Standard name
Human Ortholog
Description Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.25 0.34 0.53 0.48 0.59 0.4 0.5 0.42 0.34 0.33 0.27 0.28 0.34 0.54 0.53 0.86 0.88 0.85 0.14 0.3 0.35 0.29 0.4 0.35
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 0.06 0 0 0 0 0 0
Endosome 0.05 0 0 0 0 0 0 0 0 0 0 0 0.08 0.07 0 0 0 0 0.06 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.32 0.38 0.47 0.6 0.38 0.63 0.56 0.57 0.7 0.77 0.79 0.77 0.15 0.08 0.33 0.06 0 0 0.11 0.08 0.14 0 0.05 0.08
Nucleus 0.24 0.07 0 0.06 0 0.07 0.08 0.11 0.08 0.1 0.11 0.13 0.14 0.17 0.06 0 0 0 0.25 0.23 0.08 0.26 0.13 0.08
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0.06 0.07 0.06
Vac/Vac Membrane 0.26 0.47 0.05 0 0.09 0.06 0 0 0 0 0 0.06 0.35 0.23 0.21 0.15 0.15 0.16 0.25 0.25 0.29 0.3 0.24 0.27
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 3 5
Bud 2 1 0 3 3 3 3 7 5 6 5 8 0 1 3 0 0 0 2 1 0 1 4 7
Bud Neck 0 0 0 0 1 3 4 2 2 0 1 3 0 0 0 1 0 0 0 1 0 0 5 5
Bud Site 0 0 0 1 1 1 7 10 2 4 7 15 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0
Cytoplasm 37 29 42 75 133 87 191 124 70 93 50 87 22 97 124 145 131 149 30 32 35 29 86 107
Endoplasmic Reticulum 0 1 1 0 0 1 0 0 0 0 0 0 1 2 0 13 8 11 1 1 0 0 1 2
Endosome 7 2 0 0 7 1 3 1 0 0 0 0 5 12 3 3 1 5 13 0 4 0 3 10
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 2
Mitochondria 47 33 37 93 86 137 216 168 143 213 144 239 10 15 78 10 5 4 24 8 13 2 10 23
Nucleus 36 6 1 10 9 15 30 32 17 28 21 39 9 30 14 2 5 1 57 24 7 25 28 23
Nuclear Periphery 0 1 0 1 0 0 0 0 0 1 0 4 0 0 0 0 0 0 3 0 0 0 0 0
Nucleolus 0 0 1 0 0 0 1 1 0 1 0 0 0 0 0 0 0 0 1 0 0 0 0 2
Peroxisomes 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 1 1 2 3 3 3 1 3 2 3 0 0 0 0 0 0 20 4 3 6 14 19
Vac/Vac Membrane 38 40 4 0 21 12 16 6 4 7 5 20 23 41 49 26 23 29 57 27 28 30 53 83
Unique Cell Count 148 86 79 155 225 216 383 294 204 278 183 309 65 180 233 169 149 176 228 107 101 101 217 307
Labelled Cell Count 168 114 87 184 264 263 475 354 244 356 235 418 70 198 271 201 173 200 228 107 101 101 217 307


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.2 3.9 3.2 3.2 3.6 3.2 3.2 3.2 2.7 2.8 2.9 2.8 4.5 4.3 3.7 5.0 5.2 5.8 4.1 4.2 4.6
Std Deviation (1e-4) 1.0 1.5 0.6 1.3 1.8 1.5 1.8 1.5 1.3 1.7 1.1 1.7 1.2 0.8 1.0 1.1 0.9 1.8 0.8 1.4 1.5
Intensity Change (Log2) – – – 0.01 0.16 -0.01 -0.0 -0.0 -0.23 -0.2 -0.17 -0.21 0.5 0.41 0.19 0.65 0.68 0.84 0.35 0.4 0.52

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.3 2.3 2.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.0275 0.0002 0.0086 0.0223 0.083 0.0147 0.0338 0.0121 0.0219 0.0024 0.0003 0.0042 0.0001 0.0002 0.0002 0.0007 0.0001 0.0004
Bud 0.0002 0.0001 0.0003 0.0003 0.0008 0.0012 0.0037 0.0007 0.0009 0.0003 0.0001 0.0014 0 0.0002 0 0 0 0.0002
