Standard name
Human Ortholog
Description Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0.15 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0.06 0 0.05
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.05 0 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.05 0.06 0 0.14 0.09 0.06 0.11 0.06 0 0.06 0 – – – 0.1 0.15 0.09 0 0 0 0 0 0.09
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0.06 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0.05 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0.08 0.06 0
Mitochondria 0.3 0.09 0.17 0.17 0 0.16 0.15 0.21 0.38 0.37 0.59 0.36 – – – 0.08 0.07 0 0 0 0 0.08 0.06 0
Nucleus 0.81 0.82 0.94 0.89 0.78 0.76 0.79 0.76 0.73 0.78 0.7 0.85 – – – 0.69 0.59 0.74 0.74 0.76 0.69 0.62 0.38 0.59
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0.05 0
Vac/Vac Membrane 0 0.13 0 0 0.07 0.08 0.09 0 0 0 0.05 0 – – – 0.16 0.19 0.15 0.12 0.11 0.16 0.16 0.05 0.09
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 1 0 0 0 0 3 0
Bud 0 0 0 0 0 1 1 1 0 0 1 0 – – – 2 1 0 1 5 0 0 0 1
Bud Neck 0 0 0 0 0 0 1 1 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 1 0 0 2 4 2 2 8 3 – – – 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0 0 0 0
Cytoplasm 6 13 1 2 23 17 17 38 15 6 10 6 – – – 25 28 18 0 5 0 0 0 2
Endoplasmic Reticulum 1 0 0 0 0 0 0 1 1 0 0 0 – – – 16 9 9 0 0 1 0 0 0
Endosome 0 3 0 0 1 2 0 5 1 0 1 1 – – – 14 8 6 1 2 1 0 0 0
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 – – – 1 0 2 0 4 0 0 1 0
Mitochondria 49 22 3 14 5 30 45 69 89 75 103 69 – – – 20 12 7 6 2 1 0 1 0
Nucleus 135 209 17 71 128 147 232 252 169 160 121 162 – – – 180 108 148 138 218 51 8 8 16
Nuclear Periphery 0 0 0 0 0 1 0 3 2 0 3 1 – – – 1 1 0 4 1 0 0 0 0
Nucleolus 1 0 0 1 0 1 1 1 1 0 2 3 – – – 2 0 1 7 5 1 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – – 1 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 1 3 4 6 9 2 3 1 0 – – – 4 1 2 2 6 1 0 1 0
Vac/Vac Membrane 7 32 0 3 11 15 25 9 5 6 9 3 – – – 43 34 30 21 30 11 2 1 2
Unique Cell Count 166 255 18 80 165 193 294 332 233 204 174 190 261 182 201 188 287 74 13 21 28
Labelled Cell Count 199 281 21 93 171 218 330 393 287 252 259 248 309 202 224 188 287 74 13 21 28


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.1 5.0 5.0 4.9 6.6 5.0 5.0 5.3 4.5 4.4 4.2 4.3 – – – 6.6 6.6 6.6 – – –
Std Deviation (1e-4) 0.5 1.2 0.7 1.3 2.8 1.4 1.3 1.8 1.2 0.9 1.4 0.8 – – – 1.3 1.6 1.8 – – –
Intensity Change (Log2) – – – -0.02 0.42 0.01 0.01 0.1 -0.15 -0.19 -0.23 -0.2 – – – 0.42 0.41 0.4 – – –

