Standard name
Human Ortholog
Description Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.31 0.28 0.15 0 0 0 0 0 0
Cytoplasm 0.99 0.99 1.0 0.99 0.99 0.98 1.0 0.94 0.93 0.95 0.87 0.93 1.0 0.98 1.0 0.84 0.83 0.91 0.98 0.96 0.97 0.89 0.92 0.89
Endoplasmic Reticulum 0 0 0 0 0 0 0 0.05 0 0 0.1 0 0 0 0 0 0.05 0.1 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 1 0 0 0 2 3 3 1 0 2 0 0 0 0 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 3 2 2 3 7 1 5 6 5 7 7 0 1 2 89 71 34 0 0 1 0 0 0
Cytoplasm 233 126 181 148 164 220 211 179 202 238 241 194 160 188 209 241 207 203 244 141 181 74 171 154
Endoplasmic Reticulum 0 0 0 0 0 1 1 9 9 8 28 8 0 1 0 8 13 22 0 0 0 2 4 7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 2 2 0 2 0 1 2 1
Unique Cell Count 235 127 181 149 165 224 212 191 218 251 278 208 160 191 210 287 250 222 251 147 186 84 186 173
Labelled Cell Count 237 129 183 150 168 228 213 193 221 254 283 210 160 192 211 338 293 261 251 147 186 84 186 173


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 340.7 337.5 292.3 254.4 249.3 229.8 236.7 218.8 211.9 203.2 188.9 220.9 321.5 354.5 369.7 523.8 500.8 439.2 286.4 318.1 349.3
Std Deviation (1e-4) 70.7 75.2 63.0 68.1 54.9 56.9 54.7 52.4 63.4 61.1 57.6 72.1 72.9 85.5 97.2 138.8 151.5 146.5 70.2 72.0 99.6
Intensity Change (Log2) – – – -0.2 -0.23 -0.35 -0.3 -0.42 -0.46 -0.52 -0.63 -0.4 0.14 0.28 0.34 0.84 0.78 0.59 -0.03 0.12 0.26