Bud Neck 0.002 0.0003 0.0006 0.0008 0.0035 0.0074 0.0008 0.0003 0.0005 0.0007 0.0001 0.0033 0.0002 0 0.0001 0.0001 0.0001 0.0009
Bud Periphery 0.0002 0.0001 0.0004 0.0005 0.0026 0.0012 0.0036 0.0006 0.0013 0.0003 0 0.0027 0 0.0002 0 0 0 0.0001
Bud Site 0.0019 0.0011 0.0022 0.0018 0.0055 0.0007 0.0084 0.0014 0.0068 0.0012 0.0001 0.0003 0.0005 0.0001 0.0002 0 0.0001 0.0001
Cell Periphery 0.0001 0.0002 0.0002 0.0003 0.0002 0.0001 0.0007 0.0001 0.0002 0.0001 0 0.0001 0.0001 0 0 0 0 0
Cytoplasm 0.1064 0.2813 0.1669 0.1837 0.1614 0.2708 0.1907 0.3558 0.3259 0.2319 0.2295 0.4098 0.0278 0.0219 0.1545 0.0895 0.0504 0.2266
Cytoplasmic Foci 0.0274 0.0111 0.009 0.006 0.01 0.0101 0.0434 0.0114 0.0121 0.0179 0.0041 0.0106 0.0031 0.0063 0.0042 0.0015 0.004 0.0117
Eisosomes 0.0008 0.0001 0.0005 0.0007 0.0003 0.0002 0.0007 0.0001 0.0001 0.0001 0 0.0001 0.0003 0.0002 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0029 0.0081 0.0048 0.0064 0.0034 0.0036 0.0112 0.0048 0.0038 0.0019 0.0046 0.0034 0.0005 0.0007 0.0035 0.0021 0.0006 0.0028
Endosome 0.0073 0.0035 0.0044 0.0068 0.0084 0.0033 0.0159 0.0032 0.0065 0.0289 0.0026 0.0032 0.0004 0.0003 0.0021 0.0009 0.001 0.0034
Golgi 0.003 0.0002 0.0011 0.0032 0.0027 0.0006 0.0063 0.0002 0.0057 0.007 0.0001 0.0007 0 0.0001 0.0001 0.0001 0 0.0001
Lipid Particles 0.0216 0.0007 0.0048 0.0025 0.0044 0.0008 0.0094 0.0005 0.0022 0.005 0.0001 0.0018 0.0005 0.0005 0.0003 0.0002 0.0001 0.0003
Mitochondria 0.001 0.0004 0.0013 0.006 0.0111 0.0007 0.0577 0.0006 0.0153 0.0103 0.0005 0.0081 0.0004 0.0003 0.0005 0.001 0.0006 0.0005
None 0.6451 0.5695 0.6106 0.6209 0.4866 0.4914 0.427 0.4795 0.4053 0.4855 0.6353 0.3422 0.9027 0.9646 0.7549 0.8679 0.6976 0.6328
Nuclear Periphery 0.0046 0.0201 0.011 0.007 0.0323 0.0053 0.0275 0.0058 0.0086 0.0034 0.0084 0.0118 0.0016 0.0007 0.0054 0.0062 0.0011 0.0046
Nucleolus 0.002 0.0017 0.0034 0.0028 0.0044 0.0018 0.0038 0.0008 0.0014 0.0009 0.0003 0.0012 0.008 0.0003 0.0021 0.0005 0.0014 0.001
Nucleus 0.114 0.0741 0.147 0.1113 0.1244 0.1663 0.0911 0.1041 0.1432 0.1779 0.1101 0.1757 0.0329 0.0006 0.0612 0.0253 0.2405 0.0847
Peroxisomes 0.0148 0.0002 0.0058 0.0007 0.0293 0.0005 0.0139 0.0007 0.0038 0.0064 0.0001 0.0011 0.0001 0.0003 0.0001 0.0001 0.0001 0.0002
Punctate Nuclear 0.0157 0.0235 0.0149 0.0133 0.0209 0.0172 0.0322 0.0155 0.0253 0.0102 0.0023 0.0163 0.02 0.0021 0.0088 0.0029 0.0014 0.0283
Vacuole 0.0011 0.0031 0.002 0.0022 0.0026 0.0016 0.0112 0.0018 0.0086 0.0052 0.001 0.0015 0.0007 0.0003 0.0013 0.0004 0.0005 0.0013
Vacuole Periphery 0.0002 0.0003 0.0004 0.0006 0.0024 0.0002 0.0068 0.0002 0.0007 0.0026 0.0003 0.0005 0.0001 0.0001 0.0002 0.0002 0.0001 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.1169 7.6842 12.4408 10.765 9.6252 6.2481 10.5948 11.8385 11.9859 14.4302