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT302468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT102468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Nucleus -0.7 -1.7 -1.8 -1.6 -1.8 -2.0 -1.6 -2.2 -1.1 – – – -2.3 -2.9 -2.0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – – – 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – – – 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 – – – 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.1205 0.8859 0.8455 1.0709 0.579 0.6035 0.787 1.05 0.7635 1.1006 2.0759 0.8288 0.4081 0.4293 0.206 0.5344 0.1766 0.1305
Actin 0.0098 0.0001 0.0012 0.0043 0.0023 0.0004 0.0121 0.0001 0.0125 0.0331 0.0165 0.001 0.0142 0 0.0141 0.0033 0.0415 0.001
Bud 0.0006 0.0009 0.0004 0.0024 0.0001 0.0001 0.0004 0 0.0002 0.0013 0.0025 0.0001 0.0004 0.0001 0.0004 0.0003 0.0005 0.0001
Bud Neck 0.0033 0.0001 0.0004 0.0036 0.0002 0.001 0.0016 0.0001 0.0011 0.0013 0.0059 0.001 0.001 0.0001 0.0008 0.002 0.0012 0.001
Bud Periphery 0.0014 0.0002 0.0012 0.0048 0.0002 0.0002 0.0009 0 0.0003 0.0018 0.0065 0.0003 0.0013 0.0001 0.0009 0.0015 0.0011 0.0003
Bud Site 0.0027 0.0003 0.0011 0.0034 0.0003 0.0002 0.0016 0.0001 0.0018 0.0038 0.0555 0.0001 0.0016 0.0001 0.0012 0.0006 0.0011 0.0005
Cell Periphery 0.0004 0 0.0003 0.0006 0 0 0.0002 0 0.0001 0.0012 0.0036 0 0.0002 0 0.0002 0.0002 0.0006 0.0001
Cytoplasm 0.0046 0.0009 0.0015 0.0029 0.0004 0.0003 0.0057 0.0009 0.0017 0.0034 0.012 0.0001 0.0074 0.007 0.0015 0.0004 0.0075 0.0015
Cytoplasmic Foci 0.0145 0.0007 0.0035 0.0081 0.0044 0.001 0.0282 0 0.0058 0.0507 0.0443 0.0012 0.0068 0.0001 0.0016 0.0065 0.0116 0.0005
Eisosomes 0.0002 0 0.0001 0.0001 0 0 0.0002 0 0.0002 0.0003 0.0004 0 0.0001 0 0.0004 0.0001 0.0008 0.0001
Endoplasmic Reticulum 0.005 0.0001 0.0038 0.0013 0.0004 0.0001 0.0025 0.0001 0.0003 0.0029 0.0099 0.0003 0.0029 0.0003 0.001 0.0007 0.0059 0.0003
Endosome 0.0289 0.002 0.014 0.0299 0.0139 0.0076 0.0265 0.0001 0.003 0.039 0.056 0.0016 0.0145 0.0002 0.0028 0.0031 0.0234 0.0012
Golgi 0.0075 0.0006 0.0075 0.0166 0.006 0.0046 0.0062 0 0.005 0.0129 0.0151 0.0011 0.0034 0 0.0013 0.0016 0.0112 0.0008
Lipid Particles 0.0239 0.0042 0.002 0.0115 0.0097 0.001 0.0187 0 0.0078 0.0742 0.0157 0.0092 0.009 0 0.0021 0.007 0.0389 0.0043
Mitochondria 0.0193 0.0011 0.0094 0.0453 0.0401 0.0058 0.0126 0.0012 0.0081 0.0063 0.055 0.001 0.0055 0.0003 0.0077 0.0041 0.0159 0.0075
None 0.0052 0.0061 0.0003 0.0006 0.0004 0.0002 0.0053 0.0001 0.011 0.0137 0.0052 0.0001 0.0062 0.0028 0.005 0.0003 0.0101 0.0011
Nuclear Periphery 0.0386 0.0193 0.0132 0.0124 0.0032 0.0023 0.0108 0.0064 0.0044 0.0043 0.0268 0.0056 0.022 0.0076 0.0058 0.0067 0.0194 0.0031
Nucleolus 0.0328 0.0087 0.0134 0.0218 0.0175 0.0293 0.0095 0.0087 0.0052 0.0116 0.0094 0.0148 0.0094 0.0064 0.0076 0.0075 0.0217 0.0144
Nucleus 0.7536 0.9343 0.8947 0.7969 0.8887 0.9271 0.8188 0.9809 0.9203 0.7014 0.5368 0.9557 0.8609 0.9721 0.9288 0.9316 0.7162 0.9469
Peroxisomes 0.0093 0.0004 0.0004 0.0126 0.0068 0.0005 0.0152 0 0.0048 0.0137 0.0229 0.0016 0.0039 0 0.0053 0.0185 0.0058 0.0011
Punctate Nuclear 0.0204 0.0196 0.0229 0.0024 0.004 0.017 0.0174 0.0009 0.0061 0.0041 0.0881 0.0047 0.0233 0.0022 0.0108 0.0018 0.052 0.0139
Vacuole 0.0122 0.0003 0.0055 0.0136 0.0005 0.0009 0.0038 0.0002 0.0003 0.0174 0.0076 0.0002 0.0034 0.0005 0.0004 0.0015 0.0079 0.0003
Vacuole Periphery 0.0059 0.0002 0.003 0.005 0.0008 0.0005 0.0018 0.0002 0.0002 0.0016 0.0042 0.0005 0.0024 0.0002 0.0004 0.0008 0.0058 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.1569 7.2323 6.6052 7.4362 9.2792 5.5979 8.8595 7.7829 6.2426 8.801
Translational Efficiency 1.4499 1.4759 1.5686 1.3967 1.2039 1.8893 1.051 1.2149 1.5469 1.3726

