4.5 5.4 2.3 0 0
Cytoplasm -0.1 0.2 1.3 0 0.9 -1.5 -1.3 -2.1 -2.5 3.0 3.2 4.1 -2.5 -2.9 -1.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 1.6 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.2 0 0 2.9 1.3 3.2 3.7 3.7 4.5 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.2734 4.852 4.0202 4.2153 3.3402 4.1639 4.0287 4.4789 4.1497 3.4719 3.9503 4.3497 3.9643 6.1259 5.2481 5.0542 6.0152 5.5771
Actin 0.0309 0.0037 0.0232 0.018 0.0132 0.0024 0.0511 0.0031 0.0181 0.0009 0.0039 0.0051 0.0001 0.007 0.0312 0.0012 0.0014 0.0036
Bud 0.0007 0.0019 0.0018 0.0007 0.0003 0.0001 0.0008 0.0002 0.0004 0.0002 0.0005 0.0002 0 0.0006 0.0105 0.0001 0.0001 0.0054
Bud Neck 0.0017 0.0018 0.0039 0.0011 0.0013 0.0037 0.0031 0.0006 0.0016 0.0007 0.001 0.0035 0.0001 0.0016 0.0016 0.0027 0.0009 0.0013
Bud Periphery 0.0013 0.0015 0.0026 0.0011 0.0004 0.0005 0.001 0.0002 0.0006 0.0004 0.0009 0.0006 0 0.0007 0.0041 0.0003 0.0001 0.004
Bud Site 0.0144 0.0477 0.0201 0.0007 0.0009 0.0003 0.0109 0.0191 0.0048 0.0002 0.0007 0.0003 0 0.0327 0.0137 0.0006 0.0001 0.0005
Cell Periphery 0.0052 0.007 0.0089 0.0014 0.0027 0.0051 0.0051 0.0062 0.0059 0.005 0.0043 0.0024 0.0064 0.0028 0.0074 0.0051 0.0012 0.0027
Cytoplasm 0.7741 0.9116 0.8683 0.8267 0.8349 0.9386 0.7214 0.8933 0.8569 0.9629 0.8252 0.9202 0.7675 0.8787 0.8236 0.9281 0.9482 0.9219
Cytoplasmic Foci 0.0266 0.0041 0.0101 0.0151 0.0139 0.0074 0.0366 0.0026 0.015 0.0016 0.0109 0.0063 0.0004 0.0046 0.0182 0.004 0.0024 0.0107
Eisosomes 0.0006 0.0005 0.0003 0.0001 0.0001 0 0.0005 0.0005 0.0001 0 0.0001 0.0001 0 0.0007 0.0003 0.0001 0 0
Endoplasmic Reticulum 0.0218 0.0037 0.0088 0.0031 0.0031 0.0129 0.0135 0.0026 0.0025 0.0112 0.0058 0.0067 0.0053 0.0219 0.0107 0.0142 0.007 0.0083
Endosome 0.0239 0.0011 0.0102 0.0131 0.0239 0.0045 0.0486 0.0004 0.0119 0.0008 0.0303 0.0023 0 0.0202 0.0103 0.0013 0.0009 0.0008
Golgi 0.0103 0.0006 0.0079 0.0138 0.0089 0.0009 0.0123 0.0005 0.0039 0.0003 0.0282 0.002 0 0.0042 0.0119 0.0005 0.0006 0.0003
Lipid Particles 0.0176 0.0007 0.0021 0.0071 0.0369 0.0006 0.0112 0.0003 0.0031 0.001 0.0055 0.0006 0.0002 0.0058 0.0103 0.0027 0.0004 0.0004
Mitochondria 0.0051 0.0019 0.0092 0.0448 0.018 0.0003 0.0043 0.0001 0.0102 0 0.0459 0.0019 0 0.0041 0.0107 0 0 0.0002
None 0.0218 0.009 0.0155 0.0078 0.0025 0.0111 0.0457 0.0676 0.0465 0.006 0.0218 0.046 0.2193 0.0043 0.0189 0.0362 0.0355 0.0364
Nuclear Periphery 0.0189 0.0002 0.0006 0.0003 0.001 0.0087 0.0036 0.0002 0.0002 0.0003 0.0002 0.0002 0.0001 0.0043 0.0008 0.0005 0.0002 0.0006
Nucleolus 0.0006 0.0001 0.0003 0 0.0005 0 0.0004 0.0001 0.0001 0 0.0001 0 0 0.0003 0.0003 0 0 0.0001
Nucleus 0.0038 0.0006 0.0009 0.0004 0.0043 0.0007 0.0012 0.0004 0.0004 0.0003 0.0003 0.0002 0 0.0008 0.0007 0.0003 0.0002 0.0009
Peroxisomes 0.0077 0.0003 0.0013 0.0423 0.0265 0.0001 0.0197 0.0001 0.0149 0 0.0103 0.0004 0 0.0016 0.0111 0 0 0.0001
Punctate Nuclear 0.0086 0.0002 0.0004 0.0009 0.0037 0.0003 0.0022 0.0001 0.0002 0 0.0002 0.0001 0 0.0007 0.001 0.0002 0 0.0012
Vacuole 0.0027 0.0016 0.0031 0.001 0.0025 0.0011 0.0054 0.0018 0.0027 0.008 0.0026 0.0007 0.0004 0.0015 0.0025 0.0017 0.0008 0.0005
Vacuole Periphery 0.0018 0.0001 0.0004 0.0004 0.0005 0.0008 0.0012 0 0.0002 0.0001 0.0013 0.0001 0 0.0007 0.0005 0 0 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.3852 8.7231 13.4437 20.3657 13.1383 20.2554 24.7635 22.2086 24.6196 18.8358
Translational Efficiency 0.9323 1.7486 1.0224 1.1375 1.4176 0.8932 0.8218 1.2094 1.0341 1.3277