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
814 779 911 1033 956 1465 607 1907 1770 2244 1518 2940

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 543.80 746.31 909.37 779.65 606.69 718.09 840.69 767.52 577.77 727.89 881.91 771.78
Standard Deviation 67.82 94.59 126.63 100.27 88.63 105.10 91.47 109.83 85.68 102.46 118.75 106.73
Intensity Change Log 2 — 0.456699 0.741791 0.519750 — 0.243205 0.470614 0.339245 — 0.348061 0.605156 0.427383

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000040 0.000379 0.000625 0.001497 0.000051 0.001632 0.000394 0.000583 0.000046 0.001197 0.000532 0.000904
Bud Neck 0.005274 0.010218 0.006346 0.009952 0.004488 0.027187 0.004889 0.017031 0.004850 0.021296 0.005763 0.014543
Bud Site 0.001148 0.004429 0.010714 0.033530 0.001956 0.014186 0.002844 0.017969 0.001585 0.010799 0.007567 0.023437
Cell Periphery 0.000177 0.000145 0.000150 0.000231 0.000135 0.000130 0.000081 0.000168 0.000154 0.000135 0.000123 0.000190
Cytoplasm 0.331574 0.261864 0.070527 0.258940 0.312889 0.322924 0.043024 0.219760 0.321482 0.301727 0.059529 0.233527
Cytoplasmic Foci 0.065356 0.108786 0.003059 0.010314 0.093611 0.100853 0.000854 0.003496 0.080617 0.103607 0.002177 0.005892
Eisosomes 0.000078 0.000084 0.000040 0.000047 0.000070 0.000069 0.000029 0.000026 0.000074 0.000074 0.000036 0.000034
Endoplasmic Reticulum 0.001006 0.002169 0.006145 0.004469 0.000786 0.002161 0.005144 0.003745 0.000887 0.002164 0.005745 0.003999
Endosome 0.001762 0.008273 0.001084 0.005946 0.002484 0.009728 0.000570 0.001587 0.002152 0.009223 0.000878 0.003119
Golgi 0.000178 0.003612 0.000080 0.007932 0.000275 0.002862 0.000050 0.000358 0.000230 0.003122 0.000068 0.003019
Lipid Particles 0.005534 0.008349 0.001115 0.001410 0.007368 0.008315 0.000587 0.001039 0.006525 0.008327 0.000903 0.001169
Mitochondria 0.001806 0.011781 0.000893 0.003331 0.003310 0.014751 0.001664 0.002984 0.002618 0.013720 0.001201 0.003106
Mitotic Spindle 0.000066 0.015239 0.008185 0.029553 0.000422 0.020105 0.007641 0.021929 0.000258 0.018416 0.007967 0.024608
None 0.018934 0.007047 0.005258 0.008345 0.016590 0.004070 0.005645 0.007331 0.017668 0.005104 0.005413 0.007687
Nuclear Periphery 0.001219 0.002909 0.001230 0.002348 0.001217 0.002349 0.001435 0.003265 0.001218 0.002543 0.001312 0.002943
Nuclear Periphery Foci 0.000401 0.001011 0.000586 0.002629 0.000494 0.001145 0.000460 0.000571 0.000451 0.001099 0.000535 0.001294
Nucleolus 0.003756 0.004140 0.001222 0.000986 0.003345 0.004060 0.001230 0.000988 0.003534 0.004088 0.001225 0.000988
Nucleus 0.548622 0.508216 0.866316 0.568197 0.538313 0.392334 0.912747 0.666770 0.543054 0.432562 0.884882 0.632135
