Standard name
Human Ortholog
Description Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.06 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.41 0.46 0.61 0.66 0.71 0.65 0.61 0.58 0.44 0.41 0.38 0.35 0.45 0.59 0.63 0.2 0.22 0.18 0.32 0.31 0.37 0.34 0.29 0.37
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0.06 0.06 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.27 0.24 0 0.05 0 0.2 0.2 0.2 0.49 0.51 0.59 0.37 0.25 0 0 0.06 0.05 0.06 0.06 0.05 0.05 0.09 0.13 0.07
Nucleus 0.28 0.29 0.33 0.29 0.21 0.18 0.22 0.23 0.25 0.26 0.22 0.35 0.3 0.2 0.2 0.53 0.43 0.55 0.3 0.31 0.27 0.15 0.16 0.17
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.06 0 0 0.05
Vac/Vac Membrane 0.16 0.15 0 0 0 0 0 0 0 0 0 0 0.08 0.14 0.13 0.23 0.3 0.23 0.15 0.21 0.18 0.3 0.27 0.24
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 2 2
Bud 0 0 2 1 0 2 5 3 10 14 14 3 0 0 0 0 0 0 3 4 5 2 8 9
Bud Neck 0 0 18 9 36 18 30 16 12 7 2 16 0 1 0 0 1 0 0 1 1 0 1 5
Bud Site 0 0 0 0 1 1 6 3 11 7 6 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 5 1 1 0 2 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0
Cytoplasm 95 66 188 254 351 339 423 310 251 250 211 172 48 147 135 60 40 32 86 55 140 43 91 126
Endoplasmic Reticulum 1 0 0 0 1 0 0 0 1 0 0 2 1 0 0 8 10 7 1 1 1 2 4 0
Endosome 2 0 0 0 1 0 0 1 0 0 0 1 1 15 5 17 10 11 7 1 1 0 3 4
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 4 2 2 0 0 0 0 1 3
Mitochondria 62 35 5 19 13 105 140 106 281 309 328 182 26 7 9 18 9 10 17 8 18 11 41 24
Nucleus 65 42 102 112 102 96 156 125 144 157 123 170 32 51 44 155 77 96 83 54 102 19 51 56
Nuclear Periphery 1 0 0 0 0 1 0 0 1 1 0 1 0 0 0 0 0 0 3 0 0 0 0 1
Nucleolus 2 0 0 1 0 1 0 0 0 2 2 1 2 6 2 1 0 0 4 0 0 1 2 3
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 4 0 4 5 12 10 19 20 11 7 3 15 1 7 5 1 1 2 18 5 21 4 11 15
Vac/Vac Membrane 36 21 5 3 17 12 20 16 11 13 17 17 8 36 28 68 54 41 41 38 70 39 86 80
Unique Cell Count 232 144 306 382 493 524 694 533 574 607 556 490 106 251 215 293 181 176 275 178 383 129 315 341
Labelled Cell Count 269 164 331 405 537 585 801 600 734 768 706 584 119 270 228 332 204 201 275 178 383 129 315 341


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.9 3.7 4.6 4.1 4.7 3.6 3.8 4.2 3.4 3.4 3.2 3.8 4.1 4.2 4.1 6.4 6.7 6.9 3.9 4.0 4.3
Std Deviation (1e-4) 0.5 0.7 0.6 0.7 0.9 0.9 0.9 0.8 1.1 1.0 0.9 1.0 1.3 1.1 0.8 1.5 1.8 1.8 1.1 0.9 1.2
Intensity Change (Log2) – – – -0.17 0.02 -0.35 -0.27 -0.15 -0.44 -0.45 -0.52 -0.27 -0.16 -0.12 -0.19 0.48 0.54 0.58 -0.24 -0.21 -0.11