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1608 1055 200 1379 1460 963 1518 418 3068 2018 1718 1797

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 616.92 712.75 1033.55 871.34 744.75 755.64 910.46 912.68 677.75 733.22 924.79 880.96
Standard Deviation 83.98 106.22 114.07 121.08 85.44 94.98 106.27 118.69 106.05 103.26 114.24 121.79
Intensity Change Log 2 — 0.208313 0.744453 0.498152 — 0.020943 0.289839 0.293353 — 0.108858 0.513659 0.389755

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000033 0.000546 0.002238 0.000887 0.000065 0.000425 0.000470 0.001409 0.000049 0.000488 0.000676 0.001009
Bud Neck 0.001996 0.007236 0.005027 0.021034 0.001284 0.004146 0.005109 0.012053 0.001657 0.005761 0.005099 0.018945
Bud Site 0.000602 0.002016 0.002053 0.009271 0.000477 0.002049 0.001121 0.012483 0.000542 0.002032 0.001230 0.010018
Cell Periphery 0.000195 0.000161 0.000166 0.000151 0.000065 0.000259 0.000070 0.000139 0.000133 0.000208 0.000081 0.000148
Cytoplasm 0.105241 0.067546 0.018737 0.024247 0.062306 0.038213 0.019251 0.024701 0.084809 0.053548 0.019191 0.024353
Cytoplasmic Foci 0.008728 0.014843 0.001881 0.004593 0.009247 0.008976 0.000457 0.003843 0.008975 0.012043 0.000622 0.004419
Eisosomes 0.000021 0.000043 0.000088 0.000027 0.000017 0.000039 0.000023 0.000030 0.000019 0.000041 0.000030 0.000028
Endoplasmic Reticulum 0.000668 0.005481 0.023231 0.008157 0.001475 0.003537 0.005460 0.009080 0.001052 0.004553 0.007529 0.008372
Endosome 0.000358 0.002289 0.001464 0.002935 0.000551 0.005730 0.000439 0.004040 0.000450 0.003931 0.000558 0.003192
Golgi 0.000104 0.001664 0.000184 0.002592 0.000133 0.002252 0.000062 0.006956 0.000118 0.001945 0.000077 0.003607
Lipid Particles 0.001593 0.005005 0.001777 0.001003 0.001729 0.003426 0.000326 0.000798 0.001657 0.004251 0.000495 0.000955
Mitochondria 0.001013 0.007429 0.001196 0.003812 0.000569 0.008426 0.000961 0.005524 0.000802 0.007905 0.000989 0.004210
Mitotic Spindle 0.000339 0.006623 0.000423 0.029180 0.000635 0.005845 0.001806 0.030990 0.000480 0.006252 0.001645 0.029601
None 0.032865 0.017966 0.001648 0.007537 0.006751 0.006587 0.004439 0.007816 0.020438 0.012536 0.004114 0.007602
Nuclear Periphery 0.000840 0.003178 0.002319 0.002641 0.002340 0.002844 0.001352 0.002110 0.001553 0.003019 0.001465 0.002518
Nuclear Periphery Foci 0.000249 0.002346 0.002500 0.000971 0.000792 0.000918 0.000365 0.001263 0.000507 0.001664 0.000613 0.001039
Nucleolus 0.005151 0.013761 0.007536 0.002724 0.003683 0.010127 0.004131 0.002819 0.004452 0.012027 0.004527 0.002746
Nucleus 0.838511 0.831556 0.907506 0.864823 0.905403 0.886464 0.949831 0.862179 0.870344 0.857759 0.944904 0.864208
Peroxisomes 0.000432 0.004210 0.000653 0.000308 0.000857 0.002454 0.000195 0.000389 0.000634 0.003372 0.000248 0.000327
Vacuole 0.000866 0.005027 0.019080 0.011232 0.001464 0.006291 0.004019 0.010611 0.001151 0.005630 0.005772 0.011088
Vacuole Periphery 0.000195 0.001072 0.000294 0.001873 0.000159 0.000992 0.000114 0.000768 0.000178 0.001034 0.000135 0.001616