Peroxisomes 0.001312 0.012500 0.000318 0.001066 0.002375 0.009861 0.000345 0.000217 0.001886 0.010777 0.000329 0.000515
Vacuole 0.010718 0.027508 0.015920 0.048246 0.009481 0.058866 0.010221 0.026861 0.010050 0.047980 0.013641 0.034374
Vacuole Periphery 0.001039 0.001340 0.000188 0.001031 0.000339 0.002411 0.000149 0.003322 0.000661 0.002039 0.000173 0.002517

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -7.61 -15.24 -3.89 -2.45 -0.35 -2.67 -10.58 -5.82 1.78 0.51 -3.01 -18.37 -6.36 1.14 0.77
Bud Neck -3.20 -1.46 -3.44 0.16 -2.25 -9.25 -1.58 -7.29 4.33 -6.42 -9.73 -2.23 -8.04 4.16 -6.51
Bud Site -5.14 -3.69 -5.96 -4.61 -2.43 -6.11 -1.04 -5.76 0.87 -5.54 -7.20 -3.63 -8.51 -1.75 -3.92
Cell Periphery 1.59 2.13 0.28 -1.26 -1.59 0.53 3.02 0.59 0.15 -2.20 1.81 2.83 1.03 -0.67 -1.52
Cytoplasm 5.61 26.42 11.51 5.91 -16.81 -0.95 30.73 14.59 18.13 -22.64 2.44 39.66 18.90 18.12 -26.70
Cytoplasmic Foci -6.17 16.05 14.55 17.87 -6.19 -0.95 20.59 20.06 25.91 -6.61 -4.91 25.85 24.85 31.38 -6.92
Eisosomes -1.03 4.87 1.51 2.58 -4.62 0.30 6.38 10.08 9.68 2.43 -0.22 7.56 8.28 8.55 0.11
Endoplasmic Reticulum -3.54 -14.54 -13.80 -13.40 2.53 -4.15 -13.85 -18.22 -7.24 5.48 -4.95 -20.74 -20.58 -12.75 7.03
Endosome -6.08 1.28 -3.12 4.13 -4.81 -7.86 5.27 3.71 9.65 -2.41 -10.00 4.23 0.22 10.28 -4.66
Golgi -3.54 2.05 -1.94 0.46 -2.00 -3.86 6.18 1.50 3.99 -2.65 -5.23 5.75 -1.83 2.77 -2.15
Lipid Particles -3.05 6.80 5.88 9.79 -3.78 -0.76 10.16 9.61 9.00 -1.09 -2.33 11.98 11.27 12.23 -1.79
Mitochondria -4.55 2.40 -0.74 4.35 -2.81 -6.37 1.92 0.92 7.82 -2.17 -8.16 2.68 0.47 8.88 -4.35
Mitotic Spindle -4.64 -3.74 -7.42 -2.09 -3.88 -7.31 -2.54 -8.31 0.24 -3.75 -8.68 -4.48 -11.15 -1.02 -5.16
None 5.21 6.97 5.67 0.48 -2.65 5.82 5.39 4.68 -3.73 -2.16 8.14 8.70 7.30 -2.20 -3.71
Nuclear Periphery -2.21 -3.72 -13.09 -2.41 -11.96 -3.80 -6.25 -10.69 -5.19 -6.13 -4.03 -7.14 -15.34 -5.33 -11.51
Nuclear Periphery Foci -3.88 -2.51 -3.65 -3.04 -3.11 -2.70 -1.68 -1.31 2.13 1.02 -3.85 -3.00 -3.84 -1.89 -2.51
Nucleolus -0.57 5.24 5.28 7.48 0.22 -1.45 5.14 6.51 5.68 0.37 -1.33 7.50 8.21 8.07 0.73
Nucleus 2.46 -25.29 -3.45 -5.93 22.68 11.92 -30.23 -14.17 -30.73 20.43 11.45 -38.77 -13.66 -27.43 28.83
Peroxisomes -6.45 6.73 3.29 6.88 -2.24 -7.38 6.46 6.87 10.30 0.62 -10.01 8.61 8.03 12.13 -1.15
Vacuole -4.98 -4.23 -16.03 -13.06 -13.64 -15.99 -5.13 -14.87 3.49 -5.50 -15.75 -7.10 -20.80 -5.24 -13.43
Vacuole Periphery -0.64 2.01 1.25 3.25 -1.94 -2.92 4.36 -2.11 0.92 -2.48 -2.72 2.54 -1.22 1.42 -2.69
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages nucleus (41%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Ecm5

Ecm5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ecm5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available