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1601 1468 240 1361 1359 1588 699 852 2960 3056 939 2213

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 748.41 832.86 1255.79 1139.35 856.57 872.96 1166.63 1167.61 798.07 853.70 1189.42 1150.23
Standard Deviation 82.24 136.23 139.83 164.85 110.72 111.45 145.35 172.06 110.41 125.58 149.12 168.22
Intensity Change Log 2 — 0.154245 0.746694 0.606310 — 0.027344 0.445704 0.446915 — 0.087910 0.593894 0.523438

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000625 0.001617 0.001563 0.015516 0.000578 0.003753 0.001445 0.009520 0.000603 0.002727 0.001475 0.013207
Bud Neck 0.034464 0.024831 0.004083 0.008123 0.010096 0.036962 0.002467 0.008740 0.023276 0.031135 0.002880 0.008360
Bud Site 0.024663 0.059103 0.050309 0.122741 0.018147 0.066846 0.029370 0.097143 0.021672 0.063126 0.034722 0.112886
Cell Periphery 0.002176 0.000337 0.000577 0.002789 0.000851 0.000537 0.000414 0.001630 0.001568 0.000441 0.000456 0.002343
Cytoplasm 0.588291 0.463733 0.432308 0.610567 0.650138 0.443313 0.597497 0.540109 0.616686 0.453122 0.555276 0.583441
Cytoplasmic Foci 0.172428 0.232543 0.159402 0.085290 0.178034 0.236295 0.111242 0.124830 0.175002 0.234493 0.123551 0.100513
Eisosomes 0.002488 0.000374 0.000063 0.000357 0.000608 0.000866 0.000071 0.000244 0.001625 0.000630 0.000069 0.000314
Endoplasmic Reticulum 0.004615 0.002389 0.002276 0.001085 0.003276 0.002623 0.001002 0.001073 0.004000 0.002511 0.001327 0.001080
Endosome 0.016759 0.051338 0.020629 0.005439 0.010443 0.042655 0.006246 0.012318 0.013859 0.046826 0.009922 0.008088
Golgi 0.015167 0.014269 0.000932 0.004886 0.006885 0.021382 0.000581 0.004587 0.011364 0.017965 0.000670 0.004771
Lipid Particles 0.010402 0.005452 0.007859 0.012859 0.004812 0.006228 0.002479 0.012702 0.007836 0.005855 0.003854 0.012799
Mitochondria 0.002736 0.002489 0.000026 0.000847 0.000528 0.004529 0.000026 0.004618 0.001722 0.003549 0.000026 0.002299
Mitotic Spindle 0.001495 0.001650 0.003127 0.008018 0.000087 0.005179 0.000988 0.003159 0.000849 0.003484 0.001535 0.006147
None 0.003786 0.000743 0.000992 0.000444 0.004509 0.000868 0.000281 0.000324 0.004118 0.000808 0.000463 0.000398
Nuclear Periphery 0.000097 0.000078 0.000238 0.000065 0.000063 0.000061 0.000114 0.000076 0.000081 0.000069 0.000145 0.000069
Nuclear Periphery Foci 0.000668 0.000561 0.020093 0.004189 0.002096 0.000664 0.008583 0.003892 0.001324 0.000614 0.011525 0.004075
Nucleolus 0.000506 0.000398 0.000072 0.000166 0.000346 0.000232 0.000068 0.000073 0.000432 0.000312 0.000069 0.000130
Nucleus 0.036928 0.010709 0.012217 0.009153 0.034310 0.009999 0.014916 0.006066 0.035726 0.010340 0.014226 0.007964
Peroxisomes 0.003595 0.007419 0.001007 0.005489 0.001475 0.009807 0.000737 0.006784 0.002622 0.008660 0.000806 0.005987
Vacuole 0.076755 0.115550 0.281792 0.101186 0.072026 0.104528 0.221306 0.159735 0.074584 0.109823 0.236766 0.123727
Vacuole Periphery 0.001357 0.004417 0.000435 0.000791 0.000691 0.002672 0.000167 0.002377 0.001051 0.003510 0.000236 0.001401