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000200400600WT3HU80HU120HU1600200400600WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30200400600WT1AF100AF140AF1800200400600
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 8.0 7.5 5.0
Cytoplasm -1.1 -1.0 -1.8 -0.9 -3.4 -3.7 -3.1 -5.1 -3.6 0 -1.7 -0.9 -5.7 -5.9 -4.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 4.4 0 0 0 0 0 3.1 4.4
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 247.7904 365.8219 331.0484 279.12 323.892 331.2065 324.4983 456.684 383.6641 352.3952 324.964 374.2412 282.853 399.1479 342.4086 285.4149 326.2491 423.9381
Actin 0.0033 0.0001 0.0002 0.0001 0.0004 0.0002 0.0028 0.0001 0.0007 0.0012 0.0066 0.0002 0.0019 0.0002 0.0008 0.0008 0.0004 0.0002
Bud 0.0021 0.0001 0.0012 0.0002 0.0003 0.0002 0.0011 0.0001 0.001 0.0002 0.0034 0.0006 0.0008 0.0003 0.0009 0.0004 0.0011 0.0001
Bud Neck 0.0005 0.0003 0.0004 0.0005 0.0008 0.0011 0.0002 0.0001 0.0003 0.0004 0.0007 0.0004 0.0002 0.0001 0.0003 0.0002 0.0005 0.0003
Bud Periphery 0.001 0 0.0004 0 0.0001 0.0001 0.0009 0 0.0003 0.0001 0.0059 0.0001 0.0004 0.0001 0.0004 0.0003 0.0003 0
Bud Site 0.001 0.0002 0.0001 0.0001 0 0.0001 0.0005 0 0.0002 0.0001 0.0007 0.0001 0.0006 0.0001 0.0014 0.0001 0.0009 0
Cell Periphery 0.004 0.0026 0.0007 0.0008 0.0003 0.0011 0.0016 0.0001 0.0005 0.0012 0.0014 0.0017 0.0012 0.0001 0.0013 0.001 0.0014 0
Cytoplasm 0.7963 0.9757 0.9554 0.8252 0.927 0.9254 0.8449 0.9938 0.9339 0.9134 0.7783 0.9727 0.8854 0.9835 0.9577 0.8623 0.898 0.9877
Cytoplasmic Foci 0.0127 0.0001 0.0077 0.0457 0.0097 0.0004 0.0083 0.0001 0.0088 0.0087 0.0043 0.0023 0.002 0.0002 0.0022 0.0003 0.0143 0.0002
Eisosomes 0.001 0.0003 0.0002 0.0007 0.0003 0.0001 0.0008 0 0.0003 0.0003 0.0002 0 0.0003 0 0.0004 0.0001 0.0001 0
Endoplasmic Reticulum 0.0015 0.0004 0.0002 0.0002 0.0003 0.0003 0.0035 0.0001 0.0009 0.0002 0.0122 0.0012 0.0017 0.0001 0.0004 0.0002 0.0003 0.0001
Endosome 0.0035 0 0.0001 0.0002 0.0001 0.0002 0.0036 0 0.0049 0.0002 0.0233 0.0019 0.0009 0 0.0004 0.0006 0.0019 0
Golgi 0.0008 0 0 0.0001 0 0 0.0005 0 0.0003 0.0004 0.0022 0.0001 0.0002 0 0.0001 0.0001 0.0003 0
Lipid Particles 0.0027 0.0001 0.0014 0.0079 0.0015 0.0001 0.0022 0 0.001 0.0015 0.0014 0.0002 0.0007 0 0.0006 0.0001 0.0017 0
Mitochondria 0.0182 0.0005 0.0039 0.0224 0.0027 0.0028 0.017 0.0002 0.0067 0.037 0.0409 0.0001 0.005 0.0015 0.0048 0.0257 0.0119 0.0003
None 0.0142 0.0011 0.0033 0.0051 0.0179 0.0009 0.0099 0.0003 0.0121 0.0093 0.0224 0.0006 0.003 0.0013 0.0047 0.0008 0.0059 0.0003
Nuclear Periphery 0.0276 0.0035 0.0033 0.0125 0.0052 0.0049 0.0336 0.001 0.0083 0.0038 0.0292 0.0034 0.0442 0.0006 0.0026 0.0432 0.002 0.0019
Nucleolus 0.0193 0.0025 0.0093 0.0444 0.0099 0.0156 0.0171 0.0001 0.0042 0.0069 0.016 0.0002 0.0064 0.005 0.0047 0.0041 0.0116 0
Nucleus 0.0662 0.0093 0.0089 0.0229 0.0199 0.0273 0.0375 0.0037 0.0096 0.0105 0.0223 0.0044 0.0313 0.006 0.012 0.0308 0.0099 0.0085
Peroxisomes 0.0056 0 0.0003 0.0023 0.0002 0.0001 0.0008 0 0.0003 0.0002 0.0003 0 0.0002 0 0.0002 0.0001 0.0009 0
Punctate Nuclear 0.0017 0.0001 0.0004 0.0006 0.001 0.0005 0.0039 0 0.0012 0.0004 0.0011 0.0003 0.0005 0.0001 0.0006 0.0001 0.0003 0.0001
Vacuole 0.011 0.0025 0.0016 0.0043 0.0011 0.0117 0.0041 0.0002 0.0023 0.0025 0.0124 0.0077 0.0047 0.0006 0.0022 0.0046 0.0228 0.0001
Vacuole Periphery 0.0056 0.0003 0.0009 0.0037 0.0011 0.0068 0.0052 0.0001 0.0023 0.0016 0.0147 0.0018 0.0084 0.0002 0.0013 0.024 0.0136 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 1457.6608 1901.4985 2317.0988 2096.006 1879.1137 1531.3107 1941.6739 2077.539 2467.6115 1782.5861
Translational Efficiency 1.6911 1.6312 1.4993 1.8437 1.6451 1.3479 1.4698 1.6549 1.3589 1.6221

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2078 909 1332 1124 1828 779 1141 17 3906 1688 2473 1141