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 8.1 9.2 7.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2373 -0.4076 -0.8385 -0.4886 -0.4848 -0.5713 -0.6411 -0.4307 -0.7756 -0.4685 -0.4967 -0.5578 -0.2684 -0.4089 -0.6448 -0.6589 -0.573 -0.3246
Actin 0.0389 0.0018 0.0055 0.0095 0.0696 0.005 0.0233 0.0002 0.0059 0.0028 0.0079 0.0035 0.1072 0.0003 0.0001 0.0593 0.0014 0.0058
Bud 0.001 0.0008 0.0002 0.0002 0.0005 0.0006 0.0006 0.0001 0.0005 0.0014 0.0014 0.0005 0.0007 0.0001 0.0002 0.0003 0.0003 0.0001
Bud Neck 0.0047 0.0005 0.0023 0.0008 0.0017 0.0058 0.0031 0.0005 0.0007 0.0015 0.0015 0.0023 0.0048 0.0005 0.0006 0.0032 0.0004 0.0025
Bud Periphery 0.0018 0.0007 0.0002 0.0002 0.0006 0.0008 0.001 0 0.0006 0.0011 0.0015 0.0013 0.0009 0.0001 0.0001 0.0002 0.0005 0.0002
Bud Site 0.0097 0.0043 0.0011 0.0004 0.0011 0.0008 0.0131 0.0009 0.0016 0.0047 0.0022 0.0003 0.0074 0.0021 0.0005 0.0007 0.0011 0.0002
Cell Periphery 0.0013 0.0001 0.0001 0 0.0002 0.0002 0.0003 0 0.0001 0.0002 0.0002 0.0001 0.0005 0.0001 0 0.0001 0.0003 0.0001
Cytoplasm 0.0798 0.0695 0.0878 0.0405 0.0471 0.06 0.0812 0.0834 0.0895 0.0756 0.0512 0.0579 0.1143 0.1088 0.1152 0.0978 0.1626 0.1134
Cytoplasmic Foci 0.0376 0.0083 0.0073 0.0112 0.0368 0.0057 0.0398 0.0104 0.004 0.0262 0.0271 0.0115 0.0329 0.0037 0.0128 0.0045 0.0049 0.0044
Eisosomes 0.0008 0.0001 0.0001 0.0001 0.0002 0 0.0003 0 0.0001 0.0001 0.0001 0.0001 0.001 0 0 0.0002 0.0002 0.0001
Endoplasmic Reticulum 0.0226 0.0052 0.0032 0.0007 0.0021 0.0034 0.0059 0.0024 0.0045 0.0027 0.0026 0.0016 0.012 0.0083 0.0027 0.0012 0.0017 0.0053
Endosome 0.0429 0.0078 0.0168 0.0072 0.0655 0.0121 0.0345 0.0078 0.0062 0.0456 0.0463 0.0058 0.0281 0.004 0.004 0.0017 0.0467 0.0066
Golgi 0.0101 0.0013 0.0048 0.0145 0.03 0.0028 0.0093 0.0002 0.0016 0.027 0.046 0.0033 0.0124 0.0001 0.0002 0.0022 0.0133 0.0025
Lipid Particles 0.0173 0.001 0.0015 0.0051 0.0178 0.0031 0.0294 0.0007 0.0016 0.0157 0.0302 0.0065 0.0176 0.0015 0.0007 0.0009 0.0189 0.0087
Mitochondria 0.0266 0.0014 0.0174 0.0024 0.0097 0.0052 0.0141 0.0004 0.0081 0.0243 0.0692 0.0211 0.0047 0.0005 0.0003 0.0009 0.0334 0.0061
None 0.1339 0.2106 0.2343 0.2619 0.2473 0.0988 0.0678 0.0665 0.1309 0.1365 0.1312 0.0912 0.163 0.088 0.235 0.2009 0.1137 0.111
Nuclear Periphery 0.0479 0.0357 0.0271 0.0077 0.03 0.0104 0.0311 0.0307 0.0369 0.0168 0.0227 0.0165 0.0328 0.0238 0.0167 0.0067 0.0038 0.0218
Nucleolus 0.0055 0.0069 0.0088 0.0047 0.0054 0.0204 0.0053 0.0096 0.0068 0.0041 0.0045 0.0117 0.0057 0.0044 0.0047 0.0023 0.0023 0.0064
Nucleus 0.4211 0.6129 0.5289 0.5787 0.3948 0.7177 0.5857 0.738 0.6506 0.5797 0.4843 0.7323 0.3964 0.7107 0.5316 0.6039 0.5722 0.6609
Peroxisomes 0.0236 0.0015 0.0026 0.0033 0.0116 0.0011 0.0244 0.0001 0.0004 0.0065 0.0142 0.0012 0.0139 0.0001 0.0002 0.0013 0.0012 0.0085
Punctate Nuclear 0.063 0.0248 0.0462 0.0505 0.017 0.0383 0.0215 0.0445 0.0458 0.0218 0.0518 0.0289 0.0361 0.0401 0.072 0.0108 0.0022 0.0338
Vacuole 0.0061 0.0038 0.0026 0.0004 0.0073 0.0062 0.006 0.0031 0.0025 0.0042 0.0025 0.0019 0.0059 0.0021 0.0018 0.0008 0.0099 0.0012
Vacuole Periphery 0.0037 0.001 0.0012 0.0002 0.0036 0.0015 0.0024 0.0005 0.0009 0.0015 0.0013 0.0007 0.0017 0.0006 0.0004 0.0002 0.0091 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.6957 11.8612 10.5618 9.751 6.8813 11.1393 7.4356 10.5227 11.4925 10.4966
Translational Efficiency 0.8834 0.3686 0.5407 0.6955 0.6992 0.511 0.7398 0.561 0.6654 0.5831