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.58 -3.76 -12.52 -11.41 -11.69 -4.46 -4.07 -8.14 -3.74 -7.46 -5.52 -5.35 -14.82 -10.78 -13.91
Bud Neck 4.82 19.42 16.37 11.96 -7.10 -14.07 10.73 1.91 14.33 -5.38 -5.32 21.92 14.77 18.95 -10.02
Bud Site -11.85 -4.19 -21.04 -11.88 -11.99 -16.46 -3.40 -15.83 -3.77 -13.71 -19.77 -4.14 -26.44 -11.62 -21.85
Cell Periphery 12.22 10.98 -1.31 -10.35 -9.55 6.19 12.20 -2.78 -4.55 -5.86 13.19 14.35 -2.98 -11.07 -11.71
Cytoplasm 14.70 9.97 -0.81 -13.15 -9.91 25.13 9.33 11.34 -6.86 1.08 27.63 11.06 7.09 -15.26 -5.48
Cytoplasmic Foci -10.03 3.14 18.48 24.61 6.47 -9.62 14.13 9.15 17.24 -3.67 -14.02 14.33 20.07 30.85 2.21
Eisosomes 16.91 21.51 18.72 0.73 -11.44 -3.09 12.63 8.48 8.91 -7.72 12.43 23.49 19.61 7.16 -13.43
Endoplasmic Reticulum 3.09 4.21 5.83 3.38 3.55 0.93 4.55 4.34 3.45 -0.34 2.93 6.89 7.26 4.79 1.15
Endosome -13.15 -0.14 12.10 18.32 7.08 -16.72 7.89 -0.09 14.59 -4.07 -20.32 7.34 8.98 24.35 1.75
Golgi 1.08 21.32 9.20 8.28 -3.23 -12.31 19.86 3.37 11.90 -2.85 -8.27 27.02 9.14 14.17 -4.40
Lipid Particles 7.34 3.70 -2.35 -6.09 -4.50 -2.83 7.91 -4.52 -3.64 -5.99 4.59 11.19 -5.11 -6.95 -9.36
Mitochondria 0.60 7.20 4.38 4.80 -2.37 -4.63 13.29 -1.51 0.67 -1.80 -3.57 8.26 0.10 2.24 -2.32
Mitotic Spindle -0.35 -1.07 -3.12 -2.94 -1.02 -3.39 -1.32 -2.91 1.11 -2.02 -2.98 -1.34 -4.01 -1.56 -2.75
None 5.55 4.49 6.19 1.36 0.63 4.37 7.41 7.34 0.96 0.27 6.57 9.26 9.42 1.30 0.33
Nuclear Periphery 1.48 -7.91 2.51 0.80 8.63 0.69 -7.92 -1.08 -1.47 4.91 1.77 -10.31 1.08 -0.39 9.50
Nuclear Periphery Foci 1.60 -10.45 -11.97 -12.14 8.25 6.29 -10.23 -5.56 -8.71 5.33 5.96 -14.86 -12.28 -14.47 9.48
Nucleolus 0.91 5.45 3.38 2.58 -1.06 3.43 13.18 10.76 4.97 -0.45 2.01 8.21 5.05 3.41 -1.14
Nucleus 18.94 11.23 19.99 0.28 2.29 19.26 12.71 22.58 5.29 10.63 27.07 17.94 28.94 2.23 8.09
Peroxisomes -7.07 9.94 -2.79 3.31 -8.42 -14.94 9.58 -6.28 4.76 -7.48 -15.33 12.76 -6.49 6.13 -11.55
Vacuole -9.55 -14.44 -10.21 -1.32 11.44 -8.44 -21.76 -17.56 -12.38 8.07 -12.59 -25.99 -19.37 -9.58 16.02
Vacuole Periphery -8.17 10.19 3.11 8.97 -1.44 -11.44 18.30 -1.18 1.13 -1.83 -12.13 16.39 -0.00 6.08 -2.45
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (93%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-10

Sip5

Sip5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sip5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available