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 18117.87 20309.75 30040.48 46516.54 17615.65 20063.54 39532.58 51141.09 17882.83 20196.13 34419.97 46585.44
Standard Deviation 4192.85 5210.82 6492.14 10115.62 3730.86 4804.07 7642.08 7493.05 3991.19 5028.70 8487.50 10097.11
Intensity Change Log 2 — 0.164759 0.729495 1.360330 — 0.187718 1.166184 1.537625 — 0.176123 0.961251 1.450455

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000024 0.000082 0.000073 0.000385 0.000031 0.000085 0.000117 0.000104 0.000027 0.000083 0.000093 0.000381
Bud Neck 0.000103 0.000614 0.001661 0.001066 0.000208 0.000583 0.000938 0.001879 0.000152 0.000600 0.001327 0.001078
Bud Site 0.001036 0.001975 0.000520 0.003899 0.000576 0.001048 0.001204 0.000516 0.000821 0.001547 0.000835 0.003848
Cell Periphery 0.002284 0.007959 0.004220 0.153921 0.003533 0.008957 0.045247 0.117494 0.002868 0.008420 0.023149 0.153378
Cytoplasm 0.930855 0.837283 0.752028 0.210782 0.903015 0.831308 0.665363 0.219214 0.917826 0.834526 0.712042 0.210908
Cytoplasmic Foci 0.002146 0.009552 0.009230 0.002560 0.003457 0.012102 0.002447 0.004181 0.002759 0.010729 0.006100 0.002584
Eisosomes 0.000000 0.000002 0.000003 0.000056 0.000001 0.000002 0.000012 0.000032 0.000001 0.000002 0.000007 0.000055
Endoplasmic Reticulum 0.000082 0.000037 0.000031 0.000120 0.000028 0.000079 0.000041 0.000012 0.000056 0.000056 0.000036 0.000119
Endosome 0.000032 0.000082 0.000060 0.001031 0.000039 0.000134 0.000028 0.000015 0.000035 0.000106 0.000045 0.001016
Golgi 0.003032 0.005332 0.003079 0.000911 0.003538 0.004448 0.001202 0.000227 0.003269 0.004924 0.002213 0.000901
Lipid Particles 0.000669 0.003646 0.002161 0.003145 0.001688 0.002776 0.007564 0.013437 0.001146 0.003244 0.004654 0.003299
Mitochondria 0.000110 0.000208 0.000253 0.000357 0.000117 0.000171 0.000082 0.000013 0.000113 0.000191 0.000174 0.000352
Mitotic Spindle 0.000267 0.001464 0.000343 0.000771 0.000637 0.000919 0.000061 0.000017 0.000440 0.001212 0.000213 0.000760
None 0.009144 0.007927 0.004785 0.002065 0.010663 0.010478 0.002528 0.000097 0.009855 0.009105 0.003743 0.002036
Nuclear Periphery 0.000074 0.000471 0.001540 0.000198 0.000338 0.000421 0.000495 0.000762 0.000197 0.000448 0.001058 0.000206
Nuclear Periphery Foci 0.000996 0.002577 0.002196 0.000512 0.002325 0.002018 0.001808 0.001228 0.001618 0.002319 0.002017 0.000522
Nucleolus 0.000035 0.000367 0.000094 0.000144 0.000054 0.000122 0.000061 0.000025 0.000044 0.000254 0.000079 0.000143
Nucleus 0.040651 0.093160 0.181273 0.008021 0.056486 0.104486 0.061371 0.019697 0.048062 0.098387 0.125952 0.008195
Peroxisomes 0.000007 0.000036 0.000003 0.000066 0.000005 0.000018 0.000010 0.000003 0.000006 0.000028 0.000007 0.000065
Vacuole 0.004643 0.023212 0.032945 0.609045 0.009066 0.016885 0.207562 0.620556 0.006713 0.020292 0.113511 0.609217
Vacuole Periphery 0.003811 0.004015 0.003502 0.000945 0.004195 0.002959 0.001858 0.000491 0.003991 0.003528 0.002744 0.000938