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1724 545 195 824 1026 510 60 1211 2750 1055 255 2035

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 628.28 750.02 953.21 773.45 674.35 726.08 949.84 785.78 645.47 738.45 952.42 780.79
Standard Deviation 64.92 106.57 101.99 111.87 81.05 90.43 94.04 108.60 74.77 99.82 100.19 110.11
Intensity Change Log 2 — 0.255521 0.601386 0.299900 — 0.106631 0.494187 0.220628 — 0.180363 0.546886 0.259406

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000073 0.000544 0.001892 0.000690 0.000083 0.000495 0.000640 0.000622 0.000076 0.000521 0.001597 0.000649
Bud Neck 0.014116 0.014978 0.008149 0.006865 0.002720 0.026889 0.002146 0.008257 0.009865 0.020736 0.006737 0.007693
Bud Site 0.003593 0.008887 0.003234 0.018350 0.001055 0.014386 0.000901 0.022862 0.002646 0.011545 0.002685 0.021035
Cell Periphery 0.000182 0.000163 0.000202 0.002672 0.000172 0.000295 0.000190 0.000289 0.000178 0.000227 0.000199 0.001254
Cytoplasm 0.433848 0.335221 0.046514 0.294134 0.394831 0.293162 0.084958 0.277684 0.419291 0.314889 0.055560 0.284345
Cytoplasmic Foci 0.158765 0.147883 0.002053 0.030049 0.105149 0.212263 0.022401 0.010725 0.138762 0.179005 0.006840 0.018549
Eisosomes 0.000143 0.000093 0.000088 0.003476 0.000072 0.000169 0.000112 0.000050 0.000116 0.000130 0.000094 0.001437
Endoplasmic Reticulum 0.000561 0.001586 0.017560 0.002577 0.001169 0.001249 0.006998 0.003800 0.000788 0.001423 0.015075 0.003305
Endosome 0.005099 0.010135 0.002308 0.005290 0.003818 0.016118 0.002417 0.008222 0.004621 0.013027 0.002334 0.007035
Golgi 0.001349 0.002284 0.000141 0.001298 0.000509 0.003859 0.000082 0.008071 0.001036 0.003045 0.000127 0.005329
Lipid Particles 0.008667 0.006282 0.002290 0.004485 0.005591 0.011199 0.003299 0.000906 0.007519 0.008659 0.002528 0.002355
Mitochondria 0.005645 0.011048 0.002455 0.002250 0.001641 0.013752 0.000552 0.005539 0.004152 0.012355 0.002007 0.004208
Mitotic Spindle 0.001491 0.013002 0.004735 0.008099 0.001914 0.004398 0.000133 0.034939 0.001649 0.008842 0.003652 0.024071
None 0.010260 0.006222 0.003538 0.019275 0.011351 0.004872 0.004370 0.011201 0.010667 0.005570 0.003734 0.014470
Nuclear Periphery 0.000789 0.001122 0.002433 0.001438 0.000741 0.000655 0.001405 0.001841 0.000771 0.000896 0.002191 0.001678
Nuclear Periphery Foci 0.000771 0.000665 0.001312 0.002352 0.000889 0.000539 0.000976 0.000663 0.000815 0.000604 0.001233 0.001347
Nucleolus 0.002660 0.002814 0.003578 0.001895 0.002794 0.003938 0.001931 0.001473 0.002710 0.003357 0.003190 0.001644
Nucleus 0.327390 0.384097 0.857105 0.560111 0.444568 0.326814 0.820582 0.553002 0.371108 0.356406 0.848512 0.555881
Peroxisomes 0.004078 0.011104 0.001154 0.002145 0.001762 0.018943 0.000465 0.000534 0.003214 0.014893 0.000992 0.001187
Vacuole 0.019918 0.040013 0.038932 0.030189 0.018577 0.044601 0.045299 0.046522 0.019418 0.042230 0.040430 0.039909
Vacuole Periphery 0.000601 0.001857 0.000328 0.002360 0.000594 0.001407 0.000143 0.002798 0.000598 0.001640 0.000284 0.002621