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.40 -12.48 -13.21 -4.26 6.96 -1.84 -18.00 -6.63 -4.16 -4.32 -4.60 -20.65 -14.12 -5.63 -4.08
Bud Neck -5.74 -7.04 -13.22 -9.16 -10.11 -3.78 -13.64 -10.71 -8.49 -7.24 -6.85 -12.60 -16.31 -12.25 -11.76
Bud Site -3.97 -5.91 -5.80 -4.19 -3.34 -2.93 -3.77 -3.51 -2.81 -2.98 -4.79 -4.65 -6.84 -5.06 -5.37
Cell Periphery 0.80 -0.49 1.56 1.42 3.20 -1.23 -1.69 -4.25 0.79 -3.56 -0.98 2.11 -0.19 0.95 -4.47
Cytoplasm 6.16 11.99 17.67 10.23 -0.38 5.22 11.70 10.42 4.74 0.14 7.98 20.20 20.24 10.78 -0.86
Cytoplasmic Foci -3.69 6.84 6.30 7.87 -0.55 -0.27 7.35 5.29 5.29 -1.58 -2.91 11.75 7.75 9.17 -2.88
Eisosomes -7.38 -9.69 -7.43 2.65 7.83 -2.15 -6.75 -9.27 -1.03 -5.58 -4.58 -9.72 -12.28 0.46 -0.86
Endoplasmic Reticulum -7.83 -14.37 -24.63 -6.57 8.41 -4.36 -18.47 -11.48 -9.04 -6.07 -8.94 -23.06 -25.68 -12.15 -4.01
Endosome -5.41 -6.08 -4.71 1.07 0.33 -4.00 -0.99 -2.89 2.14 -2.76 -5.42 -3.64 -5.50 2.73 -4.45
Golgi -2.22 -3.49 -2.29 0.56 -2.02 -3.37 1.12 -1.46 -0.18 -1.49 -3.86 0.76 -2.62 0.60 -2.66
Lipid Particles -4.23 -1.01 1.83 5.91 4.59 -3.44 5.65 2.27 4.82 -2.48 -5.40 4.31 2.96 7.71 -1.72
Mitochondria -5.59 -1.07 -3.70 3.47 -3.75 -4.79 -9.22 -3.38 2.15 -2.77 -7.19 -2.26 -5.46 4.13 -4.90
Mitotic Spindle -3.55 -1.36 -7.62 -4.97 -7.50 -3.18 -3.97 -4.11 -2.87 -3.56 -4.76 -4.47 -8.64 -5.82 -7.46
None 4.54 12.03 10.21 5.41 -5.13 0.17 2.21 0.68 0.56 -1.62 4.29 10.76 9.44 5.07 -2.34
Nuclear Periphery -6.45 -7.21 -14.07 -1.89 -4.20 -0.93 0.46 -3.53 -2.08 -4.75 -4.55 -3.51 -10.22 -2.90 -8.40
Nuclear Periphery Foci -4.86 -4.62 -4.44 3.01 3.15 -0.58 0.47 -1.57 -1.34 -1.91 -4.27 -1.98 -3.00 1.60 -1.61
Nucleolus -7.00 -1.64 3.34 8.66 3.43 -5.98 -1.07 0.29 5.88 1.16 -9.19 -0.11 2.64 10.35 1.88
Nucleus 1.30 -3.83 -3.30 -4.15 1.46 2.56 -5.78 4.30 2.19 7.30 2.58 -12.46 1.08 -1.38 11.45
Peroxisomes -5.23 -1.69 2.09 5.59 5.87 -3.42 2.05 1.35 5.19 -1.71 -6.25 2.43 2.28 7.44 -0.51
Vacuole -5.98 -7.31 -10.13 -5.95 3.14 -3.49 -7.87 -6.96 -5.33 -4.90 -6.38 -10.72 -12.16 -7.81 -4.74
Vacuole Periphery -2.69 -2.07 -2.33 0.31 -1.86 -4.03 0.55 -2.13 2.43 -2.64 -4.37 0.50 -2.63 0.73 -2.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
Localization
Cell Percentages nucleus (92%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Cef1

Cef1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cef1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available