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.25 -13.28 -2.26 -1.79 -1.80 -2.36 -12.76 -3.14 -1.16 -0.22 -4.01 -18.36 -2.24 -1.84 -1.75
Bud Neck -6.03 -12.27 -4.56 -1.82 5.43 -3.13 -11.25 -2.44 -2.17 -1.75 -6.33 -15.17 -4.49 -2.14 3.70
Bud Site -2.21 1.33 -2.96 -1.75 -3.21 -1.93 -3.66 -0.86 0.53 1.18 -2.76 -1.38 -3.15 -2.30 -3.00
Cell Periphery -6.80 -5.76 -29.17 -27.59 -28.56 -4.88 -16.54 -4.34 -4.07 -2.55 -8.20 -16.56 -29.27 -27.85 -24.83
Cytoplasm 15.15 31.52 88.92 60.00 43.47 10.64 25.91 10.80 9.43 6.55 18.30 40.35 88.75 67.73 46.98
Cytoplasmic Foci -8.09 -11.70 -0.73 5.48 8.91 -6.91 0.19 -1.32 -0.30 -1.33 -10.53 -10.72 -0.14 6.89 6.48
Eisosomes -5.60 -9.99 -2.57 -2.49 -2.39 -3.15 -3.84 -4.14 -3.91 -2.59 -5.68 -5.40 -2.58 -2.51 -2.26
Endoplasmic Reticulum 0.92 0.94 -0.57 -1.81 -1.83 -0.91 -3.76 1.91 1.12 4.36 -0.00 0.68 -1.20 -1.20 -1.78
Endosome -2.86 -6.01 -1.83 -1.71 -1.70 -1.66 0.56 0.97 1.86 0.74 -2.63 -4.72 -1.82 -1.67 -1.75
Golgi -4.29 -0.88 3.62 6.67 4.39 -1.49 7.60 9.72 7.47 4.37 -4.15 3.30 4.47 6.78 2.97
Lipid Particles -6.23 -7.38 -7.52 0.74 -0.65 -2.22 -8.39 -2.34 -2.17 -1.25 -6.16 -10.61 -6.53 -0.47 4.15
Mitochondria -2.02 -10.59 -2.18 -0.98 -0.56 -1.61 1.56 5.31 3.98 6.16 -2.55 -7.69 -2.15 -1.24 -1.36
Mitotic Spindle -1.89 -1.92 -1.11 0.97 -0.68 -0.28 1.93 2.09 1.83 4.58 -1.60 1.31 -0.46 0.89 -1.07
None 1.78 8.57 7.20 5.65 2.71 0.29 10.88 14.35 11.73 10.04 1.36 13.80 8.36 7.14 1.68
Nuclear Periphery -8.05 -7.48 -10.04 5.67 7.03 -1.07 -2.78 -2.15 -1.69 -1.27 -4.58 -7.90 -0.30 5.56 8.08
Nuclear Periphery Foci -5.74 -5.63 2.74 8.45 7.88 0.96 0.78 0.79 0.33 0.46 -3.41 -3.88 7.19 10.42 10.80
Nucleolus -1.17 -12.24 -1.97 0.74 -0.40 -1.84 -0.96 0.36 1.93 1.08 -1.40 -8.17 -1.81 0.66 -0.88
Nucleus -12.71 -29.77 12.55 19.21 34.66 -10.67 -4.27 0.85 3.58 1.78 -16.51 -25.87 17.15 26.30 33.92
Peroxisomes -1.15 0.66 -1.78 -0.72 -1.82 -1.19 -2.33 0.10 1.20 2.00 -1.50 -1.01 -1.80 -1.03 -1.76
Vacuole -7.80 -13.36 -76.72 -69.35 -65.14 -3.69 -25.38 -9.10 -8.94 -5.79 -8.41 -26.69 -76.91 -72.78 -54.16
Vacuole Periphery -0.26 0.20 5.20 4.66 5.94 1.07 2.58 3.90 3.26 5.39 0.64 2.05 5.86 5.31 6.81
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Hsc82

Hsc82


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hsc82-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available