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.38 -6.15 -3.80 -0.98 4.12 -2.82 -4.83 -7.64 -1.02 1.50 -3.58 -6.63 -7.13 -1.34 4.61
Bud Neck -0.70 0.92 3.61 3.28 2.22 -7.54 -0.96 -7.95 4.97 -4.13 -5.56 -0.40 0.12 5.82 0.53
Bud Site -2.56 -1.98 -3.34 -1.45 -2.60 -3.79 -1.62 -6.74 -0.31 -5.52 -4.40 -2.88 -6.73 -1.32 -5.17
Cell Periphery 1.12 -2.94 -4.44 -4.51 -4.22 -2.10 -0.79 -0.53 1.51 0.14 -1.59 -3.04 -4.42 -3.93 -3.94
Cytoplasm 7.96 43.28 20.11 7.43 -17.42 6.85 16.24 14.91 5.30 -7.81 11.06 44.31 26.15 9.16 -20.44
Cytoplasmic Foci 1.30 35.19 28.83 15.42 -8.06 -9.99 12.25 20.23 21.68 1.54 -5.49 36.99 36.47 26.31 -3.96
Eisosomes 5.43 2.17 -4.05 -4.17 -4.11 -9.92 -3.12 1.54 10.33 3.52 -2.12 -0.62 -3.90 -3.81 -3.86
Endoplasmic Reticulum -3.43 -12.93 -12.36 -8.00 9.27 -0.22 -5.81 -11.59 -10.55 3.03 -3.19 -13.61 -17.90 -12.76 9.79
Endosome -3.95 3.81 1.22 4.20 -0.94 -5.99 0.42 -0.50 5.31 -0.69 -6.99 3.51 0.71 6.70 -1.49
Golgi -1.29 4.40 1.76 2.30 -2.16 -3.28 2.39 -2.31 0.35 -2.67 -3.25 4.90 -1.64 0.80 -2.90
Lipid Particles 2.25 7.24 6.47 4.10 -0.50 -3.41 1.51 6.75 6.75 3.11 -1.32 7.16 10.10 8.23 2.85
Mitochondria -1.67 2.29 3.42 3.13 1.11 -3.44 2.14 -1.87 2.91 -3.50 -3.45 2.15 1.78 4.15 -0.51
Mitotic Spindle -2.94 -1.90 -4.53 -0.26 -1.33 -0.96 0.76 -7.66 -6.40 -8.05 -3.03 -1.78 -8.91 -5.02 -5.26
None 2.93 6.91 -1.08 -2.84 -4.64 3.98 4.12 1.84 -3.10 -3.23 5.03 8.13 0.51 -3.89 -6.50
Nuclear Periphery -1.69 -6.62 -9.15 -9.30 -0.12 1.14 -4.89 -16.70 -16.97 -4.21 -1.08 -7.79 -14.92 -17.55 -1.11
Nuclear Periphery Foci 0.18 -2.13 -2.22 -2.36 -1.52 2.37 -1.75 -2.12 -2.83 -0.43 0.85 -2.84 -2.96 -3.50 -1.54
Nucleolus 0.27 -0.02 1.27 1.08 1.14 0.16 2.47 0.45 0.26 -2.32 0.18 0.91 0.82 0.62 -0.16
Nucleus -3.79 -28.54 -19.84 -11.07 12.10 6.79 -8.26 -10.08 -15.60 4.69 1.17 -26.92 -23.18 -18.70 13.18
Peroxisomes -3.22 2.89 5.62 4.62 0.16 -7.87 3.98 4.11 8.69 0.37 -7.57 2.97 8.23 9.38 0.60
Vacuole -6.32 -5.19 -11.84 -6.72 -1.88 -6.54 -3.40 -14.80 -7.58 0.61 -9.12 -6.18 -19.08 -10.17 -1.13
Vacuole Periphery -1.42 2.86 -0.87 0.43 -1.17 -2.62 1.68 -1.39 0.32 -2.60 -2.22 2.58 -1.62 0.55 -2.34
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (19%), nucleus (14%), mixed (42%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Mre11

Mre11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mre11-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available